Poster Draft from Bioengineering’s Capstone Design Course.
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Transcript of Poster Draft from Bioengineering’s Capstone Design Course.
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Add Dept. of BIOE and contact info
Cut
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Good decision to use bold to call attention to description of your design, but this large block of text doesn’t provide an easy entry point into the poster. Reorganize and edit!
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Why report volume in ft3?
Re-order based on importance or group by implicit logical categories
Cut “s” in “Costs”
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Don’t justify line spacing because it creates odd spaces between words.
Lower case “s”
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Nice large image to highlight design, but replace with image of device put together. Use callouts for key components.
Serif fontExplain how it works.
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Use one font consistently.
What’s the purpose of this section? The text bullets seem to explain the obvious.
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Need to describe testing.
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
What’s this?
Need to report results in more detail.
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
These aren’t conclusions. Focus on your design’s features and advantages
NanoStitch
Cutting-edge nanoshell technology offers a new wave of biomedical research that can be directly applied to the clinical setting. While current methods of wound closure, such as sutures and liquid adhesives, encounter problems arising from scarring, cost, infection and inconvenience, current research has shown promising results for the implementation of nanoshells in the field of laser tissue welding1. A significant setback to current laser wound closure techniques is the large user variability. To address the pitfalls of previous wound closure techniques, Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly program to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks to:• Andre Gobin• Dr. Jennifer West, Rice University• Dr. Oden, Rice University• CBEN• Brown Foundation Teaching Grant
Introduction
Device Concept
A Nanoshell Assisted Laser Tissue Welding Device Team Lazer, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay Maniar
Temperature Sensor
Laser Mounting Bracket
Motor
DampenedArm
ProximitySensor
Prototype Requirements
• Easily Portable
• Costs < $1500
• Volume < 3ft³
• Sensing Distance: 2-10cm
• Depth of Laser Penetration: 2-3mm
• User-friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable
Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound Less opportunity for infection
• Motorized angle adjustment allows for consistent application to skin
User Safety
• User interface alarms operator when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System
Technical Specifications
Laser• FAP I Laser System made by Coherent Inc.,• Output: 14 W/cm²• Spot Size: 5 mm spot size
Solder Solution• Gold nanoshells peak absorbance of 821 nm • Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor• Raytek MI Series• System response time of 150 ms
Proximity Sensor• Banner U-Gage S18U Analog Sensor• Measures distance between 3cm – 30cm
Software• Built in LABVIEW, easily upgradable • Easy to use Interface
Conclusions
• Current methods of wound closure are inconvenient and increase patient’s susceptibility to infection and scarring
• Incorporation of distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure
Safe and Effective Solution
Acknowledgments and References
User Interface
• Visible alarms
• Temperature at wound and distance to wound highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between trials
• Visible indication of current laser power
Nanostitch
• Insert graph of tensile strength of Nanostitch vs. Suture
•Results coming
•Insert table of Nanostitch vs handheld laser application to show increased consistency (lower standard deviation) for device
•Results coming
Use paragraph form to create more space above for testing and results.
Spell out CBEN. Italicize journals.
Capital “N”
NanoStitch
Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks:Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.
Introduction
NanoStitch Concept
A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay [email protected]
Prototype Requirements
• Easily Portable
• Maximum Safety
• Cost < $5 per use
• Cost < $1500 per device
• Operable with minimal training
• Highly Consistent & Repeatable
• Operator friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Volume < 2m³
• Sensing Distance: 2-10cm
Patient Safety
•Temperature monitoring prevents damage to skin
•Modulated laser intensity to prevent burns
•Reduced manipulation of wound Less opportunity for infection
•Motorized angle adjustment allows for consistent application to skin
Operator Safety
•Alarms when critical temperature is reached
•Proximity to skin determined in real-time
•Automatic Shut-off system
Conclusions
• NanoStitch goes one step further than conventional hand-held laser tissue welding technology.
• The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure.
