PlacentaCon v2

Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends

Not your Grandmother’s Nutrition Class

Navigating Maternal Health in the 21st Century

Chandler Marrs, PhDLucine Health Sciences

Hormones MatterHeal with Friends


Who am I? • Mom, wife, jock, researcher, writer, women’s health

advocate

• Background in maternal health and hormones• More recently, medication adverse reactions,

nutrition and mitochondrial damage I am you


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Websiteso LucineHealthSciences.com I Businesso HormonesMatter.com I online journal, medication

adverse events surveyso HealwithFriends.com I Social health

Social Media o Facebook pages: Hormones Matter, Lucine Women

Communityo Twitter: @chanatlucine, @lucinewoman,

@hormonesmatter, @healwithfriendso Email: [email protected] or

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How to find me

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Not your grandmother’s nutrition class


Not even your mother’s nutrition class


Through the wisdom of previous generations we have…


Environmental Toxicantso 2000 environmental

chemicals (EPA 2004)

o In food, air, every product on the market

o Up to 99% adults tested have chemicals in blood, urine, serumo Placenta, breast

milk, cord bloodo Infants and

children

Certain polychlorinated biphenyls, organochlorine pesticides, PFCs, phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons, and perchlorate were detected in 99–100% of pregnant women. The median number of detected chemicals by chemical class ranged from 4 of 12 PFCs to 9 of 13 phthalates. Across chemical classes, median number ranged from 8 of 17 chemical analytes to 50 of 71 chemical analytes (NHANES 2003-2004).

BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively...Females had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had higher concentrations than adolescents (p < 0.001), who in turn had higher concentrations than adults (p = 0.003). LSGM concentrations were lowest for participants in the high household income category (> $45,000/year).


Endocrine Disruptors

Endocrine disruptors are synthetic chemicals that when absorbed into the body either mimic or block hormones and disrupt the body's normal functions.

Most of the endocrine disruptors on the market are estrogenic or anti-androgenic.

For generations to come


Nutrient Stripped Foodo Highly processed food-like

productso Sugar, carbs, fats and chemicals

o Genetically culled produceo 70% reduced nutrient contento With no genetic variation ( 96%)

o Glyphosate, toxic adjuvants and moreo 8 of the 9 formulations tested were

1000X more toxic than their active principles

o Chemically laden meats o Heavy antibiotics, antibiotic

resistant bacteria, growth and other hormones


Even what appears healthy

May not be


Through the wisdom of previous generations

We are dying younger


Living Sick and Dying Young


Medication nation

Mayo Clinic Reportso 70% adults take

prescription medications chronically

o 50% take 2 or more medso 20% take 5 or more meds

“Before the SSRIs, drugs were poisons that came with risks. Now they are fertilizers to be used as widely as possible, being given in ever larger amounts to children and the elderly - the only risks the authorities can see it would seem stem from not using enough of them.” David Healy


During Pregnancyo 80% of women take at least one

medication during pregnancy o ~30% take 4 or more

medications during pregnancy

60% increase in medication use during pregnancy in 30

years


A long, inglorious history

Diethylstilbestrol (DES) – to prevent miscarriage

At least 3 generations affected, sons, daughters and grandchildren

Thalidomide -prescribed for morning sickness


Of medicating women


More recently

And yes, Flu vaccines still contain thimerosal (Johns Hopkins Inst. Vaccine Safety)


We are drowning in a sea of toxins


Medications & Toxicants Transgenerational Effects


Infants and toddlersPsychotropics prescribed in the US o 274,000 infants (0-1 year

olds)o 370,000 toddlers (1-3 year

olds)“Prescriptions of powerful antipsychotics such as Risperdal for infants and very young children have also sharply risen. Office visits for childhood bipolar disorder have risen 40-fold over the past decade in the U.S.”


We wonder whyo 1-68 children develop autism o Kids are largest growing market

for psychotropicso 14% teens

o 4-12% polypharmacy o 7X increase in antipsychotics ages

0-13 years, from 1998-2009 o 1 in 6 children are obese

o 70% to 80% have NAFLD o ~30% increase in pediatric type 2

diabetes 2001-2009


We have a perfect storm

Of over-medication, environmental

hazards and dietary deficiencies.


We all want to be healthy

Or at least that’s what we tell ourselves

What is health?


Is it about weight?

Who is healthier?


Or BMI

Maybe not


Or diet?


Is it enough?

Sure, avoiding junk food matters


Especially when it is no longer food“Everything nature can do, man can do so much better and more profitably.”

o ‘Natural’ cheese that matures in 72 hours.

o Preservatives prevent produce browning

And if we can’t, then re-defineo ‘Clean labeling’ removes the

most glaring industrial ingredients and replaces them with substitutes that sound natural and benign.

