POSITION TITLE SAKHILA K. BANU, MS, MPhil, PhD.,...

BIOGRAPHICAL SKETCH

NAME SAKHILA K BANU MS MPhil PhD

POSITION TITLE Assistant Professor

INSTITUTION AND LOCATION DEGREE (if applicable)

YEAR FIELD OF STUDY

Madurai Kamaraj University India Madurai Kamaraj University India

BSc MSc

1988 1991

Biology Biology

University of Madras India MPhil

1993 Endocrinology

University of Madras India PhD 2002 Endocrinology Laval University Canada Post doc I 2003 Reproductive Endocrinology University of Montreal Canada Post doc II 2004 Endocrine Oncology

A POSITIONS amp HONORS Positions 2001-2003 Post Doctoral Fellowship -I Reproductive Molecular Endocrinology Dept of Obstetrics amp Gynecology CHUL Laval University Quebec Canada 2003 -2004 Post Doctoral Fellowship- II Molecular Oncology Dept Pathology and Microbiology Faculty of Veterinary Medicine University of Montreal St Hyacinthe J2S 7C6 Quebec Canada 2005-2008 April Research Assistant Professor EndocrineReproductive Toxicology amp Oncology Dept of Integrative Biosciences College of Veterinary Medicine amp Biomedical Sciences Texas AampM University College Station Texas 77843 USA 2008 May-present Clinical Assistant Professor EndocrineReproductive Toxicology amp Oncology Dept of Integrative Biosciences College of Veterinary Medicine amp Biomedical Sciences Texas AampM University College Station Texas 77843 USA 2012 January-present Assistant Professor EndocrineReproductive Toxicology Dept of Integrative Biosciences College of Veterinary Medicine amp Biomedical Sciences Texas AampM University College Station Texas 77843 USA Honors Name of the Awards TypeOrganization Year Honorary Visiting Professor University of Madras India 2009 FY-08 Program Development Award VIBS Texas AampM University 2008 Winn Research Award Winn Feline Foundation USA 2008 Canine Health Foundation ACORNs Grant Award USA 2007 FY-07 Program Development Award VIBS Texas AampM University 2007

AAFP- First Grant Award American Association of Feline Practitioners USA 2006 SSR Trainee Travel Award Society for the Study of Reproduction USA 2003 CIHR Merit Award CIHR Govt of Canada 2003 Larry Ewing Memorial Award Society for the Study of Reproduction USA 2003 USDA-NRI Merit Award USDA-NRI USA 2002 CIHR Merit Award- CHIR Govt of Canada 2002 SSR Trainee Travel Award Society for the Study of Reproduction USA 2002 SSR Trainee Award-Finalist Society for the Study of Reproduction USA 2002 Senior Research Fellowship Council of Scientific and Industrial Research (CSIR)

Government of India 1997-2000

Senior Research Fellowship Lady Tata Memorial Trust amp Hospitals Mumbai India 1993-1995

SERVICE

Professional activities Served as an Ad Hoc reviewer in NIH review committee CMIR study section (Oct 2012) Serving as an Ad Hoc reviewer for the following journals American Journal of Obstetrics amp Gynecology BBA-Mol Cell Research Biology of Reproduction Canadian Veterinary Journal Cells Current Pharmaceutical Design

Domestic Animal Endocrinology Ecotoxicology and Environmental Safety Fertility amp Sterility Indian Journal of Animal Reproduction Indian Journal of Animal Sciences International Journal of Cancer International Journal of Radiation Biology Journal of Endocrinology amp Reproduction Journal of Food and Chemical Toxicology Journal of Veterinary Medicine Journal of Solution Chemistry Molecular Reproduction and Development Neurotoxicology Regulatory Toxicology and Pharmacology Reproductive Toxicology The International Journal of Biochemistry amp Cell Biology Toxicological and Environmental Chemistry Toxicology Toxicology and Applied Pharmacology and Toxicology Mechanisms and Methods

Membership in scientificprofessional Societies Active life member (1994 ndashtill date) Society for Reproductive Biology and Comparative Endocrinology Member (20001-till date) Society for Study of Reproduction External examiner University of Madras amp Bharathidasan University PhD theses (2006- till date)

RESEARCH B Selected Peer-reviewed Publications (PubMed search Banu SK or Banu KS or Banu S papers published in Indian Journals are not accessible through PubMed at present)

1 Pitchai D Banu SK amp Roy A In vitro and Insilco evaluation of NF-κB targeted costunolide action on

estrogen-negative breast cancer cells ndash A comparison with normal breast cells Phytotherapy Res

