PositiveSelect Plus LBL · 2020-01-30 · aspl asxl1 asxl2 atf1 atic atm atr atrx aurka aurkb axin1...

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Plus Tumour Mutation Load Microsatellite Instability Immunotherapy Targeted Therapy Chemotherapy Clinical Trials Most comprehensive Added Benefits with PosiveSelect Plus NGS genomic profile tesng 350 genes 350 genes covered Illumina Next Generation Sequencing 1000x coverage FFPE or liquid biospy Diagnostic information Drug resistant mutations Disease aggressiveness

Transcript of PositiveSelect Plus LBL · 2020-01-30 · aspl asxl1 asxl2 atf1 atic atm atr atrx aurka aurkb axin1...

Page 1: PositiveSelect Plus LBL · 2020-01-30 · aspl asxl1 asxl2 atf1 atic atm atr atrx aurka aurkb axin1 axin2 axl b2m babam1 bap1 bard1 bbc3 bcl10 bcl2 bcl2l1 bcl2l11 bcl6 bcor bcr birc3

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Tumour Mutation Load

Microsatellite Instability

Immunotherapy

Targeted Therapy

Chemotherapy

Clinical Trials

Most comprehensive

Added Benefits with PositiveSelect Plus

NGS genomic profile testing 350 genes

350 genes covered

Illumina Next Generation Sequencing

1000x coverage

FFPE or liquid biospy

Diagnostic information

Drug resistant mutations

Disease aggressiveness

Page 2: PositiveSelect Plus LBL · 2020-01-30 · aspl asxl1 asxl2 atf1 atic atm atr atrx aurka aurkb axin1 axin2 axl b2m babam1 bap1 bard1 bbc3 bcl10 bcl2 bcl2l1 bcl2l11 bcl6 bcor bcr birc3

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ABCB1ABCC2ABL1ACVR1ACVRLK1ADCY9AGO2AHCYL1AKAP9AKT1AKT2AKT3ALKALOX12BAMELYAMER1ANKRD11APCARARAFARID1AARID1BARID2ARID5BASPLASXL1ASXL2ATF1ATICATMATRATRXAURKAAURKBAXIN1AXIN2AXLB2MBABAM1BAP1BARD1BBC3BCL10BCL2BCL2L1BCL2L11BCL6BCOR

BCRBIRC3BLMBMPR1ABRAFBRCA1BRCA2BRD4BRIP1BTKCALRCAMTA1CARD11CARM1CASP8CBFBCBLCCDC6CCND1CCND2CCND3CCNE1CD274CD276CD74CD79ACD79BCDACDC42CDC73CDH1CDK-1CDK12CDK4CDK6CDK8CDKN1ACDKN1BCDKN2ACDKN2BCDKN2CCEBPACENPACHEK1CHEK2CICCLTCCOL1A1

CREB1CREB3L1CREB3L2CREBBPCRKLCRLF2CSDE1CSF1RCSF3RCTCFCTLA4CTNNB1CUL3CXCR4CYLDCYP19A1CYP1A1CYP1A2CYP1B1CYP2B6CYP2E1CYP3A4CYP3A5CYSLTR2DAXXDAZ1DCUN1D1DDIT3DDR2DICER1DIS3DNAJB1DNMT1DNMT3ADNMT3BDOT1LDPYDDROSHADUSP4E2F3EEDEGFL7EGFREIF1AXEIF4A2EIF4EELF3EML4

ENGEP300EPAS1EPCAMEPHA3EPHA5EPHA6EPHA7EPHB1ERBB2ERBB3ERBB4ERCC1ERCC2ERCC3ERCC4ERCC5ERFERGERRFI1ESR1ETV1ETV4ETV6EWSR1EZH1EZH2FAM123BFAM175AFAM46CFAM58AFANCAFANCCFANCD2FAT1FBXW7FEVFGF19FGF3FGF4FGFR1FGFR2FGFR3FGFR4FHFLCNFLI1FLT1

FLT3FLT4FOXA1FOXL2FOXO1FOXP1FUBP1FUSFYNGATA1GATA2GATA3GLI1GLIS3GNA11GNAQGNASGPS2GREM1GRIN2AGSK3BGSTA1GSTP1H3F3AH3F3BH3F3CHEY1HFEHGFHIST1H1HIST1H2BDHIST1H3AHIST1H3BHIST1H3CHIST1H3DHIST1H3EHIST1H3FHIST1H3GHIST1H3HHIST1H3IHIST1H3JHIST2H3CHIST2H3DHIST3H3HLA-AHLA-BHNF1AHOXB13

