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FFaaccuullttyy ooff MMeeddiicciinnee AAiinn SShhaammss UUnniivveerrssiittyy

PPoossttggrraadduuaattee SSttuuddiieess

Master of Science in Medical Biochemistry and Molecular

Biology

انكييبء انحيىيت انطبيت و انبيىنىجيب انجزيئيت درجت انبجسخيز في

Program Code: BM600

Program Guide and

Logbook

2

C a n d i d a t e C u r r i c u l u m v i t a e

[Name]

Please attach your recent photo photo here.

[telephone no]

[mobile no]

[mailing address]

[email address]

[postcode]

Experience

[organization]

[your present job title]

[start date]

[location]

[responsibilities]

[organization]

[previous job title]

[start and end date]

[location]

[responsibilities]

3

[organization]


[location]

[responsibilities]

Education

[certificates]


[school or college]

Training

[any other training that will be useful in your job]

4

Filled by post graduate authorities

Date of Registration

First semester _______________________

Second semester _______________________

Third semester _______________________

Fourth semester _______________________

TABLE OF CONTENTS: Page

I – Welcome Statement

II - Mission Statement

III – Senior supervisor and affiliated departments and Hospitals

IV – Program specifications

1 - Basic Information

2 - Professional Information

3 – Academic standards

4 – Curriculum structure and contents

5 - Program courses:

6. Program admission requirements:

7. Regulation for progression and program completion

8. Appendix: course specifications:

Immunology course specification

Phrmacology course specification

Physiology course specification

Practical Biochemistry coursespecification

Medical Biochemistry course specifications

Molecular Biology course specifications

Bioinformatics course specifications

Statistics course specifications

V - General information

5

VI – Your log book

1 – Introduction

2 – Supervisors

3 - Tables for training records

4 – Log book preview

VII - Head of department approval for the exam entry

Detachable forms:

VIII – Thesis follow up

IX - Evaluation forms

I – Welcome Statement:

The Department of Medical Biochemistry and Molecular Biology welcomes

you to the Degree of Master of science in Medical Biochemistry and Molecular

Biology. As a department we are committed to medical student education and

continuously strive to improve your educational experience.

This handbook presents information guide and logbook activity of this

master degree administered by Medical Biochemistry and Molecular Biology

Department, Faculty of Medicine, Ain Shams University.

II - Mission Statement:

The mission of the Faculty of Medicine, Ain Shams University is “The

preparation of a competent graduate, who is able to compete on both national

and regional levels, capable of lifelong learning, training and tutoring, while

adhering to the codes of practice of medical health services and ethics. The

college as well, seeks continuous development of programs and courses. It also

enhances expansion of applied scientific research and health programs for

community services and environmental development. Moreover, through

providing distinguished academic and research cadres of teaching staff,

supporting the administrative system and sustainability of own resources, the

college is able to achieve goals and objectives”. The mission of this degree is

To provide postgraduate students with a basic understanding of the biological

processes in humans at a molecular level and to correlate any molecular defect or

abnormality to medical problems

To provide postgraduate students with advanced information concerning human

genetics and the future of diagnostic and therapeutic tools.

6

To provide the environment necessary to develop skills in self-evaluation, self-

directed learning and critical appraisal enabling the medical biochemist to adapt to

the rapid progress of information and changes that will occur in the profession

throughout their careers.

To provide the postgraduate students with the opportunity to become competent

medical biochemists with the skills required to a professional of medical

biochemistry laboratory.

III – Senior Supervisor and Affilated Departments and Hospitals

Senior Supervisor

Prof.

-------------------------------

-------------------------------

-------------------------------

E-mail:

Affilated Departments and Hospitals

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine,

Ain Shams University.

IV – Program Specifications

A- Basic Information

1. Program title:

Master of science in Medical Biochemistry and Molecular Biology

2. Progm type:

Single Double Multiple

3. Faculty

Ain Shams University – Faculty of medicine

4. Department

Medical Biochemistry and Molecular Biology

5. Assistant coordinator:

Professor Samar Kamal Kasim

Professor of Medical Biochemistry and Molecular Biology

6. Coordinator:

Professor Noura Elkholy

Professor of Medical Biochemistry and Molecular Biology

7

7. Last date of program approval:

B- Professional Information:

1. Program aims:




To provide postgraduate students with advanced information concerning human

genetics and the future of diagnostic and therapeutic tools.






medical biochemists with the skills required for a professional of medical


2. Intended learning outcomes (ILOs):

a. Knowledge and understanding:

By the end of this program the student should be able to:

A1- Describe the structure function relationship of some important proteins:

hemoglobin, myoglobin, skeletal muscles, collagen, and immunoglobulins.

A2- Explain the methods of classification and regulation of enzymes as well as

kinetics of enzymes and coenzymes.

A3- Describe the structure of DNA and RNA as well as the processes of

replication, transcription, translation, regulation of gene expression, and methods

of in vivo and in vitro amplification of DNA.

A4- State the characteristics of the genetic code and the relation of various types of

mutations to genetic diseases and cancers.

A5- Describe the biochemical basis of cancer, gene therapy, stem cell therapy, and

various techniques of genetic testing.

A6- Describe the structure of biological membranes and classify the different

mechanisms of signal transduction across membranes

8

A7- Describe the metabolic pathways of carbohydrates, lipids, and proteins, their

energetics, their sites, the ways of their regulation and possible metabolic errors.

A8- Describe the components of mitochondrial ETC and their inhibitors.

A9- Describe the composition of blood and explain the mechanism of blood

clotting, anticoagulation and fibrinolysis.

b-Intellectual Skills:

By the end of the course, students should be able to:

b1- Integrate basic biochemical facts with clinical diseases.

b2- Analyse and interpret different spectrophotometric data and use them in

diagnosis of a clinical case.

B3- Interpret the results of molecular biology techniques.

B4- Identify electrophoretic bands, interpret disease-associated changes in plasma

proteins and diagnose sickle cell trait and sickle cell anemia

B5- Retrieve and analyze nucleic acids and proteins data (bioinformatics)

B6- Differtiate between inherited and aquired hypercoagulable states

B7- Solve any subject-related problems provided by staff

B8- analyze laboratory data using statistical rules.

a- Professional and Practical Skills: By the end of the course, students

should be able to:

c1- Prepare solutions of acids, bases, and buffers and adjust their concentration and

pH

c2- Use spectrophotometric assay methods to determine the concentration of

substances in biological fluids

c3- Extract DNA, amplify a certain sequence of DNA by PCR and interpret results

of DNA fingerprinting

C4- Prepare buffers and make dilutions of known concentration.

C5- Purify proteins by molecular sieving, by ion exchange or affinity

chromatography and check protein purity.

C6- Perform different types of assays as ELISA, immunodiffusion.

C7- Perform different types of electrophoretic techniques.

d- General and Transferable Skills: By the end of the course, students

should be able to:

d1- Work in a team in the lab and cooperate with their colleagues and staff.

d2- Use basic computing skills and internet to fulfill problem-based learning

d3- Communicate relevant information with teaching staff and colleagues

d4- Recognize and effectively deal with unethical behavior of other members of

lab team.

9

D5-Understand the importance of life-long self-learning and show a strong

commitment to it.

3. Academic standards: (Benchmarks)

University of Vermont, Burlington, USA, Graduate College, Department of

Biochemistry

Contact Email: E-mail:[email protected]

Website: http://www.uvm.edu

4. Curriculum structure and contents:

4 a- Program duration: two years (4 semesters)

4b- Program structure:

اننبهج

انكىد انقزراث انذراسيتانسبعبث

انعخذة

دورة أسبسيبث انبحث انعهي يخطهببث انكهيت

لانجزء األو BM6001 4 االدويت أو–انفسيىنىج أو–انبكخزيب

BM6002 2 فخزة حذريبيت عهيت ف انكييبء انحيىيت

6 انزسبنت

انجزء انثبني

BM6003 21 انكييبء انحيىيت انطبيت

BM6004 3 انبيىنىجيب انجزيئيت

BM6005 2 دراست عهيت و حطبيقيت

االخخيبريت انقزراث

يبدة واحذة ين : يخخبر انطبنب

E6009 اإلحصبء -

E6018يقبث انبيى يعهىيبحيت طبح –

E6009

E6018

2

6 كزاست األنشطت

36 انجىع

5. Program courses:

a. Compulsory

Code Course title

L P SDL

mailto:[email protected]

10

BM6001(a)

BM6001(b)

BM6001(c)

Bacteriology &immunology

Or Pharmacology

Or Physiology

54

12

BM6002

Practical Biochemistry Course

60

BM6003 Medical Biochemistry 150 60

BM6004

Molecular Biology

30

30

BM6005 Practical and applied Biochemistry

(Cases and problem solving) 30

L: Lecture, P: practical and SDL: Self directed learning

b. Elective

Code Course title No. of hours

L P SDL

E6009 Statistics 15

E6018 Bioinformatics 15

6. Program admission requirements:

-( : يشترط لقيد الطالب للحصول على درجة الماجستير:6) المادة عمى درجة البكالوريوس في الطب والجراحة من إحدى جامعات جميورية - 1 أن يكون حاصال

موافقة جية العمل -3 أن يكون قد أمضى سنة التدريب )االمتياز( -2 مصر العربية أو عمى درجة معادلة

-5( 1ريف التدريب واستيالك األجيزة واستيفاء المستندات المطموبة في الممحق )تسديد الرسوم ومصا -4 التفرغ لمدراسة لمدة فصمين دراسيين قبل دخول امتحان الجزء الثاني

