Polysaccharides - Springer978-3-319-16298... · 2017-08-24 · Editors Kishan Gopal Ramawat Botany...
Transcript of Polysaccharides - Springer978-3-319-16298... · 2017-08-24 · Editors Kishan Gopal Ramawat Botany...
Kishan Gopal RamawatJean-Michel MerillonEditors
Polysaccharides
Bioactivity and Biotechnology
With 488 Figures and 154 Tables
EditorsKishan Gopal RamawatBotany DepartmentM.L. Sukhadia UniversityUdaipur, India
Jean-Michel MerillonGroupe d’Etude des Substances Vegetales àActivite BiologiqueUniversite de Bordeaux, Institut desSciences de la Vigne et du VinVillenave d’Ornon, France
ISBN 978-3-319-16297-3 ISBN 978-3-319-16298-0 (eBook)ISBN 978-3-319-16299-7 (print and electronic bundle)DOI 10.1007/978-3-319-16298-0
Library of Congress Control Number: 2015941889
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Preface
We are pleased to present a three volume treatise on “Polysaccharides: Bioactivity
and Biotechnology.” Polysaccharides are present throughout the plant kingdom and
involved in various biological processes including defense for the plant and many
useful applications for human welfare.
This work on polysaccharides is a reference work providing state-of-the-art
knowledge composed by highly renowned scientists in their field. The book aims
to present comprehensive, up-to-date, and well-established information about com-
plex and astonishing structures, properties, and biotechnological applications of
polysaccharides and their upcoming industrial applications. The book will be a
valuable source on polysaccharides to those working in the field of industrial
production and biotechnology development. Polysaccharides are a class of impor-
tant biomacromolecules, with complex structures and various functional activities.
Polysaccharides are extremely common and wide-spread in nature, with cellulose
as the most common and abundant organic compound on the planet. It is believed
that the second most common polysaccharide in the world after cellulose is chitin.
Chitin is to shellfish what cellulose is to trees. This is a very timely compilation of
recent developments about polysaccharides as no book is available in this format.
These polysaccharides find many uses: cf. for example the significant role of
cellulose in the paper and textile industries, as a feedstock for the production of
rayon (via the viscose process), cellulose acetate, celluloid, and nitrocellulose; as
surgical threads (chitin), as sources of energy, dietary fibers, as a blood flow
adjuvant; cosmetics, emulsion stabilizer, film former, binder, viscosity increasing
agent, and skin conditioning agent; direct food additives in gums and chewing gum
bases; and as vaccines. Many polysaccharides have been developed into useful
products, including xanthan gum, dextran, welan gum, gellan gum, diutan gum, and
pullulan.
This comprehensive and thoroughly up-to-date reference book presents the
sources, identification, methods of analysis, biosynthesis, biotechnology, and appli-
cations of important polysaccharides likes starches, cellulose, chitin, gum, and
microbial polysaccharides. Polysaccharides have received much attention recently
because of the emergence of different biological activities, such as immunomodu-
latory, antibacterial, antimutagenic, radioprotective, anti-oxidative, anti-ulcer,
antidepressant, antisepticemic, anticancer, and anti-inflammatory activities.
v
New industrial applications in pharmaceutical and medical sciences are being
developed. Due to these properties and benefits, a vast body of data is being
generated.
The various polysaccharides constitute important classes of biological polymers,
which are dealt with in these volumes. The handbook is divided in several sections
to encompass the entire spectrum of developments in this field: Part I. Biology and
Biotechnology: occurrence, structure, distribution and biotechnology (bacterial
polysaccharides, fungal polysaccharides, polysaccharides from lower plants, poly-
saccharides from higher plants including gums), biosynthesis of polysaccharides,
applications in biotechnology, production by fermentation, biopolymers from
marine prokaryotes, carrageenan, dextrans, polysaccharide nanocrystals, and mod-
ified gums in drug delivery. Part II. Food: structural (pectins, cellulose, xylans,
gum, gumexudates, glycosamines), storage (starch, glycogens, fructans, minor
polysaccharides), marine polysaccharides (alginate and brown sea weeds, carra-
geenan, and red sea weeds; agar, agarose, chitosan, and chitin derivatives), bacterial
and synthetic polysaccharides (dextrans, cyclodextrins, gellans, xanthan, pullulan,
etc.), polysaccharides from edible plant parts, and as functional foods. Part III.
Methods: Extraction, identification, quantification, assays, and emerging technolo-
gies. Part IV. Bioactivity: applications in medicine, immunostimulant, polysaccha-
rides from algal, aloe, brown seaweeds, fructus, ganoderma, medicinal mushrooms,
scleroderma, and their biological activity. Most of the chapters are well illustrated,
many of them in color, for the benefit of the readers. A comprehensive index section
will assist in navigating through this book when searching for specific topics.
Well recognized international specialists in their respective fields of research
have contributed these chapters. This book will be useful to everybody working in
the field of botany, phytochemistry, pharmacy, drug delivery, molecular biology,
forestry, biotechnology, and industrial/food and medical products. This work is
arranged in 73 well illustrated chapters.
Because of the voluminous work for the treatise, this project was spread over
almost 2 years, from concept to print. We would like to acknowledge cooperation,
patience, and support of our contributors who have put their serious efforts to
ensure the high scientific quality of this book with up-to-date information.
This work could not have been completed without active support of Springer
team who took pains in streamlining the production process. We are particularly
indebted to Drs. Tobias Wassermann, Sylvia Blago, and Stephanie H€ugler for theircontinuous support from the very inception of the project. Our final and most
heartfelt thanks we want to give to our wives Marie-Claude Merillon and Manju
Ramawat, who have supported us during the entire period of this book project.
March 2015 J. M. Merillon
K. G. Ramawat
vi Preface
Contents
Volume 1
Part I Biology and Biotechnology . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1 Plant Cell Wall Polysaccharides: Structure and Biosynthesis . . . . 3
Michael A. Held, Nan Jiang, Debarati Basu, Allan M. Showalter, and
Ahmed Faik
2 Cell Wall Evolution and Diversity . . . . . . . . . . . . . . . . . . . . . . . . . 55
David S. Domozych
3 Bacterial Polysaccharides: An Overview . . . . . . . . . . . . . . . . . . . . 81
Swati Misra, Varsha Sharma, and Ashok Kumar Srivastava
4 Algal Polysaccharides and Health . . . . . . . . . . . . . . . . . . . . . . . . . 109
Ladislava Misurcová, Jana Orsavová, and Jarmila Vávra Ambrozová
5 Polysaccharides from Lower Plants: Bryophytes . . . . . . . . . . . . . 145
Laura Klavina
6 Microbial Production of Extracellular Polysaccharides from
Biomass Sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
Emrah Ozcan and Ebru Toksoy Oner
7 Tree Gum: Gum Kondagogu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Rao Beedu Sashidhar, D. Raju, and Rasineni Karuna
8 Chitosan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Surinder P. Chawla, Sweetie R. Kanatt, and A. K. Sharma
9 Cyclodextrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
Andre Sá Couto, Paulo Salustio, and Helena Cabral-Marques
10 Cellulosic Biomaterials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289
Holger Wondraczek and Thomas Heinze
vii
11 Starch Metabolism in Green Plants . . . . . . . . . . . . . . . . . . . . . . . . 329
Maria V. Busi, Diego F. Gomez-Casati, Mariana Martın,
Julieta Barchiesi, Mauricio J. Grisolıa, Nicolás Hedın, andJulieta B. Carrillo
12 Fungal Cultivation and Production of Polysaccharides . . . . . . . . . 377Carla Maısa Camelini, Márcio Jose Rossi, Francielle T. G. S.