20141499-505 doi 101002ptr5155 Epub 2014 Apr 15

2 Sivakumar KK Stanley JA Arosh JA Pepling ME Burghardt RC Banu SK Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring Dev Biol 2014 38822-34 PMID 24530425 PMCID PMC3991725 Grant support NIH (BANU PI)

3 Stanley JA Sivakumar KK Arosh JA Burghardt RC Banu SK Edaravone Mitigates Hexavalent

Chromium-Induced Oxidative Stress and Depletion of Antioxidant Enzymes while Estrogen Restores Antioxidant Enzymes in the Ovary in F1 Offspring Biol Reprod 2014 May 7 [Epub ahead of print] PubMed PMID 24804965 Grant support NIH (BANU PI)

4 Stanley JA Kirthiram KS Nithy KT Arosh JA Hoyer PB Burghardt RC amp Banu SK Postnatal

exposure to chromium through mothers milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes Free Radical Biology and Medicine 2013 61C 179-196 PMID 23470461 Grant support NIH (BANU PI)

5 Lee J McCracken JA Banu SK amp Arosh JA Intrauterine Inhibition of Prostaglandin Transporter Protein Blocks Release of Luteolytic PGF2alpha Pulses Without Suppressing Endometrial Expression of Estradiol or Oxytocin Receptor in Ruminants Biology of Reproduction 2013 PMID 23759308 (Epub ahead of print)

6 Lee J Banu SK Burghardt RC Starzinski-Powitz A amp Arosh JA Selective inhibition of prostaglandin

E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms Biology of Reproduction 2013 88 (3)77 PMID 23242524

7 Lee J McCracken JA Stanley JA Nithy TK Banu SK Arosh JA Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep Biology of Reproduction 2012 87 (4) 97 PMID 22743300

8 Lee J Banu SK Stanley JA amp Arosh JA Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple signaling pathways Mol Cell Endocrinol 2012 Jan 2 348(1)211-23

9 Stanley JA Aruldhas MM Chandrasekaran M Suthagar E Neelamohan R Annapoorna K Sharmila S

Jayakumar J Jayaraman G Srinivasan N Banu SK miR-124a modifies the expression pattern of androgen receptors in malignant and non-malignant human thyroid tumor tissues J Steroid Biochem Mol Biol 2012 130(1-2)105-24

10 Stanley JA Lee J Nithy KT Arosh JA Burghardt RC amp Banu SK Chromium-VI arrests cell cycle and

decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-Inhibitors Reprod Toxicol 2011 Jul32(1)112-23Grant support NIH (BANU PI)

11 Banu SK Stanley JA Lee J Stephen SD Arosh JA Hoyer PB Burghardt RC Hexavalent chromium-

induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members ERK12 and p53 Toxicology amp Applied Pharmacology 2011 251253-66 Grant support NIH (BANU PI) PMCID 3131794

12 Banu SK Samuel JB Burghardt RC Arosh JA Aruldhas MM Lactational exposure to chromium (VI)

impairs ovarian development decreases steroid and pituitary hormones synthesis and delays puberty in developing Wistar rats Toxicology amp Applied Pharmacology 2008 232 180-189

13 Banu SK Lee J Stephen SD Nithy TK Arosh JA Interferon tau regulates PGF2alpha release from

the ovine endometrial epithelial cells via activation of novel JAKEGFRERKEGR-1 pathways Molecular Endocrinology 2010 122315-30

14 Banu SK Lee J Speights Jr VO Starzinski-Powitz A amp Arosh JA Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of

ERK12 AKT NFkB and -catenin pathways and activation of intrinsic apoptotic mechanisms Molecular Endocrinology 2009 231291-1305

15 Banu SK Starzinski-Powitz A Speights VO Burghardt RC Arosh JA Induction of peritoneal

endometriosis in nude mice using human immortalized endometriotic epithelial and stromal cells A potential experimental tool to study molecular pathogenesis of endometriosis in human Fertility and Sterility 2009 91 2199-2209

1 16 Banu SK Lee J VO Speights Starzinski-Powitz A Arosh JA Cycloxygenase-2 regulates survival

migration and invasion of human endometriotic cells through multiple mechanisms Endocrinology 2008 149 1180-1189

17 Banu SK Lee J Starzinski-Powitz A Arosh JA Gene expression profiles and functional

characterization of human immortalized endometriotic epithelial and stromal cells Fertility and Sterility 2008 90 972-987

18 Banu SK Lee J Satterfield MC Spencer TE Bazer FW Arosh JA Molecular cloning and

characterization of prostaglandin transporter in ovine endometrium Evidence for multiple cell signaling cross-talk on transport of prostaglandin F2 alpha Endocrinology 2008 149 219-31

