Please note that the Bioscience II web page has been updated with the following additions:
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Transcript of Please note that the Bioscience II web page has been updated with the following additions:
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Please note that the Bioscience II web page has been updated with the following additions:
1) Answers to quiz 62) A practice exam for exam 53) Learning objectives for exam 54) Lecture notes containing revisions to 3/15 and 3/17
lectures (revised notes for 3/19 will be added today)
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Prophylaxis – protection from disease, as is provided by antisera
Anaphylaxis – the development of IgE-mediated hypersensitivity to relativelyharmless substances
Hypersensitivities = allergies; immune responses that cause tissue damage
Sensitized – previous exposure to antigen creating an allergy
Autoimmune disease - inappropriate response to self antigens
Immunodeficiency - ineffective immune system; inadequate response
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Topics
• Type I hypersensitivity
• Type II hypersensitivity
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Type I hypersensitivity
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Type I hypersensitivity
• Immediate IgE –mediated
• Localized anaphylaxis
• General anaphylaxis
• Immunotherapy
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18-6 Figure 18.1 - Immediate IgE – mediated
Cytokines induce IgE producing B cells in tissues under mucous membranes; more abundant in allergic individuals
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Figure 18.2 Localized anaphylaxis
“Hives”
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Hives – allergic skin reaction characterized by formation of a wheal and flareblocked by antihistamines
Hay fever – antigen is inhaled, causing localized anaphylaxis in tissuesbelow mucous membranesblocked by antihistamines
Asthma – localized anaphylaxis causes increased mucous secretion, bronchial spasmsnon-histamine mediators primarily responsible; antihistamines not effectivealbuterol – bronchodilatorsteroids – inhibit inflammatory reaction
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Generalized anaphylaxis
• Antigens become widespread via bloodstream
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Generalized anaphylaxis
• Antigens become widespread
• Shock (reduced blood pressure) – loss of fluid from blood vessels into tissues
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Generalized “systemic” anaphylaxis
• Antigens become widespread
• Shock (reduced blood pressure
• Ex. Bee stings, peanuts and penicillins
penicillin converted to hapten-protein complex
complex elicits IgE antibodies
Controlled by epinephrine (adrenalin)
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Figure 18.3Immunotherapy
Desensitization, hyposensitizationtherapy
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Type II hypersensitivity
• Cytotoxic
• Transfusion reactions
• Hemolytic diseases
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Cytotoxic
• Complement lysis
• Antibody – dependent cellular cytoxicity (ADCC)
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Table 18.2 - Transfusion reactions
IgM antibodies cause a Type II hypersensitivity reactionForeign erythrocytes are agglutinated by recipients antibodies
complement is activatedred blood cells are lysed
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Why is it surprising that people lacking the A or B antigenare found to have antibodies to the corresponding antigen?
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Figure 18.4 Hemolytic disease
Rh antigen may also beintroduced via induced orspontaneous abortion
Small amount of fetalRh antigen inducessecondary response;Mother’s IgG crosses placenta
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Why is Rh-negative blood used to transfuse the fetus or newborn?
Why do Rh-negative but not Rh-positive mothers sometimeshave babies with hemolytic disease of the newborn?