Powerpoint 1

Responsible Conduct of Animal Research at UTHSCH

Chris S. Smith, DVMCenter for Laboratory Animal

Medicine and Care

Objectives

Federal laws Overview of the UTHSC Animal Care

and Use Program Ethical considerations in planning

an animal activity UTHSC resources for animal

activities

UTHSC ANIMAL PROGRAM METRICS

2.5 million dollar CLAMC budget 15% of all active and pending

UTHSC grants include animals 150 UTHSC scientists use animals 325 approved animal protocols 11,000 animals cared for daily

Federal Laws

UTHSC-Animal Care and Use Program

Federal Laws

AWCAWCOffice

Animal Care Program (CLAMC)

Animal Care ProgramCLAMC

Veterinarian Dr. Brad Goodwin

AWC Office

AWC

ChairDr. C. Chappell

Research Staff

InstitutionalTrainingEnviron. SafetyOccup. Health

Federal RegulationsAnd Policies

Institutional OfficialDr. Peter Davies

R. Isaguirre

Investigator

Federal LawsFederal Laws

AWCAWCOffice




Research Staff




R. Isaguirre

investigator


Federal LawsFederal Regulations

And Policies

Animal Welfare Act

Health ResearchExtension Act

USDA

PHS

Animal Welfare Regulations

PHS Policy and Guide

Federal Agencies

Federal Laws RegulatingAnimal Research

Covered Animal Activities

All animal activities performed at UTHSC facilities.

All animal activities, even off site, where UTHSC funds are used to purchase the research animals.

Animal research activity performed offsite without UTHSC funds, but not approved by any other animal committee.

Federal Laws


AWCAWCOffice




Research Staff




R.Isaguirre

Investigator

Federal Laws


AWCAWCOffice



AWC OFFICEAWC


Research Staff




R. Isaguirre

Investigator

UTHSC Animal Welfare Committee

Mandated committee Appointed by the

President Composition of

membership Responsibilities

Protocols Inspections Concerns Authority

AWC Animal Protocol

Form available online Consult with AWC Coordinator if this is an

initial application Final document must be comprehensive

and well written Approval is for one year, and can be

renewed for two subsequent years, prior to expiring at the end of three years

Modifications of approved protocols can be done by memo

Animal Protocol Ethical Considerations:Justification

Research should be justified Purpose is sufficient to justify the use of

animals Model system is the best suited to

answer the scientific question Reasonable expectation that the

research methods employed will provide valid results

Animal Protocol Ethical Considerations:Personnel

Must be qualified through training or experience to accomplish experimental manipulations in a humane and scientifically acceptable manner

Animal Protocol Ethical Considerations:Species Selection and Quantity

The animals selected for a procedure should be of an appropriate species and quality and the minimum number required to obtain valid results.

Animal Protocol Ethical Considerations:Proper Use of Animals

• It is imperative to utilize methods that will avoid or minimize discomfort, distress and pain, when consistent with sound scientific practices.

Animal Protocol Ethical Considerations:Painful Procedures

Procedures that are known to cause more than momentary pain or distress, should be performed with appropriate sedation, analgesia, and/or anesthesia.

Animal Protocol Ethical Considerations:Unrelieved Pain or Distress

Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved, should be euthanized at the end of the procedure or if appropriate, during the procedure.

Animal Protocol Ethical Considerations:Environment and Well-being

The living conditions of animals should be appropriate for their species and contribute to their health and comfort.

Pertinent Laws, Policies, and Guidelines

The transportation, care and use of animals shall be in accordance with applicable federal laws, guidelines and policies.

Federal Laws


AWCAWCOffice


Animal Care ProgramCLAMC



Research Staff




R. Isaguirre

Investigator

Center for Laboratory Animal Medicine and Care

Centralized program for animal housing, care, and use

40 staff members including 5 veterinarians and 7 veterinary health and surgery technicians

CLAMC managed resources located in 6 UTHSC buildings


Present Locations- MSB/E

- IMM- DB

- Denton Cooley- MSI- UCT

Future Locations - BREF (2009/10)


Services and resources Animal housing and husbandry Veterinary consultation & care Surgical resource & support Clinical laboratory Technical assistance Import and export Transportation Canine breeding program

Other UTHSC Animal Resources:Genetically Manipulated Rodent Models

IMM - Development of transgenic and knockout mouse strains

IMM –Cryopreservation of embryos

Dr. Rick WetselDr. Eva Zsigmond

Other UTHSC Animal Resources:FMR Imaging Research Resource

3.0 and 7.0 T dedicated for research

Dr. Ponnada Narayana – Radiology, MS

Federal Laws


AWCAWCOffice



ChairDr. C Chappell

Research Staff




R. Isaguirre

Investigator

Institutional Training in Animal Care and Use

Coordinated by CLAMC

Institutional courses Introductory Species specific Offered monthly

One-on-one training

Occupational Health Environmental Health and Safety

Health and environmental risks are identified Personnel are aware of the risks Practices in place to minimize the risks Procedures in place to monitor exposure and to

provide medical intervention, if needed.

Federal Laws

AWCAWCOffice



ChairDr. C. Chapell

Research Staff




R. Isaguirre

Investigator


Good Animal Care = Good Science

Powerpoint 1

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