“For the salesman, this preparation was a technical triumph, a boon to caterers who would otherwise waste unsold food. There was a further benefit: NatureSeal is classed as a processing aid, not an ingredient, so there’s no need to declare it on the label, no obligation to tell consumers that their “fresh” fruit salad is weeks old.”


Or when healthy food

Is doused in chemicals and stripped of nutrients

• Over last 100 years (1999)• Top soil mineral

content depleted by >70%

• Fruit and vegetable vitamin and mineral content diminished ~40%


What is health?


What Medication Adverse Reactions Tell Us about NutritionA ticking time bomb


It’s all about the biochemistry


Medications & Vaccines oModify biochemistry in some manner

or anotheroEach med has a specific

o Job to do o Set of side-effects based on its particular

mechanism of action

o We believe there is no overlapo But that is not true


Meds I study oFluoroquinolone antibiotics o (Cipro, Levaquin, Avelox, etc.)

oLupron oOral ContraceptivesoHPV Vaccine o (Gardasil, Cervarix)


Primary Side Effects o Fluoroquinolones

o Tendon rupture, neuropathy, psychosis, CNS disturbances

o Lupron o Osteoporosis, psychosis, gallbladder disease, and more

oOral Contraceptiveso Blood clots, stroke, heart attack, weight gain,

depression/anxiety

oHPV Vaccine o Death, vasculitis, CNS disturbances, autoimmune diseases and

more


Digging deeperoPatterns emerge

o Thyroid diseaseo Central nervous system effectso Neuromuscularo Autoimmune o Psychosiso And many more


How can different drugs share similar side effects?

Convergence point

Deplete nutrients and/or exacerbate existing nutrient deficiencies.


At the most basic levelo Consume O2 to

produce energy from nutrients

o Mitochondria take electrons from food to produce ATP

o ATP = cellular energy/cell survival

o ROS is a by-product of energy production

o Too much or too little ROS impaired function

o Food supplies mitochondria vitamins, minerals necessary to produce cellular energy

o Without nutrients functional mitochondrial deficits and cell death

Mitochondria produce ATP.

ATP is the universal energy currency of

life.


Mitochondria: Cellular Powerhouses

oControl dozens of cell processeso Energetics, steroidogenesis, cell death, CA2+ management

oBidirectional hormone regulationo Highly susceptible to endocrine disruptors

o Interact significantly with nDNAo 90% of factors required for mitochondrial function encoded by

nDNAo Bidirectional cross talk critical for cell homeostasis

o Lack protective histones – susceptible to epigenetic alterationso Oxidative damage 10X higher than nDNA

oSit at the center of host immune functiono Sensing and sending danger signals via multiple mechanisms


Mitochondria are importanto Energy

o Mitochondria feed the cells

o W/o healthy mitochondria, cells die

o When cells die, tissues die, organs die, we die (sometimes slowly and painfully, sometimes quickly)

o Control hormoneso Regulate inflammatory pathwayso Nexus of health and illness

Damage at your own risk.


Mitochondria are the drivers of health or disease

“…mitochondria are located at the hub of the wheel of metabolism and play a central role in non-infectious cellular stress, innate immunity, inflammasome activation, and the stereotyped antiviral response, we searched for a signaling system that was both traceable to mitochondria and critical for innate immunity.” Robert Naviaux, UCSD


Technical stuffo Inherited maternally

o 37 genes that code for 13 proteins, 22 RNAs, 2 rRNAs

o Interact significantly with nDNAo 90% of factors required for mitochondrial function encoded

by nDNAo Silenced or activated genes in mom and dad can evoke

mitochondrial damage and mutations

o Interact significantly with extracellular (host) environmento Sense and send danger signals

o Medical and environmental exposures matter


Mitochondrial DNA comes from Mom o Mom’s nutrient status

matters and determines o Pregnancy/postpartum

healtho Fetal/infant/child (and

grandchildren’s health)


Dad’s health matters too!o mDNA passed from mom-

child, but mitochondria rely on nuclear DNA to function (~90%)o If Dad is unhealthy and

nutrient deficient, dysfunctional mitochondria are possible in the offspring, even if mom is healthy Dad’s health matters


Mitochondria Need Vitamins & Minerals

o >20 vitamins and minerals to process ATP

o Those nutrients come from foodo Without nutrients, ATP declines and

cascade ill health beginso Most of us don’t get the appropriate

nutrientso Devastating for maternal/fetal health


Maternal Nutrient Deficiency

Oxidative stress caused by free radicals has been implicated in many studies of the etiology of preeclampsia (38). Because ascorbic acid and vitamin E inhibit free radical formation, a double-blind randomized trial was conducted in 283 women who had either a previous history of pregnancy complications or an abnormal ultrasound (39). The supplement provided 1000 mg ascorbic acid and 400 IU vitamin E daily from week 16–22 of pregnancy, and resulted in a 76% reduction in preeclampsia, and a 21% reduction in indicators of endothelial activation and placental dysfunction.