Cardozo, A. Gomes, Ceci Sales-Campos, and Admir J. Giachini
13 Starch and Nanoparticle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 417Alain Dufresne
14 Polysaccharide Production by Submerged Fermentation . . . . . . . 451Oscar J. Sánchez, Sandra Montoya, and Liliana M. Vargas
15 Cellulose from Lignocellulosic Waste . . . . . . . . . . . . . . . . . . . . . . . 475Michele Michelin, Hector A. Ruiz, Daniel P. Silva, Denise S. Ruzene,
Jose A. Teixeira, and Maria Lourdes T. M. Polizeli
16 Sugarcane Straw and Its Cellulosic Fraction as Raw Materials
for Obtainment of Textile Fibers and Other Bioproducts . . . . . . . 513Sirlene M. Costa, Andre Aguiar, Sandra M. Luz,
Adalberto Pessoa, and Silgia A. Costa
17 Endogenous Hydrolyzing Enzymes: Isolation, Characterization,
and Applications in Biological Processes . . . . . . . . . . . . . . . . . . . . 535Waleed Ahmad Khattak, Mazhar Ul-Islam,
Muhammad Wajid Ullah, Shaukat Khan, and Joong Kon Park
18 Production of Pullulan by Microbial Fermentation . . . . . . . . . . . 581
Venkatachalam Ponnusami and Varadarajan Gunasekar
19 Biosynthesis of Extracellular Matrix Components,
Glycosaminoglycans, Proteoglycans, Collagens, Elastin and
Structural Glycoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 597
Leslie Robert
20 Polysaccharides from Bioagro-Waste for New Biomolecules . . . . 603
Paola Di Donato, Annarita Poli, Valentina Taurisano, and
Barbara Nicolaus
Volume 2
Part II Food . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 639
21 Gum of Prosopis/Acacia Species . . . . . . . . . . . . . . . . . . . . . . . . . . . 641
Yolanda L. Lopez-Franco, Francisco M. Gooycolea, and
Jaime Lizardi-Mendoza
22 Resistant Starch in Food Industry . . . . . . . . . . . . . . . . . . . . . . . . . 663
Leyla Khalili and Amir Amini
viii Contents
23 Inulin and Health Benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 675
Matthias Moser, Anke Sentko, and Helene Alexiou
24 Active Edible and Biodegradable Starch Films . . . . . . . . . . . . . . . 717Laura Sánchez-González, Elmira Arab-Tehrany, Maite Cháfer,Chelo González-Martınez, and Amparo Chiralt
25 Dextran and Food Application . . . . . . . . . . . . . . . . . . . . . . . . . . . . 735Damini Kothari, Deeplina Das, Seema Patel, and Arun Goyal
26 Galactans and Its Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . 753Guillaume Pierre, Cedric Delattre, Celine Laroche, and Philippe Michaud
27 Functional Components in Zizyphus with Emphasis onPolysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795
Tsai Hua Kao and Bing Huei Chen
28 Chitosan-Based Edible Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 829
Maher Z. Elsabee
29 Characterization of Psyllium (Plantago ovata) Polysaccharideand Its Uses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 871
Ashwini R. Madgulkar, Monica R. P. Rao, and Deepa Warrier
30 Dietary Fiber and Prebiotics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 891
Werner Praznik, Renate Loeppert, Helmut Viernstein,
Alexander G. Haslberger, and Frank M. Unger
31 Polysaccharide-Protein Complexes from Edible Fungi and
Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 927
Jian-Yong Wu
32 Oligosaccharides from Botrytis cinerea and Elicitation of
Grapevine Defense . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 939
Cassandrine Saigne-Soulard, Assia Abdelli-Belhadj, Marie
Telef-Micouleau, Jerome Bouscaut, Stephanie Cluzet,
Marie-France Corio-Costet, and Jean-Michel Merillon
33 Physical Properties of Inulin and Technological Applications . . . 959
Cesar Leyva-Porras, Ana L. Lopez-Pablos, Claudia Alvarez-Salas,
Jose Perez-Urizar, and Zenaida Saavedra-Leos
Part III Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 985
34 Microwave-Assisted Extraction of Polysaccharides . . . . . . . . . . . . 987
Ana Cristina Soria, Laura Ruiz-Aceituno, Lourdes Ramos, and
Luz Maria Sanz
35 Preparation and Characterization of Polysaccharides from
Mushrooms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1009
Fengmei Zhu, Bin Du, and Baojun Xu
Contents ix
36 Isolation, Purification, and Nanotechnological Applications of
Chitosan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1029
Joydeep Dutta
37 Enzyme-Assisted Extraction of a Marine Algal Polysaccharide,
Fucoidan and Bioactivities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1065
H. H. Chaminda Lakmal, Ji-Hyeok Lee, and You-Jin Jeon
38 Microwave-Synthesized Polysaccharide Copolymers . . . . . . . . . . 1079
Marcin Łukasiewicz, Grzegorz Kowalski, and Anna Ptaszek
39 Analytical Methods for Lignocellulosic Biomass StructuralPolysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1121
Jason S. Lupoi
40 Carbohydrate Secondary and Tertiary Structure Using Raman
Spectroscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1181
Shaun Thomas Mutter and Ewan William Blanch
41 Production, Upgrading and Analysis of Bio-oils Derived from
Lignocellulosic Biomass . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1219
Pankaj K. Kanaujia
42 HPLC Method for Microanalysis and Pharmacokinetics of
Marine Sulfated Polysaccharides, Propylene Glycol Alginate
Sodium Sulfate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1251
Yi-Ting Xue, Chun-Xia Li, Xia Zhao, and Hua-Shi Guan
43 Determination of Must and Wine Polysaccharides by Gas
Chromatography-Mass Spectrometry (GC-MS) and
Size-Exclusion Chromatography (SEC) . . . . . . . . . . . . . . . . . . . . . 1265
Zenaida Guadalupe, Belen Ayestarán, Pascale Williams, and
Thierry Doco
44 NMR Spectroscopy for the Determination of Mucoadhesive
Properties of Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299
Gloria Uccello-Barretta, Federica Balzano, and Federica Aiello
45 Transition-Metal-Catalyzed Transformation of Monosaccharides
and Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1319
Zuzana Hricovıniová
46 Surface Properties of Polysaccharides . . . . . . . . . . . . . . . . . . . . . . 1373