HRASICOSLGID3IDH1IDH2IFNGR1IGF1IGF1RIGF2IKBKEIKZF1IL10IL7RINHAINHBAINPP4AINPP4BINPPL1INSRIRF4IRS1IRS2JAK1JAK2JAK3JAZF1JUNKDM5AKDM5CKDM5DKDM6AKDRKEAP1KIF5BKITKLF4KMT2AKMT2BKMT2CKMT2DKNSTRNKRASLATS1LATS2LMO1LRP8LYNMALT1

MAP2K1MAP2K2MAP2K4MAP3K1MAP3K13MAP3K14MAPK1MAPK3MAPKAP1MAXMCL1MDC1MDM2MDM4MED12MEF2BMEN1METMGAMITFMLH1MLLMLL2MLL3MPLMRE11AMSH2MSH3MSH6MSI1MSI2MST1MST1RMTHFD1MTHFRMTORMUTYHMYCMYCL1MYCNMYD88MYOD1NBNNCOA2NCOA3NCOR1NEGR1NF1

NF2NFE2L2NFKBIANKX2-1NKX3-1NOL4NOTCH1NOTCH2NOTCH3NOTCH4NPM1NR4A3NRASNSD1NTHL1NTRK1NTRK2NTRK3NUF2NUP93NUTM1NUTM2ANUTM2BPAK1PAK7PALB2PARK2PARP1PAX3PAX5PAX7PAX8PBRM1PDCD1PDCD1LG2PDGFBPDGFRAPDGFRBPDPK1PGRPHOX2BPIK3C2GPIK3C3PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1

PIK3R2PIK3R3PIM1PLCG2PLK2PMAIP1PMS1PMS2PNRC1POLD1POLEPPARGPPM1DPPP2R1APPP4R2PPP6CPRDM1PRDM14PREX2PRKAR1APRKCIPRKD1PRKYPTCH1PTENPTP4A1PTPN11PTPRDPTPRSPTPRTRAB35RAC1RAC2RAD21RAD50RAD51RAD51BRAD51CRAD51DRAD52RAD54LRAF1RANBP2RARARASA1RASAL2RB1RBM10

RECQLRECQL4RELRETRFWD2RHEBRHOARICTORRIT1RNF43ROS1RPS4Y2RPS6KA4RPS6KB2RPTORRRAGCRRASRRAS2RRM1RTEL1RUNX1RXRARYBPSCRIBSDC4SDHASDHAF2SDHBSDHCSDHDSESN1SESN2SESN3SETD2SETD8SF3B1SH2B3SH2D1ASHOC2SHQ1SLC4A4SLX4SMAD2SMAD3SMAD4SMARCA4TERTTET1

TET2TFE3TFGTGFBR1TGFBR2TMEM127TMPRSS2TNFAIP3TNFRSF14TOP1TP53TP53BP1TP63TPM3TPMTTRAF2TRAF7TSC1TSC2TSHRTSPY4TTTY23TYMSU2AF1UGT1A1UPF1USP9YVCLVEGFAVHLVTCN1WHSC1WHSC1L1WT1WWTR1XIAPXPCXPO1XRCC1XRCC2YAP1YES1YWHAEZFHX3ZFYZNF207

ALKATF1ATICCAMTA1CLTCCOL1A1

CREB1CREB3L2EML4ERGETV1ETV6

EWSR1FEVFGFR3FLI1FOXO1FUS

HEY1METNCOA2NR4A3NTRK1NTRK3

PAX3PAX7PDGFBRANBP2RETROS1

TFE3TFGTPM3WT1WWTR1YAP1

ARAURKAAURKBBRAFCCND1CCND2CCNE1CD274CDH1CDK4

CDK6CDKN1ACDKN1BCDKN2ACDKN2BCDKN2CCRLF2EGFRERBB2ERCC1

ERCC2ERCC4ESR1FGFR1FGFR2FGFR3FGFR4FLT4IGF1RKDR

KITKRASMAP2K1MDM2METMYCNF1NF2NOTCH4NRAS

PDGFRAPDGFRAPDGFRBPGRPIK3CAPTENRAF1RB1RECQL4RICTOR

STK11TERTTP53TSC1TSC2VHLXIAP

Rearrangements

Amplifications/Loss/Copy Number Variation (CNV)