19 Lee J Banu SK Subbarao T Starzinski-Powitz A Arosh JA Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases Molecular and Cellular Endocrinology 2011 332306-13

20 Lee J McCracken JA Banu SK Rodriguez R Nithy TK Arosh JA Transport of prostaglandin F2 alpha pulses from the uterus to the ovary at the time of luteolysis in ruminants is regulated by prostaglandin transporter-mediated mechanisms Endocrinology 2010 151 3326-35

21 Lee J Banu SK Rodriguez R Starzinski-Powitz A Arosh JA Selective blockade of prostaglandin E(2)

receptor EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest Fertility and Sterility 2010 93 2498-506

22 Stanley JA Aruldhas MM Yuvaraju PB Banu SK Anbalagan J Neelamohan R Annapoorna K

Jayaraman G Is geneder difference in postnatal thyroid growth associated with specific expression patterns of androgen and estrogen receptors Steroids 2010 75 1058 ndash 1066

23 Samuel JB Stanley JA Roopha DP Vengatesh G Anbalagan J Banu SK Aruldhas MM Lactational

hexavalent chromium exposure-induced oxidative stress in rat uterus is associated with delayed puberty and impaired gonadotropin levels Human and Experimental Toxicology 2010 30 91-101

24 Banu SK Arosh JA Chapdelaine P Fortier MA Expression of prostaglandin transporter PGT in uterus and fetal membranes during pregnancy in cattle Biology of Reproduction 2005 73 230-236

25 Arosh JApara Banu SKpara Chapdelaine P Kimmins S MacLaren LA Fortier MA Effect of interferon-tau on

prostaglandin biosynthesis transport and signaling at the time of maternal recognition of pregnancy in cattle evidence of polycrine actions of prostaglandin E2 Endocrinology 2004 145 5280-5293 (para equal contribution)

26 Arosh JApara Banu SKpara Chapdelaine P Fortier MA Prostaglandin biosynthesis transport and signaling

in corpus luteum a basis for autoregulation of luteal function Endocrinology 2004 1452551-2560 (paraequal contribution)

27 Arosh JApara Banu SKpara Chapdelaine P Fortier MA Expression and regulation of COX-1 and 2 and FP

EP2 EP3 and EP4 in uterus and fetal membranes during different days of bovine pregnancy Endocrinology 2004 145407-417 (paraequal contribution)

28 Banu SK Arosh JA Chapdelaine P and Fortier MA Molecular cloning and spatio-temporal expression

of the prostaglandin transporter-PGT A basis for the action of prostaglandins in the bovine reproductive system PNAS 2003 11747-11752

29 Arosh JA Banu SK Chapdelaine P Emond V Kim JJ MacLaren LA Fortier MA Molecular cloning

and characterization of bovine prostaglandin E2 receptors EP2 and EP4 Expression and regulation in endometrium and myometrium during the estrous cycle and early pregnancy Endocrinology 2003 144 3076-3091

30 Banu SK Govindarajulu P Aruldhas MM Testosterone and estradiol differentially regulate TSH-

induced thyrocyte proliferation in immature and adult rats Steroids 2002 6 573-9 31 Banu SK Govindarajulu P Aruldhas MM Testosterone and estradiol up-regulate androgen and

estrogen receptors in immature and adult rat thyroid glands in vivo Steroids 2002 671007-1014 32 Banu SK Govindarajulu P Aruldhas MM Developmental profiles of TSH sex steroids and their

receptors in the thyroid and their relevance to thyroid growth in immature rats Steroids 2002 67137-144

33 Banu SK and Aruldhas MM Sex steroids regulate TSH-induced thyroid growth during sexual

maturation in Wistar rats Experimental and Clinical Endocrinology and Diabetes 2002 111-6

34 Banu SK Govindarajulu P Aruldhas MM Testosterone and estradiol modulate TSH-binding in the thyrocytes of Wistar rats Influence of age and sex Journal of Steroid Biochemistry and Molecular Biology 2001 78329 - 342

35 Banu SK Govindarajulu P Aruldhas MM Testosterone and estradiol have specific differential

modulatory effect on the proliferation of human thyroid papillary and follicular carcinoma cell lines independent of TSH action Endocrine Pathology 2002 12315-328

36 Banu SK Arosh JA Govindarajulu P Aruldhas MM Testosterone and estradiol differentially regulate

thyroid growth in Wistar rats from immature to adult age Endocrine Research 2001 27447-463

37 Arosh JA Banu SK Devanathan TG Kathiresan D The effect of SMB on follicular dynamics during superovulation in crossbred cows Indian Journal of Animal Reproduction 2001 22103-108