Yi Wang and Gary A. Dykes
47 Computerized Models of Carbohydrates . . . . . . . . . . . . . . . . . . . . 1397
Alfred D. French
48 Carbohydrate Microarrays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1441
Denong Wang, Jin Tang, Russell D. Wolfinger, and
Gregory T. Carroll
x Contents
49 Advanced Nano-biocomposites Based on Starch . . . . . . . . . . . . . . 1467
Fengwei Xie, Eric Pollet, Peter J. Halley, and Luc Averous
50 Chemically Modified Natural Polysaccharides to Form Gels . . . . 1555
John Garner and Kinam Park
Volume 3
Part IV Bioactivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1583
51 Extraction, Structure, and Bioactivities of the Polysaccharides
from Fructus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1585
Yanfang Wu, Xinsheng Wang, and Enguo Fan
52 Bioactivity of Chitosan Derivatives . . . . . . . . . . . . . . . . . . . . . . . . 1609
Mani Prabaharan
53 Gellan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1627
Ding Kang, Hong-Bin Zhang, Yoko Nitta, Ya-Peng Fang, and
Katsuyoshi Nishinari
54 Bioactivity and Applications of Polysaccharides from
Marine Microalgae . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1683
Maria Filomena de Jesus Raposo, Alcina Maria Miranda Bernardo
de Morais, and Rui Manuel Santos Costa de Morais
55 Pectic Polysaccharides and Their Functional Properties . . . . . . . 1729
Beda M. Yapo and Dago Gnakri
56 Recent Advances on the Development of Antibacterial
Polysaccharide-Based Materials . . . . . . . . . . . . . . . . . . . . . . . . . . . 1751
Veronique Coma, Carmen S. R. Freire, and Armando J. D. Silvestre
57 Modified Polysaccharides for Drug Delivery . . . . . . . . . . . . . . . . . 1805
Eleni K. Efthimiadou, Aikaterini-Foteini Metaxa, and George Kordas
58 Chitosan-Based Polysaccharide Biomaterials . . . . . . . . . . . . . . . . 1837
Jayachandran Venkatesan, Baboucarr Lowe, Ramjee Pallela, and
Se-Kwon Kim
59 Structure and Bioactivities of Fungal Polysaccharides . . . . . . . . . 1851
Muhammad Saeed Khan, Xuewu Zhang, Lijun You, Xiong Fu, and
Arshad Mehmood Abbasi
60 Biopolysaccharides for Skin Hydrating Cosmetics . . . . . . . . . . . . 1867
Mayuree Kanlayavattanakul and Nattaya Lourith
61 Polysaccharides from Medicinal Mushrooms and Their
Antitumor Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1893
Haixia Chen and Shuqin Li
Contents xi
62 Resistant Starch as Functional Ingredient . . . . . . . . . . . . . . . . . . . 1911
Elena Sánchez-Zapata, Manuel Viuda-Martos,
Juana Fernández-Lopez, and Jose A. Perez-Alvarez
63 Pharmaceutical Applications of Various Natural Gums . . . . . . . . 1933
Anand Shankar Deshmukh and Tejraj M. Aminabhavi
64 Cationic Polymers for the Delivery of Therapeutic
Nucleotides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1969
Anjali Jain, Hossein Hosseinkhani, Abraham J. Domb, and
Wahid Khan
65 Dietary Polysaccharides and Immune Modulation . . . . . . . . . . . . 1991
Herta Stutz Dalla Santa, Pedro Roosevelt Torres Romao,
Vanessa Sovrani, Fabio Rodrigues Oliveira, Alessandra Peres, and
Marta Chagas Monteiro
66 Bacterial Polysaccharides: Production and Applications in
Cosmetic Industry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2017
Filomena Freitas, Vıtor D. Alves, and Maria A. M. Reis
67 Effects of Polysaccharide-Based Formulations on
Human Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2045
Patrıcia Maria Berardo Goncalves Maia Campos,
Maisa Oliveira de Melo, and Flavio Bueno de Camargo Junior
68 Major Advances in the Development of Synthetic
Oligosaccharide-Based Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . 2065
Damiano Cancogni, Matteo Fusari, Niccolo Poggi, and Luigi Lay
69 Plant Polysaccharides and Their Effects on Cell Adhesion . . . . . . 2117
Xianxiang Xu
70 Polysaccharides from Aloe vera and Oral Ulcerations . . . . . . . . . 2137
Kanokporn Bhalang and Kevin Tompkins
71 Natural Polysaccharides from Mushrooms: Antinociceptive
and Anti-inflammatory Properties . . . . . . . . . . . . . . . . . . . . . . . . . 2151
Fhernanda Ribeiro Smiderle, Andrea Caroline Ruthes, and Marcello
Iacomini
72 Polysaccharides in Cancer Prevention: From Bench to
Bedside . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2179
Sanjeev Banerjee, Mansi Parasramka, and Shivani B. Paruthy
73 Polysaccharides from the Fungus Scleroderma . . . . . . . . . . . . . . . 2215
Marılia da Silva Nascimento Santos and Edda Lisboa Leite
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2233
xii Contents
About the Editors
Professor Dr. Kishan G. Ramawat is Former Pro-
fessor and Head of the Botany Department,
M.L. Sukhadia University, Udaipur, India, and can
look back on longstanding research experience.
He received his Ph.D. in Plant Biotechnology in
1978 from the University of Jodhpur, India, and after-
wards joined the university as a faculty member.
In 1991 he moved to the M.L. Sukhadia University
in Udaipur as Associate Professor and became
Professor in 2001. He served as the Head of the
Department of Botany (2001–2004, 2010–2012),
was in charge of the Department of Biotechnology
(2003–2004), was a member of the task force on medicinal and aromatic plants of
the Department of Biotechnology, Government of India, New Delhi (2002–2005),
and coordinated UGC-DRS and DST-FIST programs (2002–2012).
Professor Ramawat had done his postdoctoral studies at the University of Tours,
France, from 1983 to 1985, and later returned to Tours as visiting professor (1991).
He also visited the University of Bordeaux 2, France, several times as visiting
professor (1995, 1999, 2003, 2006, 2010), and in 2005 Poland in an academic
exchange program (2005). Through these visits in France, Prof. Ramawat and Prof.
Merillon established a strong connection, which has resulted in productive collab-
orations and several book and reference work publications.