ATMAPCARID1A

BRCA1BRCA2EGFR

ERBB2GATA3KIT

PDGFRAPTENSMAD4

MLH1MTORNF1

TP53TSC1RB1

Insertion/Deletions (Indels)

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Genes Covered in PositiveSelect Plus


CTNNB1, AXIN1 and APC expression analysis of different ... · pathway has been shown to be activated in this type of tumor. METHODS: Sixty-one medulloblastoma cases were analyzed

CTNNB1, AXIN1 and APC expression analysis of different ... · pathway has been shown to be activated in this type of tumor. METHODS: Sixty-one medulloblastoma cases were analyzed

Role of Asxl2 in non‑alcoholic steatohepatitis‑related ...

Role of Asxl2 in non‑alcoholic steatohepatitis‑related ...

Research Paper Overexpression of SMYD3 in …SMYD3 bound on the promoter of BIRC3 and up-regulated its expression by triple-methylating H3K4. Finally, knocking down SMYD3 could inhibit

Research Paper Overexpression of SMYD3 in …SMYD3 bound on the promoter of BIRC3 and up-regulated its expression by triple-methylating H3K4. Finally, knocking down SMYD3 could inhibit

Web viewDe novo truncating variants in ASXL2 are associated with a unique and recognizable clinical phenotype: further involvement of the ASXL gene family in

Web viewDe novo truncating variants in ASXL2 are associated with a unique and recognizable clinical phenotype: further involvement of the ASXL gene family in

Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR ......Molecular Cell Article Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR-Mediated Protein Complex Formation

Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR ......Molecular Cell Article Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR-Mediated Protein Complex Formation

Association between serum anti‑ASXL2 antibody levels and ......1274 INTERNATIONAL JOURNAL OF MOLEcULAR MEdIcINE 46: 1274-1288, 2020 Abstract. The aim of the present study was to

Association between serum anti‑ASXL2 antibody levels and ......1274 INTERNATIONAL JOURNAL OF MOLEcULAR MEdIcINE 46: 1274-1288, 2020 Abstract. The aim of the present study was to

Wnt Signaling through Inhibition of β-Catenin Degradation ...Wnt Signaling through Inhibition of b-Catenin Degradation in an Intact Axin1 Complex Vivian S.W. Li,1,8 Ser Sue Ng,1,8

Wnt Signaling through Inhibition of β-Catenin Degradation ...Wnt Signaling through Inhibition of b-Catenin Degradation in an Intact Axin1 Complex Vivian S.W. Li,1,8 Ser Sue Ng,1,8

ligase RNF146 pathways by regulating expression of ubiquitin · RANKL stabilizes 3BP2 and AXIN1 protein levels through suppression of the E3 ubiquitin ligase RNF146. The 3BP2/SRC

ligase RNF146 pathways by regulating expression of ubiquitin · RANKL stabilizes 3BP2 and AXIN1 protein levels through suppression of the E3 ubiquitin ligase RNF146. The 3BP2/SRC

Biological and clinical implications of BIRC3 mutations in ... · central activating kinase of the pathway, is released and activated to induce the phosphorylation and proteasomal

Biological and clinical implications of BIRC3 mutations in ... · central activating kinase of the pathway, is released and activated to induce the phosphorylation and proteasomal

Biological and clinical implications of BIRC3 mutations in ... · 3 ABSTRACT BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia but the functional implications of

Biological and clinical implications of BIRC3 mutations in ... · 3 ABSTRACT BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia but the functional implications of

LL - PosterSessionOnline.eu · Poster presented at EHA 21 on: P aponi 11th June 2016.2016 LL. SAPIENZA UNIVERSITÀ DI ROMA Copy number analysis of the BIRC3 gene by droplet digital

LL - PosterSessionOnline.eu · Poster presented at EHA 21 on: P aponi 11th June 2016.2016 LL. SAPIENZA UNIVERSITÀ DI ROMA Copy number analysis of the BIRC3 gene by droplet digital

Mechanistic insight into Myc stabilization in breast …Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression Xiaoli Zhanga, Amy S. Farrella,

Mechanistic insight into Myc stabilization in breast …Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression Xiaoli Zhanga, Amy S. Farrella,