38 Arosh JA Banu SK Devanathan TG Kathiresan D Estradiol profile and ovarian response embryo

recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows Indian Journal of Animal Sciences 2001 71421-424

39 Arosh JA Banu SK Devanathan TG Kathiresan D The pattern of superoestrus and its influence on

ovarian response embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows Indian Journal of Animal Sciences 2001 71425-429

40 Arosh JA Banu SK Devanathan TG Kathiresan D Progesterone estradiol luteinizing hormone and

follicle stimulating hormone profiles and their relationship with embryo production and quality of embryos in crossbred cows treated with prostaglandin F2 alpha and Folltropin Indian Journal of Animal Sciences 2001 71910-914

41 Arosh JA Banu SK Devanathan TG Kathiresan D Progesterone profile and ovarian response embryo


42 Arosh JA Banu SK Devanathan TG Kathiresan D Luteinizing hormone profile and its correlation with


43 Arosh JA Banu SK Devanathan TG Kathiresan D Follicle simulating hormone profile and its correlation

with ovarian response embryo recovery and quality of embryos in prostaglandin F2 alpha and syncro-mate B induced superovulated crossbred cows Indian Journal of Animal Sciences 2000 70679-683

44 Vanathy B Banu SK Aruldhas MM Manimaran MM Arunakaran J Govindarajulu P Effect of

testosterone on basal and thyrotropin induced changes on thyroidal adenosine triphosphatases Journal of Endocrinology and Reproduction 1997 135-49

C BOOK CHAPTER 1 Sakhila K Banu Heavy metal toxicity and the ovary Patricia B Hoyer (Ed) From Ovarian

Toxicology Taylor amp Francis Inc 2014 2 Jone A Stanley Ramalingam Neelamohan Esakky Suthagar Kannan Annapoorna Sridharan

Sharmila Jayaraman Jayakumar Narashiman Srinivasan Sakhila K Banu Maharajan Chandrasekaran and Michael M Aruldhas Androgen receptor expression in human thyroid cancer tissues a potential mechanism underlying the gender bias in the incidence of thyroid cancers Sudhakaran Perumana (Ed) From Perspectives in Cancer Prevention-Translational Cancer Research Springer India 2014

D Research Support Ongoing Research Support

1 Source USDA (2011-03140) The Role of Intraluteal prostaglandins in luteolysis and luteal protection in sheep Role Co-Investigator Duration 09012013 to 08312017 $499986 The goal of the project is to determine the factors regulating intraluteal PGF2a and PGE2 biosynthesis and signaling during luteolysis and establishment of pregnancy using sheep as a ruminant model

2 Source NIHNIEHS (1R21ES020561-01) Project title Chromium VI-induced toxicity on female reproductive function Role Principal Investigator Duration 08162011 to 07312013 The goal of this project is to study molecular and cellular aspects of chromium (VI)-induced follicular atresia and granulosa cell apoptosis 3 Source NIHNICHD (1R21HD065138-01A1) Project title Molecular Basis of Treating Endometriosis by Prostaglandin E2 Receptor Inhibitors Role Co-Investigator (PI- Joe Arosh) Duration 09302011 to 08312013 The goal of this project is to study molecular and cellular aspects of PGE2 signaling in apoptosis immunomodulation and estrogen biosynthesis in the pathogenesis of endometriosis

4 Source NIHNICHD (1R21HD066248-01A1) Project title Prostaglandin E2 Signaling in Growth and Pains of Endometriosis Role Co-Investigator (PI- Joe Arosh) Duration 10012011 to 09302013 The goal of this project is to study molecular and cellular aspects of PGE2 signaling in pains of endometriosis

Recently Completed Research Support

1 Source USDA (Dr Arosh PI) Project title Cellular transport of Prostaglandins in Ovine Uterus Role Co-Principal Investigator Duration 2009 to 2012 The goal of this research project is to identify the molecular and cellular aspects of prostaglandin transport in ovine endometrium

2 Source American Association of Feline Practitioners Project title Prostaglandin E2 signaling in feline mammary cancer a potential target for chemotherapy Role Principal Investigator Duration 060106 to 123109

3 Source Winn Feline Foundation Project title Prostaglandin E2 Biosynthesis in Feline mammary cancers Role Principal Investigator Duration 030208 to 030109

4 Source American Kennel Club Canine Health Foundation Project title Epidermal growth factor receptor and Cyclooxygenase-2 crossndashtalk in canine mammary cancers