Professor Ramawat has published more than 170 well-cited peer-reviewed
papers and articles, and edited several books and reference works on topics such
as the biotechnology of medicinal plants, secondary metabolites, bioactive mole-
cules, herbal drugs, and many other topics. His research was funded by several
funding agencies.
In his research group, Prof. Ramawat has supervised doctoral thesis of
25 students. He is an active member of several academic bodies, associations,
and editorial boards of journals.
xiii
Professeur Dr. Jean-Michel Merillon Directeur de
l’EA 3675/Faculte de Pharmacie/Universite de
Bordeaux is the “Directeur de l’EA 3675 (Groupe
d’Etude des Substances Vegetales à Activite
Biologique + Polyphenols Biotech)” at the Faculte
de Pharmacie, Universite de Bordeaux, Institut des
Sciences de la Vigne et du Vin, in Villenave d’Ornon,
France. He received his M.Pharma. (1979) and Ph.D.
(1984) from the University of Tours in France.
He joined the University of Tours as assistant
professor in 1981, and became associate professor in
1987. In 1993 he moved to the faculty of Pharmacy,
University of Bordeaux, France, accepting a position as full professor. He is
currently leading the “study group on biologically active plant substances” at the
Institute of Vine and Wine Sciences, which comprises 25 scientists and research
students. The group has been working on phenolic compounds from vine and wine
for many years, mainly complex stilbenes and their involvement in health. Profes-
sor Merillon has supervised the doctoral theses of 19 students. He is involved in
developing teaching on plant biology, natural bioactive compounds, and
biotechnology.
Professor Merillon has published more than 145 research papers in internation-
ally recognized journals, resulting in an H index of 35 (documents published
between 1996 and 2015). He has co-edited books and reference works on secondary
metabolites and biotechnology.
Throughout his career, Prof. Merillon has traveled widely as a senior professor.
Scientists from several countries have been and are working in his laboratory, and
his research is supported by funding from the Aquitaine Regional Government,
the Ministry of Higher Education and Research, and various private companies.
In 2004, he founded the technology transfer unit “Polyphenols Biotech,” providing
support for R&D programs for SMEs and major groups from the cosmetic,
pharmaceutical, agricultural, and health-nutrition sectors.
xiv About the Editors
Contributors
Arshad Mehmood Abbasi College of Light Industry and Food Sciences, South
China University of Technology, Guangzhou, China
Department of Environmental Sciences, COMSATS Institute of Information Tech-
nology, Abbottabad, Pakistan
Assia Abdelli-Belhadj Groupe d’Etude des Substances Vegetales à Activite
Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de
Bordeaux, Villenave d’Ornon, France
Andre Aguiar Institute of Natural Resources, Federal University of Itajubá,Itajubá, Brazil
Federica Aiello Department of Chemistry and Industrial Chemistry, University of
Pisa, Pisa, Italy
Helene Alexiou BENEO Institute, Mannheim, Germany
Claudia Alvarez-Salas Facultad de Ingenierıa, Universidad Autonoma de San
Luis Potosı, San Luis Potosı, SLP, Mexico
Vıtor D. Alves CEER-Biosystems Engineering, Instituto Superior de Agronomia,
Universidade de Lisboa, Lisbon, Portugal
Jarmila Vávra Ambrozová Department of Food Analysis and Chemistry, Faculty
of Technology, Tomas Bata University in Zlın, Zlın, Czech Republic
Tejraj M. Aminabhavi Department of Pharmaceutical Engineering, S.E.T’s
College of Pharmacy, Dharwad, Karnataka, India
Amir Amini Department of Food Science and Technology, Faculty of Nutrition,
Tabriz University of Medical Sciences, Tabriz, Iran
Elmira Arab-Tehrany Universite de Lorraine, LIBio, ENSAIA, Vandœuvre-les-
Nancy, France
Luc Averous BioTeam/ICPEES-ECPM, UMR 7515, Universite de Strasbourg,
Strasbourg, France
Belen Ayestarán Instituto de Ciencias de la Vid y del Vino, Universidad de la
Rioja, Gobierno de La Rioja y CSIC, Logrono, Spain
xv
Federica Balzano Department of Chemistry and Industrial Chemistry, University
of Pisa, Pisa, Italy
Sanjeev Banerjee Department of Pathology, Barbara Ann Karmanos Cancer
Institute, Detroit, MI, USA
School of Medicine, Wayne State University, Detroit, MI, USA
Julieta Barchiesi Molecular Biology and Plant Biotechnology Laboratory, Centro
de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad
Nacional de Rosario, Rosario, Argentina
Debarati Basu Department of Environmental and Plant Biology, Molecular and
Cellular Biology Program, Ohio University, Athens, OH, USA
Kanokporn Bhalang Faculty of Dentistry, Chulalongkorn University, Bangkok,
Thailand
Ewan William Blanch School of Applied Sciences, RMIT University, Melbourne,
VIC, Australia
Jerome Bouscaut INRA, Institut des Sciences de la Vigne et du Vin (ISVV),
UMR Sante et Agroecologie du Vignoble (1065), Villenave d’Ornon, France
Maria V. Busi Molecular Biology and Plant Biotechnology Laboratory, Centro
de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad
Nacional de Rosario, Rosario, Argentina
Helena Cabral-Marques Instituto de Investigacao do Medicamento, Faculdade
de Farmácia, Universidade de Lisboa, Lisboa, Portugal
Carla Maısa Camelini Laboratorio de Cultivo de Fungos Comestıveis, Instituto
Nacional de Pesquisas da Amazonia, Universidade Federal do Amazonas, Manaus,
Brazil
Damiano Cancogni Department of Chemistry, University of Milan, Milan, Italy
Francielle T. G. S. Cardozo Laboratorio de Virologia, Departamento de
Molestias Infecciosas e Parasitárias, Instituto de Medicina Tropical, Universidade
de Sao Paulo, Sao Paulo, Brazil
Julieta B. Carrillo Molecular Biology and Plant Biotechnology Laboratory,
Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),
Universidad Nacional de Rosario, Rosario, Argentina
Gregory T. Carroll Sunstar Engineering Americas, Springboro, OH, USA
Maite Cháfer Departamento de Tecnologıa de Alimentos, Instituto de Ingenierıa
de Alimentos para el Desarrollo, Universitat Politecnica de Valencia, Valencia,
Spain
Surinder P. Chawla Food Technology Division, Bhabha Atomic Research
Centre, Mumbai, India
xvi Contributors
Bing Huei Chen Department of Food Science, Fu Jen University, Taipei, Taiwan
