ppt of m.pharm

7/27/2019 ppt of m.pharm

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Presented by -

Kiran Dhakane,I Sem. M. Pharm.

Guided by-Mr. Kiran Bhusare,Dept.of Pharmacology,SBCOP, Aurangabad.

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CONTENTS

Introduction

Manufacture techniques

Mechanism

Usefulness

Literature surveys

Requirement

Marketed preparation 2


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INTRODUCTION Mouth Dissolving tablet are solid single unit dosage forms that

are placed in mouth , allowed to disperse or dissolve in saliva

without need of water for frequently release of drug for quick

onset of action.

Mouth dissolving tablet disappears rapidly before

swallowing.

Disintegrates in less than 3 minute.

Also called as fast dissolving tablet, orodispersible tablet, melt

in mouth tablet, repimelts tablet, porous tablet. 3


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ADVANTAGES OVER THE

CONVENTIONALDOSAGE FORM Convenient for administration and compliant.

Good mouth feel can achieve.

Rapid dissolution of drug and absorption which may

produce rapid, onset of action.

Ability to provide advantages of liquid medication in the form

of solid preparation.

Improved bioavailability by pregastric absorption. 4


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IDEAL REQUIREMENT

On oral administration its dissolve/ disperse/

disintegrate in mouth in few seconds without

necessitate of water.

Have a pleasing mouth feel.

Have an acceptable taste masking property .

Be harder and less friable.

Have physical and environmental stability.

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MANUFACTURE TECHNIQUES

Direct compression.

Spray drying.

Moulding.

Lyophiliation.

Sublimation.

Mass extrusion. Fig. Tablet compression machine

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MECHANISM OF MOUTH DISSOLVIG

TABLET

Swelling .

Wicking .

Deformation.

Particle Repulsive force.

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USEFULNESS For bed ridden and unco-operative patients

For gediatric and pediatric patient

For psychic patients

No need of water to swallow the tablet ,which is highlyconvenient feature for patients .

Who are traveling and do not have immediate access to water.

No risk of chocking or suffocation during oral administration.

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LITERATURE SURAVEY

Deebjit Bhowmik et al / (2009) Fast dissolvin tablet : anoverview.

Ganesh Kumar et al / (2010) formuliion and evaluation of

fast dissolving tablet ofchlopromazine hcl

Shailendra Kumar Singh et al / (2010) fast disintegrating

combination tablets of omeprazole and domperidone.

Susijit Sahoo et al / ( 2010) Fast Dissolving Tablet: As A

Potential Drug Delivery System

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Sr.

No.

Requirement Availability

1 Tablet Compression Machine Yes

2 UV -Visible Spectrophotometer Yes

3 Disintegration Test Apparatus Yes

4 Dissolution Test Apparatus Yes

5 Infra-red Spectrophotometer Yes

6 Hardness Tester Yes

7 Friability Test Apparatus Yes

REQUIREMENT FOR FORMULATION OF

MOUTH DISSOLVIG TABLET


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MARKETED PREPARTION

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SR.NO PRODUCT NAME CONTAIN MFG.NAME

1 Tab Almox 125 DT Amoxyilline Alkem

2 Tab Gudcef 100 Cefodoxime Proxetil Lifestar

3 Tab Vomikind MD 4 Ondansetron Mankind

4 Tab Domoperi 5 DT Domperidone Ipca

5 Tab Dolonex DT Piroxicam D Pfizer

6 Tab Nimos MD Nimusulide Mankind

7 Tab Zifi 100 DT Cifixime FDC

8 Tab Odoxil 125 DT Cefadoxil Lupine

9 Tab Disnee Nimusulide , Caffine Horizon

10 Tab Pacimol XP Paracetamol Ipca


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REFERNCE

1)Ganesh kumar Gudas et al/ Journal of PharmaceuticalScience and Technology, Vol.2(1), 2010, 99-102

2)International Journal of Pharmacy and Pharmaceutical

Sciences, Vol. 1, Supple 1, Nov.-Dec. 2009

3)Asian Journal of Pharmaceutical and Clinical Research Vol.2

Issue 3, July-September 2009

5) Susijit Sahoo et al. / Drug Invention Today 2010,2(2),130-133


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