Role Principal Investigator Duration 060107 to 050108

5 Source NIHNIEHS (ES016605-01A21) Project title Effects of Lactational Exposure to Chromium (VI) on Ovarian Development Role Principal Investigator Duration 2009 to 2012 The goal of this research project is to identify the mechanism of lactational exposure to chromium on ovarian development in F1 female rats

TEACHING

VIBS 489689 ENDOCRINE TOXICOLOGY 2015

Credit 3 Taught every spring Time 1110 AM ndash 1225 PM

Days Tuesdays and Thursdays Class room VMA 329

DirectorInstructor Sakhila K Banu MSc MPhil PhD Assistant Professor Department of Veterinary Integrative Biosciences College of Veterinary Medicine amp Biomedical Sciences Texas AampM University TAMU 4458 College Station Texas 77843 Room 105 VMR building Phone 979-458-3613 Fax 979-847-8981

Email skbanucvmtamuedu Course Description VIBS 489 VIBS 689 Credit 3 Environmental and occupational use of endocrine disrupting chemicals (EDCs) structure toxicokinetics and mechanism of action of EDCs effects of EDCs on the development and function disorders and diseases (including cancers) of the endocrine and reproductive organs Detailed study on the endocrine toxicology of PCB PBB PAH DIOXIN and BPA plasticizers pesticides diethylstilbestrol genistein and coumestrol and heavy metal endocrine disruptors and vinclozolin and atrazine persistent

organic pollutants (POPs) Clinical perspectives of EDCs and their effects on estrogen and androgen receptor

signaling ovarian failure oxidative stressantioxidants epigenetics and an overview of research methodology to study EDCs Course learning outcomes Upon completion of the course students will be able to 1 Describe the most prevalent environmental endocrine disrupting chemicals (EDCs) in the environment describe properties and the biological processes of EDCsrsquo which modulate their toxicokinetics

2 Understand molecular cellular and pathophysiological responses of the endocrine organs resulting from exposure to EDCs 3 Identify underlying mechanisms those contribute to endocrine diseasesdisorders and intervention strategies to mitigateprevent adverse effects of EDCs 4 Explain research approaches to understand adverse effects of EDCs on endocrine organs

Graduate Students ( VIBS) Undergraduate Students (VIBS) 489

Pre-requisite

Graduate classification and approval of the instructor

Senior classification Approval of the instructor

Evaluation

Exam-1 Multiple Choice type 20 Exam-2 Multiple Choice type 20 Exam-3 Multiple Choice type 20 Exam-4 Case study report 40 Total 100 Case Study Report All students will be required to prepare a case study report (maximum total of 10 pages 20 line spaced 1 inch margins 12 pt Arial or Times Roman font 10 references minimum) The case study will require examining a chemical in a specific contaminated site (eg chromium in California and New Jersey) or a chemical that affects a more specific target endocrine organ (eg organochlorine and thyroid gland or dioxin and endometriosis) or choose one of the ldquoWorldrsquos worst polluted placesrdquo and select one particular EDC and its clinical endocrinological relevance on the health of the people living in that environment Alternatively choose an EDC that is more relevant to occupational exposure etc (the student can obtain help from the instructor to choose the topic) The case study will examine sources pathways transport levels of contamination in the environment remediation process (if any) and receptors in the target endocrine organ and end-point diseases or disorders The paper should be submitted according to a required format and will reference peer‐reviewed work and reviews website

information reports from USEPA andor ATSDR The Blacksmith Institute etc

Exam-1Multiple Choice type 20 Exam-2Multiple Choice type 20 Exam-3Multiple Choice type 20 Exam-4Descriptive (short essays) 40 Total 100

Students will be asked essay questions and should be answered in the given page limit Exams 1 2 amp 3 are class room exams and exam 4 is a take home assignment Case study report not required

Grading

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F

Study Hand out of the lecture will be given (Most of the Hand out of the lecture will be given (most

Materials

objective questions will be taken from lectures) Particular book chapters or interested journals could be referred Course material will be derived from the following books amp reviews 1 Casarett amp Doulls Essentials of Toxicology by Curtis D Klaassen and John B Watkins III

2 Endocrine Toxicology Third Edition by J

Charles Eldridge and James T Stevens 3 Our Stolen Future by

Theo Colborn Dianne Dumanoski John Peterson Myers published by Dutton 4 Environmental Endocrine Disrupters An Evolutionary Perspective by A Crain L J Guillette Jr published by Taylor amp Francis 5 Endocrine Disrupting Chemicals An Endocrine Society Scientific Statement Endocrine Reviews 2009 30 293-342 (i) 6 In utero effects of chemicals on reproductive tissues in females Miller KP et al