Evidence from experimental animals supports the concept that in addition to primary deficiencies, secondary embryonic and fetal nutritional deficiencies can be caused by diverse factors including genetics, maternal disease, toxicant insults and physiological stressors that can trigger a maternal acute phase response. These secondary responses may be significant contributors to the occurrence of birth defects. An implication of the above is that the frequency and severity of pregnancy complications may be reduced through an improvement in the micronutrient status of the mother.

Micronutrient status in fetal and early life may alter metabolism, vasculature, and organ growth and function, leading to increased risk of cardiometabolic disorders, adiposity, altered kidney function, and, ultimately, to type 2 diabetes and cardiovascular diseases.

http://ajcn.nutrition.org/content/81/5/1206S.full#ref-38

http://ajcn.nutrition.org/content/81/5/1206S.full#ref-39


Poor nutrition, high toxic load

Foundation from which most parents-to-be approach reproduction

With the cascade of ill-health already in

progress.


Environmentally induced mitochondrial dysfunction

mtDNA damage

Functional deficits

mtDNA mutations

Altered ETCDecreased

ATPMito damage

Increased ROS

Oxidative stress

Toxic ExposuresMedications, Vaccines, Environmental

Direct Induce mitochondrial

membrane permeability changes

Alter channel open times Activate death pathways

Indirect Block critical nutrient co-

factors for ATP Alters hormone activity

(endocrine disruptors) Activate/deactivate critical

transcription and repair proteins (epigenetics)

Cell death & disease


Mitochondria are targets

Sensors of cell danger


How prevalent is mito disease?

“Disorders of the mitochondrial respiratory chain affect at least 1 in 8000 of the population, making them among the most common genetically determined diseases.”

Patrick Chinnery, Medical School, Newcastle upon Tyne.

Prevalence is likely underestimated because functional mitochondrial damage is often overlooked and most mitochondrial deficits, especially those emerging later in life, remain undiagnosed.

Not widely recognized

1 in 500


What mitochondrial dysfunction does

“These are partial defects. Mitochondrial dysfunction doesn’t really cause anything, what it does is predisposes towards seemingly everything. It’s one of many risk factors in multifactorial

disease. It can predispose towards epilepsy, chronic fatigue, and even autism, but it doesn’t do it alone. It does it in combination with other factors, which is why in a family with a single mutation

going through the family, everyone in the family is affected in a different way. Because it predisposes for disease throughout the entire system.”

Dr. Richard Boles, Director of the Metabolic and Mitochondrial Disorders Clinic at Children’s Hospital Los Angeles


First signs of mitochondrial distress

As Hans Selye observed many decades ago, one of the first, and most consistent of the sickness behaviors, no matter the disease, is lethargy, fatigue and sleepiness.

Excessive sleeping, fatigue, anorexia

http://www.stress.org/about/hans-selye-birth-of-stress/

http://www.stress.org/about/hans-selye-birth-of-stress/


What does it look like? oManifests broadly and variably

o Fatigue, hypersomniao Migraines, seizures

o Muscle weakness, neuropathieso Hair losso Cognitive & psychiatric symptomso Gait, balance and tremorso GI disturbances

o Food intoleranceso Gastroparesis, dysmotility, cyclic vomiting,

anorexiao Autonomic dysregulation

o Temperatureo Cardiovascular – Cardiometabolic o Salt/potassium balance

o Thyroid damage o Likely other endocrine disruptions


Mitochondrial dysfunction


Cascade of ill health


All comes back to nutrients


NAVIGATING MATERNAL

HEALTH


Avoid the toxinsClean up the dietFeed the deficiencies


Counterbalance


Nutrients are key


Exercise helps too!


Feed your body what it needs to survive and

thrive


Whole food• Eat only or mostly• Organic, non-GMO

• Embrace variety, dark richly colored fruits and vegetables

• Minimize or eliminate processed food• Avoid sugar, corn syrup, additives, artificial

colors• Gluten, breads and pastas, if necessary• Avoid ‘gluten-free’ marketed foods


Supplement Deficiencies• We’re all deficient in something

• Medications leach nutrients• Agro chemicals leach nutrients• Exercise uses nutrients

• Begin with the basics and work from there• Mitochondria need

• B vitamins, magnesium, coQ10, L-carnitine, fatty acids, cholesterol, vitamin C, lipoic acid, glutathione and more

• Everyone needs vitamin D


You did then what you knew how to do,

And when you knew better,

You did better. Maya Angelou


Websiteso LucineHealthSciences.com I Businesso HormonesMatter.com I online journal, medication

adverse events surveyso HealwithFriends.com I Social health

Social Media o Facebook pages: Hormones Matter, Lucine Women

Communityo Twitter: @chanatlucine, @lucinewoman,

@hormonesmatter, @healwithfriendso Email: [email protected] or

[email protected]

How to find me



PlacentaCon v2

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