-الماجستير األوراق التالية :ة يقدم طالب اإللتحاق لدرج ( :1ملحق ) -5 شبيادة المبيالد أو مسبتخرج رسبمي -4 يبازشبيادة اإلمت -3 شبيادة البكبالوريوس -2 طمبب إلتحباق -1

صبور فوتوررافيببة 6عبدد -7 موافقببة جيبة العمبل عمبى التسبجيل والتفبرغ المطمببوب -6 الموقبف مبن التجنيبد بالنسبة لموافدين يقدم الطالب موافقة السفارة ويحدد جية تحمل النفقات كما يقدم شيادة صحية -8 جديدة

7. Regulation for progression and program completion

يببتم التسببجيل لمماجسببتير مببرة واحببدة فببي السببنة تبببدأ مببن أول يوليببو حتببى أخببر أرسببطس (: 8مااادة )ويجبوز قببول تسبجيل النبواب والمعيبدين والوافبدين فبي الفتبرة عمى أن تبدأ الدراسة في شير أكتوبر من كل عبام

دخول إمتحان الجزء األول إال بعد إنقضاء فتبرة الدراسبة من أول نوفمبرحتى أخر ديسمبر عمى أال يسمح ليم ب .المطموبة

تببوزا الدراسببة فببى كببل عببام جببامعى عمببى فصببمين دراسببيين مببدة كببل منيمببا خمسببة عشببر (: 9مااادة )اسبببوعا ي يبببدا االول فببى أول أكتببوبر ويبببدا الثببانى فببى منصببف فبرايببري مببف تنكببيم فصببل دراسببى صببيفى مكثببف

11

تم التسببجيل لمفصبل الدراسببى قبببل اسببوعين مببن بدايتبو عمببى االقببل بعبد إسببتيفاء الشببروط لمبدة سببتة اسبابيف ي و يببسببباعات معتمبببدةي 6حسبببب المقبببررات المسبببجمةي والينبدبببى أن يزيبببد العببببء الدراسبببى فبببى الفصبببل الواحبببد عبببن

جبوز ويجوز لمطالب تعبديل المقبررات خبالل اسببوعين مبن بدايبة الفصبل الدراسبى )بالحباف او االضبافة(ي كمبا ي لو االنسحاب خالل ستو اسابيف من احد المقرارت دون احتسابو راسبا فيوي

: مدة الدراسة لمحصول عمى درجة الدبموم أو الماجستير ىى أربعة وعشرون شيرا ( 11المادة ) )أربعة فصول دراسية( عمى جزئين يجتاز فييا الطالب برنامجا تدريبيا متكامال طبقا لمساعات المعتمدة

وال يسمح لو بدخول األنشطة الموضحة بالباب الرابف ويستوفى خالليا المطموب منة فى كتيب متابعة اإلمتحان قبل إستيفاء ثالثة أرباا المطموب منة في كل جزء من البرنامج

يجتاز بعدىا واحد الدبموم والماجستير الجزء األول فصل دراسي فيمدة الدراسة ( :11المادة )ب إمتحانا وال يشترط النجاح فيو بالكامل لإلنتقال لمدراسة في الجزء الثانيي والجزء الثاني يتطمب تفرغ الطال

يبأحد المستشفيات أو المراكز المعتمدة من الكمية لمدة فصمين دراسيين لمتدريبالطالب ي أو يقوم الدارس لدرجة الماجستير بتسجيل موضوا الرسالة عمى شكل بحث نكر ( : 11مادة )

عمى من التسجيل عممي بعد إستيفاء فصل دراسي واحد عمى األقل ويجوز أن يناقش رسالتة بعد ستة شيور صاألقل عمى أن يكون قد نجح فى مقررات الجزء األول بالكامل وقبل دخول إمتحان الجزء الثاني وال يخص

تليا درجامعة قبل تسجيل الرسالة ومتطمبات يقوم دارس الماجستير بإستيفاء متطمبات الجا( : 11مادة )

متطمبات الجامعة ىي الحصول عمى شيادة التويفل في المدة و يالكمية قبل دخول إمتحان الجزء الثانيدرجة عمى األقل( ومتطمبات الكمية ىي حضور دورات معتمدة من لجنة الدراسات 454اإلنجميزية بمجموا )

واإلحصاء الطبى أو بإجتياز إختبارات خاصة تحددىا المجنةي مىمناىج البحث العمالعميا بالكمية في مجال يجوز لمحاصمين عمى درجة الدبموم إستكمال درجة الماجستير بتسجيل رسالة (: 11مادة )

الماجستير خالل أربف سنوات من الحصول عمى درجة الدبموم ويحصل عمى الدرجة بعد إستيفاء متطمبات الة بنجاحي الجامعة والكمية ومناقشة الرس

الساعات المعتمدة لدراسة الدبموم والماجستير ثالثون ساعة معتمدة عمى األقل (: 16مادة )وتشمل ست ساعات عمى األقل لمجزء األول وثماني متابعة األنشطة يخصص منيا ست ساعات لكتيب ويضاف إلييا ست ساعات لمرسالة فى الماجستيري عشرة ساعة عمى األقل لمجزء الثاني

يلماجستير أربف سنواتامدة القيد لدرجة (: 11مادة ) درجة لمجزء 344درجة منيا 1244مماجستير لمجموا درجات االمتحان النيائى (: 11مادة )

يمماجستيردرجة ل 344يوازى مى التراكمى بما صاألولي ويضاف الييا المعدل الفمن كل عام ويعقد إمتحان الدور الثاني يعقد إمتحان الدور األول في أكتوبر ونوفمبر (: 11مادة )

12

فى أبريل ومايو من كل عامي % من 64يكون النجاح فى كل مادة من الدبموم العالى والماجستير بعد الحصول عمى (: 16مادة )

% من درجة64الدرجة الكمية لكل لجان المادة مجتمعة ويكون النجاح فى مواد الدكتوراه بعد الحصول عمى ممي واالكمينيكى والشفوي كل عمى حدةيالتحريري والع

(: فبى حالببة إسببتنفاا مبدة القيببد يمكببن لطالبب الدراسببات العميببا إعبادة التسببجيل مببرة أخببرى وال 19)مااادة يعتد بالنجاح فى الجزء األول أو الرسالة ويجب إعادتيماي

Assessment Schedule and Weighing of Assessments

Item Mark

Po

ints

GP

A s

core

ةطان

اننححا

Stu

den

t

sta

te

During

semester

End of

semester Total

First semester (If present) 100 300 400

Second semester 100 100

Third semester 100 100

Fourth

semester

Final exam

Written

900 900

Oral

Practical

/Clinical

Total 300 1200 1500

عه انىج انتان:يهحىظح: تعادل درجاخ انطانة طثقا نهقاط

نقبط 4 : % فأكثز 09 -2 A

نقبط 3663 : % 09% حخ أقم ين 55ين -1 A-

نقبط 3633 : %55% حخ أقم ين 59ين - 3 B+

نقبط 3699 : %59حخ أقم ين %35ين - 4 B

نقبط 1663 : %35% حخ أقم ين 39ين - 5 B-

نقبط 1633 : %39% حخ أقم ين 65ين - 6 C+

نقبط 1699 : %65% حخ أقم ين 61ين -3 C

نقبط 2663 : %61% حخ أقم ين 69ين - 5 C-

F صفز : %69أقم ين - 0

درجح نهجسء 011درجح يها 0011يجىع درجاخ االيتحا انهائ نهدتهىو انعان واناجستير

درجح نهجسء األول إ وجد. 011درجح يها 0011األول ويجىع درجاخ االيتحا انهائ نهدكتىرا

درجح 011دتهىو انعان واناجستير ودرجح نه 011ه انتراك تا يىازي صويضاف إنيها انعدل انف

.نهدكتىرا

13

( عهى ساىاش يجىىع حاضىم نىرب قىاط كىم يقىرر يضىروتا GPAويتى حساب انعدل انفصه )

ف عدد ااعات انعتدج يقسىيا عه انساعاخ انعتدج نهقرراخ انت دراىها انطانىة فى انفصىم اندرااى.

( عهى ساىاش يجىىع حاضىم نىرب انقىاط انتى حصىم CGPAانعدل انتراك نهطانة ) كا يتى حساب

عهيها انطانة ف كم يقرر يضروتا ف عدد ااعات انعتدج يقسىيا عه يجىع انساعاخ انعتدج انكهيح.

يىىتى سو انىىدكتىرا واناجسىىتير فىى انىىدتهىو سقىىرراخ انفىى حانىىح انراىىىب فىى يىىادج سو يجىعىىح يىى

ويتى حساب انتقىدير انفعهى انىيي يحصىم عهيى فى سول إعىادج فقىظ سيىا إ ا ىعح فقظ. اإلعادج ف انادج سو انج

قاط اي 0.01% فقظ )اي01تكرر راىتح فيحسة ن عد انجاح تقدير -

C)6

Microbiology and Immunology course specification University: Ain Shams University Faculty: of Medicine

Course specifications

Program on which the course is given: Master degree in Medical Biochemistry

and Molecular Biology.

Major or minor element of programs: Major

Department offering the program: Medical Biochemistry and Molecular

Biology.

Department offering the course: Microbiology and Immunology Department.

Academic Level: Master – 1st semester

Date of specification approval: …………………………..


Title: Microbiology and Immunology course Code: BM6001(a)

Credit Hours: hour Lecture: /week Total:

Coordinator

Microbiology and Immunology Department.

B - Professional Information 1- Course Aims:

The overall aim of the course:

1. To introduce the candidate to bacterial and viral genetics

2. To enable the candidate to cope with the international standards of

Immunology.

