Cell Division Meiosis Cell Division Meiosis Abnormal Meiosis.
PowerPoint Presentation - Meiosis · MEIOSIS CREATES GENETIC VARIATION During normal cell growth,...
Transcript of PowerPoint Presentation - Meiosis · MEIOSIS CREATES GENETIC VARIATION During normal cell growth,...
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SEXUAL REPRODUCTION
Fusion of two gametes to produce a single zygote.
Introduces greater genetic variation, allows genetic
recombination.
With exception of self-fertilizing organisms (e.g. some
plants), zygote has gametes from two different
parents.
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CHROMOSOMES
46 in all somatic cells (diploid)
23 in all sex cells (haploid)
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MEIOSIS
A REDUCTION DIVISION PROCESS
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HOMOLOGUES
Chromosomes exist in homologous pairs in diploid cells.
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Exception: Sex chromosomes (X, Y).
Other chromosomes are known as autosomes,
they have homologues.
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IN HUMANS …
23 chromosomes donated by each parent (total =
46 or 23 pairs).
Gametes (sperm/ova):
Contain 22 autosomes and 1 sex chromosome.
Are haploid (haploid number “n” = 23 in humans).
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IN HUMANS …
Fertilization/syngamy results in zygote with 2
haploid sets of chromosomes - now diploid.
Diploid cell; 2n = 46. (n=23 in humans)
Most cells in the body produced by mitosis.
Only gametes are produced by meiosis.
M E I O S I S K M 9
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CHROMOSOME NUMBERS
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All are even numbers –
diploid (2n) sets of
homologous
chromosomes!
Ploidy = number of
copies of each
chromosome.
Diploidy
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MEIOSIS 1
First division of meiosis
Prophase 1: Each chromosome duplicate's and remains closely associated. These are called sister chromatids. Crossing-over can occur during the latter part of this stage.
Metaphase 1: Homologous chromosomes align at the equatorial plate.
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CROSSING OVER
M E I O S I S K M 13
Chiasmata – sites of crossing
over, occur in synapsis.
Exchange of genetic material
between non-sister chromatids.
Crossing over produces
recombinant chromosomes.
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MEIOSIS 1
First division of meiosis
Anaphase 1: Homologous pairs separate with sister chromatids remaining together.
Telophase 1: Two daughter cells are formed with each daughter containing only one chromosome of the homologous pair.
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MEIOSIS II
Second division of meiosis: Gamete formation
Prophase 2: DNA does not replicate.
Metaphase 2: Chromosomes align at the
equatorial plate.
Anaphase 2: Centromeres divide and sister
chromatids migrate separately to each pole.
Telophase 2: Cell division is complete. Four
haploid daughter cells are obtained.
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ANIMATION
M E I O S I S K M 18
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INDEPENDENT ASSORTMENT
M E I O S I S K M 19
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INDEPENDENT ASSORTMENT
Number of combinations: 2n
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e.g. 2 chromosomes in haploid
2n = 4; n = 2
2n = 22 = 4 possible combinations
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IN HUMANS
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e.g. 23 chromosomes in haploid
2n = 46; n = 23
2n = 223 = ~ 8 million possible combinations!
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RANDOM FERTILIZATION
At least 8 million combinations from Mom, and another 8
million from Dad …
>64 trillion combinations for a diploid zygote!!!
M E I O S I S K M 22
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MEIOSIS CREATES GENETIC VARIATION
During normal cell growth, mitosis produces daughter cells identical to parent cell (2n to 2n)
Meiosis results in genetic variation by shuffling of maternal and paternal chromosomes and crossing over.
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MEIOSIS CREATES GENETIC VARIATION
No daughter cells formed during meiosis are genetically identical to either mother or father
During sexual reproduction, fusion of the unique haploid gametes produces truly unique offspring.
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MITOSIS VS. MEIOSIS
M E I O S I S K M 25
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M E I O S I S K M 26
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