Haixia Chen Tianjin Key Laboratory for Modern Drug Delivery and High-
Efficiency, School of Pharmaceutical Science and Technology, Tianjin University,
Tianjin, China
Amparo Chiralt Departamento de Tecnologıa de Alimentos, Instituto de
Ingenierıa de Alimentos para el Desarrollo, Universitat Politecnica de Valencia,
Valencia, Spain
Stephanie Cluzet Groupe d’Etude des Substances Vegetales à Activite
Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de
Bordeaux, Villenave d’Ornon, France
Veronique Coma University of Bordeaux, CNRS, LCPO, UMR 5629, Pessac,
France
LCPO, ENSCBP, Bordeaux University, Talence, France
Marie-France Corio-Costet INRA, Institut des Sciences de la Vigne et du
Vin (ISVV), UMR Sante et Agroecologie du Vignoble (1065), Villenave
d’Ornon, France
Silgia A. Costa School of Arts, Sciences and Humanities, University of Sao Paulo,
Sao Paulo, Brazil
Sirlene M. Costa School of Arts, Sciences and Humanities, University of Sao
Paulo, Sao Paulo, Brazil
Marılia da Silva Nascimento Santos Laboratory of Glycobiology, Department of
Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil
Deeplina Das Department of Bio-Engineering, National Institute of Technology
Agartala, West Tripura, India
Flavio Bueno de Camargo Junior Pharmaceutical Sciences of Ribeirao Preto,
University of Sao Paulo, Ribeirao Preto, Brazil
Maria Filomena de Jesus Raposo CBQF - Centro de Biotecnologia e Quımica
Fina – Laboratorio Associado, Escola Superior de Biotecnologia, Universidade
Catolica Portuguesa/Porto, Porto, Portugal
Maisa Oliveira deMelo Pharmaceutical Sciences of Ribeirao Preto, University of
Sao Paulo, Ribeirao Preto, Brazil
Alcina Maria Miranda Bernardo de Morais CBQF - Centro de Biotecnologia e
Quımica Fina – Laboratorio Associado, Escola Superior de Biotecnologia,
Universidade Catolica Portuguesa/Porto, Porto, Portugal
Rui Manuel Santos Costa de Morais CBQF - Centro de Biotecnologia e Quımica
Fina – Laboratorio Associado, Escola Superior de Biotecnologia, Universidade
Catolica Portuguesa/Porto, Porto, Portugal
Contributors xvii
Cedric Delattre Institut Pascal UMR CNRS 6602, Clermont Universite,
Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France
Anand Shankar Deshmukh Department of Pharmaceutical Research, Shree
Dhanvantary Pharmacy College, Surat, Gujarat, India
Thierry Doco INRA, Joint Research Unit, Sciences for Enology, Montpellier,
France
Abraham J. Domb School of Pharmacy, Faculty of Medicine, The Hebrew
University of Jerusalem and Jerusalem College of Engineering (JCE), Jerusalem,
Israel
David S. Domozych Department of Biology and Skidmore Microscopy Imaging
Center, Skidmore College, Saratoga Springs, NY, USA
Paola Di Donato CNR-National Research Council of Italy, Institute of Biomo-
lecular Chemistry, Pozzuoli, NA, Italy
Department of Sciences and Technologies, University of Naples Parthenope,
Naples, Italy
Bin Du Hebei Normal University of Science and Technology, Qinhuangdao,
Hebei, China
Alain Dufresne Grenoble Institute of Technology (Grenoble INP) – The Interna-
tional School of Paper, Print Media and Biomaterials (Pagora), Saint Martin
d’Heres, France
Joydeep Dutta Department of Chemistry, Amity School of Applied Sciences,
Amity University Haryana, Gurgaon, Haryana, India
Gary A. Dykes School of Science, Monash University, Bandar Sunway, Selangor,
Malaysia
School of Chemistry, Monash University, Clayton, VIC, Australia
Eleni K. Efthimiadou Sol–gel Laboratory, Institute of Nanoscience and Nano-
technology, Athens, Greece
Maher Z. Elsabee Department of Chemistry, Faculty of Science, Cairo Univer-
sity, Cairo, Egypt
Ahmed Faik Department of Environmental and Plant Biology, Molecular and
Cellular Biology Program, Ohio University, Athens, OH, USA
Enguo Fan Institute of Biochemistry and Molecular Biology, University of
Freiburg, Freiburg, Germany
Ya-Peng Fang Glyn O. Phillips Hydrocolloids Research Centre School of Food
and Pharmaceutical Engineering, Hubei University of Technology Wuchang,
Wuhan, China
xviii Contributors
Juana Fernández-Lopez IPOA Research Group, Agro-Food Technology Depart-
ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,
Alicante, Spain
Carmen S. R. Freire CICECO and Department of Chemistry, University of
Aveiro, Aveiro, Portugal
Filomena Freitas REQUIMTE/CQFB, Chemistry Department, Faculdade de
Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
Alfred D. French Southern Regional Research Center, Agricultural Research
Service, U.S. Department of Agriculture, New Orleans, LA, USA
Xiong Fu College of Light Industry and Food Sciences, South China University of
Technology, Guangzhou, China
Matteo Fusari Department of Chemistry, University of Milan, Milan, Italy
John Garner Akina, Inc., West Lafayette, IN, USA
Admir J. Giachini Laboratorio de Bioprocessos, Departamento de Microbiologia,
Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,
Brazil
Dago Gnakri Subunit of Pedagogy in Biochemistry and Microbiology, Unit of
Training and Research in Agroforestry, University of Jean Lorougnon GUEDE
(UJLoG), Daloa, Cote d’Ivoire
A. Gomes Laboratorio de Bioprocessos, Departamento de Microbiologia,
Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,
Brazil
Diego F. Gomez-Casati Molecular Biology and Plant Biotechnology Laboratory,
Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),
Universidad Nacional de Rosario, Rosario, Argentina
Chelo González-Martınez Departamento de Tecnologıa de Alimentos, Instituto
de Ingenierıa de Alimentos para el Desarrollo, Universitat Politecnica de Valencia,
Valencia, Spain
Francisco M. Gooycolea Institute for Plant Biology and Biotechnology (IBBP),
University of M€unster, M€unster, Germany
Arun Goyal Department of Biotechnology, Indian Institute of Technology
Guwahati, Guwahati, Assam, India
Mauricio J. Grisolıa Molecular Biology and Plant Biotechnology Laboratory,
Centro de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET),
Universidad Nacional de Rosario, Rosario, Argentina
Zenaida Guadalupe Instituto de Ciencias de la Vid y del Vino, Universidad de la
Rioja, Gobierno de La Rioja y CSIC, Logrono, Spain
Contributors xix
Hua-Shi Guan Key Laboratory of Marine Drugs, Ministry of Education, Shan-
dong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of
Medicine and Pharmacy, Ocean University of China, Qingdao, China