Intended Learning Outcomes:

a- Knowledge and understanding:

At the end of the course the candidate will be able to:

a1- Describe bacterial genetics and antimicrobial drugs

a2- Undestand viral structure, classification, and genetics

14

a3- Understand the natural defense mechanisms.

a4- Define the terms, antigens, hapten.

a5- Recognize the factors affecting immunogenicity of antigens

a6- Understand the phenomenon of self and non-self recognition by the immune

system.

a7- Describe the two limbs of the immune response (namely, antibody mediated

and cell mediated )

a8- Understand how active and passive immunity can be acquired and to know the

indications for immunization.

a 9- Define the term antibody and to know the structure and biological functions of

each class of immunogobulins

a10- Understand the nature of the Ag-Ab interaction and its in vitro applications in

the diagnostic microbiological lab.

a11- Understand the cellular cooperation and interaction in an immune response

and the different mediators involved in immunoregulatory mechanisms

a12- Understand the immunological processes underlying protection against

microbial disease and tumors.

a13- Explain the beneficial role of the immune system in protection against

microbial infections and development of tumors.

a14-Discuss means and types of immunization against medically important

microorganisms.

a15- Explain the detrimental role of the immune system in hypersensitivity

reactions, transplant rejection and development of autoimmune diseases.

a16- Understand the concept of immune deficiency diseases

b- Intellectual Skills:

By the end of the course, students should be able to: b1- Integrate basic immunological facts with clinical diseases.

b2- Classify oncogenic viruses that place individuals at risk of malignancy

b3- Demonstrate abilities to retrieve, analyze, evaluate, and present scientific

information by involvement in problem solving activities.

c- Professional and Practical Skills:


C1- Use informational technologies and library resources in the field of

immunology and microbiology.

C2- Communicate information with teaching staff and collegues

C3- Use the internet to retrieve and to present information.

15

C4- Apply safety measures in the laboratory to prevent contamination of the lab

and equipments.

d- General and Transferable Skills:


d1- Adopt the principles of life-long learning

d2- Retrieve, manage, and manipulate information by all means, including

electronic means.

d3- Present information orally, electronically, or by written means

d4- Effectively manage time and resources and set priorities

d5- Work in a team in the lab. and cooperate with colleagues and staff.

D6- Utilize problem solving skills in a variety of theoretical and practical

situations.

Contents of the course:

No. of hours

L T C/

P

SD

L

General bacteriology:

10 8

Virology:

1- Viral structure

2- Classification of viruses

3- Viral replication

4- Viral genetics.

10

Immunology:

I. THE INNATE IMMUNE SYSTEM

A. The Innate Immune System: An Overview

B. Pathogen-Associated Molecular Patterns

(PAMPs), Pattern-Recognition Receptors

(PRRs), and Cytokines

C. Cells Involved in Body Defense

D. Anatomical Barriers, Mechanical Removal,

Intraepithelial T-Lymphocytes and B-1 Cells,

Bacterial Antagonism by Normal Flora, and

35 4

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/innate.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/anatbar.html



16

Antigen-Nonspecific Antimicrobial Chemicals

Produced by the body

E. The Complement System :

F. Phagocytosis

G. Natural Killer (NK) Cells

H. Inflammation

I. Nutritional Immunity

J. Fever

K. The Acute Phase Response

II. ADAPTIVE IMMUNITY

A. Overview of Adaptive Immunity

B. Major Cells and Key Cell Surface Molecules

Involved in the Immune Responses

C. The Lymphoid System

D. An Overview of the Steps Involved in Adaptive

Immune Responses

IIa. HUMORAL IMMUNITY

A. Antibodies (Immunoglobulins)

B. Ways That Antibodies Help to Defend the Body

C. Naturally and Artificially Acquired Active and

Passive Immunity

D. Monoclonal Antibodies

IIb. CELL-MEDIATED IMMUNITY

A. The Steps Involved in Cell-Mediated Immunity

B. Ways That Cell-Mediated Immunity Help to Defend

the Body



http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/complement.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/nkcell.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/inflammation.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/nutimm.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/fever.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit4/innate/acutephase.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/intro/overview/overview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/intro/overview/overview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/intro/lymphoid/lymphoid.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/intro/lymphoid/lymphoid.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/intro/gensteps/gensteps.html



http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/overview/overview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/activepassive/activepasive.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/activepassive/activepasive.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/activepassive/activepassive.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/monoclonal/monoclonal.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/humoral/monoclonal/monoclonal.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/cellular/cmioverview/cmioverview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/cellular/cmioverview/cmioverview.html

17

D. Active and Passive Immunotherapy to Stimulate

Cell-Mediated Immunity against Tumors

III. IMMUNODEFICIENCY

A. Primary Immunodeficiency

B. Secondary Immunodeficiency

IV. HYPERSENSITIVITIES

A. Immediate Hypersensitivities

B. Delayed Hypersensitivities (Type IV)

C. Superantigens

Learning methods:

1. Lectures and small group discussion

2. Seminars

3. Practical classes

4. Self directed learning

Methods of assessment:

1. Written exam to assess knowledge, understanding and intellectual skills

1. Oral exam to assess the ability to identify and apply immunological

knowledge in a comprehensive oral way.

2. Practical exam assess practical and intellectual skills

Weighing of Assessments:

End-semester MCQ &Written Exam 150 marks

End-semester Oral Examination……………. 30 marks

End-semester Practical Examination 20 marks

Total ……………. 200 marks

List of references

Course notes: Medial microbiology and Immunology Department books

Essential books:

Lecture Notes: Immunology (Todd and Spickett) Recommended Books

Medical Immunology (Parslow, Stites, Terr & Imoboden)

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/cellular/adoptive/adoptive.html



http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/immunodeficiency/overview/overview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/immunodeficiency/overview/overview.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/immunodeficiency/primary/primary.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/immunodeficiency/secondary/secondary.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/immunodeficiency/secondary/secondary.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/hypersensitivity/type4/type4.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/hypersensitivity/type4/type4.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/hypersensitivity/superantigen/superantigen.html

http://student.ccbcmd.edu/courses/bio141/lecguide/unit5/hypersensitivity/superantigen/superantigen.html

18

Immunobiology (Janeway, Travers, Walport, Shlomchik)

Medical Microbiology & immunology (Levinson & Jawetz)

Pharmacology course specification University: Ain Shams University Faculty: of Medicine





Department offering the program: Medical Biochemistry and Molecular Biology

Department.

Department offering the course: Pharmacology Department.




Title: pharmacology course Code: BM6001(b)

Credit Hours: 4hour Lecture: /week Total:

Coordinator

Pharmacology Department.

B - Professional Information

1- Course Aims:

The aim of this course is to provide students with an understanding of the

principles of pharmacology related to dosing, pharmacokinetics, biotransformation,

mechanisms of action, side effects, drug interactions, and compliance issues,

2- Intended Learning Outcomes (ILOs) from the Course:

a- Knowledge and understanding

By the end of the course the candidate will be able to:

a1) Discuss the pharmacokinetic, pharmacodynamic and pharmaco-

therapeutic properties of drugs.

a2) Discuss the adverse and toxic effects of drugs, and their management.

a3)Give an account on limitations to the use of drugs such as

contraindications and drug interactions.

a4) Define clinically relevant age, sex and genetic related variations that

affect response to drugs.

a5) Define the principles, the indications, the relative advantages and

disadvantages of various pharmacotherapy modalities.

19

A6) Recognize the rational and general guidelines of the use of drugs in the

proper dose in special population such as pediatrics, geriatrics, pregnancy and

lactation and in cases of liver and kidney impairment.

b- Intellectual skills


b1) Calculate accurately drug’s dosage, bioavailability, plasma half life and

volume of distribution in different patient populations.

b2) Document drug adverse reactions.

b3) Observe, record and analyze the effect of drugs on biological tissues

c- Professional skills


c1) Think independently, evaluate and reflect, set tasks and select appropriate and

reasoned approaches to solve problems;

c2) Use knowledge and understanding of the pharmacological sciences to

formulate and apply the principles of scientific inquiry to address pharmacology-

related problems;

c3) Apply the knowledge and understanding of the pharmacological sciences to

plan and undertake hypothesis-driven pharmacological research.

c4) Demonstrate confidence and competency in understanding, analysing and

interpreting pharmacological data

d- General and transferable skills


D1 - Understand the importance of life-long self-learning and show a strong

commitment to it.

D2 - Use current I.T. for appropriate drug database to reach information about a

specific medication.

D3- Respect ethics related to drug prescription and use especially to drugs liable to

produce abuse.

3- Course content:

Topics No of hours

(1) General pharmacology: L C/P SDL

20

Evaluation of new drugs

Pharmacokinetics

Biotransformation

Pharmacodynamics

Adverse Drug Interaction

Pharmacogenetic disorders

Drug Allergy

Drug interactions

(2) Pharmacology of Blood

Drug therapy of thrombosis

Anticoagulants

Antiplatelet drugs ( Anti-Thrombotics )

Fibrinolytics ( Thrombolytics )

Drugs used in bleeding disorders

Vitamen K

Fibrinolytic Inhibitors ( Antiplasmin )

Drug therapy of Anemia

Drug-induced blood disorders

Drug therapy of hyperlipidemia

Management of Hyperlipidemias

(3)- Renal Pharmacology

Diuretics

Drugs and Potassium Homeostasis

Disturbances in K+ serum level

Drugs and Acid-Base Balance

21

Treatment of renal stones

(4)-Endocrine Pharmacology

Insulin & oral antidiabetic drugs

Drugs Affecting Bone calcium Homeostasis

Hypothalamic & pituitary hormones

Thyroid hormones and antithyroid drugs

Anti thyroid drugs

Corticosteroids

Sex hormones

(5)- Chemotherapy

Antibacterial Chemotherapy

Cytotoxic drugs

L: Lectures and SDL: Self directed learning

4 - Student Assessment Methods

4.1 written exam to assess knowledge, skills

4.2 Oral exam to assess General and transferable skills

4.3 Practical exam to assess practical and intellectual skills

Weighing of assessment





5 -- List of References

5.1- Course Notes (paper and / or electronic): Deparment Book

5.2- Essential Books (Text Books)

5.3- Recommended Books

Principles of Clinical Pharmacology

5.4- Periodicals, Web Sites, etc

22

http://www.centerwatch.com/drug-information/fda-approvals/drug-

areas.aspx?AreaID=8

http://www.medilexicon.com/drugsearch.php?a=19

http://www.chilanti.com/olbooks/medbooks/Cochrane_Musculoskeletal_Group.ht

m

Medical Physiology Course Specification: University: Ain Shams University Faculty: of Medicine






Department.