(i) Toxicol Appl Pharmacol 2004 198111-31

Review (ii) 7 Reproductive Toxicology 3rd Edition R W kapp R W Tyl CRC Press 2009 (iii) 8 Endocrine Disruptors Part 1 H G (CONN) Dorr Springer 2001 (iv)

of the questions will be taken from lectures) Particular book chapters or interested journals could be referred Course material will be derived from the following books amp reviews 1 Casarett amp Doulls Essentials of Toxicology by Curtis D Klaassen and John B Watkins III

2 Endocrine Toxicology Third Edition by

J Charles Eldridge and James T

Stevens 3 Our Stolen Future by

Theo Colborn Dianne Dumanoski John Peterson Myers published by Dutton 4 Environmental Endocrine Disrupters An Evolutionary Perspective by A Crain L J Guillette Jr published by Taylor amp Francis 5 Endocrine Disrupting Chemicals An Endocrine Society Scientific Statement Endocrine Reviews 2009 30 293-342 (ii) 6 In utero effects of chemicals on reproductive tissues in females Miller KP et al

(v) Toxicol Appl Pharmacol 2004

198111-31 Review (vi) 7 Reproductive Toxicology 3rd Edition R W kapp R W Tyl CRC Press 2009 (vii) 8 Endocrine Disruptors Part 1 H G (CONN) Dorr Springer 2001 (viii)

Americans with Disabilities Act (ADA) Policy Statement The Americans with Disabilities Act (ADA) is a federal anti-discrimination statute that provides comprehensive civil rights protection for persons with disabilities Among other things this legislation requires that all students with disabilities be guaranteed a learning environment that provides for reasonable accommodation of their disabilities If you believe you have a disability requiring an accommodation please contact the Department of Student Life Services for Students with Disabilities in Cain Hall or call 845-1637 For additional information visit httpdisabilitytamuedu Attendance Policies It is mandatory for all the students to have a 100 attendance under normal circumstances When absences can be anticipated such as for many University sponsored activities and religious observances or mandatory admission interviews for professional or graduate school that cannot be rescheduled the student should inform the instructor of the situation as far in advance as possible Failure to notify andor document properly may result in an unexcused absence and may compromise the final grade The student should provide satisfactory evidence such as a letter from the physician in case of sick leave to the instructor to substantiate the reason

for absence Falsification of documentation is a violation of the Honor code For unanticipated or emergency absences where advance notification to the instructor is not possible the student should contact the instructor as soon as possible by e-mail phone (979-255-3946) or by contacting the main office of the department (979-845-2828) When the student is unable to make direct contact with the instructor and is unable to leave word with the instructors department because of circumstances beyond the students control and in cases of bereavement the student or the students representative should contact the department or instructor to let know the circumstances See student rule 7 for details (httpstudent-rulestamuedurule07) Academic Integrity Statement ldquoAn Aggie does not lie cheat or steal or tolerate those who dordquo The student to the Honor Council Rules and Procedures can be found on the web httpaggiehonortamuedu Lec WEEK Day amp

Time DATE

TitleTopic

1

2

Week 1

Tuesday 1110 AM-1225 PM

1202015 An Overview on the Industrial Revolution Endocrine Disruptors Irreversible Contamination of Drinking Water and Their Impact on Endocrine Diseases and Disorders in the Human

Thursday 1110 AM-1225 PM

1222015 Introduction to Environmental Endocrine Disrupting Chemicals (EDC)

3

4

Week 2

Tuesday 220-335PM

1272015 Influence of EDCs on Learning and Memory and Their Effects on Neurocognitive Disorders


1292015 Structure and Toxicokinetics of Polychlorinated biphenyls (PCBs) Polybrominated Biphenyls (PBBs) amp Polycyclic Aromatic Hydrocarbons (PAH) and Their Effects on Hypothalamo-Pituitary-Thyroid (HPT) Axis

5

6

Week 3


232015 Effects of PCBs and PBBs on Male and Female Reproductive System


252015 Effects of EDCs on Mammary Gland Development and Cancers

7

8

Week 4


2102015 Structure and Toxicokinetics of Dioxins amp Bisphenol A (BPA) and Their Effects on Male and Female Reproduction and Fetal Development

T7hursday 1110 AM-1225 PM

2122015 Endocrine Disruptors and Endometriosis

Week 5


2172015 REVIEW AND DISCUSSION - 1


2192015 EXAM - 1

Phase II Plasticizers pesticides diethylstilbestrol genistein and coumestrol bioremediation of EDCs and heavy metal endocrine disruptors

9

Week 6


2242015 Structure and Toxicokinetics of Plasticizers Phthalates and Reproductive and Developmental Toxicity of Phthalates