Varadarajan Gunasekar School of Chemical and Biotechnology, SASTRA
University, Thanjavur, Tamil Nadu, India
Peter J. Halley Australian Institute for Bioengineering and Nanotechnology,
The University of Queensland, Brisbane, QLD, Australia
Alexander G. Haslberger Department of Nutritional Research, University of
Vienna, Vienna, Austria
Nicolás Hedın Molecular Biology and Plant Biotechnology Laboratory, Centro de
Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad
Nacional de Rosario, Rosario, Argentina
Thomas Heinze Institute for Organic Chemistry and Macromolecular Chemistry,
Center of Excellence for Polysaccharide Research, Friedrich Schiller University of
Jena, Jena, Germany
Michael A. Held Department of Chemistry and Biochemistry, Molecular and
Cellular Biology Program, Ohio University, Athens, OH, USA
Hossein Hosseinkhani Graduate Institute of Biomedical Engineering, National
Taiwan University of Science and Technology (TAIWAN TECH), Taipei, Taiwan
Zuzana Hricovıniová Institute of Chemistry, Center for Glycomics, Slovak
Academy of Sciences, Bratislava, Slovak Republic
Marcello Iacomini Department of Biochemistry and Molecular Biology, Federal
University of Paraná, Curitiba, Brazil
Anjali Jain Department of Pharmaceutics, National Institute of Pharmaceutical
Education and Research (NIPER), Hyderabad, India
You-Jin Jeon Laboratory of Marine Bioresource Technology, School of Marine
Biomedical Sciences, Jeju National University, Jeju, Republic of Korea
Nan Jiang Department of Environmental and Plant Biology, Molecular and
Cellular Biology Program, Ohio University, Athens, OH, USA
Sweetie R. Kanatt Food Technology Division, Bhabha Atomic Research Centre,
Mumbai, India
Pankaj K. Kanaujia Analytical Sciences Division, Mass Spectrometry Area,
Electron Microscopy Area, CSIR-Indian Institute of Petroleum, Dehradun,
Uttarakhand, India
Ding Kang Shanghai Jiao Tong University, Shanghai, China
Mayuree Kanlayavattanakul School of Cosmetic Science, Mae Fah Luang
University, Chiang Rai, Thailand
xx Contributors
Tsai Hua Kao Department of Food Science, Fu Jen University, Taipei, Taiwan
Rasineni Karuna Department of Biochemistry, University College of Science,
Osmania University, Hyderabad, Telangana, India
Leyla Khalili Department of Nutrition, Faculty of Nutrition, Tabriz University of
Medical Sciences, Tabriz, Iran
Muhammad Saeed Khan College of Light Industry and Food Sciences, South
China University of Technology, Guangzhou, China
Shaukat Khan Department of Chemical Engineering, Kyungpook National
University, Daegu, South Korea
Wahid Khan Department of Pharmaceutics, National Institute of Pharmaceutical
Education and Research (NIPER), Hyderabad, India
Waleed Ahmad Khattak Department of Chemical Engineering, Kyungpook
National University, Daegu, South Korea
Se-Kwon Kim Department of Marine-bio Convergence Science and Marine
Bioprocess Research Center, Pukyong National University, Busan, South Korea
Laura Klavina Department of Environmental Science, University of Latvia, Riga,
Latvia
George Kordas Sol–gel Laboratory, Institute of Nanoscience and Nanotechnol-
ogy, Athens, Greece
Damini Kothari Department of Biotechnology, Indian Institute of Technology
Guwahati, Guwahati, Assam, India
Grzegorz Kowalski Department of Engineering and Machinery in Food Industry,
Faculty of Food Technology, Agriculture University in Krakow, Krakow, Poland
H. H. Chaminda Lakmal Department of Marine Life Science, Jeju National
University, Jeju, Republic of Korea
Celine Laroche Institut Pascal UMR CNRS 6602, Clermont Universite,
Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France
Luigi Lay Department of Chemistry, University of Milan, Milan, Italy
Ji-Hyeok Lee Department of Marine Life Science, Jeju National University, Jeju,
Republic of Korea
Edda Lisboa Leite Laboratory of Glycobiology, Department of Biochemistry,
Federal University of Rio Grande do Norte, Natal, Brazil
Cesar Leyva-Porras Centro de Investigacion de Materiales Avanzados (CIMAV-
Unidad Monterrey), Apodaca, Mexico
Contributors xxi
Chun-Xia Li Key Laboratory of Marine Drugs, Ministry of Education, Shandong
Provincial Key Laboratory of Glycoscience and Glycotechnology, School of
Medicine and Pharmacy, Ocean University of China, Qingdao, China
Shuqin Li Tianjin Key Laboratory for Modern Drug Delivery and High-
Efficiency, School of Pharmaceutical Science and Technology, Tianjin University,
Tianjin, China
Jaime Lizardi-Mendoza CTAOA, Biopolymers Group, Research Center for
Food and Development, Centro de Investigacion en Alimentacion y Desarrollo,
A.C. (CIAD), Hermosillo, Sonora, Mexico
Renate Loeppert Department of Pharmaceutical Technology and Biopharmaceutics,
Faculty of Life Sciences, University of Vienna, Vienna, Austria
Yolanda L. Lopez-Franco CTAOA, Biopolymers Group, Research Center for
Food and Development, Centro de Investigacion en Alimentacion y Desarrollo,
A.C. (CIAD), Hermosillo, Sonora, Mexico
Ana L. Lopez-Pablos Coordinacion Academica Region Altiplano, Universidad
Autonoma de San Luis Potosı, Matehuala, Mexico
Nattaya Lourith School of Cosmetic Science, Mae Fah Luang University, Chiang
Rai, Thailand
Baboucarr Lowe Department of Marine-bio Convergence Science and Marine
Bioprocess Research Center, Pukyong National University, Busan, South Korea
Marcin Łukasiewicz Department of Carbohydrate Technology, Faculty of Food
Technology, Agriculture University in Krakow, Krakow, Poland
Jason S. Lupoi Queensland Alliance for Agriculture and Food Innovation,
University of Queensland, St. Lucia, QLD, Australia
Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville,
CA, USA
Sandra M. Luz Department of Energy, University of Brasılia, Gama, Brazil
Ashwini R. Madgulkar Department of Pharmaceutics, AISSMS College of
Pharmacy, Pune, India
Patrıcia Maria Berardo Goncalves Maia Campos Pharmaceutical Sciences of
Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
Mariana Martın Molecular Biology and Plant Biotechnology Laboratory, Centro
de Estudios Fotosinteticos y Bioquımicos (CEFOBI-CONICET), Universidad
Nacional de Rosario, Rosario, Argentina
Jean-Michel Merillon Groupe d’Etude des Substances Vegetales à Activite
Biologique, Universite de Bordeaux, Institut des Sciences de la Vigne et du Vin,
Villenave d’Ornon, France
xxii Contributors
