Population Genetic Hardy-Wienberg Law Genetic drift Inbreeding Genetic Bottleneck Outbreeding...
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Transcript of Population Genetic Hardy-Wienberg Law Genetic drift Inbreeding Genetic Bottleneck Outbreeding...
Population Genetic
• Hardy-Wienberg Law• Genetic drift• Inbreeding• Genetic Bottleneck• Outbreeding• Founder event• Effective population size• Gene flow
Genotype and Phenotype• Genotypes AA, aa (Homozygous), Aa (Heterozygous)• Phenotype trait X = AA and Aa , trait Y = aa• Alleles A and a
• If p = proportion of allele A and if q = proportion of allele a• Then p+q = 1• Knowing p and q the Hardy-Wienberg Equilibrium gives the
expected frequency of the three genotypes as:
• (p+q)2 = p2 +2pq + q2 = 1 AA = p2, aa = q2 and Aa = 2pq
Hardy-Wienberg EquilibriumAssumptions
• Population size is very large• Random mating is occurring• No mutation is taking place• No immigration (geneflow)• No selection is occurring