10


2262015 Effects of Pesticides [methoxychlor chlorpyrifos and dichlorodiphenyltrichloroethane (DDT)] on Neuroendocrine System

11

12

Week 7


332015 Endocrine Disruption of Diethylstilbestrol (DES) ndash I [Effects on Male and Female Reproductive Toxicity amp Developmental Toxicity]


352015 Overview of Endocrine Disruption and Reproductive Health from a Clinical Perspective

13

14

Week 8


3102015 Endocrine Disruption of Phytoestrogens Genistein and Coumestrol Bioremediation of EDCs


3122015 Heavy Metal Toxicity amp Endocrine Disruption

31615 ndash 32015 SPRING BREAK

Week 9




3262015 EXAM - 2

15

Phase III Vinclozolin and atrazine Persistent Organic Pollutants (POPs) Clinical perspectives Epigenetics and ER-signaling and EDCs ovarian failure oxidative stressantioxidants and EDCs and mechanistic toxicology and research methodology to study EDCs

Week 10


3312015 Endocrine disruption of fungicides (vinclozolin)

16

17

Thursday 1110 ndash 1225

422015 Endocrine Disruption of Herbicides (atrazine)

Week 11


472015 Epigenetics and Environmental Endocrine Disruptors

18

19


492015 Endocrine Disruptor Interaction with Biomolecules

Week 12


4142015 Occupational and Environmental Exposure to EDCs and Reproductive Failure

20

21


4162015 The Roles of Oxidative Stress in Endocrine Disruption

Week 13


4212015 Last day for Q drop

(ix) In vivo and In vitro Research Approaches to Understand the Basic Mechanisms of Endocrine Disruption

(x) Policies and Regulations of EDCs (xi) Bioremediation

ANNOUNCEMENTS ABOUT CASE STUDY REPORT ndash ASSIGNMENT QUESTIONS


4232015

REVIEW AND DISCUSSION - 3

Week 14


4282015 Preregistration for the 2015 first term second term 10-week summer semester and fall semester


4302015

EXAM ndash 3

Week 15


552015 Exam preparation no classes

FINAL EXAM ndash ASSIGNMENTS ndash CASE REPORT DUE


572015

Return the case study report and assignment to Dr Banu Email skbanucvmtamuedu

VIBS 604 Bio Neuro Endo Disorders Co-Instructor

Fall 2014 (Taught every Fall) Biomedical Neuroendocrinology and Endocrine Disorders (3-0) Credit 3 Gross and functional anatomy and endocrine functions of neuroendocrine systems hypothalamus and pituitary Neuroendocrine control of puberty sexual behavior menstruation ovulation pregnancy labor lactation testis thyroid growth stress diabetes obesity sleep memory learning and aging and their disorders Overview biosynthesis transport and signaling of neuropeptides prostaglandins peptide and steroid hormones Prerequisite Approval of instructor Cross-listed with NRSC 604

11-13-14 Thu 2-330PM

Dr Banu

Neuroendocrine Control of Thyroid Functional Anatomy Endocrine Regulations and Endocrine Disorders

11-18-14 Tue 2-330PM

Dr Banu

Neuroendocrine Control of Parathyroid Functional Anatomy Endocrine Regulations and Endocrine Disorders

11-20-14 Thu 2-330PM

Dr Banu

Neuroendocrine Control of Aging Endocrine Regulations and Endocrine Disorders

11-25-14 Tue 2-330PM

Dr Banu

Neuroendocrine Control Learning and Memory Functional Anatomy of the brain Endocrine Regulations and Endocrine Disorders

11-27-14 Thu

Thanks giving week-end No Class

2-330PM 12-02-14 Tue

Dr Banu

REVIEW AND DISCUSSION-3 TAKE HOME FINAL EXAM ASSIGNMENT WILL BE GIVEN

Domestic Animal Endocrinology Ecotoxicology and Environmental Safety Fertility amp Sterility Indian Journal of Animal Reproduction Indian Journal of Animal Sciences International Journal of Cancer International Journal of Radiation Biology Journal of Endocrinology amp Reproduction Journal of Food and Chemical Toxicology Journal of Veterinary Medicine Journal of Solution Chemistry Molecular Reproduction and Development Neurotoxicology Regulatory Toxicology and Pharmacology Reproductive Toxicology The International Journal of Biochemistry amp Cell Biology Toxicological and Environmental Chemistry Toxicology Toxicology and Applied Pharmacology and Toxicology Mechanisms and Methods

Membership in scientificprofessional Societies Active life member (1994 ndashtill date) Society for Reproductive Biology and Comparative Endocrinology Member (20001-till date) Society for Study of Reproduction External examiner University of Madras amp Bharathidasan University PhD theses (2006- till date)