Department offering the course: Medical Physiology Department.




Title: Medical Physiology course Code: BM6001(c)

Credit Hours: 4 hour Lecture: /week Total:

Coordinator

Medical Physiology Department.


1- Course Aims:

a- To understand functions of different body systems and organs.

b- To integrate regulatory mechanisms of different body functions in

health & disease states




a1-Recognize the functions of different body systems and the

mechanisms involved in its regulation

http://www.centerwatch.com/drug-information/fda-approvals/drug-areas.aspx?AreaID=8

http://www.centerwatch.com/drug-information/fda-approvals/drug-areas.aspx?AreaID=8

http://www.medilexicon.com/drugsearch.php?a=19

http://www.chilanti.com/olbooks/medbooks/Cochrane_Musculoskeletal_Group.htm

http://www.chilanti.com/olbooks/medbooks/Cochrane_Musculoskeletal_Group.htm

23

a2-Describe how different body functions are integrated to maintain

homeostasis

a3-Interprete & explain disturbed body functions in different diseases



b1- Analyze the given information.

b2- Think and expect the outcome of disturbed function

b3- Solve problems through case study and choose the

best from multiple .

b4- Hypothesize and experiment physiological principles



c1- Carry out all experiments in practical physiology classes

Blood tests .e.g. Blood groups , E.S.R.. Haemostatic function

(bleeding time,clotting time),hemoglobin, hematocrite value and

capillary fragility.

metabolic rate – oxygen consumpt

perform isolated perfused organ study, nerve & muscle preparation.

C4-Use different equipments in physiology department for scientific rsearch.



d1- communicate with medical students in practical classes and small group

discussions.

d2-communicate with staff members in physiology department and other

departments.

d3- present seminars in different issues in physiology in scientific meetings &

medical conferences.

3- Course contents

Topics No. of hours

L P SDL

24

(I) General & cellular Basis of Medical Physiology:

1. Homeostasis and feedback mechanisms.

2. Cell membrane (structure, characteristics

& channels).

3. Transport across cell membrane.

4. Membrane potentials (resting membrane

potential and action potentials).

5. Second messenger pathways.

6. Cellular organelles and their functions.

7. Cybernetics in physiology.

8. Receptors in physiology.

9. Body fluids and water balance.

10

٭

(II) Physiology of Nerve and Muscle:

1. Types of muscles (skeletal, cardiac & smooth

muscles).

2. Electrical activity of nerve & muscle (resting

membrane potential and action potential).

3. Neuromuscular junctions and excitation

contraction coupling.

4. Conduction of nerve impulse.

5. Energy sources & metabolism of skeletal

muscle.

6. Physiology of smooth muscles.

7. Assessment of muscle and nerve functions.

8. Effects of nerve lesions (degeneration &

regeneration).

٭ 10

(III) Physiology Of Blood:

1. Physiology of red blood cells.

2. Normal and abnormal haemoglobins.

3. Haematopoiesis, anaemias and polycythemia.

4. Blood groups and blood transfusion.

5. Physiology of leucocytes.

6. Immune mechanisms, allergy , anaphylaxis &

autoimmune disorders.

7. Platelet physiology .

8. Haemostasis, coagulation, fibrinolysis and

anticlotting mechanisms. Common coagulation

disorders.

9. Hormones affecting the different components of

10

25

blood.

10. Plama proteins: types, origins, concentrations

and functions- hypoproteinemia.

11. Functions of spleen and reticulo-endothelial

system.

12. Physiology of tissue macrophage system.

13. Physiology of lymph.

(IV) Energy & General Metabolism:

1. Thermoregulation and fever hypo-&

hyperthermia.

2. Energy balance, control of food intake,

obesity, under & malnutrition, leptin.

3. Metabolic rate and BMR

4. Respiratory Quotient(R.Q)

5

(V) Endocrine Physiology:

1. General concepts in endocrine physiology.

2. Mechanism of action of hormones.

3. Control of endocrine functions (role of

hypothalamus,hypothalamic–pituitary

relationship).

4. Physiology of pituitary gland and its disorders.

5. Physiology of thyroid gland its disorders.

6. Physiology of adrenal cortex and its disorders.

7. Calcium homeostasis and Tetany.

8. Glucose homeostasis and pancreas & diabetes

mellitus.

9. Physiology of growth–Insulin like growth

factors.

10. Physiology of puberty.

11. Magnesium homeostasis.

12. Phosphorus homeostasis and physiology of

bone.

13. Ectopic hormones.

14. Prostaglandins and their physiologyical

significance.

10

26

VI) Physiology of Kidney and Body Fluids:

1. Functional structure.

2. Kidney functions in the regulation of body

fluids. Role of ADH in the regulation of total

body water.

3. Renal circulation and renal blood flow.

4. Glomerular filteration and autoregulation.

5. Tubular function reabsorption and secretion.

6. Plasma clearance, renal handling of Na,

glucose. Bicarbonate & NH3.

7. Regulation of excretion Na, CI & K.

8. Acid–base balance and its disturbances.

Anion gap.

9. Concentration, dilution & acidification of

urine.

Micturition and its disorders.

10

Practical Course For M.Sc. Physiology

(1) Smooth Muscle and Autonomic Receptors:

(2) Blood Physiology:

Determination of hemoglobin content.

Determination of packed cell volume

(Haematocrit value)- Anemia – Polycythemia –

Blood indices.

Erythrocyte sedimentation rate (ESR).

Osmotic fragility test.

Evaluation of hemostatic function of blood:

a. Determination of the bleeding time.

b. Determination of whole blood clotting time.

c. Determination of prothrombin time (PT).

d.Determination of activated partial

thromboplastin time (APTT). - (Purpura–

Haemophilia–Hypoprothrombinemia-

Hypofibrinogenemia – Hypercoagulability

states).

Blood groups:

a. ABO.

12

L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning

27

4 – Teaching and Learning Methods

4.1-Practical lessons

4.2-Discussion sessions

4.3-Research assignment

4.4-Self directed learning

4.5-E-learning

5- Student Assessment Methods

5.1 Written Exam. to assess:Knowledge & understanding and intellectual skills

5.2 Practical Exam to assess: Professional& practical skills

5.3 Oral Exam to assess|:General & transferable skills

Weighing of assessment:






6.1- Course Notes: Lecturer notes


o Review of medical physiology By: William F. Ganong

o Text Book of medical physiology By: Guyton.

o BEST AND TAYLOR ’ s Physiological basis of Medical practice.

6.3- Recommended Books:

o Human physiology from cell to system By: Lauralee Sherwood.

6.4- Periodicals, Web Sites, … etc

o www. Pubmed.com.

o Ain Shams medical journal

o Am. J. of physiology.

o http:// mic2.shams.eg ( Faculty web site)

Course specifications of Practical Biochemistry University Ain Shams Faculty of Medicine Programme(s) on which the course is given: Master of Science in Medical

Biochemistry and Molecular Biology

Major or minor element of programmes: Major

Department offering the programme:Medical Biochemistry & Molec. Biology

Department offering the course: Medical Biochemistry and Molecular Biology

Academic Level: MSc., first semester

28

Date of specification approval:


Title: Master of Science in Medical Biochemistry and Molecular Biology

Code: BM6002

Credit Hours: 2 credit hours

Lecture: h Tutorial: Practical: h Total: h

Co-ordinator: Department of Medical Biochemistry and Molecular Biology B - Professional Information 1- Course Aims:

1- To provide the students with a solid background of practical biochemistry

concepts and skills and relate them to the theoretical biochemical information.

2- To equip the students with preliminary knowledge and skills necessary for

Biochemistry research


a- Knowledge and understanding By the end of the course the candidate should be able to:

a1) Describe how to express the concentration of solution using SI units,

and how to change the concentration by dilution.

a2) Understand the steps of preparation of acids and bases.

a3) Describe the mechanism of buffering and important physiological

buffers.

a4) State the laws of spectrophotometry, compare qualitative to

quantitative assays, and compare direct to coupled enzyme assays.



b1- Integrate laboratory biochemical results with clinical data.

b2- Analyse and interpret the results of biochemical experiments.

c- Professional and Practical skills

By the end of the course the candidate should be able to:

c1-Demonstrate a professional attitude and good communication skills by effective

participation in cooperative problem solving, in small group exercises directed

towards understanding the biochemical and genetic bases of disease origins,

diagnoses and treatments

c2- Apply different methods for expression of concentration and calculation of the

dilution of solution.

29

c3- Demonstrate ability to prepare buffers and chose the proper buffer for each

medium.

c4- Use spectrophotometric assay methods to determine the concentration of proteins and enzymes.

