Precision Medicine - Center for Cancer Research · Precision Medicine: Report of the Surgeon...
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1 Precision Medicine
Transcript of Precision Medicine - Center for Cancer Research · Precision Medicine: Report of the Surgeon...
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Precision Medicine
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Disease classification
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Research strategy
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Information commons
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Lung cancer
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Geographical map
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Smoke exposure
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Never smokers
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Worldwide cancers
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Early stage lung cancer
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Exposome
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p53
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Chronic inflammation and infection
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Pro-inflammatory cytokines
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IL-6 and IL-8
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Genome
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Chemical agents
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TP53 mutations
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Mutational processes
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NSCLC evolution
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TP53 mutations
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Patient prognosis
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Transcriptome
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MicroRNA
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microRNA mechanisms
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Hypothesis
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Upregulated microRNA
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Increased miR-21 expression
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miR-21 expression
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Cancer biomarkers
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microRNA secretion
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4-gene classifier
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Meta-Analysis
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Mechanistic cancer bimarkers
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miR-21 and 4 coding genes
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Non-coding RNA
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Proof of Principle
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Epigenome
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DNA methylation
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Prognostic epigenetic signature
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Survival curve
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Metabolome
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Tumor metabolism
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Urinalysis
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Survival curve
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Creatine ribose
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Lung cancer risk
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Creatine riboside and NANA
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Lung cancer screening
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Spiral CT scans
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Low dose CT
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Unmet needs
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Precision medicine goals
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Coworkers and collaborators
