Lack o

f G

FP

mark

s m

uta

nt

clo

ne

Loss of sav/hpo/wts/mob increases cell division

Loss of sav/hpo/wts/mob decreases apoptosis

merlin and expanded function redundantly to control proliferation

Overexpression of expanded or hippo

Hyperactivate Hpo signaling pathway

Hippo acts downstream of expanded/merlin

Hippo acts upstream of warts

Dong et al., Cell 2007

Course of Wallerian axon degeneration.

Wang J T et al. J Cell Biol 2012;196:7-18

© 2012 Wang et al.

Fig. 1 Identification of mutations that suppress Wallerian degeneration.

J M Osterloh et al. Science 2012;337:481-484

Published by AAAS

Fig. 2 Mutations in dsarm block Wallerian degeneration.

J M Osterloh et al. Science 2012;337:481-484

Published by AAAS