C5- Follow proper method of disposal of biohazardous samples

(infectious, carcinogenic, etc.).

C6- Use the computer to retrieve and compare practical biochemistry data



d1 – Develop the skill of working in teams

d2 – Develop appropriate relationships with patient and family

d3- Use basic computing skills and internet to follow electronic lectures


3- Course content:

PRACTICAL BIOCHEMISTRY L C/P SDL

Lab orientation and lab safety 2

Sampling procedures and tubes 2

Expression of concentration of solutions

Conversion to SI units

2

Changing concentration by dilution

2

Preparation of acids and bases

2

Diffusion through membranes:

-Dialysis

-Osmosis

-Osmotic behaviour of living cells

2

Water dissociation and pH

Acids and bases

Strong and weak acids

Ka and pKa of weak acids

2

Preparation of buffers

2

Spectrophotometry:

-Lambert’s law

6

30

-Beer’s law

-Qualitative spectrophotometric assays.

- Quantitative spectrophotometric assays.

- Construction and properties of a spectro-

photometer.

- Direct and coupled enzyme assay

Measurement of total serum proteins

Measurement of Blood glucose:

OGTT

Glycosylated Hb and fructosamine

2

Assessment of serum lipid profile 2

L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning


5.1- Class Discussions: to detect weak points and to emphasize important points

5.2- Practical exam: to assess professional and practical skills.

Weighing of Assessments: (1) End first semester practical exam 100 marks


Any formative only assessments: Non


5.1- Course Notes (paper and / or electronic)

Practical Biochemistry Department book provided by the staff of Medical


………………………………………

…5.2- Essential Books (Text Books)

Experimental Biochemistry Theory and Exercises in Fundamental

Methods, Robert Switzer and Liam Garity, 3rd

edition

Analytical Biochemistry, David J Holme and Hazel Peck, 1998, Pearson

educ., Addison Wesley Longman limited.

Medical Biochemistry course specification University: Ain Shams University Faculty: of Medicine

31


Program on which the course is given: Master degree in Medical biochemistry

and Molecular Biology



Department

Department offering the course: Medical biochemistry and Molecular Biology

Department

Academic Level: Master – Second semester



Title: Medical biochemistry course. Code: BM6003

Credit Hours: 12 hour Lecture: /week Total:

Coordinator: Medical Biochemistry and Molecular Biology Department

a- Professional Information

1 – Overall Aims of Course





medical biochemists with the skills required to be a professional of medical






2 – Intended Learning Outcomes of Course (ILOs)

b- Knowledge and Understanding: By the end of the course, students

should be able to:

a1-Discuss normal biochemical pathways and the etiology and pathogenesis of the

biochemical disorders of disease

a2- Describe the structure function relationship of some important proteins:

hemoglobin, myoglobin, skeletal muscles, collagen, and immunoglobulins.

32

a3- Explain the methods of classification and regulation of enzymes as well as

kinetics of enzymes and coenzymes.

a4- Describe the structure of biological membranes and classify the different

mechanisms of signal transduction across membranes

a5- Describe the metabolic pathways of carbohydrates, lipids, and proteins, their

energetics, their sites, and the ways of their regulation.

A6- Define the possible metabolic errors arising from deficiency of certain

metabolic enzyme

A7- Describe the components of mitochondrial ETC and their inhibitors.

A8- Point out sources and fate of ammonia in human body and the causes of

ammonia intoxication. A9- Define which nitrogenous compounds are derived from each amino acid and

describe their synthesis, degradation and functions.

a10- Explain the different patterns of fuel metabolism in different organs, during

the fast and fed states

a11- Describe the composition of blood and explain the mechanism of blood

clotting, anticoagulation and fibrinolysis.

a12- Summarize the functions and deficiency diseases of vitamins and minerals.

a13-Summarize the various mechanisms of xenobiotic metabolism

a14- Identify cell adhesion molecules

b-Intellectual Skills: By the end of the course, students should be able to:

b1- Integrate basic biochemical facts with clinical diseases.

B2- Identify electrophoretic bands, interpret disease-associated changes in plasma

proteins and diagnose sickle cell trait and sickle cell anemia

B3- Solve any subject-related problems provided by staff

B4- analyze laboratory data using statistical rules.

c- Professional and Practical Skills: By the end of the course, students

should be able to:

C1- Demonstrate ability to choose the type of protein assay in a given biologic

fluid.

C2- Separate proteins by molecular sieving, and by ion exchange or thin layer

chromatography

C3- Perform different types of assays as ELISA, immunodiffusion.

C4- Identify and interpret electrophoresis results of different types.

C5- Apply methods to prevent contamination of the lab and equipments.

C6- Follow proper method of disposal of biohazardous samples (infectious,

carcinogenic, etc.).

C7- Perform urine and stone analysis.

33

d- General and Transferable Skills: By the end of the course, students

should be able to:

d1- Work in a team in the lab and cooperate with their colleagues and staff.

d2- Use basic computing skills and internet to fulfill problem-based learning


3- Contents

Topic L C/P SDL

Water, acids, bases and buffers

Chemistry of amino acids and proteins

Protein structure-function relationship:

-Hemoglobin and Myoglobin

-Immunoglobulins

-Collagin and elastin

-Plasma Proteins

-Muscle proteins

Enzymes

Carbohydrate chemistry and metabolism

Bioenergetics and Biological oxidation

Lipid chemistry and metabolism metabolism

O2 toxicity and free radical injury

Metabolism of ethanol

Protein Metabolism:

General protein metabolism

Individual amino acid metabolism

Integration of Metabolism

Starvation

Diabetes mellitus

Biological membranes

Biosignalling

Apoptosis

Cell adhesion molecules

Metabolism of Nucleotides

Iron and Heme Metabolism

Nutrition-malnutrition and obesity

Vitamins and Mineral Metabolism

Metabolism of Zenobiotics

34

Blood composition,

Blood coagulation and fibrinolysis

PRACTICAL BIOCHEMISTRY

Urine analysis

Stone analysis

Protein purification:

- Molecular sieving

- Ion exchange chromatography

- Affinity chromatography

- Thin layer chromatography

- How to check protein purity

Assay of proteins in biologic fluids:

-Simple colorimetric assay

-Turbidimetric assay

-ELISA

-RIA

-Immunohistochemistry

-Immunodiffusion

Electrophoresis:

- General principals

- Cellulose acetate membrane electophoresis

- Polyacrylamide gel electroph.

-DNA and RNA electrophoresis using agarose gel

- Gel photography

Blood coagulation testing

4– Teaching and Learning Methods

4.1- Lectures: using data show and overhead projectors

4.2- Practical Training

4.3- Discussion sessions: as journal clubs and seminars

4.4- Collection of information using the internet


35


5.2- Quizes at the end of each subject to assess understanding and weak points

5.3- Oral exam: to assess knowledge, understanding and information presentation

ability

5.4- Practical exam: to assess practical skills aquired by students

5.5- Written end-year exam to assess knowledge and understanding.

Weighing of Assessments: (1) Periodic quizzes 70 marks

(2) Written exam 200 marks

(4) Practical exam (Cases and Skills) 240 marks

(5) Oral exam 090 marks





Lectures notes and Practical Biochemistry book provided by the staff of Medical

Biochemistry and Molecular Biology Department.


Lippincott's Illustrated Reviews: Biochemistry, Champe PC, 4th

edition.

Lippincott Williams & Wilkins Pub., 2009.

Harper's Illustrated Biochemistry, Robert K. Murray RK, Granner DK, Mayes PA

and Rodwell VW 27th edition, McGraw-Hill Medical Pub., 2006.

Lehninger Principles of Biochemistry, Nelson DL and Cox MM, 5th

edition,

Freeman Pub, 2009.

Biochemistry lecture notebook, Berg JM, Tymoczko JL and Stryer L, 6th

edition,

Freeman Pub., 2006.


Biochemistry: A Case Oriented Approach, Montgomery R et al, 6th

edition, Mosby,

1996.

USMLE Road Map Biochemistry, Macdonald R, 1st edition. McGraw-Hill Medical

Pub., 2007.

Textbook of Biochemistry with Clinical Correlations, Devlin TM, 6th

edition,

Wiley-Liss, Inc. Pub., 2005.

http://www.amazon.com/exec/obidos/search-handle-url/ref=ntt_athr_dp_sr_1?%5Fencoding=UTF8&sort=relevancerank&search-type=ss&index=books&field-author=Robert%20K.%20Murray

http://www.amazon.com/exec/obidos/search-handle-url/ref=ntt_athr_dp_sr_2?%5Fencoding=UTF8&sort=relevancerank&search-type=ss&index=books&field-author=Darryl%20K.%20Granner

http://www.amazon.com/exec/obidos/search-handle-url/ref=ntt_athr_dp_sr_3?%5Fencoding=UTF8&sort=relevancerank&search-type=ss&index=books&field-author=Peter%20A.%20Mayes

http://www.amazon.com/exec/obidos/search-handle-url/ref=ntt_athr_dp_sr_4?%5Fencoding=UTF8&sort=relevancerank&search-type=ss&index=books&field-author=Victor%20W.%20Rodwell

36


http://mic2.shams.edu.eg/moodle

www.medicaleducationonline.org

www.eul.edu.eg

www.wilkpedia.com

www.encyclopedia.com

Molecular Biology Course specifications: University Ain Shams Faculty of Medicine Programme(s) on which the course is given: Master of Science in Medical



Department offering the programme: Medical Biochemistry and Molecular

Biology


Academic Level: MSc. 1st part




Code: BM6004


Lecture: Tutorial: Practical: Total:

Co-ordinator: Department of Medical Biochemistry and Molecular Biology B - Professional Information

1- Course Aims:

1- To provide the postgraduate students with the opportunity to become competent

medical biochemists with the skills required to be an effective consultant for

clinical colleagues and a professional of medical biochemistry laboratory.

