pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Featured Research from universities, journals, and other organizations

Date:

Source:

Summary:

November 10, 2014

Boston University Medical Center

It is possible to distinguish between different hemorrhagic fevers,including Marburg (Ebola cousin) and Lassa before the person becomessymptomatic, new research has found. This study will allow for thedevelopment of better diagnostics, especially during the early stages ofdisease, when treatments have a greater chance of being effective.

Share This

ARelated Articles

new study has found it is possible to distinguish between differenthemorrhagic fevers, including Marburg (Ebola cousin) and Lassabefore the person becomes symptomatic.

The study, which appears in the journal BMCGenomics will allow for the development of betterdiagnostics, especially during the early stages ofdisease, when treatments have a greater chance ofbeing effective.

Hemorrhagic fevers include Lassa, which is endemic inWestern Africa and Marburg, which causes sporadicoutbreaks in Africa associated with high rates ofmortality. The early symptoms of these viruses (fever,flu-like symptoms) are not unique, making it difficult todiagnose properly. More disease-specific symptoms

Related Topics

Health & Medicine

Plants & Animals

Pre-symptomatic markers for hemorrhagic viruses like Ebola identified

Save/Print: Share:

Breaking News:Baby Photos of a Scaled-Up Solar System

Related Stories

Bats Are Reservoir for Ebola Virus inBangladeshJan. 16, 2013 Ebola virus antibodies werecirculating in ~4% of the 276 bats scientistsscreened in ... full story

Scientists Identify Protective Role for

Email to a friend Facebook Twitter LinkedIn Google+ Print this page

EbolaPandemicErikson's stages ofpsychosocialdevelopment

Stem cell treatmentsVaccinationYellow fever

EbolaVirusesInfectious Diseases

VirologyMicrobes and MoreBird Flu Research

Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins

Mobile: iPhone Android Web Follow: Facebook Twitter Google+ Subscribe: RSS Feeds Email Newsletters HEALTH PHYSICAL/TECH ENVIRONMENT SearchEnter keyword or phrase ...QUIRKYSOCIETY/EDUCATION

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

and the ability to spread the virus from person toperson, do not begin until virus has accumulated in theblood. Current diagnostics detect the virus after it spillsout of primary sites of infection into the blood. The ability to identify the infection priorto this point would significantly aid early intervention and containment, and couldimprove outcomes.

Researchers from Boston University School of Medicine (BUSM) approached thediagnostic dilemma by trying to "see" infection prior to the point where viruses enterthe blood stream. Collaborating with researchers at the U.S. Army Medical researchInstitute (USAMRIID), they used two experimental models: one that had involved Lassavirus, and one that involved Marburg virus infection. The researchers extracted geneticmaterial (RNA) from a sample of white blood cells from each infection group at multipletimes after the models were infected. Using next-generation sequencing techniques,gene expression changes in hosts cells that "recognize" early stages of infection wereidentified. This was seen prior to clinical symptom onset and before the modelsbecame infectious.

According to the researchers, distinguishing between these viruses early can guidetreatment and containment efforts. "The ability to distinguish between different types ofinfection before the appearance of overt clinical symptoms has important implicationsfor guiding triage and containment during epidemics," explained corresponding authorNacho Caballero, a PhD candidate at Boston University School of Medicine (BUSM)."We hope that our study will help in the development of better diagnostics, especiallyduring the early stages of disease, when treatments have a greater chance of beingeffective," he added.

As exciting as the prospect of this testing is, the research team is setting a realistictime line. "We want to stress that this is not a finding that can be translated into a testtomorrow. This study supports the idea that early markers of infection are there, butsignificant work will still need to be done to extend these findings," said Caballero.

Story Source:

The above story is based on materials provided by Boston University MedicalCenter. Note: Materials may be edited for content and length.

Scientists Identify Protective Role forAntibodies in Ebola Vaccine StudyJan. 14, 2013 Researchers have found that anexperimental vaccine elicits antibodies that canprotect nonhuman primates from Ebola virusinfection. Ebola virus causes severe hemorrhagicfever in humans and ... full story

Scientists Question Designation of SomeEmerging DiseasesNov. 13, 2012 The Ebola, Marburg and Lassaviruses are commonly referred to as emergingdiseases, but leading scientists say these life-threatening viruses have been around for... full story

Small Molecules May Prevent EbolaInfectionJan. 19, 2011 Scientists report they'vediscovered small molecules that appear to bind tothe outer protein coat of the Ebola virus, possiblyblocking the virus from entering human cells. Thefinding may open ... full story

Experimental Marburg VaccinePrevents Disease Two DaysAfter InfectionJune 16, 2010 An experimentalvaccine developed to prevent

outbreaks of Marburg hemorrhagic fever continuesto show promise in monkeys as an emergencytreatment for accidental exposures to the virus thatcauses ... full story

Yellow fever

more related stories

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

MLA APA Chicago

Boston University Medical Center. "Pre-symptomatic markers for hemorrhagicviruses like Ebola identified." ScienceDaily. ScienceDaily, 10 November 2014..

Share This

Easy-to-Use InsulinPumpmyomnipod.com

The OmniPod - Reliable, Safe and Tubeless.Get Your Demo Kit Now!