Safe and Effective Solution
Acknowledgments and References
NanoStitch User Interface
Method of Wound Closure
Young's Modulus Yield Point Ultimate Tensile Stress
NanoStitch (n=5)0.044 ± 0.009
N/mm²0.019± 0.027
N/mm²0.013 ± 0.0038
N/mm²
Handheld (n=5)0.028 ± 0.016
N/mm² 0.013± 0.022
N/mm²0.008 ± 0.0055
N/mm²
Suture (n=5)0.030 ± 0.016
N/mm²0.012 ± 0.006
N/mm²0.015 ± 0.011
N/mm²
• Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch • No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, <0.05)
• NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, <0.05)
• Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing
Set Up
• Laser adjusted to desired conditions
• Distance and temperature sensor calibrated
Sample Preparation
• Chicken samples isolated
• Nanoshell solder applied directly to wound
Commence Annealing Process
• Laser shined over wound to begin closure
• Motor adjusts angle of laser to maintain surface
exposure
Safety Feedback Mechanisms
• If temperature becomes too high, alarms trigger
operator and laser intensity ramped down
• Operator notified of distance to wound in real-time to
ensure consistency
Safe, Successful Wound Closure!!
How it Works
NanoStitch
Current methods of wound closure, such as sutures and liquid adhesives, lead to increased scarring, cost, inconvenience, and possibility for infection. A new approach that combines nanoshell technology with laser tissue welding1 appears promising. However, the problem of user variability remains to be solved. Team Lazer has designed and built a prototype of an easily applicable device and a user-friendly software to address the concerns of safety and consistency arising from the variables of laser distance, angle, and motion along with the surface temperature of the skin.
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ, Drezek RA, West JL. Near infrared laser-tissue welding using nanoshells as an exogenous absorber. Lasers Surg Med. 2005 Aug;37(2):123-9.
Special Thanks:Team Lazer would like to thank Andre Gobin, Dr. Jennifer West, Dr. Maria Oden, Joseph Gesenhues, the Center for Biological and Environmental Nanotechnology and the Brown Foundation Teaching Grant for all of their help and support throughout the entire design process.
Introduction
NanoStitch Concept
A Nanoshell Assisted Laser Tissue Welding System Team Lazer, Department of Bioengineering, Rice University
Presented by Karl Balsara, Marc Burrell, Mike Cordray and Sanjay [email protected]
Prototype Requirements
• Easily Portable
• Maximum Safety
• Cost < $5 per use
• Cost < $1500 per device
• Operable with minimal training
• Highly Consistent & Repeatable
• Operator friendly computer interface
Safety Concerns Addressed
• Size of Wound: 2-5cm
• Volume < 2m³
• Sensing Distance: 2-10cm
Patient Safety
•Temperature monitoring prevents damage to skin
•Modulated laser intensity to prevent burns
•Reduced manipulation of wound Less opportunity for infection
•Motorized angle adjustment allows for consistent application to skin
Operator Safety
•Alarms when critical temperature is reached
•Proximity to skin determined in real-time
•Automatic Shut-off system
Conclusions
• NanoStitch goes one step further than conventional hand-held laser tissue welding technology.
• The incorporation of real-time feedback controlled distance and temperature sensors into a user-friendly software program results in a safer and more consistent wound closure.
Safe and Effective Solution
Acknowledgments and References
NanoStitch User Interface
Method of Wound Closure
Young's Modulus Yield Point Ultimate Tensile Stress
NanoStitch (n=5)0.044 ± 0.009
N/mm²0.019± 0.027
N/mm²0.013 ± 0.0038
N/mm²
Handheld (n=5)0.028 ± 0.016
N/mm² 0.013± 0.022
N/mm²0.008 ± 0.0055
N/mm²
Suture (n=5)0.030 ± 0.016
N/mm²0.012 ± 0.006
N/mm²0.015 ± 0.011
N/mm²
• Mechanical tensile failure tests were implemented to determine efficacy of NanoStitch • No significant difference between tensile strength of NanoStitch and Suturing Technique (two-sample t-test, <0.05)
• NanoStitch exhibits significantly greater Young’s Modulus over Handheld technique (two-sample t-test, <0.05)
• Qualitative analysis illustrate more frequent failure at grip site, rather than welding site, during NanoStitch testing
Set Up
• Laser adjusted to desired conditions
• Distance and temperature sensor calibrated
Sample Preparation
• Chicken samples isolated
• Nanoshell solder applied directly to wound
Commence Annealing Process
• Laser shined over wound to begin closure
• Motor adjusts angle of laser to maintain surface
exposure
Safety Feedback Mechanisms
• If temperature becomes too high, alarms trigger
operator and laser intensity ramped down
• Operator notified of distance to wound in real-time to
ensure consistency
Safe, Successful Wound Closure!!
How it Works
Overall, revised poster contains an appropriate balance of text and visuals.
Excellent use of images, text boxes, and arrows to represent the device and how it works. Use of red/blue in this section provides additional coherence.
Layout is accessible.
Material is comprehensible. Formatting is consistent.