Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes...
-
Upload
marjory-arnold -
Category
Documents
-
view
216 -
download
4
Transcript of Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes...
![Page 1: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/1.jpg)
Precocious “AGE’ing” in Diabetes
Precocious “AGE’ing” Effect of Type 1 Diabetes
Background
• T1DM increases formation of advanced glycation end products (AGEs)- AGEs accumulate in tissues over time- Tissue burden is a function of chronologic age
• AGES are implicated in the development and progression of diabetes complications
![Page 2: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/2.jpg)
Precocious “AGE’ing” in Diabetes
Objectives
•To examine the relationship between chronologic age and T1DM on skin AGEs in children
•Assess accumulated skin AGEs estimated from SIF 405c/420c data in diabetic children versus non-diabetic subjects
![Page 3: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/3.jpg)
Precocious “AGE’ing” in Diabetes
• Study included:
• Children with T1DM (n=133; mean age 13 years )
• Children with T2DM (n=20; mean age 15 years)
• Healthy children (n=91; mean age 10 years)
• Healthy adults (n=129; mean age 40 years)
• Mean duration of T1DM was 6 years and T2DM was 4 years
• Current and former smokers were excluded
• Skin AGEs were estimated by measuring skin intrinsic fluorescence (SIF)
Patients and Methods
![Page 4: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/4.jpg)
Precocious “AGE’ing” in Diabetes
Results
•When adjusted for chronologic age, SIF 420c was higher in children with T1DM and T2DM versus children without diabetes (p<0.05)
•In subjects without diabetes, SIF 420c increased with chronologic age
•43% of children with T1DM and 55% with T2DM had SIF values comparable to adults without diabetes
•Skin AGEs were associated with HbA1c but not with mean blood glucose levels
![Page 5: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/5.jpg)
Precocious “AGE’ing” in Diabetes
SIF 420c
![Page 6: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/6.jpg)
Precocious “AGE’ing” in Diabetes
Relationship of Chronologic Age with SIF 420c
![Page 7: Precocious “AGE’ing” in Diabetes Precocious “AGE’ing” Effect of Type 1 Diabetes Background T1DM increases formation of advanced glycation end products.](https://reader036.fdocuments.in/reader036/viewer/2022072014/56649e995503460f94b9c55b/html5/thumbnails/7.jpg)
Precocious “AGE’ing” in Diabetes
Conclusions
• Many children with T1DM and T2DM have estimated skin AGE levels comparable to those that would be naturally observed only in adults 20 to 40 years of age
• Diabetes duration of 4 to 6 years is comparable to about 30 years of chronologic aging
• Investigators speculated that factors predisposing to precocious accumulation of skin AGEs may predispose patients to precocious development of diabetes complications