RESEARCH B Selected Peer-reviewed Publications (PubMed search Banu SK or Banu KS or Banu S papers published in Indian Journals are not accessible through PubMed at present)

1 Pitchai D Banu SK amp Roy A In vitro and Insilco evaluation of NF-κB targeted costunolide action on

estrogen-negative breast cancer cells ndash A comparison with normal breast cells Phytotherapy Res

20141499-505 doi 101002ptr5155 Epub 2014 Apr 15

2 Sivakumar KK Stanley JA Arosh JA Pepling ME Burghardt RC Banu SK Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring Dev Biol 2014 38822-34 PMID 24530425 PMCID PMC3991725 Grant support NIH (BANU PI)

3 Stanley JA Sivakumar KK Arosh JA Burghardt RC Banu SK Edaravone Mitigates Hexavalent

Chromium-Induced Oxidative Stress and Depletion of Antioxidant Enzymes while Estrogen Restores Antioxidant Enzymes in the Ovary in F1 Offspring Biol Reprod 2014 May 7 [Epub ahead of print] PubMed PMID 24804965 Grant support NIH (BANU PI)

4 Stanley JA Kirthiram KS Nithy KT Arosh JA Hoyer PB Burghardt RC amp Banu SK Postnatal

exposure to chromium through mothers milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes Free Radical Biology and Medicine 2013 61C 179-196 PMID 23470461 Grant support NIH (BANU PI)

5 Lee J McCracken JA Banu SK amp Arosh JA Intrauterine Inhibition of Prostaglandin Transporter Protein Blocks Release of Luteolytic PGF2alpha Pulses Without Suppressing Endometrial Expression of Estradiol or Oxytocin Receptor in Ruminants Biology of Reproduction 2013 PMID 23759308 (Epub ahead of print)

6 Lee J Banu SK Burghardt RC Starzinski-Powitz A amp Arosh JA Selective inhibition of prostaglandin

E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms Biology of Reproduction 2013 88 (3)77 PMID 23242524

7 Lee J McCracken JA Stanley JA Nithy TK Banu SK Arosh JA Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep Biology of Reproduction 2012 87 (4) 97 PMID 22743300

8 Lee J Banu SK Stanley JA amp Arosh JA Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple signaling pathways Mol Cell Endocrinol 2012 Jan 2 348(1)211-23
















































































TEACHING










Pre-requisite



Evaluation





Grading

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F


Materials
















Time DATE

TitleTopic

1

2

Week 1





3

4

Week 2

Tuesday 220-335PM




5

6

Week 3





7

8

Week 4





Week 5




2192015 EXAM - 1


9

Week 6



10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu

















































































TEACHING










Pre-requisite



Evaluation





Grading

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F


Materials
















Time DATE

TitleTopic

1

2

Week 1





3

4

Week 2

Tuesday 220-335PM




5

6

Week 3





7

8

Week 4





Week 5




2192015 EXAM - 1


9

Week 6



10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu




Pre-requisite



Evaluation





Grading

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F

90-100 A 80-8999 B 70-7999 C 60-6999 D Less than 60 F


Materials
















Time DATE

TitleTopic

1

2

Week 1





3

4

Week 2

Tuesday 220-335PM




5

6

Week 3





7

8

Week 4





Week 5




2192015 EXAM - 1


9

Week 6



10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu


Materials
















Time DATE

TitleTopic

1

2

Week 1





3

4

Week 2

Tuesday 220-335PM




5

6

Week 3





7

8

Week 4





Week 5




2192015 EXAM - 1


9

Week 6



10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu



Time DATE

TitleTopic

1

2

Week 1





3

4

Week 2

Tuesday 220-335PM




5

6

Week 3





7

8

Week 4





Week 5




2192015 EXAM - 1


9

Week 6



10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu


10



11

12

Week 7





13

14

Week 8






Week 9




3262015 EXAM - 2

15


Week 10



16

17



Week 11



18

19



Week 12



20

21



Week 13







4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu



4232015


Week 14




4302015

EXAM ndash 3

Week 15





572015




11-13-14 Thu 2-330PM

Dr Banu


11-18-14 Tue 2-330PM

Dr Banu


11-20-14 Thu 2-330PM

Dr Banu


11-25-14 Tue 2-330PM

Dr Banu


11-27-14 Thu


2-330PM 12-02-14 Tue

Dr Banu


POSITION TITLE SAKHILA K. BANU, MS, MPhil, PhD.,...

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Transcript of POSITION TITLE SAKHILA K. BANU, MS, MPhil, PhD.,...