2- To equipping the students with the specialized knowledge and skills necessary

for future research.


http://www.medicaleducationonline.org/

http://www.eul.edu.eg/

http://www.wilkpedia.com/

http://www.encyclopedia.com/

37



a1) Understand the structure, function and organization of human genomes

a2) Describe the main principles of methods for preparation and extraction

of DNA and RNA.

a3) Understand the main principles of methods for DNA amplification

(PCR, RT-PCR, Real-time PCR, etc.)

a4) Identify the main principles of methods for DNA sequencing

a5) Describe the main principles of DNA and RNA blotting

a6) Understand the concepts of recombinant DNA technology

a7) Understand the applications of molecular biology techniques in the

diagnosis, taxonomy, species and strain differention of

microorganisms.

.a8) Understand the applications of molecular biology techniques in genetic

testing, in paternity testing, studying drug resistance, and vaccine and

drug development.

a9) Point out the principle of microarrays



b1- Integrate basic molecular biology facts with clinical data.

b2- Identify the appropriate experimental technique required to diagnose a

genetic disease.

b3- Analyse and interpret the results of molecular biology techniques.



c1- Incorporate new molecular biology knowledge and tools into research

projects

c2- Use the computer to retrieve and compare molecular biology data

c3- Solve any subject-related problems provided by staff

c4- Apply methods to prevent contamination of the lab and equipments.

c5- Follow proper method of disposal of biohazardous samples

(infectious, carcinogenic, etc.).

c6- Demonstrate the ability to extract DNA and RNA

c7- Interpret the results of PCR and RT-PCR, blotting teckniques, and DNA

finger printing

38



d1 – develop the skill of working in teams

d2 – develop appropriate relationships with patient and family



d5) Search gene and protein Database.

d6) Use molecular biology software.

3- Course content:

Basic principles in molecular biology L (1h) P SDL

1- Nucleic acid structure and organization 6

2- Cell cycle, DNA replication and repair 6

3- RNA transcription and processing 6

4- Regulation of gene expression 4

5-The Genetic code, mutation and protein

synthesis

6

6- Cloning:

Gene (DNA) cloning

Reproductive cloning

Therapeutic cloning

6

7- Techniques of genetic analysis

-Extraction of DNA & RNA

- PCR & RT-PCR

- DNA electrophoresis

- Blotting techniques

- RFLP

- Microarray

8 10

8- Genetic variation &

DNA finger printing

4

9- Molecular biology of cancer

- Oncogenes,

- Tumor suppressor genes,

- Apoptosis

- Telomerase

- invasion and metastasis

- Angiogenesis

4

39

10- Transgenesis &

Gene Therapy

6

11- Stem cells

4

13-Ethical, Legal, and Social implications of

genetic knowledge

4

14- Personalized Medicine

2

L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed

learning



5.2- Quizes at the end of each subject to assess understanding and weak points

presentation ability

5.3- Written final exam to assess knowledge and understanding.

Weighing of Assessments: (1) Written end-year exam 150 marks


Any formative only assessments: Quizes at the end of each







edition, Mosby,

1996.


Pub., 2007.


edition,


40



edition.





edition,

Freeman Pub, 2009.


edition,

Freeman Pub., 2006.


http://www.web-books.com/MoBio/

http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_mo

lecular_biology.htm

http://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm

http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_st

ructure/cell_structure.htm

http://www.cellsalive.com/cells/3dcell.htm

http://www.johnkyrk.com/DNAanatomy.html

http://www.johnkyrk.com/DNAreplication.html

http://www.johnkyrk.com/DNAtranscription.html

http://www.johnkyrk.com/DNAtranslation.html

http://www.rothamsted.ac.uk/notebook/courses/guide/

http://www.bio.com/protocolstools/protocol.jhtml?id=p1242

http://users.ugent.be/~avierstr/principles/pcr.html

http://depts.washington.edu/genetics/courses/genet371b-

aut99/PCR_contents.html [animation]

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.h

tml [animation]

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/mole

cularbiology.html (animated techniques

Course specifications of Applied Biochemistry University Ain Shams Faculty of Medicine Programme(s) on which the course is given: Master of Science in Medical







http://www.web-books.com/MoBio/

http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology.htm

http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology.htm

http://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm

http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_structure.htm

http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_structure.htm

http://www.cellsalive.com/cells/3dcell.htm

http://www.johnkyrk.com/DNAanatomy.html

http://www.johnkyrk.com/DNAreplication.html

http://www.johnkyrk.com/DNAtranscription.html

http://www.google.com/url?sa=D&q=http%3A%2F%2Fwww.johnkyrk.com%2FDNAtranslation.html

http://www.rothamsted.ac.uk/notebook/courses/guide/



http://users.ugent.be/~avierstr/principles/pcr.html

http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html%20%5banimation%255d

http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html%20%5banimation%255d

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.html

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.html

41

Department offering the programme: Medical Biochemistry and Molecular

Biology


Academic year: MSc. Second Part




Code: BM6005


Lecture: h Tutorial: Practical: h Total: h

Co-ordinator: Department of Medical Biochemistry and Molecular Biology B - Professional Information 1- Course Aims:

To provide the postgraduate students with the opportunity to apply biochemical

knowledge and molecular biology information in problem solving and case

interpretation

Equipping of the students with the specialized knowledge and skills necessary to

be a professional of medical biochemistry laboratory.


a- Knowledge and understanding By the end of the course the candidate should be able to:

a1) Point out the various metabolic and genetic diseases related to each

course topic.

a2) Understand how to use biochemical and molecular biology knowledge

in the diagnosis and interpretation of clinical picture of patients.



b1- Integrate basic biochemical and molecular biology information with

clinical disease

b2- Analyse and interpret laboratory and clinical data to reach a diagnosis

and predict the course of a disease.


42

By the end of the course the candidate should be able to:

c1-Demonstrate a professional attitude and good communication skills by effective

participation in cooperative problem solving, in small group exercises directed

towards understanding the biochemical and genetic bases of disease origins,

diagnoses and treatments

c2- Apply different methods for expression of concentration and calculation of the

dilution of solution.

c3- Demonstrate ability to prepare buffers and chose the proper buffer for each

medium.

C4- Demonstrate ability to interpret different molecular biology techniques in the

diagnosis of hereditary diseases

C5- Identify and interpret electrophoresis results of different types.

c-6 Interpret the results of PCR and RT-PCR and DNA finger printing



d1 – Develop the skill of working in teams

d2 – Develop appropriate relationships with his colleagues and staff members.



Course contents:

L P

Problems related to:

Preparation of solutions

Changing concentration by dilution

Preparation of acids, bases, and buffers

Osmosis, dialysis, ..

Cases and problems related to:

Protein folding and misfolding

e.g. Alzheimer D

e.g. Prion disease


-Hemoglobinopathies

-Collagin and elastin

Cases and Problems related to:

Enzyme kinetics

Enzyme inhibitors

Enzymes in clinical diagnosis

43


Carbohydrate metabolism


Bioenergetics and Biological oxidation


Lipid metabolism metabolism


Metabolism of ethanol


Protein Metabolism:


Integration of Metabolism

Starvation

Metabolism of special organs


Diabetes mellitus


Biological membranes

Biosignalling

Cell adhesion molecules


Defective nucleotide metabolism:

e.g. Gout


Hyperbilirubinemia

Porphyria


Malnutrition


Nutrition

Obesity

Vitamin deficiency


Defective mineral metabolism:

e.g. Hypocalcemia and hypercalcemia

e.g.Wilson D

e.g. Congenital and aquired iron overload

44

Cases of Blood diseases

hemophilia

Hypercoagulable states


DNA damage and repair

Posttranscriptional modification

Genetic code and mutations

Techniques of genetic testing

DNA finger printing



5.2- Written exam: to assess knowledge and understanding.

Weighing of Assessments: (1) End sec part written exam 100 marks









edition, Mosby,

1996.


Pub., 2007.


edition,



45


edition.





edition,

Freeman Pub, 2009.


edition,

Freeman Pub., 2006.


http://mic2.shams.edu.eg/moodle

www.medicaleducationonline.org

www.eul.edu.eg

www.wilkpedia.com

www.encyclopedia.com

Medical statistics course specification

University: Ain Shams University Faculty: of Medicine


Program on which the course is given: MSc in Medical Biochemistry and

Molecular Biology



Department offering the course: Community, Environmental and Occupational

Medicine

Academic Level: M.Sc. (elective course)



Title: Medical statistics course Code: E6009

Credit Hours: 1 hour





http://www.medicaleducationonline.org/

http://www.eul.edu.eg/

http://www.wilkpedia.com/

http://www.encyclopedia.com/

46

Coordinator

Community, Environmental and Occupational Medicine Department


1- Course Aim:

To enable the M.Sc. candidate to plan, conduct, analyze and interpret the results of

a research in his specific field. This course unit introduces the application of

statistical ideas and methodology to medical research.




a1 - Define medical statistics and identify uses and importance of medical

statistics in medical research

a2 – Define:

Types of variables.

Descriptive statistics.

Presentation and summarization of data.

Measures of central tendency and scatter.

Principles of probability and probability distributions.

Concepts of inferential statistics: confidence interval and hypothesis testing.

Different tests of statistical significance.

Difference between parametric and nonparametric tests of significance.