Aikaterini-Foteini Metaxa Sol–gel Laboratory, Institute of Nanoscience and
Nanotechnology, Athens, Greece
Philippe Michaud Institut Pascal UMR CNRS 6602, Clermont Universite,
Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France
Michele Michelin Departamento de Biologia, Faculdade de Filosofia, Ciencias e
Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Swati Misra Department of Biochemical Engineering and Biotechnology, Indian
Institute of Technology – Delhi, Hauz Khas, New Delhi, India
Ladislava Misurcová Department of Food Analysis and Chemistry, Faculty of
Technology, Tomas Bata University in Zlın, Zlın, Czech Republic
Marta Chagas Monteiro Laboratory of Clinical Microbiology and Immunology,
Faculty of Pharmacy, Federal University of Pará (UFPA), Belem, Brazil
Sandra Montoya Bioprocess and Agro-Industry Plant, Institute of Agricultural
Biotechnology, Universidad de Caldas, Manizales, Colombia
Matthias Moser BENEO Institute, Mannheim, Germany
Shaun Thomas Mutter Manchester Institute of Biotechnology and Faculty of
Life Sciences, The University of Manchester, Manchester, UK
Barbara Nicolaus CNR-National Research Council of Italy, Institute of Biomo-
lecular Chemistry, Pozzuoli, NA, Italy
Katsuyoshi Nishinari Glyn O. Phillips Hydrocolloids Research Centre School of
Food and Pharmaceutical Engineering, Hubei University of Technology Wuchang,
Wuhan, China
Yoko Nitta Okayama Prefectural University, Okayama, Japan
Fabio Rodrigues Oliveira Laboratory of Clinical Microbiology and Immunology,
Faculty of Pharmacy, Federal University of Pará (UFPA), Belem, Brazil
Jana Orsavová Language Centre, Faculty of Humanities, Tomas Bata University
in Zlın, Zlın, Czech Republic
Emrah Ozcan Department of Bioengineering, Gebze Institute of Technology,
Gebze, Turkey
Ramjee Pallela Synthetic Biology and Biofuels Group, International Centre for
Genetic Engineering and Biotechnology, New Delhi, India
Mansi Parasramka Division of Cancer Biology,Mayo Clinic, Jacksonville, FL, USA
Joong Kon Park Department of Chemical Engineering, Kyungpook National
University, Daegu, South Korea
Kinam Park Departments of Biomedical Engineering and Pharmaceutics, Weldon
School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
Contributors xxiii
Shivani B. Paruthy Department of Surgery, VM Medical College and Safdarjung
Hospital, Guru Gobind Singh Indraprastha (GGSIP) University, New Delhi, India
Seema Patel Bioinformatics and Medical Informatics Research Center, San Diego
State University, San Diego, USA
Alessandra Peres Laboratory of Immunology, Department of Basic Health
Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA),
Porto Alegre, Brazil
Jose A. Perez-Alvarez IPOA Research Group, Agro-Food Technology Depart-
ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,
Alicante, Spain
Jose Perez-Urizar Facultad de Ciencias Quımicas, Universidad Autonoma de San
Luis Potosı, San Luis Potosı, Mexico
Adalberto Pessoa Department of Biochemical and Pharmaceutical Technology,
University of Sao Paulo, Sao Paulo, Brazil
Guillaume Pierre Institut Pascal UMR CNRS 6602, Clermont Universite,
Universite Blaise Pascal - PolyTech Clermont Ferrand, Aubiere, France
Niccolo Poggi Department of Chemistry, University of Milan, Milan, Italy
Annarita Poli CNR-National Research Council of Italy, Institute of Biomolecular
Chemistry, Pozzuoli, NA, Italy
Maria Lourdes T. M. Polizeli Departamento de Biologia, Faculdade de Filosofia,
Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto,
Sao Paulo, Brazil
Eric Pollet BioTeam/ICPEES-ECPM, UMR 7515, Universite de Strasbourg,
Strasbourg, France
Venkatachalam Ponnusami School of Chemical and Biotechnology, SASTRA
University, Thanjavur, Tamil Nadu, India
Mani Prabaharan Department of Chemistry, Hindustan Institute of Technology
and Science, Chennai, Padur, India
Werner Praznik Department of Pharmaceutical Technology and
Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria
Anna Ptaszek Department of Engineering and Machinery in Food Industry,
Faculty of Food Technology, Agriculture University in Krakow, Krakow, Poland
D. Raju Department of Biochemistry, University College of Science, Osmania
University, Hyderabad, Telangana, India
Lourdes Ramos Departamento de Análisis Instrumental y Quımica Ambiental,
Instituto de Quımica Orgánica General (CSIC), Madrid, Spain
xxiv Contributors
Monica R. P. Rao Department of Pharmaceutics, AISSMS College of Pharmacy,
Pune, India
Maria A. M. Reis REQUIMTE/CQFB, Chemistry Department, Faculdade de
Ciencias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
Leslie Robert Laboratoire de Recherches Ophtalmologiques, Faculte de
Medecine Paris Descartes, Hopital Hotel Dieu, Universite Paris-V, Paris, France
Pedro Roosevelt Torres Romao Laboratory of Immunology, Department of
Basic Health Sciences, Federal University of Health Sciences of Porto Alegre
(UFCSPA), Porto Alegre, Brazil
Márcio Jose Rossi Laboratorio de Bioprocessos, Departamento de Microbiologia,
Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis,
Brazil
Hector A. Ruiz Food Research Department, Biorefinery Group, School of
Chemistry, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico
Laura Ruiz-Aceituno Departamento de Análisis Instrumental y Quımica
Ambiental, Instituto de Quımica Orgánica General (CSIC), Madrid, Spain
Andrea Caroline Ruthes Department of Biochemistry and Molecular Biology,
Federal University of Paraná, Curitiba, Brazil
Denise S. Ruzene Center for Exact Sciences and Technology, Federal University
of Sergipe, Aracaju, Brazil
Andre Sá Couto Instituto de Investigacao do Medicamento, Faculdade de
Farmácia, Universidade de Lisboa, Lisboa, Portugal
Zenaida Saavedra-Leos Coordinacion Academica Region Altiplano,
Universidad Autonoma de San Luis Potosı, Matehuala, Mexico
Cassandrine Saigne-Soulard Groupe d’Etude des Substances Vegetales àActivite Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite
de Bordeaux, Villenave d’Ornon, France
Ceci Sales-Campos Laboratorio de Cultivo de Fungos Comestıveis, Instituto
Nacional de Pesquisas da Amazonia, Universidade Federal do Amazonas, Manaus,
Brazil
Paulo Salustio Instituto de Investigacao doMedicamento, Faculdade de Farmácia,Universidade de Lisboa, Lisboa, Portugal
Oscar J. Sánchez Bioprocess and Agro-Industry Plant, Institute of Agricultural
