Positive Lymph Nodes: Analysis of the Breast International ...

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Accepted Manuscript Postmastectomy Radiotherapy in Women with T1–T2 Tumors and One to Three Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial Youssef H. Zeidan, Joyce G. Habib, Lieveke Ameye, Marianne Paesmans, Evandro de Azambuja, Richard D. Gelber, Ian Campbell, Bo Nordenskjöld, Jorge Gutiérez, Michael Anderson, Ana Lluch, Michael Gnant, Aron Goldhirsch, Angelo Di Leo, David J. Joseph, John Crown, Martine Piccart-Gebhart, Prudence A. Francis PII: S0360-3016(18)30230-X DOI: 10.1016/j.ijrobp.2018.01.105 Reference: ROB 24767 To appear in: International Journal of Radiation Oncology • Biology • Physics Received Date: 24 October 2017 Revised Date: 15 January 2018 Accepted Date: 26 January 2018 Please cite this article as: Zeidan YH, Habib JG, Ameye L, Paesmans M, de Azambuja E, Gelber RD, Campbell I, Nordenskjöld B, Gutiérez J, Anderson M, Lluch A, Gnant M, Goldhirsch A, Di Leo A, Joseph DJ, Crown J, Piccart-Gebhart M, Francis PA, Postmastectomy Radiotherapy in Women with T1–T2 Tumors and One to Three Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial, International Journal of Radiation Oncology • Biology • Physics (2018), doi: 10.1016/ j.ijrobp.2018.01.105. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Transcript of Positive Lymph Nodes: Analysis of the Breast International ...

Page 1: Positive Lymph Nodes: Analysis of the Breast International ...

Accepted Manuscript

Postmastectomy Radiotherapy in Women with T1–T2 Tumors and One to ThreePositive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial

Youssef H. Zeidan, Joyce G. Habib, Lieveke Ameye, Marianne Paesmans, Evandrode Azambuja, Richard D. Gelber, Ian Campbell, Bo Nordenskjöld, Jorge Gutiérez,Michael Anderson, Ana Lluch, Michael Gnant, Aron Goldhirsch, Angelo Di Leo, DavidJ. Joseph, John Crown, Martine Piccart-Gebhart, Prudence A. Francis

PII: S0360-3016(18)30230-X

DOI: 10.1016/j.ijrobp.2018.01.105

Reference: ROB 24767

To appear in: International Journal of Radiation Oncology • Biology • Physics

Received Date: 24 October 2017

Revised Date: 15 January 2018

Accepted Date: 26 January 2018

Please cite this article as: Zeidan YH, Habib JG, Ameye L, Paesmans M, de Azambuja E, GelberRD, Campbell I, Nordenskjöld B, Gutiérez J, Anderson M, Lluch A, Gnant M, Goldhirsch A, Di Leo A,Joseph DJ, Crown J, Piccart-Gebhart M, Francis PA, Postmastectomy Radiotherapy in Women withT1–T2 Tumors and One to Three Positive Lymph Nodes: Analysis of the Breast International Group02-98 Trial, International Journal of Radiation Oncology • Biology • Physics (2018), doi: 10.1016/j.ijrobp.2018.01.105.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service toour customers we are providing this early version of the manuscript. The manuscript will undergocopyediting, typesetting, and review of the resulting proof before it is published in its final form. Pleasenote that during the production process errors may be discovered which could affect the content, and alllegal disclaimers that apply to the journal pertain.

Page 2: Positive Lymph Nodes: Analysis of the Breast International ...

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ACCEPTED MANUSCRIPT

Postmastectomy Radiotherapy in Women with T1–T2 Tumors and One to Three Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial

Youssef H. Zeidan1*, Joyce G. Habib2*, Lieveke Ameye 3, Marianne Paesmans3,

Evandro de Azambuja4, Richard D. Gelber5, Ian Campbell6, Bo Nordenskjöld7, Jorge

Gutiérez8, Michael Anderson9, Ana Lluch10, Michael Gnant11, Aron Goldhirsch12, Angelo

Di Leo13, David J. Joseph14, John Crown15, Martine Piccart-Gebhart16, Prudence A.

Francis17.

1. Department of Radiation Oncology, American University of Beirut Medical Center, Beirut, Lebanon.

2. Department of Medical Oncology, Fouad Khoury and Makassed General Hospital, Beirut, Lebanon.

3. Data Centre, Jules Bordet Institute, Université Libre de Bruxelles (U.L.B), rue Hégèr Bordet 1, 1000, Brussels, Belgium

4. Medical Oncology Clinic, Université Libre de Bruxelles, Brussels, Belgium. 5. IBCSG Statistical Center, Dana-Farber Cancer Institute, Harvard TH Chan School of

Public Health, Harvard Medical School, and Frontier Science and Technology Research Foundation, Boston, MA,USA

6. Department of Surgery, Waikato Hospital, Hamilton, University of Auckland School of Health Sciences, New Zealand

7. Swedish Breast Cancer Group and Department of Oncology, Linkoping University, Sweden.

8. Grupo Oncologico Cooperativo Chileno De Investigacion, Clinica Las Condes, Santiago, Chile.

9. Department of Oncology, Copenhagen University Hospital Rigshospitalet, and Danish Breast Cancer Cooperative Group, Copenhagen, Denmark

10. Department of Hematology and Medical Oncology, Hospital Clínico Universitario de Valencia / INCLIVA, Universidad de Valencia. On behalf the Grupo Español de Investigación en Cáncer de Mama (GEICAM)

11. Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austriaand Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria

12. European Institute of Oncology, Milan, Italy and International Breast Cancer Study Group (IBCSG), Bern, Switzerland.

13. Sandro Pitigliani’ Medical Oncology department, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy.

14. Department of Radiation Oncology, Sir Charles Gairdner Hospital, University of Western Australia, Genesis Cancer Care and Edith Cowan University, Perth, Australia; Breast Cancer Trials Australia & New Zealand.

15. Department of Medical Oncology, St Vincent's University Hospital, Dublin, Ireland 16. Department of Medicine, Université Libre de Bruxelles, Brussels, Belgium.