Correlation and regression

Concept of statistical modeling using multivariable and multivariate

statistical methods.

Combining evidence from different studies and meta-analysis

Importance and methods of sampling and how to determine the suitable

sample size.

Different types of research methodology:

Observational and intervention studies and the different

statistical issues related to the design, conduct, analysis and

interpretation of the results of each study type.

Ethical aspects of medical research including those specifically applied to

clinical trials.



47

b1 - Interpret correctly the results of statistical analyses and critically

evaluate the use of statistics in the medical literature.

b2 - Integrate and evaluate information from a variety of sources.



c1- Select appropriate study designs to address questions of medical

relevance

c2- Select and apply appropriate statistical methods for analyzing data

typically encountered in medical applications.

c3- Use selected software packages for statistical analysis and data

management.



d1 - Work effectively in a group from different backgrounds.

d2 - Respects the role of staff and co-staff members regardless of degree or

occupation.

d3 - Communicate effectively with professional statisticians and the wider

medical community, including the ability to present results of

statistical analyses through written and oral presentations

d4 - Use of computer data bases and other computer skills.

d5 - Handle data appropriately and analyze them through: decision

processes, objective criteria, problem definition, project design and

evaluation, risk management, teamwork and coordination.

d6 - Learn independently with open-mindedness and critical enquiry.

3- Course content:

Topics

T C/P

Introduction to medical statistics and its uses

1

Types of variables and Descriptive statistics

1

Graphic presentation of data

1

Introduction to probability theory and rules

1

Sample and population: sampling distribution of mean and 1

48

proportion

Confidence interval of a mean and a proportion

1

Confidence interval of a difference between two mean /proportion

1

Testing a hypothesis about population mean/proportion

1

Testing a hypothesis about the difference between two

means/proportion

1

Comparing between more than two means-Introduction to

factorial analysis

1

Cross-tabulation and introduction to categorical data analysis

1

Simple correlation and simple regression

1

Introduction to multivariable and multivariate analysis

1

Study designs: observational studies

1

Study designs: Intervention studies: clinical trials

1

Study designs: Experimental animal studies

1

Study designs: Bias and Confounding 1

Ethical issues in medical research

1

Sample size estimation for continuous and binary outcome

measures.

1

Meta-analysis and publication bias.

1

T: Tutorial and C/P: Clinical or Practical and SDL: Self directed learning


4-1 Written exam to assess knowledge and understanding and will

concentrate on problem solving questions

4-2 Weighing of assessment

Written exam 50

Total 50

49

5 - List of References


Student Notes on Medical Statistics and Research Methods. Prof. Mohsen

Abdel Hamid and Dr Moustafa El Houssinie. Department of Community,

Environmental and Occupational Medicine.


Statistics in Clinical Practice. avid Coggon. BMJ Books. 2nd

edition 2003


Handbook of Epidemiology. Springer 2005


www.brettscaife.net/statistics/introstat/

onlinestatbook.com/rvls/

www. Epidemiolog.net

http://www.shef.ac.uk/scharr/spss/

Bioinformatics Elective Course Specifications

University: Ain Shams University Faculty: of Medicine

Program on which the course is given: Master degree in Medical biochemistry

and Molecular Biology



Department

Department offering the course: Medical biochemistry and Molecular Biology

Department

Academic Level: Master – Second part



Title: Medical biochemistry and Molecular Biology course. Code: E6018

Credit Hours: 1 Lectures:8

Tutorials :4 Practical:10 Total: 22 hours

Coordinator: Medical Biochemistry and Molecular Biology Department

B- Professional Information

1 – Overall Aims of Course

50

Bioinformatics has been defined as the science of examining the

structure and function of genes and proteins through the use of

computational analysis, statistics, and pattern recognition. The field of

bioinformatics changes so rapidly that it is nearly impossible to keep up

with all the different areas of progress. A Bioinformatics postgraduate

course mainly aims at teaching students current state-of-the-art

bioinformatics status. There should be a solid understanding of the scope

of bioinformatics. It is also necessary to become aware of the tools and

techniques used in research and in applications. It is therefore necessary

to learn how to access new information and how to assimilate it into the

whole, in order to continue to learn beyond the limits of this course.

2 – Intended Learning Outcomes of Course (ILOs)

a- Knowledge and Understanding:

By the end of the course, students should be able to

a1- Understand bioinformatics, the application of

computational methods to interpret the rapidly expanding

amount of biological information.

a2- Describe the range of applications of bioinformatics to

molecular biology, clinical medicine, pharmacology,

biotechnology, agriculture, forensic science, anthropology

and other disciplines.

a3- State the role of computers and computer science in the

investigations and applications of the data.

d- Intellectual Skills

By the end of the course, students will be able to

b1- Understand the language of both experimental biologist

and computing scientist, and can bridge the gap between

them.

b2- Understand how sequence-structure relationships will form

the bridge to protein structure

b3- Gain to think about solving some health problems through

bioinformatics.

e- Professional and Practical Skills


c1- Gain access to the data through the world wide web and use

the right methods for their analysis.

51

c2- Retrieve information, and calculate with the data, and

extend these skills by self-directed 'field work' on the web.

f- General and Transferable Skills


d1- Discuss among partners involved in the bioinformatics

problems (biologists, statisticians and computer

professionals).

d2- Use the Web and other resources for gene and protein

surveys.

52

3- Contents

T /P Lecture No. of

hours

Topic Week

1 1 What is Bioinformatics?

1. 1

1 1 DNA structure and flow of

genetic information

2. 1

1 1 Regulation of gene expression 3. 3

1 1 Protein structure 4. 4

2 2 1 Sequences:

Biological DNA and protein

sequences, the genetic code

Sequence tools

5. 5

2 2 Handling sequences in biological

databases

6. 6

2 1 3 Sequence comparison:

Identity, similarity, and

homology.

7. 5

1 2 3 Pairwise sequence alignment

8. 9

2 1 1 Multiple Sequence Alignment

9. 2

9

2 2 3 Microarray 10. 1

2

1 2 3 Final Exam 11.

53

4– Teaching and Learning Methods

4.1- Power point slide presentations.

4.2- Practical online training.

4.3- Students presentations.

4.4- Open discussions.


5.1 Genetic code, translation and mutation exercises to assess their

understanding to the basic molecular biology concepts.

5.2 Weblems to assess their ability of doing WWW surveys.

5.3 Constructing phylogenetic trees to assess their ability to use

different bioinformatics programs.

5.4 Student presentations to assess understanding the basics and

ability to transfer knowledgeable skills.

Assessment Schedule

Assessment 1: The flow of genetic information. Week 4

Assessment 2: Sequence analysis tools and comparison. Week 9

Assessment 3: Data bases and protein structure. Week 12

Weighing of Assessments

Class discussion participation 5%

Homework (exercises, reading assignments) 10%

Practical work 10%

Individual presentations 15%

Final-term Examination 60%

Oral Examination. 0%

Total 100%

Any formative only assessments

6- List of References

6.1- Course Notes

The power point presentations.

PDF handouts.


54

Introduction to Bioinformatics by Arthur M. Lesk (2005).

Papers and handouts relevant to presented topics will be

distributed as needed.


Discovering Genomics, Proteomics, and Bioinformatics

by A. Malcolm Campbell, Laurie J. Heyer

Introduction to Bioinformatics: A Theoretical and

Practical Approach by Stephen A., Ph.D. Karwetz

(Editor), David D., Ph.D. Womble (Editor)

Bioinformatics For Dummies (For Dummies (Math &

Science))

by Jean-Michel Ph. D. Claverie, Cedric Ph.D. Notredame

Introduction to Protein Science: Architecture, Function,

and Genomics by Arthur M. Lesk


http://www.ncbi.nlm.nih.gov/

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM

http://www.ensembl.org/index.html

http://www.expasy.org/

http://www.bioinformatik.de

http://post.queensu.ca/~forsdyke/bioinfor.htm

http://www.techfak.uni-bielefeld.de/bcd/ForAll/Basics

http://www.dnaftb.org/dnaftb/

http://www.perl.com/pub/q/documentation

http://www.pdg.cnb.uam.es/cursos/FVi2001/GenomAna/GeneIdentif

ication/SearchContent/main.html

http://www.rcsb.org

http://scop.mrc-lmb.cam.ac.uk/scop/

http://www.genebee.msu.su/services/phtree_reduced.html

http://evolution.genetics.washington.edu/phylip/software.html

http://copland.udel.edu/~schmidtc/html/internet_links.html

7- Facilities Required for Teaching and Learning

PCs, Data show, whiteboard and markers, Printer and papers,

copying machine, and Internet connection

http://www.amazon.com/Introduction-Bioinformatics-Arthur-M-Lesk/dp/0199277877/sr=1-1/qid=1169964350/ref=sr_1_1/002-9037896-6094443?ie=UTF8&s=books

http://www.amazon.com/exec/obidos/search-handle-url/102-3727164-5784157?%5Fencoding=UTF8&search-type=ss&index=books&field-author=A.%20Malcolm%20Campbell

http://www.amazon.com/exec/obidos/search-handle-url/102-3727164-5784157?%5Fencoding=UTF8&search-type=ss&index=books&field-author=Laurie%20J.%20Heyer

http://www.amazon.com/exec/obidos/search-handle-url/102-3727164-5784157?%5Fencoding=UTF8&search-type=ss&index=books&field-author=Stephen%20A.%2C%20Ph.D.%20Karwetz

http://www.amazon.com/exec/obidos/search-handle-url/102-3727164-5784157?%5Fencoding=UTF8&search-type=ss&index=books&field-author=David%20D.%2C%20Ph.D.%20Womble

