Pre eclampsia complication /jordan uni of science and technology
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PRE-ECLAMPSIA DURING PREGNANCY Presented by :wesam telfah Supervised by :dr bayan obeidat
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my presentation is talking about preeclampsia and it complication during pregnancy
Transcript of Pre eclampsia complication /jordan uni of science and technology
PRE-ECLAMPSIA DURING PREGNANCY
Presented by :wesam telfahSupervised by :dr bayan obeidat
PRE-ECLAMPSIA :Definition :
a disorder associated with pregnancy consisting of hypertension, proteinuria and new-onset dependent oedema, most commonly after 20 weeks of gestation”
ECLAMPSIADefinition-
“pre eclampsia complicated with seizures”
The preeclampsia stages :
PREECLAMPSIA STAGES :
Altered placenta formation
Reduced utero placental blood
Fetal restriction growth Oxidative stress Inflamation Apoptosis Structural damage
Proteinuria elevated
Hypertyension Angio spasm in
brain Brain edema lead
to sever epileptic seizures -eclampsia
Stage 1 Stage 2
HELLP SYNDROME Undiagnosed pre-eclampsia progresses to
cause- HaemolysisElevated Liver enzymesLow Platelets
NORMAL PLACENTA VER UB NORMAL
MECHANISM OF PLACENTA DYSFUNCTION:
FEATURING :
Hypertension : systol > 140mmHgor 30mm above pre-preg diastolic > 90 mmHgor 15mm above pre-preg Two abnormal measurements, on two occasions,
more than 6 hours apart
Proteinuria :
Is defined as 300 mg/day
Sever form of PE is hemolysis = elevated in liver enzyme and low platelet syndrome =
( HELLP ) .
EPIDEMIOLOGY : Freq (US)
pre-eclampsia: 6-8% of pregnancies
eclampsia: 0.05-0.2%
COMPLICATIONS/PROGNOSIS Permanent neuro damage Renal insufficiency Abruption Death 25% of eclamptics will be so in future
pregnancies Increased risk of essential hypertension
MORTALITY/MORBIDITY Maternal: 8-36% most frequently related
to seizure activity
Foetal: 13-30% most frequently related to iatrogenic prematurity
INVESTIGATION : Hypertension Urinalysis- proteinuria greater than 3+ Blood tests CT head
SIGNS AND SYMPTOMS :
SYMPTOMS : Headache Oedema Visual disturbance Focal neurology, fits, anxiety, amnesia Abdominal pain low urine output Sensitivity of eye to bright light None
SIGNS : Hypertension Tachycardia and tachypnoea Creps or wheeze on auscultation Neurological deficit Hyperreflexia Petechiae, intracranial haemorrhage Generalised oedema Small uterus for dates
RISK FACTORS : Low socioeconomic class Multiple foetuses, or hydatid Maternal age <20 or >35yrs Gestational or pre-gestational DM Renal disease Family history- four times the risk Inadequate diet (vit C/E, Ca ,zink ,n-3
FA) Homocysteine Obesity and over wt
PE FREQ OVER AGE :
RISK FACTOR TO DEVELOPE OF PREECLAMPSIA WITH INSULIN RESISTANCE:Pre- pregnancy Pregnancy
Elevated serum insulin ,FFA ,TG
Genetic predisposition to HTN
Disrupted platelet function Hormonal and metabolic changed Renal disease
Nutritional status
OUTCOME OF EXISTENCE OF PE:Mother Newborn Early delivery by cesarean section
Growth restriction
Acute renal dysfunction Respiratory distress dysfunction
Increased risk of GD,HTN,DM T 2Rupture of placenta
POTENTIAL PREVENTION :
CALCIUM INFLUENCE :
DRUGS :
P dR E iE C eLA tM P SIA
NUTRITION INTERVENTION: 1000 mg calcium daily = normal blood vessel 600 mcg folate include 400 mcg folic acid Vit C & E (200mg,400 Iu) respectivly 5 or more serving veg & fruit Consumption of low glycemic index No restriction of sodium intake Moderate exersise
U-TUBE VIDEO ABOUT PREECLAMPSIA: http://www.youtube.com/watch?
v=wsS8rxA31jw http://www.youtube.com/watch?
v=xzw1jhOP5b0 http://www.youtube.com/watch?v=Ft-
_0Bj9NNs
ANY QUSTIONS ?
THANKS …….)
REFERENCES:
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