Biotechnology, Universidad de Caldas, Manizales, Colombia
Laura Sánchez-González Laboratoire d’ingenierie des biomolecules (LIBio),
ENSAIA, Universite de Lorraine, Vandœuvre-les-Nancy, France
Elena Sánchez-Zapata Gluten Free Fibers S.L., Elche, Alicante, Spain
Contributors xxv
Luz Maria Sanz Departamento de Análisis Instrumental y Quımica Ambiental,
Instituto de Quımica Orgánica General (CSIC), Madrid, Spain
Rao Beedu Sashidhar Department of Biochemistry, University College of
Science, Osmania University, Hyderabad, Telangana, India
Anke Sentko BENEO Institute, Mannheim, Germany
Department Regulatory Affairs and Nutrition Communication, BENEO GmbH,
Obrigheim, Germany
A. K. Sharma Food Technology Division, Bhabha Atomic Research Centre,
Mumbai, India
Varsha Sharma Department of Biochemical Engineering and Biotechnology,
Indian Institute of Technology – Delhi, Hauz Khas, New Delhi, India
Allan M. Showalter Department of Environmental and Plant Biology, Molecular
and Cellular Biology Program, Ohio University, Athens, OH, USA
Daniel P. Silva Center for Exact Sciences and Technology, Federal University of
Sergipe, Aracaju, Brazil
Armando J. D. Silvestre CICECO and Department of Chemistry, University of
Aveiro, Aveiro, Portugal
Fhernanda Ribeiro Smiderle Department of Biochemistry and Molecular Biol-
ogy, Federal University of Paraná, Curitiba, Brazil
Ana Cristina Soria Departamento de Análisis Instrumental y Quımica Ambiental,
Instituto de Quımica Orgánica General (CSIC), Madrid, Spain
Vanessa Sovrani Department of Biochemistry and Molecular Biology, Life
Sciences - Polytechnic Center Campus, Federal University of Paraná (UFPR),
Curitiba, Brazil
Ashok Kumar Srivastava Department of Biochemical Engineering and Biotech-
nology, Indian Institute of Technology – Delhi, Hauz Khas, New Delhi, India
Herta Stutz Dalla Santa Department of Food Engineering, Midwest State
University-UNICENTRO, Guarapuava, Brazil
Jin Tang Tumor Glycomics Laboratory, Biosciences Division, SRI International,
Menlo Park, CA, USA
Valentina Taurisano CNR-National Research Council of Italy, Institute of
Biomolecular Chemistry, Pozzuoli, NA, Italy
Department of Sciences and Technologies, University of Naples Parthenope,
Naples, Italy
Jose A. Teixeira Center of Biological Engineering, University of Minho, Braga,
Portugal
xxvi Contributors
Marie Telef-Micouleau Groupe d’Etude des Substances Vegetales à Activite
Biologique, Institut des Sciences de la Vigne et du Vin (ISVV), Universite de
Bordeaux, Villenave d’Ornon, France
Ebru Toksoy Oner Department of Bioengineering, Industrial Biotechnology and
Systems Biology (IBSB) Research Group, Marmara University, Istanbul, Turkey
Kevin Tompkins Faculty of Dentistry, Chulalongkorn University, Bangkok,
Thailand
Gloria Uccello-Barretta Department of Chemistry and Industrial Chemistry,
University of Pisa, Pisa, Italy
Mazhar Ul-Islam Department of Chemical Engineering, Kyungpook National
University, Daegu, South Korea
Muhammad Wajid Ullah Department of Chemical Engineering, Kyungpook
National University, Daegu, South Korea
Frank M. Unger Department of Pharmaceutical Technology and
Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria
Liliana M. Vargas Bioprocess and Agro-Industry Plant, Institute of Agricultural
Biotechnology, Universidad de Caldas, Manizales, Colombia
Jayachandran Venkatesan Department of Marine-bio Convergence Science
and Marine Bioprocess Research Center, Pukyong National University, Busan,
South Korea
Helmut Viernstein Department of Pharmaceutical Technology and
Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria
Manuel Viuda-Martos IPOA Research Group, Agro-Food Technology Depart-
ment, Escuela Politecnica Superior de Orihuela, Miguel Hernández University,
Alicante, Spain
Denong Wang Tumor Glycomics Laboratory, Biosciences Division, SRI Interna-
tional, Menlo Park, CA, USA
Xinsheng Wang School of Chemical Engineering and Pharmacy, Henan Univer-
sity of Science and Technology, Luoyang, Henan, China
Pharmaceutical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu,
China
Yi Wang School of Science, Monash University, Bandar Sunway, Selangor,
Malaysia
Deepa Warrier Department of Pharmaceutics, AISSMS College of Pharmacy,
Pune, India
Pascale Williams INRA, Joint Research Unit, Sciences for Enology, Montpellier,
France
Contributors xxvii
Russell D. Wolfinger SAS Institute Inc., Cary, NC, USA
Holger Wondraczek Institute for Organic Chemistry and Macromolecular
Chemistry, Center of Excellence for Polysaccharide Research, Friedrich Schiller
University of Jena, Jena, Germany
Jian-Yong Wu State Key Laboratory of Chinese Medicine and Molecular Phar-
macology in Shenzhen, Department of Applied Biology and Chemical Technology,
The Hong Kong Polytechnic University, Kowloon, Hong Kong, China
Yanfang Wu Pharmaceutical School, Xinxiang Medical University, Xinxiang,
Henan, China
Fengwei Xie Australian Institute for Bioengineering and Nanotechnology,
The University of Queensland, Brisbane, QLD, Australia
Baojun Xu Food Science and Technology Program, United International College,
Beijing Normal University - Hong Kong Baptist University, Zhuhai, Guangdong,
China
Xianxiang Xu Department of Pharmacology, School of Biomedical Science,
Huaqiao University, Quanzhou City, Fujian Province, China
Yi-Ting Xue Key Laboratory of Marine Drugs, Ministry of Education, Shandong
Provincial Key Laboratory of Glycoscience and Glycotechnology, School of
Medicine and Pharmacy, Ocean University of China, Qingdao, China
Beda M. Yapo Subunit of Pedagogy in Biochemistry and Microbiology, Unit of
Training and Research in Agroforestry, University of Jean Lorougnon GUEDE
(UJLoG), Daloa, Cote d’Ivoire
Lijun You College of Light Industry and Food Sciences, South China University
of Technology, Guangzhou, China
Hong-Bin Zhang Shanghai Jiao Tong University, Shanghai, China
Xuewu Zhang College of Light Industry and Food Sciences, South China
University of Technology, Guangzhou, China
Xia Zhao Key Laboratory of Marine Drugs, Ministry of Education, Shandong
Provincial Key Laboratory of Glycoscience and Glycotechnology, School of
Medicine and Pharmacy, Ocean University of China, Qingdao, China
Fengmei Zhu Hebei Normal University of Science and Technology,
Qinhuangdao, Hebei, China
xxviii Contributors