http://www.amazon.com/exec/obidos/search-handle-url/002-9037896-6094443?%5Fencoding=UTF8&search-type=ss&index=books&field-author=Jean-Michel%20%20Ph.%20D.%20Claverie

http://www.amazon.com/exec/obidos/search-handle-url/002-9037896-6094443?%5Fencoding=UTF8&search-type=ss&index=books&field-author=Cedric%20%20Ph.D.%20Notredame

http://www.amazon.com/Introduction-Protein-Science-Architecture-Function/dp/0199265119/sr=1-1/qid=1169965071/ref=pd_bbs_sr_1/002-9037896-6094443?ie=UTF8&s=books

http://www.amazon.com/Introduction-Protein-Science-Architecture-Function/dp/0199265119/sr=1-1/qid=1169965071/ref=pd_bbs_sr_1/002-9037896-6094443?ie=UTF8&s=books

http://www.ncbi.nlm.nih.gov/

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM

http://www.ensembl.org/index.html

http://www.expasy.org/

http://www.bioinformatik.de/

http://post.queensu.ca/~forsdyke/bioinfor.htm

http://www.techfak.uni-bielefeld.de/bcd/ForAll/Basics

http://www.dnaftb.org/dnaftb/

http://www.perl.com/pub/q/documentation

http://www.pdg.cnb.uam.es/cursos/FVi2001/GenomAna/GeneIdentification/SearchContent/main.html

http://www.pdg.cnb.uam.es/cursos/FVi2001/GenomAna/GeneIdentification/SearchContent/main.html

http://www.rcsb.org/

http://scop.mrc-lmb.cam.ac.uk/scop/

http://www.genebee.msu.su/services/phtree_reduced.html

http://evolution.genetics.washington.edu/phylip/software.html

http://copland.udel.edu/~schmidtc/html/internet_links.html

55

Your log book 1- Introduction

The aim of this book is to give you a guide to the expectations for each

item. It will be a guide for both you and your teachers to what you should be seeing

and doing.

It will give you a list of the important topics that you should think about and

should be covered in:

1. Clinical or practical sessions

or

2. Lectures

or

3. Self-directed learning (SDL)

For each item there is also a list of

1. Clinical conditions or Practical sessions to be seen or

attended (According to each degree)

2. Practical procedures to be seen and done

Remember

This document is only a guide. It is not an exhaustive list. It is not just a checklist

to score points. It is a guide to encourage you to read and learn more. This book is

for your benefit. It will form a record of your clinical training and experience.

2 - Supervisors

……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………… 3–Tables for Training Records Requirements Candidates are required to fulfill 75% of the listed activities in order to be eligible

for the exam entry. The minimum number required for each activity = 75%. You

are free to attend more and record your extra attendance.

56

Weekly Department Plan Day

/time

Saturday Sunday Monday Tuesday Wednesday Thursday

Lectures 9-11 am 9-11 am

Practical

Sessions

9am-12pm

Seminars

11am -1 pm

Journal

Club

12-2 pm

Conferences attendance

(NB. Minimum number required is 2)

No

Da

te

Pla

ce

Topics Supervisor

signature

1

2

Thesis attendance


No Date Place Name of the thesis Supervisor

signature

1

2

3

4

Journal club attendance


No

Da

te

Pla

ce

Topics Supervisor

signature

1

57

2

3

4

5

6

7

8

Seminars attendance


No

Da

te

Pla

ce

Topics Supervisor

signature

1

2

3

4

5

6

7

8

Practical skills Practical skills (Agreement Scale) of

Medical Biochemistry and Molecular Biology

Weighing and preparation of solutions


No Date Place Performance Supervisor

signature

1

2

3

4

5

Buffer preparation



signature

1

2

3

4

5

Specimen Collection and processing



signature

1

2

3

4

5

59

Spectrophotometric assays



signature

1

2

3

4

5

6

Urine Analysis



signature

1

2

3

4

Urinary stone analysis



signature

1

2

DNA extraction



signature

1

2

60

Electrophoresis



signature

1

2

AP =ASSISTED PERFORMANCE

IP =INDEPENDENT PERFORMANCE

O =OBSERVATION

P =POOR S= Satisfactory E= Excellent GOOD

Assignments


No Date Score Topic Supervisor

signature

1 Assessment of a diabetic case by OGTT

2 Assessment of a dyslipidemic case by

spectrophotometry

3 Calculations of concentration and

dilution of solutions

4 Preparation and presentation of a

seminar (advanced biochemistry and

molecular biology)

5 Preparation and presentation of one

article in Journal club sessions

6 Design primers for a specific gene

7 Check validity of a PCR primer

sequence for a specific gene

8 Analyze the results of DNA

fingerprinting

5 - Log book preview

The candidate logbook will be reviewed and patients seen/ skills

performed summarized by diagnosis groups during the semester evaluation and at

the end of the course in the table below. The results of this review will be totaled

in the summary chart below.

61

Summary

1

st

Semester

2nd

Semester

3rd

Semester

4th

Semester

Total

Activity No No No No

Conferences

attendance

Thesis attendance

Journal club

attendance

Seminar attendance

Practical skills:

Weighing and

preparation of solutions

Preparation of buffers

Specimen collection

and processing

Spectrophotometric

assays

Urine analysis

Urinary stone analysis

DNA extraction

Electrophoresis

Assignments:

Assessment of a

diabetic case by OGTT

Assessment of a

dyslipidemic case by

spectrophotometry

Preparation and

presentation of a

seminar

Preparation and

presentation of one

article in Journal club

sessions

Design PCR primers

for a specific gene

62

Check validity of a

PCR primer sequence

for a specific gene

Analyze the results of

DNA fingerprinting

Supervisor signature

VII - Head Of Department Approval For The Exam Entry

__________________________________________________________________

__________________________________________________________________

________________________________________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________ __________________________________________________________________

____________________________

63

VIII – Thesis Follow up

انخقزيز اننصف انسنىي نعبو / انخبريخ/

عن انطبنب /

انقيذ نذرجت ) يبجسيخز (

بقسى /

حقزيز انسبدة االسبحذة انشزفين

بذأ جع انبدة انعهيت و كخببت انقذيت

ع شىطب يحذوداقط

أوشك عه اإلنخهبء

إنخه ين انجع

بذأ انجزء انعه

قطع شىطب يحذودا


إنخه ين انخحهيم

بذأ ينبقشت اننخبئج



إنخه ين انخحزيز

بذأ عت اننهبئيت يع انشزفانزاج



إنخهج حبيب

إسخزار قيذ انطبنب رأي انسبدة انشزفين

يذ انقيذ

شطب قيذ انطبنب

نعى حى حشكيم نجنت اننبقشت

ال

ريخ انخشكيم حب

/ /

يذ / شطب انقيذ

وكيم انكهيت حىقيع انسبدة انشزفين

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عن انطبنب /

ذ نذرجت ) يبجسيخز (انقي

بقسى /














بذأ انزاجعت اننهبئيت يع انشزف



إنخهج حبيب


يذ انقيذ

ذ انطبنب شطب قي


ال

حبريخ انخشكيم

/ /



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عن انطبنب /


بقسى /





ين انجعإنخه












إنخهج حبيب


يذ انقيذ



ال


/ /



69


عن انطبنب /


بقسى /

السبحذة انشزفينحقزيز انسبدة ا
















إنخهج حبيب


يذ انقيذ



ال


/ /



71

VIII – Evaluation Forms

To be completed at -------------------------------------

Candidate

Supervisor

Location

Aim of training

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

Agreed educational objectives and timescale in which objectives should be

achieved.

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

Comments by Candidate

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

Comments by Supervisor

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

Date of next meeting

Signed by candidate

Signed by Supervisor

Date

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Candidate

Supervisor

Location

Aim of training

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


achieved.

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


Signed by candidate


Date

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Candidate

Supervisor

Location

Aim of training

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


achieved.

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


Signed by candidate


Date

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Candidate

Supervisor

Location

Aim of training

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


achieved.

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________

__________________________________________________________________


Signed by candidate


Date

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Degree Program Evaluation Form by The Candidate

To be completed at the end of your degree.

Please consider each pair of statements and decide which most clearly reflects your

view and tick one box or answer the question.

I. Individual Information

1. Are you a graduate of ASU?

yes no to some degree

2. Year and semester when studies began:

II. General Questions

1. What are the advantages/disadvantages of the general study environment at the

University ASU?

2. What were your expectations when you applied to the degree?

3. Do you feel that the degree program prepares you well for your future studies or

employment according to the demands and expectations of those institutions?


4. Has the time limit of the program (two or three academic years) caused you any

difficulties or inconveniences?


III. Structure of Degree Program

1. Did you receive enough guidance in planning your study schedule in the

beginning of the program?


2. What were the main difficulties in the planning of your study schedule?

3. What is your general opinion on the structure of the degree program?

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4. In your opinion, does the degree program offer a good balance of lectures,

seminars, conferences, and book exams?


a) General Studies

i) Do you feel that you have received enough guidance on academic writing?


ii) Do you feel that you have acquired sufficient knowledge on research skills (eg.

quantitative and qualitative research methods)?


b) Courses

i) Have you had some special difficulties in completing some of the courses?

Please specify.

ii) Has there been a sufficient variety of courses offered for your optional studies?


iii) Have you received enough guidance for the preparation of your thesis?


IV. Concluding Points

1. Did the degree program meet your expectations?


2. What aspects of the degree program do you particularly like?

3. What aspects of the degree program do you particularly dislike?

4. What are your suggestions on how to improve the program?

Thank you!

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