Malware Removal

Journal Reference:

1. Ignacio S Caballero, Judy Y Yen, Lisa E Hensley, Anna N Honko, Arthur J Goff,John H Connor. Lassa and Marburg viruses elicit distinct host transcriptionalresponses early after infection. BMC Genomics, 2014; 15 (1): 960 DOI:10.1186/1471-2164-15-960

Cite This Page:

More From ScienceDaily

Strange & Offbeat Stories

Health & Medicine

Mind & Brain

Email to a friend Facebook Twitter LinkedIn Google+ Print this page

Body Weight Heavily Influenced by Gut Microbes:Genes Shape Body Weight by Affecting GutMicrobes

Images of a Nearly Invisible MouseAll Kidding Aside: Medical Clowns Calm ChildrenDuring Uncomfortable Allergy Test

Having a Y Chromosome Doesn't Affect Women'sResponse to Sexual Images, Brain Study Shows

The Female Nose Always Knows: Do WomenHave More Olfactory Neurons?

Ghost Illusion Created in the LabFor Leaders, Looking Intelligent Is Less ImportantThan Looking Healthy

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

More Health & Medicine News Monday, November 10, 2014

Featured Research from universities, journals, and other organizations

Featured Videos from AP, Reuters, AFP, and other news services

newer top stories | older top stories

In Other News

Living & Well

... from NewsDaily.com

Science News

Health News

Ancient DNA showsearliest Europeangenomes ...

Genesis of genitalia: Wehave one. Lizards ...

Rare 2.5-billion-year-oldrocks reveal hot ...

New bioenergeticorganelle found in plants

Seeing dinosaur feathersin a new light

Massive geographicchange may havetriggered ...

Synthetic biology forspace exploration

Origin of the uniqueventilatory apparatus of...

New Target for BloodCancer TreatmentDiscoveredNov. 10, 2014 A therapeutictarget that could lead to the

development of new treatments for specific bloodcancers has been identified by researchers. Usinglaboratory models, they found that 'switching off' half... full story

Hypertension; Blood Clots; Anemia; Lymphoma

New Target for Blood Cancer Treatment DiscoveredStatins Reverse Some Learning Disabilities?Thousands of Newly Found Human Genome VariationsBirthweight Charts Aimed at Ethnic Groups NeededClassification of Mutations in a Cancer May Help'Darting' Mice May Hold Clues to Neuro DiseasesCombo Therapy for Quicker Eradication of Hep CFirst Steps in Formation of Pancreatic CancerBrown Fat: Fighting Type 2 Diabetes and ObesityModerate Drinking: Healthy Only for Some?

Than Looking HealthyDirect Brain Interface Between HumansThis Just In: Political Correctness Pumps UpProductivity on the Job

Neuroscience of Choking Under Pressure: NewInsight

Election Day: The Saddest Day of the Year?Dance Choreography Improves Girls'Computational Skills

New Tech Aims to Improve CommunicationBetween Dogs, Humans

Liberal or Conservative? Reactions to Disgust Area Dead Giveaway

Prostate Cancer Risk Reduced by Sleeping WithMany Women, but Increased With Many Men,Study Finds

Robot 'dolphins' give clues to Antarctic melt indata revolution

Breakthrough Prizes in science, math earnwinners $3 million each

Three space station crewmen return safely toEarth in Kazakhstan

European comet mission gears up for tough probelanding

U.S. OKs genetically modified potato with lowercancer risk

Merck expects no writedowns for Zetia, Vytorincholesterol drugs

McDonald's recalls lollipop whistles over chokingconcerns

More bicyclists, many helmetless and drunk,dying

U.S. releases low 2015 Obamacare enrollment

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Free Subscriptions

Get the latest science news with ScienceDaily's freeemail newsletters, updated daily and weekly. Or viewhourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDailyvia social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- wewelcome both positive and negative comments.Have any problems using the site? Questions?

Find with keyword(s):

Search ScienceDaily Number of stories in archives: 140,361

Search

Enter a keyword or phrase to search ScienceDaily for related topicsand research stories.

Save/Print: Share:

Environment News

Technology News

About ScienceDaily | Editorial Staff | Awards & Reviews | Contribute | Advertise | Privacy Policy | Terms of Use

The Best Apps ForYoga Enthusiasts

Laundry DetergentPods Harmful To Kids,Poison Control Warns

Ambulance DroneProvides SpeedyTreatment for CardiacArrest

New York City MightBe Next To RelaxMarijuana Rules

forecastDendreon files for bankruptcy as cancer vaccinedisappoints

Early snow falls on northern U.S., cold sweepingsouth

5.8-magnitude earthquake strikes northern Chile:USGS

Japan raises chance of El Nino emerging in winterColdest air of the season set to blast 42 U.S.states: forecasters

Philippines remembers thousands killed a yearafter typhoon Haiyan

Obama pressures FCC for strong net neutralityrules

Exclusive: Fullscreen to buy online video producerRooster Teeth

U.S. Postal Service data breach maycompromise staff, customer details

Alibaba shopping festival sells $2 billion in firstone hour

Apple iOS bug makes most devices vulnerable toattack: researchers

Email Newsletters RSS Feeds

Facebook Twitter Google+

iPhone Android Web

Leave Feedback Contact Us

pdfcrowd.comopen in browser PRO version Are you a developer? Try out the HTML to PDF API

Copyright 2014 by ScienceDaily, LLC or by third-party sources, where indicated. All rights controlled by their respective owners.Content on this website is for informational purposes only. It is not intended to provide medical or other professional advice.

Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners.