YEAR in REVIEW

2018Department of Anesthesia and Perioperative Care

Pioneers in Perioperative Medicine

Published by the UCSF Department of Anesthesia and Perioperative Care

500 Parnassus Avenue MUE 4th Floor, Box 0648 San Francisco, CA 94143-0648 415/476-4244 https://anesthesia.ucsf.edu

Send all inquiries to UCSFAnesthesiaNews@ucsf.edu

DEPARTMENT CHAIR AND EDITOR-IN-CHIEF: Michael Gropper, MD, PhD

EDITOR:Morgen Ahearn

PRINCIPAL WRITER:Andrew Schwartz

DESIGNER:Laura Myers Design

PHOTOGRAPHERS: Stephan Babuljak; Martin Backhauss; Elisabeth Fall; Elena Graham; Adam Jacobson; Susan Merrell; Afra Pourdad; Maurice Ramirez, Barbara Ries, Isobel Russell, MD, PhD; Marco Sanchez, UCSF Documents and Media; Richard Schlobohm, MD

©2019 The Regents of the University of California

CONTENTS

2 Clinical

5 Quality and Safety

6 Research

10 Education

12 Global Health

14 Diversity

18 Philanthropy

19 Department Hail & Farewell

20 New Faculty & Residents

23 Peer Reviewed Publications

32 Active Research Grants

34 Alumni

Since the birth of our department in 1958, we have been pioneers in perioperative medicine, pushing the boundaries of our specialty and leading revolutions in health.

This Year in Review report provides an overview of our department’s efforts over our 60th year.

In the clinical realm, we discuss how integrated, interdisciplinary care that focuses on function, not pain scores, results in the best outcomes for our chronic pain patients, and describe some of our efforts to tackle the devastating opioid epidemic. We are also pleased to include an inspiring story of one young patient’s resilience and strength as they navigated their recovery with the help of the Integrated Pediatric Pain and Palliative Care team (IP3).

Message from the ChairCelebrating 60 Years of Pioneering

In research, we are questioning assumptions and uncovering new insights through the analysis of large health care data sets. We also describe our work to use real-time biostatistical analysis of the electronic health record and point of care data to transform and personalize individual patients’ care. We detail the history and current work of the White Mountain Research Station in the Eastern Sierras, where we have been performing studies elucidating the effects of hypoxia on humans for over 40 years.

With the creation of the “Anesthesia Education Day,” our Education Division has been working hard to improve the anesthesia resident educational experience, more than doubling the amount of protected resident education time and expanding beyond didactics to include innovative learning workshops, problem-based learning discussions, simulations, and a more robust focus on wellness. With more team members and educational opportunities, our Division of Global Health is also expanding, improving anesthesia care and advancing health worldwide.

As we move into our 7th decade as a department, we reaffirm our commitment to growing and refining our diversity and inclusion efforts. This has included the appointment of Dr. Jennifer Lucero as the Department’s first Vice Chair for Diversity and Inclusion, the creation of a multidisciplinary diversity committee with both staff and faculty representatives, as well as more focused work on the recruitment and retention of those underrepresented in medicine.

As always, thank you for reading. We look forward to your comments.

Sincerely,Michael A. Gropper, MD, PhDChair, UCSF Anesthesia and Perioperative Care

YEAR in REVIEW 2018 1

Concerns about the dangers of opioid use, the need to effectively address acute pain,

and the long-term health effects of experiencing chronic pain tend to be heightened when treating children. Among the complicating factors: Families and clinicians worry about the effects of both drugs and pain on the developing brain and, for clinicians, working effectively with concerned families is essential, but requires much more than technical expertise.

That’s why, in 2018 the UCSF Department of Anesthesia and Perioperative Care hired Amber Borucki, MD, as its dedicated pediatric pain director. Fellowship-trained in both pediatric anesthesiology and pediatric and adult pain management, Borucki says managing acute and chronic pain in children demands sensitive, multi-disciplinary and coordinated care across inpatient and outpatient settings.

According to Mark Schumacher, MD, PhD, chief of the UCSF Division of Pain Medicine, Borucki’s presence is the culmination of a vision that began before UCSF Benioff Children’s Hospital moved to Mission Bay. With the support of Schumacher and the vision of Chief Medical Officer Stephen Wilson, MD, PhD, who helped launch the Integrated Pediatric Pain and Palliative Care (IP3) Service, clinicians from various disciplines cross-trained to create a group that today works collaboratively across UCSF Benioff Children’s Hospital San Francisco to address complex, chronic or life-limiting pain concerns, using everything from medication and regional pain procedures through integrative care and psychosocial support.

“Someone with Amber’s expertise can boost all of the foundational work that has come before,” says Schumacher.

Managing Concerns About OpioidsThese days, addressing concerns about opioid use is often top-of-mind for pain management. Schumacher says that he and Borucki can help their clinical colleagues understand that, “A combination of alternative techniques can often reduce the requirement for opioids, making it much safer for our patients.”

To that end, when Borucki arrived, she became involved with the hospital’s opioid task force, which has taken a multi-faceted approach to ensuring responsible opioid management, including:

■■ Implementing changes in the hospital’s electronic health record (EHR) to increase provider awareness of appropriate order sets.

■■ Changing lectures to residents – who write many hospital orders – to include discussions of best practices for opioid prescribing.

Expanding the Options for Managing Pediatric Pain

CLINICAL

Amber Borucki, MD (left), and Karen Sun, MD

■■ Creating detailed clinical pathways for patients who enter the hospital with an acute pain crisis.

■■ Developing guidelines for how to appropriately prescribe and administer opioids for children, including requiring opioid contracts for children and families, enrolling them in a prescription drug monitoring program and teaching parents about safely locking up medications.

Karen Sun, MD, chief of Pediatric Hospital Medicine at UCSF Benioff Children’s Hospital San Francisco and associate director of the IP3 service, adds, “We are also fortunate to have Amber join our team, because of her ability to do pediatric regional anesthesia, which can be an opioid-sparing modality.”

A Comprehensive Approach for Postoperative Pain

Sun and Borucki say that one of the IP3’s key functions is consulting with surgeons when patients are undergoing procedures likely to cause considerable postoperative pain. To that end, the team is helping to create enhanced recovery

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after surgery (ERAS) protocols for a number of common procedures in kids.

“ERAS protocols are among the things we can do to optimize care and make sure opioids are given responsibly or that we use appropriate alternatives,” says Borucki. The protocols include pre- and intraoperative pain management. In some cases, such as when children undergo a total pancreatectomy, the procedures can be quite complicated with intravenous analgesics and radiologic placement of nerve infusion catheters and use of an infusion pump for postoperative pain control. In both cases, Borucki helps determine the right pharmacologic mix, which can range from opioids to low-dose ketamine and lidocaine.

The protocols also offer a full menu of integrative approaches, including having children and families work with the team’s psychologist on developing coping skills for pain, preoperative exercise regimens, massage therapy, acupuncture, mindfulness training and educational videos.

The Oncology OverlapPain management in kids can be especially complicated when they are undergoing treatment for cancer. Because survival rates for most childhood cancers are high, Schumacher says it’s especially important to pay attention to quality of life during treatment.

“Cancer pain management has many moving parts, including understanding complications from surgery and radiation, contraindications and the potential side effects of chemotherapy,” says the department’s Ann Shah, MD, a fellowship-trained pain specialist, who has undergone advanced training in cancer pain at both Memorial Sloan Kettering Cancer Center and the Dana-Farber Cancer Institute. In addition, she says, cancer patients often underreport their pain levels because they are worried the pain indicates that curative therapy has failed.

In general, she says, medication is typically offered first, sometimes along with integrative techniques, partly because both methods are easier to deliver and partly because patients and families tend to be less comfortable with interventional procedures for pain.

“Our goal is to provide a plan that minimizes side effects and which allows patients to regain meaningful function.”— Mark Schumacher, MD, PhD (pictured above, center)

Nevertheless, a number of things can change that mindset, from concerns about opioid use through situations where patients have not responded to pain medications or alternative therapies, or have experienced side effects from medication.

In those cases, says Shah, “Inter-ventional procedures can be a way to decrease overall risk from medications. Most of the procedures are relatively safe and also have a better analgesic effect than oral medications.” The options include targeted nerve blocks or implantable devices such as neuro-stimulators or intrathecal pumps. The latter might deliver a single medication (typically an opioid or calcium channel inhibitor) or a combination of an opioid, local anesthetic and other medications. Such pumps are not only a more effective choice for pain relief, but may also have a significantly decreased risk for addiction than oral opioids.

Of course, deciding on the proper pain management approach involves a close collaboration with the treating oncologist. Shah and Schumacher are now working with oncology and palliative care to create a dedicated, interdisci-plinary pain management resource for all cancer patients, including children.

Transitional and Outpatient Care Borucki and Sun note that the focused attention on pain management does not and should not end when children leave the hospital. The UCSF Benioff Children’s Hospital’s Pediatric Pain Clinic – which includes Borucki, two pediatricians, a neurologist, rheumatologist, psychologist, physical therapist, massage therapist, acupuncturist and dietitian – provides an expert support network for patients and families post-hospitalization.

“We include all the disciplines and emphasize communication because there are often co-morbid conditions associated with pain,” says Borucki. “Psychiatry, for example, can be very important because pain can lead to depression – and depression or anxiety can increase pain levels.” Similarly, patients and families concerned about the side effects and long-term effects of drugs, might turn to alternatives like physical or massage therapy and other rehabilitation techniques. And when drugs are

necessary, in some cases it makes more sense to turn to interventional procedures for administering them.

“Whether it’s cancer patients or those with non-malignant pain syndromes who have failed usual plans, chronic pain is not one more day of acute pain,” says Schumacher. “It’s rare anyone will find one single cause or treatment. Our goal is to provide a plan that minimizes side effects and which allows patients to regain meaningful function.”

“And one of the nice things about working with kids is that they can be more open-minded about the alternative therapies,” says Sun.

Borucki adds that effectively working with families can also make a tremendous difference. “It can take some time to build trust, but when you have a good relationship, things tend to go much better, especially when people focus on functioning, not pain scores. Is the child going to school? Engaged in activities? Spending time with friends? Recent literature says that function is a better predictor of outcomes.”

And improving outcomes is, of course, the end game of bringing Borucki – who clearly enjoys the work – aboard. She says, “Our team is wonderful and I’m so grateful to have met these patients and families and to have worked with them through tough times and seen their recovery.” ■

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Alex Gomez began experiencing chronic pain as a toddler. At 13, they were diagnosed with

Crohn’s disease but the diagnosis offered little relief. Over the next five years, the pain, especially severe abdominal pain, forced Alex into a disheartening routine of medications, emergency department visits and hospital stays. Then, in 2016, Alex developed abscesses and fistulae that resisted healing. It ultimately lead to a total proctocolectomy in 2017, which caused a massive wound in their perineum.

“No one could figure it out and I wound up back in the hospital,” they say. “I was there for about nine months and was bed bound for so long I lost my ability to walk. I was on so many opiates and nothing worked…. I was screaming 24 hours a day. Nurses were crying because they couldn’t do anything and the doctors started blaming me, telling me I should tough it out.” At that point, Alex’s insurer okayed their transfer to UCSF Benioff Children’s Hospital San Francisco, despite Alex having recently turned 19. “That first day at UCSF,

doctors from almost every specialty showed up,” they say. A dermatologist quickly diagnosed pyoderma gangreno-sum, a condition believed to be an autoimmune disease, which can lead to deep ulcers and chronic wounds – and the interdisciplinary team, including the Integrated Pediatric Pain and Palliative Care (IP3) team – initiated a new treatment regimen.

“It included autoimmune therapies, new methods for treating the physical wound and working toward getting Alex off the opioids, in part by integrating tools like physical therapy, massage, acupuncture, music and art,” says Amber Borucki, MD, pediatric pain director for the UCSF Department of Anesthesia and Perioperative Care.

Simultaneously, IP3 psychologist Cristina Benki, PhD, began working with Alex on their psychological wounds, which included post-traumatic stress disorder from a lifetime of pain and disability.

“I felt like a car that needed to be in a junkyard and after experiencing all the trauma and malpractice in other places, trust was hard,” Alex says. “UCSF and

Cristina changed that. It was huge for me, having somebody to talk to. I still have triggers – like when I have to come back to the hospital for a procedure – but I’m working hard with Cristina to develop coping mechanisms.”

After a five-month stay at UCSF, Alex returned home, where they continue to make progress. The wound is 60 percent healed, they are walking again, completely off hydromorphone and weaning off methadone.

In addition, Alex has become a powerful advocate. They work closely with various groups and have served as an honored hero at a walk for the Crohn’s & Colitis Foundation. “UCSF encourages advocacy and don’t feel threatened by a patient who has knowledge or suggestions. I was part of the care team,” says Alex, who is planning to return to college and eventually make their way to medical school. “I’ve begun to believe I can accomplish all of the things I dream of.” ■

Expert, Collaborative Care Restores a Young Person’s Hope

Amber Borucki, MD (left), and patient Alex Gomez at UCSF Benioff Children’s Hospital.

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ClinicalHIGHLIGHTS

UCSF Pediatric Cardiac Anesthesiology Team – Providing Expert Care for Little Hearts (tinyurl.com/Anesth18AR04)

Improving Patient Care at ZSFG with Enhanced Recovery after Surgery Pathways (tiny.ucsf.edu/Anesth18AR01)

Amber Borucki, MD, Director of Pediatric Pain at UCSF, Examines the Use of Functional Pain Scales for Pediatric Patients (tiny.ucsf.edu/Anesth18AR02)

Trauma Anesthesiology Society Annual Meeting (tiny.ucsf.edu/Anesth18AR03)

Inpatient Pain Services Leadership Announcement (tiny.ucsf.edu/Anesth18AR05)

Eula Lewis, BS, RRT, CTTS, AE-C Featured in AARC Times Magazine (tiny.ucsf.edu/Anesth18AR06)

Hung Nguyen, MD, Wins 2018 UCSF Exceptional Physician Award (tiny.ucsf.edu/Anesth18AR00)

2017 2018

Mission Bay Hospitals 12,397 15,704

Orthopaedic Institute 1,942 2,058

Parnassus Hospital 15,849 18,476

Mount Zion Hospital 5,789 5,997

Pediatric Cases 5,681 6,361

Total UCSF Health Clinical Cases 35,977 42,266

Mario De Pinto and Team Win 2017-2018 Caring Wisely Award to Improve Care for Back and Neck Pain(tiny.ucsf.edu/Anesth18AR08)

Seema Gandhi, MD, Featured in Asparagus Magazine, “A Greener Bill of Health: UCSF’s Dr. Seema Gandhi Tackles Sleeper Pollutants in the Operating Room” (tinyurl.com/Anesth18AR12)

Congratulations for Anesthesia Resident-Led True North Leadership Rounds (tiny.ucsf.edu/Anesth18AR07)

UCSF Anesthesia and Perioperative Care 2018 Patient Safety Award Winners (tiny.ucsf.edu/Anesth18AR14)

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QUALITY & SAFETYAnesthesia and Perioperative Care Case Volume

— UCSF Health

From left: William Ng, MBBS, Kathryn Rouine-Rapp, MD, and Hung Nguyen, MD, in the pediatric cardiac operating room. (Photo courtesy Isobel Russell, MD, PhD.)

YEAR in REVIEW 2018 5

As health care data sets continue to grow at astounding rates, they are enabling researchers to

uncover new insights, both through secondary data analysis and through advances in statistical and analytical tools that could enable more timely and robust clinical decision support.

Yet the types of research that rely on so-called “big data” also generate concerns and skepticism. Three researchers from the UCSF Department of Anesthesia and Perioperative Care are trying to address the concerns, even as they advance their fields.

Questioning Assumptions About Surgery, Anesthesia and Cognitive DeclineElizabeth Whitlock, MD, MS, is using secondary data analysis to examine the longstanding assumption that surgical procedures requiring general anesthesia accelerate cognitive decline. In one recent study, conducted in partnership with M. Maria Glymour, ScD, MS, an epidemiologist with a focus on cognition in late life, they compared the cognitive results of a control group – those who need catheterization due to heart disease – to those undergoing coronary artery bypass graft (CABG) procedures and found that those who underwent CABG did only marginally worse on measures of cognition post procedure – and that both groups saw a decline.

The study used data from the Health and Retirement Study, a longitudinal survey of a representative sample of Americans over age 50 in which researchers interview approximately 20,000 respondents every two years on subjects that include health care, housing assets, pensions, employment and disability.

“Our results suggest that being acutely ill may be more of a factor in cognitive decline than the procedure,” says Whitlock. She says future studies will model how people were doing cognitively before the procedure and reveal how the two groups recover over, say, a five-year period. If the trajectories come back together, good surgical candidates who have been avoiding CABG for fear of cognitive decline might choose the procedure, which research has shown has longer lasting effects than catheter-delivered therapies for addressing heart disease.

To continue pursing this line of inquiry, Whitlock intends to use data from the same study to examine whether chronic hip and knee pain is more of a predictor of cognitive decline than hip and knee replacement surgeries.

Studies like Whitlock’s illustrate how the large numbers involved in secondary data analysis can generate important insights and hypotheses for large, randomized clinical trials to confirm. “If you’re looking for a subtle effect like cognitive change, you need a large population. We also are particularly interested in long-term cognitive outcomes, and this population-based longitudinal data source is perhaps the only feasible way to study cognitive change in a large population across years or decades after surgery,” she says.

Researchers Rise To Challenge of Turning Data Into Insights

RESEARCH

Do Unnecessary Preoperative Tests Increase Patient Risk?Catherine Chen, MD, MPH, uses secondary data analysis on large data sets to open new windows on a number of health services questions. In one arm of her work, she uses Medicare data to study the downstream consequences of preoperative testing for minor surgeries. Working with R. Adams Dudley, MD, MBA, from the UCSF Department of Medicine, Chen showed that despite randomized control data that clearly proved routine preoperative testing does not affect outcomes for cataract surgery, physicians were still ordering the tests. In follow-up work, Chen explored whether there is a link between the unnecessary tests, delays in surgery and an increased risk of falling due to patients’ compromised eyesight while awaiting surgery.

Because falls are not well documented in claims data, Chen relied on a previously published algorithm that uses specific claims occurring during emergency room encounters, primary

Elizabeth Whitlock, MD, MS

6 YEAR in REVIEW 2018

care visits, and hospitalizations as proxies for when a patient might have fallen. These claims include diagnosis and treatment codes for common fall-related injuries (such as a wrist fracture), as well as tests performed to evaluate injuries that may arise from a fall (such as wrist X-rays to rule out a fracture, even if a fracture did not actually occur).

“It’s not a perfect algorithm, but we looked at it using a few different ways and we believe the data shows that patients of doctors who use more preoperative tests have longer wait times before their cataract surgery and increased risk of falling,” says Chen.

In 2017, Chen also became one of seven researchers to win access to a proprietary claims and EHR database from OptumLabs, as part of a partnership with the University of California. Her winning proposal will use the data to study the impact of policies and new product introductions on postoperative prescribing of opioids, by looking at data that has not typically been part of the analyses surrounding the concerns about opioid use.

“Most studies focus on the last 5-10 years, but a lot of changes in prescribing patterns would have happened around the turn of century because Oxycontin was introduced in 1996, and because the Joint Commission identified pain as the fifth vital sign in 2001, increasing pressure on providers to better manage pain in the hospital,” she says.

Can Individual Patient Data Improve Trauma Care in Real Time?Romain Pirracchio, MD, PhD, comes at big data from a different angle. His work combines electronic health record and other point-of-care data with biostatistical analyses in the hope of transforming and personalizing patient care at the bedside, in real time. He believes that the advent of cloud storage, increased interoperability and advanced analytics – especially in the field of machine learning – have created an inflection point for advancing this work, especially if people take advantage of opportunities for collaboration among clinicians, basic scientists, engineers, data scientists and biostatisticians.

The wealth of talent in those fields in the Bay Area drew him to UCSF in 2018. One of his first projects will draw on these resources to try to improve trauma

care for patients with everything from acute lung injury to traumatic brain injury.

“If we collect blood samples from every trauma patient, produce proteomics and genomics to characterize each patient and then combine that with clinical data and physiological signals, we should be able generate predictive analytics and eventually prescriptive analytics to assist clinical decisions,” says Pirracchio.

The thinking is that the technological advances can draw on terabytes of information that characterize a patient more fully (e.g., heart rate, blood pressure and pulse oximeter readings, along with clinical notes), synthesize the patient data with what we already know about the general population and generate predictions of various therapeutic options in a way that no single physician could do him or herself in real time.

Pirracchio argues that while this may change how clinicians operate, it does not diminish their importance, because they are essential to identifying the clinically relevant questions that inform the algorithms – and because when the analyses arrive at the bedside, the clinicians remain the ultimate decisionmakers.

“That’s why we will have to be actively involved as these innovations occur,” says Pirracchio. One key role is to insist that clinical facilities subject these inno-vations to the same type of validation process as any new medication or medical device.

“The algorithms should work blindly in the background so we can test their results and stay safe,” he says. “My fear is that people are pushing to produce something as fast as possible and it could be like autonomous cars; people will see the first patient who dies due to

an error, rather than the thousands of patients with improved outcomes.”

Validation and Transparency Are Critical Similarly, Chen and Whitlock have concerns about people putting too much faith in the large numbers involved in secondary data analysis – without understanding the limitations.

“The large data sets we use can be hypothesis-generating because they show correlation, but they cannot show causation like a randomized, controlled trial,” says Chen. “In most cases, we can’t adjust for all the possible unidentified risks if a key variable is not collected in the original data set. Consumers of the research don’t always appreciate that.”

In addition, she notes that it’s incumbent upon each researcher to understand the limitations of their particular data set. “We will get different results depending on what we include and exclude, which is why it’s so important to be transparent about our methods and the definitions we’re using,” she says.

“Secondary data lends itself to people doing a whole bunch of analyses until they find one that looks significant, which can lead to spurious correlations,” says Whitlock. That’s why the community is moving toward setting commonly agreed upon standards, including having researchers commit to a pre-specified analysis plan before looking at the data, and to doing a follow-up or sensitivity analysis.

“The important thing is to be committed to sound methodology and an openness to whatever conclusion that methodology leads you to. That can keep us honest,” says Whitlock. “If we do this right, secondary data can harmonize well with randomized control trials and step in where the primary world fails.” ■

Catherine Chen, MD, MPH (above) and Romain

Pirracchio, MD, PhD

YEAR in REVIEW 2018 7

Ascending To A Better Understanding of Lung Physiology

Since 1958 when the legendary John Severinghaus, MD, of the UCSF Department of Anesthesia

and Perioperative Care founded the UCSF Hypoxia Research Laboratory, faculty, fellows and residents from the department have been journeying to the University of California’s White Mountain Research Station – a multi-campus research unit – to study the effects of hypoxia on humans. Located in the Eastern Sierras, in one of California’s most beautiful and otherworldly landscapes – high desert dotted with ancient bristlecone pines – the station is among the highest altitude research labs in the world.

“We are lucky to have it right in our backyard,” says Philip Bickler, MD, PhD, the lab’s current director.

Researchers use the setting to study oxygen transport, oxygen measurement, and high-altitude physiology.

How it WorksEach summer, the researchers offer research subjects an all-expense, weeklong trip to the mountains. It begins with a drive that goes from sea level to 14,000 feet in a day. After taking a day to acclimate, the researchers typically put the subjects through various levels of exertion and test for physiological changes in such things as brain blood flow, tissue oxygenation and cognition.

“How humans adapt at high altitude has helped us understand processes of oxygen uptake in the lung, which for anesthesiologists is important, because we observe the human body physiologically through watching people breathe and stop breathing,” says John Feiner, MD, who has been part of the lab’s leadership team since the early 1990s.

“Lung physiology is the basis of so much critical care medicine,” says Bickler, noting for example, that understanding the cellular and

molecular contributors to pulmonary edema can provide insights into critical care concerns ranging from pneumonia to sepsis.

And, in fact, the lab has contributed a steady and significant stream of research tracing back to seminal studies by Severinghaus and Norman Staub, MD – another department stalwart — who are considered among the founding fathers of lung physiology.

Acute Mountain SicknessThe lab is also one of the leading centers for understanding acute mountain sickness (AMS), which affects many more people than is commonly understood. “Primary care people get asked about it all the time, and millions of people actually live at high altitude,” say Feiner.

“Mostly, AMS is a temporary illness without lasting effects,” says Bickler. “But for people who live permanently at high altitude, there is a condition called chronic mountain sickness where their ability to adapt declines, there is

8 YEAR in REVIEW 2018

ResearchHIGHLIGHTS

Anesthesia Research Funding Awards (tiny.ucsf.edu/Anesth18ARre01)

Professor Isobel Russell, MD, PhD, Honored with The Edward A. Dickson Emeritus Professorship Award (tiny.ucsf.edu/Anesth18ARre02)

Assistant Professor in Residence Elizabeth Whitlock, MD, MS, Awarded NIH R03 Grant to Study Cognitive Change in Elderly after Cardiac Surgery (tiny.ucsf.edu/Anesth18ARre03)

Pain Medicine Fellow Neelesh Anand, MD, Wins First Place Poster at the 2018 North American Neuromodulation Society Meeting (tiny.ucsf.edu/Anesth18ARre04)

Professor Roland Bainton, MD, PhD, Receives PBBR Funding (tiny.ucsf.edu/Anesth18ARre05)

Vice Chair for Anesthesia Research, Dr. Judith Hellman, Appointed the Inaugural William L. Young Endowed Professor (tiny.ucsf.edu/Anesth18ARre20)

2018-2019 Severinghaus Assistant Professors (tiny.ucsf.edu/Anesth18ARre21)

Assistant Professor in Residence Catherine Chen, MD, MPH, First Author on Anesthesiology Online First Editorial (tiny.ucsf.edu/Anesth18ARre22)

Associate Professor Helen Kim, MPH, PhD, Appointed Director of the UCSF Center for Cerebrovascular Research (tiny.ucsf.edu/Anesth18ARre23)

Assistant Professor in Residence, Catherine Chen, MD, MPH, First Author on Article Featured in JAMA Weekly Highlights (tiny.ucsf.edu/Anesth18ARre24)

Professor Emeritus Adrian Gelb, MB ChB, First Author on Canadian Journal of Anesthesia’s Most Downloaded (7200) Article of 2018 (tinyurl.com/Anesth18ARre25)

Results of Dr. Elizabeth Whitlock’s Study of Cognitive Change after Cardiac Surgery Highlighted in a Society of Thoracic Surgeons News Release (tinyurl.com/Anesth18ARre26)

Assistant Professor in Residence Catherine Chen, MD, MPH, First Author on Anesthesiology Online First Editorial (tiny.ucsf.edu/Anesth18ARre11)

Assistant Professor in Residence, Catherine Chen, MD, MPH, First Author on Article Featured in JAMA Weekly Highlights (tiny.ucsf.edu/Anesth18ARre12)

worsening hypoxia and heart failure, and the five-year mortality rate is very high.”

Understanding what drives AMS – one theory ties it to an overexpression of cytokines – had led some to believe that anti-inflammatories like ibuprofen could help address the condition. But in June 2018, the lab’s faculty published a study in High Altitude Medicine & Biology, which found that “ibuprofen, at the package-recommended adult dose, did not have a significant effect on altitude-related increases in cytokines, AMS scores, blood, or tissue oxygenation in a population of healthy subjects with a high incidence of AMS.”

Combining Work and FunFor all of the serious work that takes place at the lab, the researchers and subjects also often treasure what can feel like a week at camp. There is an onsite cook, a variety of recreational activities and the excitement of waking up each morning in a uniquely stunning landscape. That’s what keeps many of them returning each year.

“It’s a great combination of science and fun,” says Feiner. ■

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YEAR in REVIEW 2018 9

Despite its well-earned reputation as one of the world’s finest training grounds for anesthesia

residents, the UCSF Department of Anesthesia and Perioperative Care found itself with a significant educational challenge in early 2017. Its residents were among those voicing concerns that the department’s longstanding model for didactic education needed updating.

As the clinical environment became increasingly complex and challenging, residents had begun to feel that 90-minute, bi-weekly lectures before rushing off to a full day in the operating room (OR) were less than satisfying. They knew colleagues in other UCSF residency programs who had half- or full-day didactic sessions on a regular basis. In addition, many residents had become accustomed to a more active learning model than the traditional lecture.

The department’s leadership heard the concerns and did not wait to act. They created Anesthesia Education Day (AED) – a full day of education programming that included clinical didactics and wellness education, as well as mentorship and advising. Because of the large size of the program, the department set aside two AED days per month, with each of the department’s 75 residents relieved from clinical duties to participate in one AED monthly.

This teaching model is a rarity among the nation’s anesthesia residency programs and there were significant logistic challenges to overcome, including the need to adapt resident, fellow and faculty responsibilities to provide continuous coverage in the OR and other clinical settings during each

AED. But in just its first year of imple-mentation, the change has received rave reviews from the participants and generated considerable interest from prospective residents.

“It’s been night and day,” says Annie Park, MD, one of the department’s two chief residents for 2017-2018. “You have time to focus on your own education and self-improvement. I can’t quantify how important that is. We don’t have to think about anything else that day and the faculty work super hard to make sure we have an active, tailored experience. The residents are extremely excited and tremendously proud when talking to prospective applicants.”

How It Works According to Manuel Pardo, MD, program director of the UCSF Anesthesia residency and the department’s vice chair for education, the dramatically increased complexity and expectations of modern-day anesthesia and perioperative care have shifted residency from an apprenticeship model to one that demands more focused education and training.

In order to develop the structure of the AED, Pardo began by researching and speaking with representatives from the few anesthesia programs in the country that have expanded didactics for their residents. He then asked John Turnbull, MD – who is in charge of resident didactics – to lead the effort to create the AED.

Anesthesia Education Days Dramatically Improve Resident Experience

EDUCATION

Because the AED more than doubled the amount of protected education time for residents, the first major decision was how to allocate the major blocks of time. Approximately half is now dedicated to clinical didactics, and the increased time footprint has allowed for more use of novel teaching methods, such as workshops and problem-based learning discussions. (The department’s Joyce Chang, MD, received a grant to create a series of such discussions.) In addition, two hours of each AED focus on physician wellness, leaving the remainder of the time for feedback, mentoring and recognition of resident achievement.

“It was a big ask of all of us, because we not only needed more coverage but we needed faculty to teach and develop substantially more curriculum,” says Pardo. That plus the administrative aspect of coordinating the AED and clinical resident schedules created a new set of logistical challenges, for which Turnbull worked closely with administrative staff member Cindy Chin to manage.

The expanded workshops include dedicated time on ultrasound, regional airway procedures and lung isolation. One AED – at Priscilla Chan and Mark Zuckerberg San Francisco General Hospital and Trauma Center – drew on the expertise there in trauma care and high-fidelity simulation. Another innovation, an end-of-life curriculum, included simulations with standardized patients.

10 YEAR in REVIEW 2018

EducationHIGHLIGHTS

“We look at the ABA (American Board of Anesthesiology) content outlines, but we don’t just teach to the test and – more and more – we use a type of flipped classroom concept, says Turnbull. He notes, however, they are careful not to add too many time demands on the residents. “We also implemented a board review session for CA-1s.”

“And we carved out specific time for feedback from leadership to the residents, everything from career or fellowship advice to just generally checking in on how it’s going,” says Pardo.

The wellness curriculum – which Kevin Thornton, MD, and Kristina Sullivan, MD, developed – is a response to heightened concerns about job stress, burnout, depression and even suicide. “In the past, we would dedicate an hour or two a year to this topic; now we have a couple of hours of wellness-themed activities each month,” says Pardo. During most wellness sessions, groups work with others in their residency “houses” to provide a level of comfort and continuity in dealing with what are often challenging emotional topics.

Applause from the Residents “This was the first truly protected

education time we’ve had in residency and the response from all the residents has been overwhelmingly positive,” says Chief Resident Jason Lang, MD.

“The AED also builds community,” says Turnbull. “Informally, residents seem to socialize more after the day and it’s a very positive sign that they want to spend time together.”

“I’ve loved every single aspect of it,” says Park. “The department invested heavily in us and, as residents, we are so grateful and happy to be part of this.” ■

Anesthesia Interest Group Skills Session 2018 (tiny.ucsf.edu/Anesth18ARedu6)

Professor Mark Schumacher, MD, PhD, Discusses the Development of Chronic Pain Curriculum in the UCSF School of Medicine (tiny.ucsf.edu/Anesth18ARedu2)

UCSF Anesthesia and Perioperative Care at WARC 2018 Cindy Chin Wins School of Medicine Star Achievement Award (tiny.ucsf.edu/Anesth18ARedu5)

Professor Kristina Sullivan, MD, Appointed Director, UCSF Anesthesia Residency Program and Associate Chair, Anesthesia Education (tiny.ucsf.edu/Anesth18ARedu13)

Professor Kristina Sullivan, MD, Appointed the Sol Shnider Endowed Chair for Anesthesia Education (tiny.ucsf.edu/Anesth18ARedu4)

Assistant Professor Solmaz Manuel, MD, Selected to Serve on the UCSF School of Medicine Committee for Curriculum and Educational Policy (tiny.ucsf.edu/Anesth18ARedu7)

Vincent Lew Wins Excellence in Teaching Award from the UCSF Academy of Medical Educators (tiny.ucsf.edu/Anesth18ARedu8)

Fleet Week Peer to Peer Medical Exchange (http://tiny.ucsf.edu/Anesth18ARedu9)

Ask the Expert: Chief of Vascular Anesthesia Ahmed Shalabi, MD, Leads Session on Anesthesia for Emergent Endovascular Surgeries at 2018 ASA (http://tiny.ucsf.edu/Anesth18ARedu10)

Pain Medicine Fellow Neelesh Anand, MD, Wins First Place Poster at the 2018 North American Neuromodulation Society Meeting (tiny.ucsf.edu/Anesth18ARedu11)

William C.K. Ng, MBBS, Wins Chancellor’s Fund Award for Difficult Airway Course (tinyurl.com/Anesth18ARedu12)

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YEAR in REVIEW 2018 11

The fall was a busy and productive time for our Division of Global Health Equity. We

have expanded training opportunities and our team. In September, our 6 Global Health Clinical Scholars residents (Ashley Sharp, Jared Brown, Chris Cosden, Sanjay Belani, Liz Liu, Amy Chen) completed our two-week introductory global health course. We also hosted multiple journal clubs and seminars on campus with excellent multidisciplinary attendance. In October we presented 5 abstracts and 3 podium presentations at the American Society of Anesthesiologists’ (ASA) annual meeting, as well as hosted a global health social event with more than 60 colleagues from more than 20 countries.

Elliot Wollner joined us as the 2018-19 Global Health Equity Fellow at ZSFG and spent a portion of the Fall in Uganda learning and teaching alongside collaborators. Dr. Will Booth has joined us for one year as a visiting scholar to conduct research with the division.

Tyler Law, 2017-18 Global Health Equity Fellow and now Assistant

Professor at UCSF, presented at (ASA) as well as the Association of Anaesthesiologists of Uganda Conference, and Maytinee Lilaonitkul presented at the ASA, Society for Obstetric Anesthesia and Perinatology (SOAP) and helped teach the Anesthesia for Global Outreach Course in Boston, as well as the SAFE OR anesthesia course in Uganda and India. Michael Lipnick presented at the ASA and the College of Surgeons of East, Central and South Africa Annual Conference in Rwanda.

Global Health Fellowship PathwaysWe have continued to expand our formal global health training opportunities with 3 pathways for anesthesia global health training post residency:

■■ The first pathway (the Anesthesia Global Health Equity Fellowship) is a non-ACGME fellowship pathway based at Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG). Fellows are based clinically at ZSFG

Division of Global Health Expanding

GLOBAL HEALTH

and are supported for up to six months per year to work on research, education and policy projects focusing on health equity at ZSFG or international partnering sites. This pathway can also be tailored to include a Master of Science in Global Health through the UCSF Institute for Global Health Sciences. Dr. Tyler Law completed the fellowship in 2018, followed by our current fellow Dr. Elliot Wollner.

■■ The second fellowship pathway is the Health, Equity, Action, Leadership (HEAL) Initiative. HEAL is a unique, fellowship opportunity designed for providers (from the US and abroad) who are passionate about global health equity and global health delivery. This fellowship is open to most healthcare disciplines, including physician anesthesiologists and CRNAs. The HEAL cohort includes 70 fellows who spend 2 years working in Native American reservations and international partner sites located in the poorest communities around the world.

■■ The third fellowship pathway offered by UCSF Anesthesia is done in partnership with the World Federation of Societies of Anaesthesiologists (WFSA). This program is available exclusively for anesthesia medical educators from low and middle-income countries. Fellows spend up to 2.5 months in San Francisco to complete intensive training on medical education and simulation methodology, then return to their home institutions to implement mentored education projects. In 2017 we hosted our first fellow Dr. Fred Bulamba (Uganda). The 2018 fellow is Dr. Cornelius Sendagire (Uganda) who is going on to pursue a PhD in medical education. ■

From left: Zuckerberg San Francisco General Hospital and Trauma Center, Dr. Elliot Wollner, Dr. Tyler Law, and Dr. Maytinee Lilaonitkul

Division of Global Health Equity curriculum meeting

12 YEAR in REVIEW 2018

plus links/titles to smaller clinically related articles we’ve published on our website over the year (to be provided), plus clinical statistics (to be provided), plus any clinically related honors/awards/appointments

Global HealthHIGHLIGHTS

Global Health Bootcamp 2018 (tiny.ucsf.edu/Anesth18ARgh5)

Professor Emeritus Adrian Gelb, MB ChB, 2018 Recipient of the Canadian Anesthesiologists’ Society Gold Medal Award (tinyurl.com/Anesth18ARgh2)

Professor Emeritus Adrian Gelb, MB ChB, Honored as a Fellow of the Chinese Society of Anesthesiology(tiny.ucsf.edu/Anesth18ARgh3)

Professor Adrian Gelb, MB, ChB, Awarded First Honorary Professorship in Anesthesia at Capital Medical University in Beijing, China(tiny.ucsf.edu/Anesth18ARgh4)

Welcome Elliott Wollner, MBBS, 2018-2019 Global Health Anesthesia Fellow(tiny.ucsf.edu/Anesth18ARgh6)

Team Additions■■ New Faculty – Visiting Clinical

Instructor and Global Health Fellow – Elliot Wollner

■■ Global Health Visiting Scholar – Will Booth

■■ WFSA-UCSF Anesthesia Simulation Fellow – Cornelius Sendagire

Global Health GrantsWFSA Fresenius Kabi Innovation Award given to Mazi Nourian (MS4 Univ Utah) and Michael Lipnick for research on novel methods of capnography designed for resource-constrained settings.

Global Health–Related Publications

Gelb AW, Morriss WW, Johnson W, Merry AF; International Standards for a Safe Practice of Anesthesia Workgroup. World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA)

International Standards for a Safe Practice of Anesthesia. Can J Anaesth. 2018 May 7. doi: 10.1007/s12630-018-1111-5.

With 7200 total downloads, this was the most downloaded article in the Canadian Journal of Anesthesia for 2018.

Gelb AW, Morriss WW2, Johnson W3, Merry AF4, Abayadeera A, Belîi N, Brull SJ, Chibana A, Evans F, Goddia C, Haylock-Loor C, Khan F, Leal S, Lin N, Merchant R, Newton MW, Rowles JS, Sanusi A, Wilson I, Velazquez Berumen A; International Standards for a Safe Practice of Anesthesia Workgroup. World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia. Anesth Analg. 2018 Jun;126(6):2047-2055.

Hudspeth JC, Rabin TL, Dreifuss BA, Schaaf M, Lipnick MS, Russ CM, Autry AM, Pitt MB, Rowthorn V. Reconfiguring a One-Way Street: A Position Paper on Why and How to Improve Equity in Global Physician Training. Acad Med. 2018 Nov 5.

Lipnick MS, Mavoungou P, Gelb AW. The Global Capnography Gap: A Call to Action. Anaesthesia. 2018 Oct 20.

Adrian Gelb, MB, CHB

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Global Health Fellows at Bootcamp 2018

YEAR in REVIEW 2018 13

Despite well-meaning programs, individual efforts and increasing evidence that a diverse health

care workforce contributes to health improvements, progress in the United States has often been slow. Determined to be an exception, the UCSF Depart-ment of Anesthesia and Perioperative Care is pushing hard to grow and refine its diversity and inclusion efforts.

Through an active diversity committee led by Jennifer Lucero, MD – who in 2018 became vice chair for diversity and inclusion – and support from department and university leadership, the most recent numbers show reasons for optimism and room for improvement. As of March 2018, individuals from groups underrepresented in medicine (UIM) made up 9.4 percent of department faculty and 10.3 percent of staff. For its 2018-2019 residency match, the department saw an uptick in the number of applicants and interviewees, with 24 percent of those matching coming from UIM groups.

Equally important, say committee members, an environment is taking shape within the department that they believe can inspire more individuals from UIM groups to come and build their careers at UCSF.

A Multi-Talented, Multi-Disciplinary TeamIn assuming her position, Lucero has assembled a diverse team of advocates from across clinical sites who are committed to bringing UIM individuals to the department and, once they arrive, helping them navigate the unique

environment of academic medicine. The committee focuses on five key areas: recruitment, retention, developing more health disparities research in anesthesia, career development, and infusing all aspects of resident education with an awareness of diversity and inclusion issues.

“With support from department leadership and the School of Medicine’s Office of Diversity, we’ve begun to move forward,” says Lucero, who grew up in southern California, a first generation college student from a Latino/Native American family.

“[Department Chair] Michael Gropper has been fantastic in explaining to the entire faculty why diversity and inclusion issues are important,” says Gabriel Sarah, MD, a first generation Syrian-American who grew up in Tucson, Arizona. “He wants our department to be on the forefront of change and understands it will take a committed effort from staff, faculty and learners.”

“It’s definitely a priority,” says Charlene Blake, MD, PhD. “Before I arrived, three years ago, there was only one black woman in the department. Since then, we’ve added three other young black faculty members, which is tough because there are not that many of us in anesthesia.”

Odi Ehie, MD, is one of those faculty members. Having grown up in Alabama,

A Determined, Multi-Pronged Approach to Improving Department Diversity

DIVERSITY

the daughter of Nigerian parents, Ehie attended the historically black college, Xavier, before moving on to medical school at the University of Wisconsin, Madison, residency at NYU and a fellowship at Stanford. When she was looking for the place where she could most comfortably begin a career, she says, “UCSF was the best fit for me. I felt they had a strong diversity outreach effort – the strongest of all the different institutions I’ve been in.”

An Emphasis on Resident Recruiting and SelectionOne of the key measures of success for those seeking to create a more diverse health care workforce is the percentage of UIM residents a department is able to attract. Claire Harmon – staff lead on the diversity committee – manages trainee enrollment for the department’s National Institutes of Health T32 training grant; the resident pool is the main pipeline for T32 trainees.

“Every time we reapply [every five years], we need to include a plan to recruit and retain people from diverse backgrounds,” says Harmon. Thus, the department has become increasingly active in advertising in settings more likely to capture the attention of UIM applicants and sending representatives from the department to pertinent group meetings at UCSF and across the country, including those of the Student

Jennifer Lucero, MD (left) and Claire Harmon

14 YEAR in REVIEW 2018

National Medical Association and the Latino Medical Student Association.

Heather Hervey-Jumper, MD, is among those who have spoken at multiple forums where medical students of color congregate and is also involved with the anesthesia interest group at UCSF School of Medicine, because, she says, “I want to be one of the first faces that introduces them to the field, especially since there are not many women or people of color in anesthesia and I can help them see it’s a vibrant field with lots of opportunity.”

In addition to the outreach efforts, members of the committee are also working with the UCSF Graduate Medical Education committee to drum up support for moving toward standardizing the consideration of community activities, leadership roles, life experience, research involvement and other less numbers-based measures for screening applicants across all specialties.

“It’s a goal to look at UIM or other minority group applicants for residencies and fellowships through a different lens – consider all different parts of their application so we can increase our interview pool,” says Sarah. He says it is well documented why UIM students don’t always perform as well on numbers-based measures and that a more holistic look can open doors to students equally well-prepared to succeed than those who do well on tests. “And once we get these people into the interview process, we are helping to develop ways to fairly rank them so they can successfully match.”

Creating a PipelineAttracting those already in medical school is critically important, but more dramatic change will likely come when the pool of UIM applicants grows – an understanding that has the department speaking to UIM individuals in undergraduate science programs, as well as to those in high school and middle school.

For example, Lucero leads the undergraduate residency internship (URI) program in anesthesia, part of a broader program sponsored by the UCSF Department of Obstetrics, Gynecology and the Reproductive Sciences and Kaiser Permanente. URI offers undergraduate students from UC Berkeley mentorship, shadowing oppor-

tunities, research experience and a virtual handbook for how they can make it to and through medical school.

For her part, with the department’s full support, Blake designed and coordinated what will be an annual program for UIM high school students from San Francisco public schools, called UCSF SCORE (Students Capturing the Operating Room Experience). During the daylong program, young students interact with a diverse group of UCSF operating room clinicians and engage in simulation sessions where they gain hands-on experience with common procedures.

Keeping Sight of Staff Harmon says that having UIM faces on staff is also an important factor in attracting more diverse faculty, residents and staff. “Our staff diversity recruiting had been quite good for some time. Martie Santos put in a lot of work going to job fairs and creating a recipe for success that has worked,” says Harmon. “But now that diversity efforts have become more centrally managed, it’s up to us to be accountable to ourselves for continuing the work of the past.”

As part of that effort, Harmon completed the staff diversity and inclusion certificate program, which is coordinated by the UCSF Office of Diversity and Outreach. The program provides foundational knowledge about how to enhance diversity and inclusion programs. Her capstone project involves organizing a fall retreat for staff leadership, in which they will explore how to build on past successes, receive training on such things as how to become an ally for younger or newer staff members and deepen their understanding of concepts like privilege and social justice.

The Retention ChallengeYet even as the department becomes more diverse, convincing people to stay can pose an even more difficult challenge. There are numerous factors, but two seem to predominate that are a challenge across UCSF. First, African Americans and Latinos are now only a small and shrinking part of the city, with the African American population in particular declining precipitously in recent years. And, second, the city has one of the country’s highest costs of living, but salaries in academic medicine

are typically lower than they are in private practice and many people from UIM communities do not have the intergenerational wealth to compensate.

“We want people here who are diverse socioeconomically as well as UIM and while I hate to put those two together, it is disproportionately people from UIM communities that are also socioeconomically disadvantaged,” says Lucero.

She says that UCSF might consider looking at other health care institutions in the area that do a good job of addressing the area’s financial realities, through some combination of salary, stipends, scholarships and quality-of-life benefits. Yet because addressing the economics is extremely complex and not always something the School can fully control, the committee and department try to compensate by helping address quality of life concerns. In part, this is as simple as reminding people of the extraordinary beauty and culture of a world-class city like San Francisco, but it also means building a community for UIM individuals within the department.

That work occurs on many levels, both informal and formal. For Lucero, it began a few years back with a dinner she held in her home modeled on something she’d experienced at Yale: a dinner for medical students and residents from UIM populations.

“I decided to invite all UIM faculty and residents – my husband and I love to cook – and it was a lot of fun for all of us,” she says. When the department caught wind of it, they offered to support the dinners, which Lucero now tries to hold quarterly.

“My house is also used for a global welcome event, but we designed this UIM dinner to build community for people who need a safe space, where they can be among others who are not in the majority,” she says. “It’s especially important because this is a big department, spread across multiple campuses and it’s not always easy to connect with each other.”

Such events can have important, lasting effects, including creating a much-needed network for UIM communities to help each other, much as majority communities have done for years. “When I was looking at coming out here, I had questions,” says Hervey-Jumper. “Where do I live? Where do I put my kids in school?

YEAR in REVIEW 2018 15

Who do I ask, because my children’s experience in school will not be the same as someone who is not under-represented? Meeting other faculty of color in the department was very helpful.”

Those connections and conversations can be particularly important for retaining residents – and can even be institutionalized to great advantage. Programs like the department’s newly instituted Anesthesia Education Day, for example, created more time for wellness discussions and mentorship, where all residents – including UIM residents – can ask questions that range from how to establish an academic career to balancing childcare with the demands of the job.

Creating an Open EnvironmentOther questions – ones that directly address the degree that everything from blatant racism to unconscious insensitivity exist and impact people’s daily lives – can be more difficult. Harmon notes that one of the challenges in creating a welcoming environment for UIM groups so they will choose to stay is figuring out how people can effectively talk about what are, by definition, thorny issues.

“It’s something I absolutely need to work on,” she says. “My default is to

avoid the issue, but all of the training asks us to have the awkward, difficult conversations. How else will somebody know they offended you? We can’t expect to solve things in one conversation – we should expect non-closure – but it’s still important to listen to another person’s perspective, especially if you don’t share it…We all have to learn how to empathize.”

“And we all have to understand why it might not be as welcoming here as we perceive it to be,” says Sarah. “Medicine can be very rigid and slow to adapt…and it’s up to us who have been here to learn to be an ally – to understand how the system has hurt people and how we can use our power and our privilege to help bring everybody up.”

“To affect real change, we have to change the institution as well as individuals,” says Harmon. “What can we put on paper about the steps we must take for everything from routine hiring practices to how we will be accountable and to whom?”

Career Development MattersThat includes being accountable for creating genuine opportunities for all staff, faculty and residents.

For staff, Sarah says learning opportunities can be prohibitively expensive and if people can’t access opportunities for growth or lack department support for engaging in opportunities, they may well leave. For residents and faculty, Ehie believes it is extremely important for those people who have been recruited from UIM groups to be further supported in their attempts to find research opportunities and speaking engagements - the kinds of things that can make or break an academic career.

“Often times, we don’t find a lot of people who look like us and we know that for people who don’t have those connections, it can be challenging to find a mentor or sponsor,” says Sarah. “That’s complicated by impostor syndrome – that you never feel like you’re good enough after being marginalized throughout your education, so you don’t ask for help or permission or funding.”

Lucero says this is part of the reason the diversity committee chose to make research one of its foci. Bringing more health disparities research into anesthesia could both raise awareness of some of the ways concepts like unconscious bias and micro-aggression come into play in clinical practice and research, while also creating more opportunities for minority researchers to make their mark.

“It’s a wonderful department.”—Charlene Blake, MD, PhD (at left)

Clockwise from top: Charlene Blake, MD, PhD;

Claire Harmon; Jennifer Lucero, MD;

Heather Hervey Jumper, MD; and Kathryn Rouine-Rapp, MD

16 YEAR in REVIEW 2018

DiversityHIGHLIGHTS

Arthur Wood, MD (pictured above), Honored as a John A. Watson Scholar (tiny.ucsf.edu/Anesth18ARdiv1)

Byron Decuire, RT, Selected for Office of Diversity and Outreach Video(tiny.ucsf.edu/Anesth18ARdiv2)

Jennifer Lucero, MD, Appointed Director of Diversity and Inclusion(tiny.ucsf.edu/Anesth18ARdiv3)

Assistant Professor Laura Lang, MD, Precepts Local High School Students for FACES Outreach Program(tiny.ucsf.edu/Anesth18ARdiv4)

Students Capturing the Operating Room Experience 2018(tiny.ucsf.edu/Anesth18ARdiv5)

Charlene Blake, MD, PhD, Honored as a John A. Watson Faculty Scholar (tiny.ucsf.edu/Anesth18ARdiv6)

One Day at a TimeThroughout all of this work, the committee members recognize that the issues of how any culture deals with topics like race, ethnicity, and gender are extremely complex. “The concept of privilege is evolving,” says Sarah. “Somebody privileged in one situation may not be in another. I’m a doctor now, but my parents are immigrants from Syria, who did not speak English and I grew up in a community where a large number of people were hostile to who I am.”

That type of complexity can also make change painfully slow. “I am still coming to grips with that,” says Harmon. “I was born in 1959…and during the ‘70s, I felt a lot of optimism, but we’re still having many of the same conversations and same problems.”

Yet Hervey-Jumper notes that it’s also important to recognize what’s changed and what’s working, pointing, for example, to the presence of women in the department. “Women have a completely different experience in medicine and I like how we all come together, which I felt was lacking in previous places where I’d worked,” she says.

“It’s a wonderful department,” says Blake. “I love Lundy Campbell and the cardiothoracic group. The nine of us are family and a pretty diverse group…and eight other great individuals support me. Part of life is being fulfilled, being supported and loved and loving what you do.”

All agree, however, that there is much more that needs to be done, so it’s important to stay engaged, even though such engagement can impose demands on their time that add to already busy schedules. “I think about what’s changed over the last 50 years and what others have done to make it happen, and it makes me that much more committed,” says Ehie. “The only way to ease our burden is to make sure that those of us who are here are present, so we can recruit more people and keep them here.”

“We have an imperative to advocate for each other,” says Lucero. “It can be exhausting, but there are great wins and when we reach out to new faculty or residents [the way some people reached out to me when I arrived], it can be very empowering to remind people that we all bring something different and deserve a voice.” ■

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YEAR in REVIEW 2018 17

$100 – $500 Anonymous | Gift to the William L. Young Research Endowment

Thomas M. Grove | Gift to the Ronald D. Miller Distinguished Professorship

Phillip E. Evans | Gifts to the Center for Cerebrovascular Research

$500 – $1,000 Barry D. Bergquist | Gift to the Ronald D. Miller Distinguished Professorship

Daniel G. Solomon | Gift to Global Partners in Anesthesia and Surgery – Anesthesia Global Health

$1000 – $5000Lisa Zhu Lisha | Gift to the Anesthesia Department General Fund

Dorothy Ford Bainton and Cedric R. Bainton Gift to the Anesthesia Department General Fund

$5000 – $10,000Gustavo Villalona | Gift to Global Partners in Anesthesia and Surgery – Anesthesia Global Health

Gail Miller and Ronald D. Miller | Gift to Anesthesia Academic Programs

$10,000 – $50,000Laura Case Trust | Gift to Global Partners in Anesthesia and Surgery – Anesthesia Global Health

Community Foundation of Orange and Sullivan | Gift to the Center for Cerebrovascular Research

$100,000Hellman Foundation | Gift to Global Health Equity Programs

$2,000,000Anonymous | Patricia Sander Awards

2017-18Honor Roll of Donors

PHILANTHROPY

Anonymous Gift to Establish Patricia Sander Awards for Anesthesia Researchers

The Department of Anesthesia and Perioperative Care has received a $2,000,000 donation from an anonymous donor to establish an endowment that will fund the

Patricia Sander Awards for Anesthesia Researchers. UCSF has long been a national leader in driving anesthesia research that improves the quality of patient care. Two Patricia Sander Awards will be given every two years—one for a junior faculty member and the other for a mid-career faculty member who are conducting promising research. Faculty will be invited to apply for the awards in a similar fashion as they do for the Department Research Awards. The Patricia Sander Award Committee members will be Drs. Helen Kim, Jacqueline Leung, Romain Pirracchio, and Michael Gropper. The Department and the donor are particularly interested in using the awards to help mitigate the challenges faced by early- and mid-career faculty members trying to balance the demands of work and home life. Supporting these individuals at this critical juncture of their academic careers will maximize their chances of academic success. We are very thankful that this donor has recognized and supports our academic mission.

Dr. Judith Hellman on How She Will Use the William L. Young Endowed Professorship Funds

“In addition to being a prolific researcher in his own right, Dr. Bill Young dedicated his career to developing clinical scientists in anesthesiology. He developed and implemented our department’s innovative

Research Scholars Track of the Anesthesia Residency and Pathway of Scientific Independence, both of which are still going strong. I intend to use the William L Young M.D. Endowed Professorship funds to continue to support the research training and career development of anesthesiologists in our department.”

READ MORE ONLINE...

(tiny.ucsf.edu/Anesth18ARre20)

18 YEAR in REVIEW 2018

DEPARTMENT HAIL & FAREWELL

Leadership Additions

As the department has grown to over 600 members, with well over 200 faculty, it has become clear that we need to increase the size of our leadership team. There are increasing administrative responsi-

bilities related to our clinical and academic footprint, beyond what a single vice-chair or service chief can manage. To that end, we have put a lot of thought into how to better structure the department for the rapid growth of our missions, and we have asked the following faculty to assume the following leadership positions: Associate Chair for Education Kristina Sullivan, MD; Associate Chair for Finance Marc Steurer, MD, MHA; and Associate Chair for Clinical Services, UCSF Health, Christina Inglis-Arkell, MD. You can read more at: http://tiny.ucsf.edu/Anesth18ARd00

Ernest Guy, MD, Chief of Anesthesia at SFGH from 1959–1973, Has Passed Away (tiny.ucsf.edu/Anesth18ARd01)

Giant of Anesthesia – Ted Eger – Has Passed Away (tinyurl.com/Anesth18ARd04)

Former Anesthesia Department Chair and Vice Dean for UCSF Clinical Affairs, William K. Hamilton, Has Passed Away (tiny.ucsf.edu/Anesth18ARd02)

Anesthesia History Timeline (tiny.ucsf.edu/Anesth18ARd05)

READ MORE ONLINE...

From left: Dr. Ernest Guy, Dr. Edmond “Ted” Eger, Dr. William “Bill” K. Hamilton

Department members at (from top): Zuckerberg San Francisco General Hospital and Trauma Center, UCSF Parnassus Medical Center, and San Francisco VA Health Care System

For a complete list of Department honors, awards, and appointments for 2018, please visit: tiny.ucsf.edu/AnesthesiaHonors

YEAR in REVIEW 2018 19

NEW FACULTY & RESIDENTS

Nandini Palaniappa, MDAssistant Clinical ProfessorJoined Faculty August 2018MEDICAL SCHOOL:Icahn School of Medicine at Mount SinaiINTERNSHIP: General Surgery, Icahn School of Medicine at Mount SinaiRESIDENCY: Anesthesiology, Icahn School of Medicine at Mount SinaiFELLOWSHIP: Critical Care Medicine, UCSF

Katherine Shea, MDAssistant Clinical ProfessorJoined Faculty November 2018MEDICAL SCHOOL:SUNY Downstate College of MedicineINTERNSHIP: Categorical, Brigham and Women’s HospitalRESIDENCY: Anesthesiology, Brigham and Women’s HospitalFELLOWSHIP: Obstetric Anesthesiology, Brigham and Women’s HospitalPREVIOUS EMPLOYMENTAttending Anesthesiologist, Baptist Hospital of Miami

Angela Wight, MDClinical Instructor Non-ACGME Advanced Clinical FellowJoined Faculty September 2018MEDICAL SCHOOL:David Geffen School of Medicine at UCLAINTERNSHIP: Internal Medicine, Harbor-UCLA Medical CenterRESIDENCY: Anesthesiology, UCSF

Peter Yeh, MDAssistant Clinical ProfessorJoined Faculty August 2018MEDICAL SCHOOL:Temple University School of MedicineRESIDENCY: Anesthesiology, University of Pittsburgh Medical Center

FELLOWSHIP: Obstetric Anesthesiology, UCSF

Career Faculty

Neelesh Anand, MDAssistant Clinical ProfessorJoined Faculty October 2018MEDICAL SCHOOL:University of Arizona College of MedicineINTERNSHIP: Wayne State University – Crittenton Hospital

RESIDENCY: Anesthesiology, Brigham and Women’s Hospital

FELLOWSHIP: Pain Medicine, UCSF

Ashish Agrawal, MDAssistant Clinical ProfessorJoined Faculty July 2018MEDICAL SCHOOL: UCSF

INTERNSHIP: Anesthesiology, UCSF

RESIDENCY: Anesthesiology, UCSF

FELLOWSHIP: Research, UCSF

Andrew Bishara, MDAssistant Clinical ProfessorJoined Faculty July 2018MEDICAL SCHOOL: Harvard Medical School

INTERNSHIP: Transitional,Beth Israel Deaconess Medical CenterRESIDENCY: Anesthesiology, UCSF

Denise Chang, MDAssistant Clinical ProfessorJoined Faculty September 2018MEDICAL SCHOOL: Case Western Reserve University

INTERNSHIP: Anesthesiology, UCSF

RESIDENCY: Anesthesiology, UCSF

FELLOWSHIP: Pediatric Anesthesiology, UCSF

Thomas “TJ” Krall, MDAssistant Clinical ProfessorJoined Faculty July 2018MEDICAL SCHOOL:Rutgers-New Jersey Medical SchoolINTERNSHIP RESIDENCY: Anesthesiology, UCSFRESIDENCY: Anesthesiology, UCSFFELLOWSHIPS: Critical Care Medicine, UCSF,Cardiac Anesthesiology, UCSF

20 YEAR in REVIEW 2018

Kristen Kiroff, MBBSVisiting Assistant ProfessorJoined Faculty August 2018MEDICAL SCHOOL:The University of Western Australia, Perth, WAINTERNSHIP: Emergency Medicine, Neurology, General Surgery, High Dependency Unit, Plastic Surgery Royal Perth Hospital RESIDENCY: Anesthesiology, Royal Perth Hospital,Sir Charles Gairdner Hospital, Princess Margaret Hospital, King Edward Memorial Hospital, Fremantle HospitalFELLOWSHIP: Upper Gastrointestinal Anesthesiology and Regional AnesthesiologyNorth Shore Hospital, Auckland (ANZCA approved)PREVIOUS EMPLOYMENT:Locum Anesthetist, Whyalla, Australia

Ottilia Magnusson, MBBSVisiting Assistant ProfessorJoined Faculty August 2018MEDICAL SCHOOL:University of South WalesINTERNSHIP: General Medicine, Surgery, Vascular, Emergency, GeriatricsFremantle Hospital, PerthRESIDENCY: Royal Perth Hospital, Sir Charles Gairdner Hospital, Princess Margaret Hospital

FELLOWSHIP: Obstetric and Gynecologic Anesthesiology King Edward Memorial Hospital for WomenSimulation, Joondalup Health Campus, Perth

Elliot Wollner, MBBS, MPHVisiting Health Sciences Clinical InstructorNon-ACGME Global Health FellowJoined Faculty September 2018ADVANCED DEGREE:MPH, Columbia UniversityMEDICAL SCHOOL:University of MelbourneINTERNSHIP: Western Health

RESIDENCY: Anesthesiology, Various hospitals, including: Royal Melbourne, The Austin, Peter MacCallum Cancer Centre, Royal Women’s, Royal Children’s

James Zeng, MBBSVisiting Assistant ProfessorJoined Faculty August 2018MEDICAL SCHOOL:University of MelbourneRESIDENCY: AnesthesiologyRoyal Melbourne Hospital, Western Health, Albury Wodonga Hospitals, Royal Children’s Hospital, Royal Women’s Hospital, Austin Health, Victorian Comprehensive Cancer CenterFELLOWSHIP: Clinical, Royal Children’s Hospital

Visiting Faculty

Wen Hao Jonathan Chiong, MBBS, FANZCA, CICMVisiting Assistant ProfessorJoined Faculty May 2018MEDICAL SCHOOL:University of Melbourne, AustraliaRESIDENCY: Anesthesiology, North-Western Anaesthetic Training Program, Victoria, Australia

FELLOWSHIP: North-Western Anaesthetic Training Program, Victoria, Australia

Hemra Cil, MDVisiting Assistant ProfessorJoined Faculty May 2018MEDICAL SCHOOL:Hacettepe University Faculty of Medicine, TurkeyRESIDENCY: Anesthesiology, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Turkey

PREVIOUS EMPLOYMENT: Attending Anesthesiologist, Agri Diyadin Government Hospital, TurkeyAssistant Specialist, Department of Orthopaedic Surgery, UCSF

Vivienne Hannon, MBBS, BSc, FRCAVisiting Clinical Instructor and Non-ACGME Liver Transplant Anesthesiology FellowJoined Faculty August 2018ADVANCED DEGREE:BSc, The History of MedicineUniversity College London Medical SchoolMEDICAL SCHOOL:University College London Medical SchoolRESIDENCY: Anesthesiology, North Thames School of Anaesthesia

FELLOWSHIP: Neuroanesthesiolgy, Trauma and Cardiothoracic Anesthesiology, Liver Transplant Anesthesiology, North Central Thames School of Anaesthesia

Zaki Ibrahim, MBBS, FANZCA, ACEMVisiting Assistant ProfessorJoined Faculty November 2018MEDICAL SCHOOL:University of Newcastle Upon Tyne, UKINTERNSHIP: General Surgery, Emergency and General Medicine, Respiratory Medicine, North Tyneside General Hospital, UK

RESIDENCY: Anaesthesia and Intensive Care, Trauma and Orthopaedics, Emergency Medicine, Wansbeck General Hospital and Rockingham General Hospital, UK

FELLOWSHIP: Emergency Medicine Simulation Fellowship, Fiona Stanley Hospital

YEAR in REVIEW 2018 21

Christine Choi

Elliott Callahan

Adam Daoud Gray

Willie Du

Nate Gamsky

Stephanie Gilbert

Kaveh Hemati

Sarah Jarjour

Jonathan Kim

Shikha Sharma

Stew Smith

Norver Trinidad

Michelle Wang

Danielle Williamson

David Wong

Ed Labovitz

Man-Cheung Lee

Anthony Little

Genevieve Manahan

Hai Pham

Manoj Sekar

Russell Romano-Kelly

Kiran Sembhi

New Residents Class of 2021

22 YEAR in REVIEW 2018

Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR; SARP Investigators. Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort. Am J Respir Crit Care Med. 2018 Jul 1;198(1):39-50.

Barnes-Daly MA, Pun BT, Harmon LA, Byrum DG, Kumar VK, Devlin JW, Stollings JL, Puntillo KA, Engel HJ, Posa PJ, Barr J, Schweickert WD, Esbrook CL, Hargett KD, Carson SS, Aldrich JM, Ely EW, Balas MC. Improving Health Care for Critically Ill Patients Using an Evidence-Based Collaborative Approach to ABCDEF Bundle Dissemination and Implementation. Worldviews Evid Based Nurs. 2018 Jun;15(3):206-216.

Barrington MJ, Gray AT. Is temporal association between popliteal-sciatic block and nerve injury sufficient evidence to assign etiology? Muscle Nerve. 2018 Mar;57(3):E113.

Bartels DD, McCann ME, Davidson AJ, Polaner DM, Whitlock EL, Bateman BT. Estimating pediatric general anesthesia exposure: Quantifying duration and risk. Paediatr Anaesth. 2018 Jun;28(6):520-527.

Behrends M, Yap EN, Zhang AL, Kolodzie K, Kinjo S, Harbell MW, Aleshi P. Preoperative Fascia Iliaca Block Does Not Improve Analgesia after Arthroscopic Hip Surgery, but Causes Quadriceps Muscles Weakness: A Randomized, Double-blind Trial. Anesthesiology. 2018 Sep;129(3):536-543.

Behrends M, Larson MD, Neice AE, Bokoch MP. Suppression of pupillary unrest by general anesthesia and propofol sedation. J Clin Monit Comput. 2018 May 21.

Berger M, Schenning KJ, Brown CH 4th, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z; Perioperative Neurotoxicity Working Group. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 Oct 9.

Abrecht CR, Cornelius M, Wu A, Jamison RN, Janfaza D, Urman RD, Campbell C, Smith M, Haythornthwaite J, Edwards RR, Schreiber KL. Prediction of Pain and Opioid Utilization in the Perioperative Period in Patients Undergoing Primary Knee Arthroplasty: Psychophysical and Psychosocial Factors. Pain Med. 2018 Mar 7.

Adelmann D, Roll GR, Kothari R, Syed S, Burdine LJ, Tavakol M, Niemann CU. The Impact of Deceased Donor Liver Extraction Time on Early Allograft Function in Adult Liver Transplant Recipients. Transplantation. 2018 Jul 25.

Adelmann D, Olmos A, Liu LL, Feiner JR, Roll GR, Burdine L, Tavakol M, Syed S, Orandi BJ, Niemann CU. Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy. Transplantation. 2018 May;102(5):e229-e235.

Adelmann D, Bicknell L, Niemann CU, Feiner J, Roll GR, Burdine L, Whitlock EL. Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis. Clin Transplant. 2018 May;32(5):e13238.

Aeppli N, Lindauer B, Steurer MP, Weiss M, Dullenkopf A. Endotracheal tube cuff pressure changes during manual cuff pressure control manoeuvres: An in-vitro assessment. Acta Anaesthesiol Scand. 2018 Aug 21.

Aksel S, Lang L, Steinauer JE, Drey EA, Lederle L, Sokoloff A, Carlisle AS. Safety of Deep Sedation Without Intubation for Second-Trimester Dilation and Evacuation. Obstet Gynecol. 2018 Jul;132(1):171-178

Alexander MD, Hippe DS, Cooke DL, Hallam DK, Hetts SW, Kim H, Lawton MT, Sekhar LN, Kim LJ, Ghodke BV. Targeted Embolization of Aneurysms Associated With Brain Arteriovenous Malformations at High Risk for Surgical Resection: A Case-Control Study. Neurosurgery. 2018 Mar 1;82(3):343-349.

Ammanuel S, Alexander MD, Damato B, Cooke DL, Halbach VV, Amans MR, Dowd CF, Higashida RT, Hetts SW. Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma. Interv Neuroradiol. 2018 Jun;24(3):345-350.

Berger M, Schenning KJ, Brown CH 4th, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z; Perioperative Neurotoxicity Working Group. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 Oct 9.

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 Feb 1;197(3):313-324.

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy. Am J Respir Crit Care Med. 2018 Oct 18.

Bickler MP, Rhodes LJ. Accuracy of detection of carboxyhemoglobin and methemoglobin in human and bovine blood with an inexpensive, pocket-size infrared scanner. PLoS One. 2018 Mar 7;13(3):e0193891.

Bickler P, Feiner JR, Lundeberg J. Response to Burtscher re: “Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels”. High Alt Med Biol. 2018 Sep;19(3):304-305.

Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 Oct 2;57(39):5748-5758.

PEER REVIEWED PUBLICATIONS

YEAR in REVIEW 2018 23

Borrat X, Ubre M, Risco R, Gambús PL, Pedroso A, Iglesias A, Fernandez-Esparrach G, Ginés À, Balust J, Martínez-Palli G. Computerized tests to evaluate recovery of cognitive function after deep sedation with propofol and remifentanil for colonoscopy. J Clin Monit Comput. 2018 Mar 27.

Brinson EL, Thornton KC. Preoperative Risk Assessment of Respiratory Failure. Int Anesthesiol Clin. 2018 Winter;56(1):26-46.

Brinson EL, Yu JS, Liu LL, Bokoch MP. Desmopressin Reverses Overly Rapid Serum Sodium Correction in a Hyponatremic Patient Undergoing Living Donor Liver Transplantation: A Case Report. A A Pract. 2018 Aug 1;11(3):82-84.

Brzezinski M. Intensive care practitioner: I forgot half the things I learned and the other half seems to be all wrong! Curr Opin Anaesthesiol. 2018 Apr;31(2):127-128.

Bulfone TC, Samuel SP, Bickler PE, Lewin MR. Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. J Trop Med. 2018 Jul 30;2018:4320175.

Bull LN, Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Dodge JL, Emerick K, Wanty C, Wali S, Blanchard S, Lacaille F, Byrne JA, van Eerde AM, Kolho KL, Houwen R, Lobritto S, Hupertz V, McClean P, Mieli-Vergani G, Sokal E, Rosenthal P, Whitington PF, Pawlowska J, Thompson RJ. Outcomes of surgical management of familial intrahepatic cholestasis 1 and bile salt export protein deficiencies. Hepatol Commun. 2018 Mar 30;2(5):515-528.

Burkes RM, Gassett AJ, Ceppe AS, Anderson W, O’Neal WK, Woodruff PG, Krishnan JA, Barr RG, Han MK, Martinez FJ, Comellas AP, Lambert AA, Kaufman JD, Dransfield MT, Wells JM, Kanner RE, Paine R 3rd, Bleecker ER, Paulin LM, Hansel NN, Drummond MB; SPIROMICS Investigators. Rural Residence and COPD Exacerbations: Analysis of the SPIROMICS Cohort. Ann Am Thorac Soc. 2018 Mar 27.

Burkhardt JK, Chen X, Winkler EA, Weiss M, Yue JK, Cooke DL, Kim H, Lawton MT. Early Hemodynamic Changes Based on Initial Color-Coding Angiography as a Predictor for Developing Subsequent Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2018 Jan;109:e363-e373.

Butler M, Drum E, Evans FM, Fitzgerald T, Fraser J, Holterman AX, Jen H, Kynes M, Kreiss J, McClain CD, Newton M, Nwomeh B, O’Neill J, Ozgediz D, Politis G, Rice H, Rothstein D, Sanchez J, Singleton M, Yudkowitz FS. Guidelines and checklists for short-term missions in global pediatric surgery: Recommendations from the American Academy of Pediatrics Delivery of Surgical Care Global Health Subcommittee,

American Pediatric Surgical Association Global Pediatric Surgery Committee, Society for Pediatric Anesthesia Committee on International Education and Service, and American Pediatric Surgical Nurses Association, Inc. Global Health Special Interest Group. Paediatr Anaesth. 2018 May;28(5):392-410.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O’Kane CM, McAuley DF; Irish Critical Care Trials Group. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018 Sep;6(9):691-698.

Cheah JW, Sing DC, Hansen EN, Aleshi P, Vail TP. Does Intrathecal Morphine in Spinal Anesthesia Have a Role in Modern Multimodal Analgesia for Primary Total Joint Arthroplasty? J Arthroplasty. 2018 Jun;33(6):1693-1698.

Chen CL, Neuman MD. Do Anesthetic Choices Signal Quality? Anesthesiology. 2018 Mar; 128(3):429-430.

Chen CL, Clay TH, McLeod S, Chang HP, Gelb AW, Dudley RA. A Revised Estimate of Costs Associated With Routine Preoperative Testing in Medicare Cataract Patients With a Procedure-Specific Indicator. JAMA Ophthalmol. 2018 Mar 1;136(3):231-238.

Chiu C, Aleshi P, Esserman LJ, Inglis-Arkell C, Yap E, Whitlock EL, Harbell MW. Improved analgesia and reduced post-operative nausea and vomiting after implementation of an enhanced recovery after surgery (ERAS) pathway for total mastectomy. BMC Anesthesiol. 2018 Apr 16;18(1):41.

Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 Aug 21.

Coburn M, Sanders RD, Maze M, Nguyên-Pascal ML, Rex S, Garrigues B, Carbonell JA, Garcia-Perez ML, Stevanovic A, Kienbaum P, Neukirchen M, Schaefer MS, Borghi B, van Oven H, Tognù A, Al Tmimi L, Eyrolle L, Langeron O, Capdevila X, Arnold GM, Schaller M, Rossaint R; HIPELD Study Investigators. The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. Br J Anaesth. 2018 Jan;120(1):127-137.

Collins S, Dykes P, Bates DW, Couture B, Rozenblum R, Prey J, O’Reilly K, Bourie PQ, Dwyer C, Greysen SR, Smith J, Gropper M, Dalal AK. An informatics research agenda to support patient and family empowerment and engagement in care and recovery during and after hospitalization. J Am Med Inform Assoc. 2018 Feb 1;25(2):206-209.

Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. Transl Stroke Res. 2018 Feb;9(1):20-33.

Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock. Crit Care Med. 2018 Aug;46(8):1334-1356.

Coopersmith CM, De Backer D, Deutschman CS, Ferrer R, Lat I, Machado FR, Martin GS, Martin-Loeches I, Nunnally ME, Antonelli M, Evans LE, Hellman J, Jog S, Kesecioglu J, Levy MM, Rhodes A. Surviving sepsis campaign: research priorities for sepsis and septic shock. Intensive Care Med. 2018 Sep;44(9):1400-1426.

Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. Cryo-EM structure of the v8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 Aug;25(8):698-704.

Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H; BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Pediatr Crit Care Med. 2018 Oct;19(10):930-938.

Daniels KM, Yang Yu E, Maine RG, Heng Y, Yang L, Shi B, Corlew DS, Hoffman WY, Gregory GA. Palatal Fistula Risk after Primary Palatoplasty: A Retrospective Comparison of a Humanitarian Organization and Tertiary Hospitals. Cleft Palate Craniofac J. 2018 Jul;55(6):807-813.

DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10;18(1):58.

Deiss T, Chen LL, Sarin A, Naidu RK. Patient-reported outcomes 6 months after enhanced recovery after colorectal surgery. Perioper Med (Lond). 2018 Aug 23;7:19.

24 YEAR in REVIEW 2018

Delucchi K, Famous KR, Ware LB, Parsons PE, Thompson BT, Calfee CS; ARDS Network. Stability of ARDS subphenotypes over time in two randomised controlled trials. Thorax. 2018 May;73(5):439-445.

Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD. Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury. Neurosurgery. 2018 Jun 1;82(6):870-876.

Donovan AL, Aldrich JM, Gross AK, Barchas DM, Thornton KC, Schell-Chaple HM, Gropper MA, Lipshutz AKM; University of California, San Francisco Critical Care Innovations Group. Interprofessional Care and Teamwork in the ICU. Crit Care Med. 2018 Jun;46(6):980-990.

Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV; National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP). Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 Mar 1;128(3):997-1009.

Elsharkawy H, Kashy BK, Babazade R, Gray AT. Ultrasound Detection of Arteria Comitans: A Novel Technique to Locate the Sciatic Nerve. Reg Anesth Pain Med. 2018 Jan;43(1):57-61.

Eskey CJ, Meyers PM, Nguyen TN, Ansari SA, Jayaraman M, McDougall CG, DeMarco JK, Gray WA, Hess DC, Higashida RT, Pandey DK, Peña C, Schumacher HC; American Heart Association Council on Cardiovascular Radiology and Intervention and Stroke Council. Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association. Circulation. 2018 May 22;137(21):e661-e689.

Fang X, Matthay MA. Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions. Methods Mol Biol. 2018 1809:121-128.

Federspiel CK, Itenov TS, Mehta K, Hsu RK, Bestle MH, Liu KD. Duration of acute kidney injury in critically ill patients. Ann Intensive Care. 2018 Feb 23;8(1):30.

Fielding-Singh V, Matthay MA, Calfee CS. Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Crit Care Med. 2018 Nov;46(11):1820-1831.

Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK. Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L52-L58.

Gambus P, Shafer SL. Artificial Intelligence for Everyone. Anesthesiology. 2018 Mar;128(3):431-433.

Garcia-Rodriguez C, Razai A, Geren IN, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD. A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes. Toxins (Basel). 2018 Mar 1;10(3).

Gattinoni L, Pesenti A, Matthay M. Understanding blood gas analysis. Intensive Care Med. 2018 Jan;44(1):91-93.

Gelb AW, Morriss WW, Johnson W, Merry AF; International Standards for a Safe Practice of Anesthesia Workgroup. In reply: Encouraging a bare minimum while striving for the gold standard: a response to the updated WHO-WFSA guidelines. Can J Anaesth. 2018 Aug 29.

Gelb AW, Morriss WW, Johnson W, Merry AF, Abayadeera A, Belîi N, Brull SJ, Chibana A, Evans F, Goddia C, Haylock-Loor C, Khan F, Leal S, Lin N, Merchant R, Newton MW, Rowles JS, Sanusi A, Wilson I, Velazquez Berumen A; International Standards for a Safe Practice of Anesthesia Workgroup. World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia. Anesth Analg. 2018 Jun;126(6):2047-2055.

Gelb AW, Morriss WW, Johnson W, Merry AF; International Standards for a Safe Practice of Anesthesia Workgroup. World Health Organization–World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia. Can J Anaesth. 2018 May 7.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 Sep 6;36(9):899.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ,

Nolte-’t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 Sep;36(8):746-757.

Go AS, Hsu CY, Yang J, Tan TC, Zheng S, Ordonez JD, Liu KD. Acute Kidney Injury and Risk of Heart Failure and Atherosclerotic Events. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):833-841.

Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L25-L40.

Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 Feb 1;197(3):280-281.

Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A. Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. J Heart Lung Transplant. 2018 Jun;37(6):782-791.

Guo L, Li Y, Han R, Gelb AW. The Correlation Between Recordable MEPs and Motor Function During Spinal Surgery for Resection of Thoracic Spinal Cord Tumor. J Neurosurg Anesthesiol. 2018 Jan;30(1):39-43.

Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 May;36(5):796-806.

Hadaya IA, Gray AT, Braehler MR. Baclofen Pump Replacement in a Patient With End-Stage Amyotrophic Lateral Sclerosis: A Case Report Demonstrating Transversus Abdominis Plane Block as the Sole Anesthetic. A A Pract. 2018 May 15;10(10):251-253.

Haghighi B, Choi S, Choi J, Hoffman EA, Comellas AP, Newell JD Jr, Graham Barr R, Bleecker E, Cooper CB, Couper D, Han ML, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EAC, Martinez FJ, O’Neal W, Rennard SI, Woodruff PG, Lin CL. Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). Respir Res. 2018 Sep 18;19(1):178.

YEAR in REVIEW 2018 25

Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J. Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Clin Transplant. 2018 Apr;32(4):e13210.

Han MK, Tayob N, Murray S, Woodruff PG, Curtis JL, Kim V, Criner G, Galban CJ, Ross BD, Hoffman EA, Lynch DA, Kazerooni E, Martinez FJ; COPDGene and SPIROMICS Investigators. Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials. Am J Respir Crit Care Med. 2018 Jul 15;198(2):265-267.

Hellman J, Bahrami S, Boros M, Chaudry I, Fritsch G, Gozdzik W, Inoue S, Radermacher P, Singer M, Osuchowski MF, Huber-Lang M. Part III: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. Shock. 2018 Jun 19.

Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018 Jun 27;3(1):e000171

Hendrickson CM, Matthay MA. Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Pulm Circ. 2018 Apr-Jun;8(2):2045894018769876.

Hirabayashi KE, Kalin-Hajdu E, Bever GJ, Vagefi MR, de Alba Campomanes AG, Cooke DL, Dowd CF, Kersten RC. Normalization of Congenital Venous Stasis Retinopathy Following Sclerotherapy of a Macrocystic Lymphatic Malformation. Ophthalmic Plast Reconstr Surg. 2018 Jan/Feb;34(1):e19-e21.

House LM, McKay RE, Eagan JT Jr, McCormick ZL. Nocturnal phantom shock cessation with zolpidem. Heart Lung. 2018 Jan - Feb;47(1):76-79.

Howard BM, Kornblith LZ, Redick BJ, Conroy AS, Nelson MF, Calfee CS, Callcut RA, Cohen MJ. Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry. J Trauma Acute Care Surg. 2018 Jan;84(1):97-103.

Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Can J Kidney Health Dis. 2018 Aug 2;5:2054358118789158.

Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M. Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Anesthesiology. 2018 May;128(5):921-931.

Hu S, Park J, Liu A, Lee J, Zhang X, Hao Q, Lee JW. Mesenchymal Stem Cell Microvesicles Restore Protein Permeability Across Primary Cultures of Injured Human Lung Microvascular Endothelial Cells. Stem Cells Transl Med. 2018 Aug;7(8):615-624.

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS. Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Intensive Care Med. 2018 Sep;44(9):1388-1399.

Jha P, Behr S, Morgan T, Washburn E, Lucero J, Chen LM, Poder L. Imaging findings of concealed intra-amniotic hemorrhage in the setting of placenta previa and placenta accreta spectrum disorder. Emerg Radiol. 2018 Jun 17.

Jin M, Lee EC, Ra SW, Fishbane N, Tam S, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Leung JM, Sin DD. Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD. Chest. 2018 Aug;154(2):266-273.

Jooste EH, Scholl R, Wu YH, Jaquiss RDB, Lodge AJ, Ames WA, Homi HM, Machovec KA, Greene NH, Donahue BS, Shah N, Benkwitz C. Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery. J Cardiothorac Vasc Anesth. 2018 Jun 5.

Kallet RH, Ho K, Lipnick MS, Matthay MA. Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome. J Thorac Dis. 2018 Aug;10(8):5030-5038.

Kallet RH, Lipnick MS. Is there still a role for alveolar recruitment maneuvers in acute respiratory distress syndrome? J Thorac Dis. 2018 Jan;10(1):85-90.

Kallet RH, Zhuo H, Yip V, Gomez A, Lipnick MS. Spontaneous Breathing Trials and Conservative Sedation Practices Reduce Mechanical Ventilation Duration in Subjects With ARDS. Respir Care. 2018 Jan;63(1):1-10.

Kao CC, Yang WS, Fang JT, Liu KD, Wu VC. Remote organ failure in acute kidney injury. J Formos Med Assoc. 2018 May 21.

Kinjo S, Lim E, Magsaysay MV, Sands LP, Leung JM; Perioperative Medicine Research Group. Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies. Acta Anaesthesiol Scand. 2018 Jul 27.

Kisilevsky A, Gelb AW, Bustillo M, Flexman AM. Response to: ‘Patient blood management in intracranial neurosurgery-do we have sufficient data to define a transfusion threshold?’ (Br J Anaesth 2018; 121: 974-76). Br J Anaesth. 2018 Oct;121(4):976-977.

Kisilevsky A, Gelb AW, Bustillo M, Flexman AM. Anaemia and red blood cell transfusion in intracranial neurosurgery: a comprehensive review. Br J Anaesth. 2018 May;120(5):988-998.

Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C. Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors. J Pain Symptom Manage. 2018 Aug 30.

Kondapavulur S, Cooke DL, Kao A, Amans MR, Alexander M, Darflinger R, Dowd CF, Higashida RT, Damato B, Halbach VV, Matthay KK, Hetts SW. Estimation of intra-arterial chemotherapy distribution to the retina in pediatric retinoblastoma patients using quantitative digital subtraction angiography. Interv Neuroradiol. 2018 Apr;24(2):214-219.

Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ. Perhaps It’s Not the Platelet: Ristocetin Uncovers the Potential Role of von Willebrand Factor in Impaired Platelet Aggregation Following Traumatic Brain Injury. J Trauma Acute Care Surg. 2018 Jul 5.

Kotas ME, Matthay MA. Mesenchymal stromal cells and macrophages in sepsis: new insights. Eur Respir J. 2018 Apr 26;51(4).

Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 Aug 3;3(26).

Kwong YD, Liu KD. Selection of Intravenous Fluids. Am J Kidney Dis. 2018 Jul 3.

26 YEAR in REVIEW 2018

Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine R 3rd, Ortega VE, Peters SP, Krishnan JA, Bowler RP, Couper DJ, Woodruff PG, Martinez FJ, Martinez CH, Han MK. NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort. Respir Med. 2018 Jul;140:87-93.

Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018 Feb 13;4:7.

LaHue SC, Kim H, Pawlikowska L, Nelson J, Cooke DL, Hetts SW, Singh V. Frequency and characteristics associated with inherited thrombophilia in patients with intracranial dural arteriovenous fistula. J Neurosurg. 2018 Apr 6:1-5.

Lee BJ, Hsu CY, Parikh RV, Leong TK, Tan TC, Walia S, Liu KD, Hsu RK, Go AS. Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study. BMC Nephrol. 2018 Jun 11;19(1):134.

Lee BJ, Go AS, Parikh R, Leong TK, Tan TC, Walia S, Hsu RK, Liu KD, Hsu CY. Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury Kidney Int. 2018 Apr;93(4):968-976.

Lee JW, Kato H. Should We Stop for Growth Arrest-specific 6 in Acute Respiratory Distress Syndrome? Anesthesiology. 2018 Jul;129(1):8-10.

Lee NK, Zhang Y, Su Y, Bidlingmaier S, Sherbenou DW, Ha KD, Liu B. Cell-type specific potent Wnt signaling blockade by bispecific antibody. Sci Rep. 2018 Jan 15;8(1):766.

Lee NK, Bidlingmaier S, Su Y, Liu B. Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes. Methods Mol Biol. 2018 1701:61-82.

Lee SM, Tenney R, Wallace AW, Arjomandi M. E-cigarettes versus nicotine patches for perioperative smoking cessation: a pilot randomized trial. PeerJ. 2018 Sep 28;6:e5609.

Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight. 2018 Feb 8;3(3).

Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Paul Man SF, Aaron SD, Reed RM, Sin DD; Canadian Respiratory Research Network (CRRN).

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD. Respir Res. 2018 Feb 14;19(1):30.

Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L638-L644.

Lewin MR, Gutiérrez JM, Samuel SP, Herrera M, Bryan-Quirós W, Lomonte B, Bickler PE, Bulfone TC, Williams DJ. Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom. Toxins (Basel). 2018 Sep 20;10(10).

Li H, Zuo M, Gelb AW, Zhang B, Zhao X, Yao D, Xia D, Huang Y. Chinese Anesthesiologists Have High Burnout and Low Job Satisfaction: A Cross-Sectional Survey. Anesth Analg. 2018 Mar;126(3):1004-1012.

Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R 3rd, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA; SPIROMICS Research Group. Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet. 2018 Aug 1;19(1):134.

Lieberman JA, Lyon R, Jasiukaitis P, Berven SH, Burch S, Feiner J. The reliability of motor evoked potentials to predict dorsiflexion injuries during lumbosacral deformity surgery: importance of multiple myotomal monitoring. Spine J. 2018 Jul 17.

Lieberman JA, Feiner J, Rollins M, Lyon R, Jasiukaitis P. Correction to: Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations. J Clin Monit Comput. 2018 Jun;32(3):581.

Lieberman JA, Feiner J, Rollins M, Lyon R. Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations. J Clin Monit Comput. 2018 Jun;32(3):541-548.

Lim S, Kinjo S. Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. Saudi J Anaesth. 2018 Jan-Mar;12(1):112-114.

Lipnick MS, Cahill EA, Feiner JR, Bickler PE. Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects. Anesth Analg. 2018 Feb;126(2):579-587.

Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL. Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury. Front Immunol. 2018 Aug 20;9:1898.

London MJ. Type 2 Perioperative Myocardial Infarction: Can We Close Pandora’s Box? Anesthesiology. 2018 Jun;128(6):1055-1059.

Lou J, Wen W, Conrad F, Meng Q, Dong J, Sun Z, Garcia-Rodriguez C, Farr-Jones S, Cheng LW, Henderson TD, Brown JL, Smith TJ, Smith LA, Cormier A, Marks JD. A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A. Toxins (Basel). 2018 Feb 15;10(2).

Louie A, Feiner JR, Bickler PE, Rhodes L, Bernstein M, Lucero J. Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion. Anesthesiology. 2018 Mar;128(3):520-530.

Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler PE. Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels. High Alt Med Biol. 2018 Sep;19(3):249-258.

MacKenzie KK, Britt-Spells AM, Sands LP, Leung JM. Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis. Anesthesiology. 2018 Sep;129(3):417-427.

Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N. ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol. 2018 Feb 15;19(1):36.

Manuel SP, Roberts JP, Bakhtary S. Preoperative autologous blood collection in adult living liver donors: Are we wasting donor blood and increasing exposure to risk? Transplantation. 2018 Jun 26.

Manuel SP, Grewal GK, Lee JS. Millennial Resident Study Habits and Factors that Influence American Board of Anesthesiology In-Training Examination Performance: A Multi-Institutional Study. J Educ Perioper Med. 2018 Apr 1;20(2):E623.

YEAR in REVIEW 2018 27

Mao Q, Jay M, Hoffman JL, Calvert J, Barton C, Shimabukuro D, Shieh L, Chettipally U, Fletcher G, Kerem Y, Zhou Y, Das R. Multicentre validation of a sepsis prediction algorithm using only vital sign data in the emergency department, general ward and ICU. BMJ Open. 2018 Jan 26;8(1):e017833.

Markey J, Maine R, Daniels K, Yu EY, Gregory G, Hoffman W, Palacios J. Otologic Disease Following Palatoplasty In International Cleft Palate Cohort. Cleft Palate Craniofac J. 2018 Feb;55(2):162-167.

Markley JC, Farber MK, Perlman NC, Carusi DA. Neuraxial Anesthesia During Cesarean Delivery for Placenta Previa With Suspected Morbidly Adherent Placenta: A Retrospective Analysis. Anesth Analg. 2018 Oct;127(4):930-938.

Markley JC, Farber MK, Perlman NC, Carusi DA. In Response. Anesth Analg. 2018 May 17.

Markley JC, Farber MK, Perlman NC, Carusi DA. In Response. Anesth Analg. 2018 Nov;127(5):e81.

Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O’Neal WK, Paine R 3rd, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM; SPIROMICS Investigators. Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol. 2018 Jan;141(1):429-432.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA. At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551.

Matthay MA, Abman SH. Exosome-based Therapy for Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2018 Jan 1;197(1):10-12.

McKay RE, Neice AE, Larson MD. Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions. A A Pract. 2018 May 15;10(10):279-282.

McLaughlin DC, Cheah JW, Aleshi P, Zhang AL, Ma CB, Feeley BT. https://www.ncbi.nlm.nih.gov/pubmed/29473421 J Shoulder Elbow Surg. 2018 Apr;27(4):686-691.

Mehta NJ, Latoures R, Stechert MM, Fidler RL, Hirsch J. Interventions to improve the mechanical ventilation fidelity of the Laerdal SimMan® 3G simulation mannequin. Can J Anaesth. 2018 May;65(5):600-602.

Meng L, Li J, Flexman AM, Tong C, Zhou X, Gelb AW, Wang T, McDonagh DL. Perceptions of Perioperative Stroke Among Chinese Anesthesiologists: Starting a Long March to Eliminate This Underappreciated Complication. Anesth Analg. 2018 Jul 21.

Meybodi AT, Kim H, Nelson J, Hetts SW, Krings T, terBrugge KG, Faughnan ME, Lawton MT; Brain Vascular Malformation Consortium HHT Investigator Group. Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study. Neurosurgery. 2018 Jan 1;82(1):35-47.

Meyers PM, Higashida RT. Commentary on Optimal Treatment Strategy for Tandem Stroke. JACC Cardiovasc Interv. 2018 Jul 9;11(13):1300-1301.

Mi MY, Matthay MA, Morris AH. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2018 Aug 30;379(9):884-887.

Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Schumacher M, Conley YP, Hammer M, Cheung S, Borsook D, Levine JD. Contribution of Loss of Large Fiber Function to Pain in Two Samples of Oncology Patients. Clin J Pain. 2018 Sep 21.

Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD. Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors. J Pain Symptom Manage. 2018 Jul;56(1):88-97.

Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD. Impact of chemotherapy-induced neurotoxicities on adult cancer survivors’ symptom burden and quality of life. J Cancer Surviv. 2018 Apr;12(2):234-245.

Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD. Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. 2018 Feb;32:1-11.

Miller J, Kim S, Adelmann D, Hill B, Schlichting N, Smith N, DeMaria S Jr, Zerillo J. In Response. Anesth Analg. 2018 Aug 16.

Miller J, Kim S, Adelmann D, Hill B, Schlichting N, Smith N, DeMaria S Jr, Zerillo J. Profound Intraoperative Hypotension Associated With Transfusion via the Belmont Fluid Management System. Anesth Analg. 2018 Apr 5.

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 Aug 29.

Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS. Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg. 2018 Feb;84(2):365-371.

Moore PK, Hsu RK, Liu KD. Management of Acute Kidney Injury: Core Curriculum 2018. Am J Kidney Dis. 2018 Jul;72(1):136-148.

Morris MA, Jacobson SR, Kinney GL, Tashkin DP, Woodruff PG, Hoffman EA, Kanner RE, Cooper CB, Drummond MB, Barr RG, Oelsner EC, Make BJ, Han MK, Hansel NN, O’Neal WK, Bowler RP. Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). Chronic Obstr Pulm Dis. 2018 Jan 24;5(1):46-56.

Morrison J, Alexander MD, Dowd CF, Cooke DL. Flanking the fenestration: circumferential limb-to-limb stent-assisted coiling of a basilar artery fenestration aneurysm. J Neurointerv Surg. 2018 Jun;10(6):e12.

Muffly MK, Singleton M, Agarwal R, Scheinker D, Miller D, Muffly TM, Honkanen A. The Pediatric Anesthesiology Workforce: Projecting Supply and Trends 2015-2035. Anesth Analg. 2018 Feb;126(2):568-578.

Muñoz JE, Gambús P, Jensen EW, Vallverdú M. Time-frequency Features for Impedance Cardiography Signals During Anesthesia Using Different Distribution Kernels. Methods Inf Med. 2018 Jan;57(1):e1-e9.

Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, Pickkers P, Price S, Ricci Z, Rich JB, Sajja LR, Weaver FA, Zarbock A, Ronco C, Kellum JA. Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group. J Am Heart Assoc. 2018 Jun 1;7(11).

28 YEAR in REVIEW 2018

Nguyen E, Sarah G, Ferschl MB. Images in Anesthesiology: Intraoral Lipomas. Anesthesiology. 2018 Mar;128(3):636.

Niemann CU, Broglio K, Malinoski D. Comments on “Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation”. Am J Transplant. 2018 Mar;18(3):763.

Nisson PL, Fard SA, Meybodi AT, Mooney MA, Kim H, Jahnke H, Walter CM, Dumont TM, Lemole GM Jr, Lawton MT, Spetzler RF. The Unique Features and Outcomes of Microsurgically Resected Cerebellar Arteriovenous Malformations. World Neurosurg. 2018 Sep 3.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018 Oct;46(5):745-747.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018 Oct;46(5):687-691.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock. 2018 Oct;50(4):377-380.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Joost Wiersinga W, Xiao X, Zingarelli B. Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS):

an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp. 2018 Aug 14;6(1):26.

Pais FM, Sinha P, Liu KD, Matthay MA. Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials. Respir Care. 2018 Aug;63(8):1060-1069.

Palevsky PM, Liu KD. What endpoints should not be used for clinical studies of acute kidney injury? Intensive Care Med. 2018 Mar;44(3):363-365.

Pan JZ, Eckenhoff RG. Between a ROCK and an IR Place. Anesth Analg. 2018 Mar;126(3):750-751.

Pan JZ. Genomics and Proteomic Techniques. Methods Enzymol. 2018 603:221-235.

Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS. Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients. Am J Respir Crit Care Med. 2018 Mar 1;197(5):621-631.

Park J, Kim S, Lim H, Liu A, Hu S, Lee J, Zhuo H, Hao Q, Matthay MA, Lee JW. Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia. Thorax. 2018 Aug 3.

Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. After asthma: redefining airways diseases. Lancet. 2018 Jan 27;391(10118):350-400.

Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Kim H, Faughnan ME; Brain Vascular Malformation Consortium HHT Investigator Group. Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia. Mol Genet Genomic Med. 2018 May;6(3):350-356.

Pecanac KE, Brown RL, Steingrub J, Anderson W, Matthay MA, White DB. A psychometric study of the decisional conflict scale in surrogate decision makers. Patient Educ Couns. 2018 Nov;101(11):1957-1965.

Peniche A, Poree L, Schumacher M, Yu X. Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report. A A Pract. 2018 Jun 1;10(11):285-287

Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour

NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV; National Heart, Lung and Blood Institute Severe Asthma Research Program 3. Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 2018 Mar 7.

Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Koskimäki J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IA. Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH). Neurosurgery. 2018 Apr 11.

Pun BT, Balas MC, Barnes-Daly MA, Thompson JL, Aldrich JM, Barr J, Byrum D, Carson SS, Devlin JW, Engel HJ, Esbrook CL, Hargett KD, Harmon L, Hielsberg C, Jackson JC, Kelly TL, Kumar V, Millner L, Morse A, Perme CS, Posa PJ, Puntillo KA, Schweickert WD, Stollings JL, Tan A, D’Agostino McGowan L, Ely EW. Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. Crit Care Med. 2018 Oct 18.

Putcha N, Paul GG, Azar A, Wise RA, O’Neal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN; SPIROMICS investigators. Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS. PLoS One. 2018 Apr 12;13(4):e0194924.

Queiroz VNF, da Costa LGV, Barbosa RP, Takaoka F, De Baerdemaeker L, Cesar DS, D’Orto UC, Galdi JR, Gottumukkala V, Cata JP, Hemmes SNT, Hollman MW, Kalmar A, Moura LAB, Mariano RM, Matot I, Mazzinari G, Mills GH, Posso IP, Teruya A, Vidal Melo MF, Sprung J, Weingarten TN, Treschan TA, Koopman S, Eidelman L, Chen LL, Lee JW, Ariño Irujo JJ, Tena B, Groeben H, Pelosi P, de Abreu MG, Schultz MJ, Serpa Neto A; AVATaR and PROVE Network investigators. International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan. BMJ Open. 2018 Aug 23;8(8):e021643.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Oct 21.

YEAR in REVIEW 2018 29

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB. Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Am J Respir Crit Care Med. 2018 Aug 1.

Remick DG, Ayala A, Chaudry I, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski M. Premise for Standardized Sepsis Models. Shock. 2018 Jun 5.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 Mar 22;3(6).

Robel R, Caroccio P, Maze M. Methods for Defining the Neuroprotective Properties of Xenon. Methods Enzymol. 2018 602:273-288.

Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. J Trauma Acute Care Surg. 2018 Jul;85(1):148-154.

Romig M, Carolan H, Ravitz A, Schell-Chaple H, Yoon E, Dwyer C, Thornton K, Gropper M, Pronovost PJ, Sapirstein A. Intensive care unit providers more quickly and accurately assess risk of multiple harms using an engineered safety display. Health Informatics J. 2018 Sep 17:1460458218796638.

Ross JT, Matthay MA, Harris HW. Secondary peritonitis: principles of diagnosis and intervention. BMJ. 2018 Jun 18;361:k1407.

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 Apr;46(4):577-585.

Russo M, Cousins MJ, Brooker C, Taylor N, Boesel T, Sullivan R, Poree L, Shariati NH, Hanson E, Parker J. Effective Relief of Pain and Associated Symptoms With Closed-Loop Spinal Cord Stimulation System: Preliminary Results of the Avalon Study. Neuromodulation. 2018 Jan;21(1):38-47.

Rylova A, Maze M. Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. J Neurosurg Anesthesiol. 2018 Feb 21.

Saxena S, Uchida Y, Maze M. Restoring Order to Postoperative Neurocognitive Disorders. JAMA Neurol. 2018 May 1;75(5):535-536.

Saxena S, Maze M. Impact on the brain of the inflammatory response to surgery. Presse Med. 2018 Apr;47(4 Pt 2):e73-e81.

Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA. Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Am J Crit Care. 2018 Jan;27(1):43-50.

Schober A, Feiner JR, Bickler PE, Rollins MD. Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance. Anesthesiology. 2018 Jan;128(1):97-108.

Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA. Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-, IL-1, and IFN-. Physiol Rep. 2018 Aug;6(16):e13831.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI; CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators. Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med. 2018 Oct;72(4):457-466.

Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ; PROVHILO* and the PROVE** investigators. Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis. Eur J Anaesthesiol. 2018 Sep;35(9):702-709.

Settecase F, McCoy DB, Darflinger R, Alexander MD, Cooke DL, Dowd CF, Hetts SW, Higashida RT, Halbach VV, Amans MR. Improving mechanical thrombectomy time metrics in the angiography suite: Stroke cart, parallel workflows, and conscious sedation. Interv Neuroradiol. 2018 Apr;24(2):168-177.

Sewell D, Gelb AW, Meng L, Chui J, Flexman AM. Anesthesiologists’ perception of perioperative stroke risk during non-neurologic and non-cardiac surgery. Can J Anaesth. 2018 Feb;65(2):225-226.

Shah AC, Ng WCK, Sinnott S, Cravero JP. Population analysis of predictors of difficult intubation with direct laryngoscopy in pediatric

patients with and without thyroid disease. J Anesth. 2018 Feb;32(1):54-61.

Shirvalkar P, Veuthey TL, Dawes HE, Chang EF. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain. Front Comput Neurosci. 2018 Mar 26;12:18.

Siew ED, Liu KD. Contrast-Induced Acute Kidney Injury in the PRESERVE Trial: Lessons Learned. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):949-951.

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS; NHLBI ARDS Network. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med. 2018 Oct 5.

Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH. Physiological Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Sep 13.

Sinskey JL, Rollins MD, Whitlock E, Moon-Grady AJ, Vu L, Feiner JR, Ferschl MB. Incidence and Management of Umbilical Artery Flow Abnormalities during Open Fetal Surgery. Fetal Diagn Ther. 2018 43(4):274-283.

Sinskey JL, Vecchione TM, Ekstrom BG, Boretsky K. Benefits of Ultrasound Imaging for Placement of Caudal Epidural Blockade in 3 Pediatric Patients: A Case Report. A A Pract. 2018 Jun 1;10(11):307-309.

Sleigh JW, Vacas S, Flexman AM, Talke PO. Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Anesth Analg. 2018 Oct;127(4):951-959.

Smith BM, Traboulsi H, Austin JHM, Manichaikul A, Hoffman EA, Bleecker ER, Cardoso WV, Cooper C, Couper DJ, Dashnaw SM, Guo J, Han MK, Hansel NN, Hughes EW, Jacobs DR Jr, Kanner RE, Kaufman JD, Kleerup E, Lin CL, Liu K, Lo Cascio CM, Martinez FJ, Nguyen JN, Prince MR, Rennard S, Rich SS, Simon L, Sun Y, Watson KE, Woodruff PG, Baglole CJ, Barr RG; MESA Lung and SPIROMICS investigators. Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E974-E981.

Souter MJ, Eidbo E, Findlay JY, Lebovitz DJ, Moguilevitch M, Neidlinger NA, Wagener G, Paramesh AS, Niemann CU, Roberts PR, Pretto EA Jr. Organ Donor Management: Part 1. Toward a Consensus to Guide Anesthesia Services During Donation After Brain Death. Semin Cardiothorac Vasc Anesth. 2018 Jun;22(2):211-222.

Southwell DG, Birk HS, Han SJ, Li J, Sall JW, Berger MS. Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies. J Neurosurg. 2018 Sep;129(3):567-575.

30 YEAR in REVIEW 2018

Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 6;3(17).

Su Y, Bidlingmaier S, Lee NK, Liu B. Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens. Methods Mol Biol. 2018 1701:331-347

Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD. Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution. Am J Med Qual. 2018 May/Jun;33(3):329.

Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Integrin v8-expressing tumor cells evade host immunity by regulating TGF- activation in immune cells. JCI Insight. 2018 Oct 18;3(20).

Talke P, Anderson BJ. Pharmacokinetics and pharmacodynamics of dexmedetomidine- induced vasoconstriction in healthy volunteers. Br J Clin Pharmacol. 2018 Jun;84(6):1364-1372.

Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4.

Tith S, Bining G, Bollag L. Management of eight labor and delivery patients dependent on buprenorphine (Subutex™): A retrospective chart review. F1000Res. 2018 Jan 3 [revised 2018 Feb 14];7:7.

Vide S, Gambús PL. Tools to screen and measure cognitive impairment after surgery and anesthesia. Presse Med. 2018 Apr;47(4 Pt 2):e65-e72.

Vide S, Costa CM, Gambus PL, Amorim PP. Effects of Ketamine on Pupillary Reflex Dilation: A Case Report. A A Pract. 2018 Jan 15;10(2):39-41.

Vutskits L, Sall JW. Targeting Microglia: A New Avenue for Anesthesia Neuroprotection after Brain Injury? Anesthesiology. 2018 Aug;129(2):232-234.

Waikar SS, Rebholz CM, Zheng Z, Hurwitz S, Hsu CY, Feldman HI, Xie D, Liu KD, Mifflin TE, Eckfeldt JH, Kimmel PL, Vasan RS, Bonventre JV, Inker LA, Coresh J; Chronic Kidney Disease Biomarkers Consortium Investigators. Biological Variability of Estimated GFR and Albuminuria in CKD. Am J Kidney Dis. 2018 Oct;72(4):538-546.

Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 Oct 1;128(10):4343-4358.

Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA. Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2018 Oct 1.

Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax. 2018 Sep;73(9):840-846.

Wei M, Lyu H, Huo K, Su H. Impact of Bone Fracture on Ischemic Stroke Recovery. Int J Mol Sci. 2018 May 22;19(5).

Whitlock EL, Finlayson E. Depth of Propofol Sedation and Postoperative Delirium: The Jury Is Still Out. JAMA Surg. 2018 Aug 8.

Wiegele M, Schaden E, Koch S, Bauer D, Krall C, Adelmann D. Thrombin generation in patients with severe thermal injury. Burns. 2018 Oct 13.

Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH. Antibody engineering to improve manufacturability. Protein Expr Purif. 2018 Sep;149:75-83.

Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 Jan 5:1-11.

Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2018 Feb;153(2):378-386.

Wu CX, Ma L, Chen XZ, Chen XL, Chen Y, Zhao YL, Hess C, Kim H, Jin HW, Ma J. Evaluation of Angioarchitectural Features of Unruptured Brain

Arteriovenous Malformation by Susceptibility Weighted Imaging. World Neurosurg. 2018 Aug;116:e1015-e1022.

Yu JF, Nicholson AD, Nelson J, Alexander MD, Tse SH, Hetts SW, Hemphill JC 3rd, Kim H, Cooke DL. Predictors of intracranial hemorrhage volume and distribution in brain arteriovenous malformation. Interv Neuroradiol. 2018 Apr;24(2):183-188.

Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Li XY, Maze M, Ma D. Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Ann Surg. 2018 May 8.

Zhang M, Deng YN, Zhang JY, Liu J, Li YB, Su H, Qu QM. SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. Aging Dis. 2018 Apr 1;9(2):273-286.

Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 Oct 22.

Zhou Y, Zou H, Yau C, Zhao L, Hall SC, Drummond DC, Farr-Jones S, Park JW, Benz CC, Marks JD. Discovery of internalizing antibodies to basal breast cancer cells. Protein Eng Des Sel. 2018 Jan 1;31(1):17-28.

Zhu W, Chen W, Zou D, Wang L, Bao C, Zhan L, Saw D, Wang S, Winkler E, Li Z, Zhang M, Shen F, Shaligram S, Lawton M, Su H. Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model. Stroke. 2018 May;49(5):1232-1240.

Zimmerman KO, Wu H, Laughon M, Greenberg RG, Walczak R, Schulman SR, Smith PB, Hornik CP, Cohen-Wolkowiez M, Watt KM. Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass. Anesth Analg. 2018 Aug 22.

Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Aug 16.

Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA. Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop. Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1113-1123. ■

YEAR in REVIEW 2018 31

Pedram AleshiPrincipal InvestigatorAnesthesia Dept, 7/1/2017–6/30/2019Anesthesia Department Research Award / $34,996

Roland BaintonPrincipal InvestigatorProgram for Breakthrough Biomedical Research, 1/16/2018–1/15/2019Interrogating the Biologic Cost of Robust Chemoprotection of the Brain: Using ICA to identify Novel Genomic Markers of Neuro-Protection and Age-Related CNS Pathogensis / $121,793

Philip BicklerPrincipal InvestigatorVarious Industry Sponsors, 9/1/1986–12/31/2018Accuracy of pulse oximeters with profound hypoxia / $150,000

Michael BokochPrincipal InvestigatorAnesthesia Dept, 7/1/2017–7/31/2019Anesthesia Department Clinical Research Award / $39,990

Catherine ChenFAER, 1/1/2017–12/31/2018Unintended Consequences of Routine Preoperative Testing in Cataract Surgery Patients / $175,000

Principal InvestigatorAnesthesia Dept, 7/1/2017–6/30/2019Anesthesia Department Research Award / $40,000

Principal InvestigatorMt Zion Health Fund, 9/1/2017–8/31/2019Postoperative Opioid-Prescribing Patterns, Multimodal Analgesia, and the Prescription Opioid Epidemic$40,000

Anne DonovanPrincipal InvestigatorAnesthesia Dept, 7/1/2016–6/30/2019Anesthesia Department Clinical Research Award / $27,052

Seema GandhiPrincipal InvestigatorCity & County of San Francisco, 1/1/2018-12/31/2019Health Waste Diversion Program (Zero Waste Grant) / $85,000

Principal InvestigatorAnesthesia Dept, 1/1/2018–12/31/2019Anesthesia Department Clinical Research Award / $24,988

Adrian GelbPrincipal InvestigatorUCSF Academic Affairs, 7/1/2017–6/30/2019Fostering Quality and Safety in Anesthetic Practice in the Developing World / $10,000

Michael GropperFAER, 1/1/2018–12/31/20182018 Medical Student Anesthesia Research Fellowship Program$6,200

Zhonghui GuanPrincipal InvestigatorAnesthesia Dept, 7/1/2016–6/30/2019Anesthesia Department Research Award / $80,000

Principal InvestigatorNIH/NINDS, 7/1/2017–6/30/2022Regulation of Nerve Injury-induced Gene Expression in Neuropathic Pain$1,733,595

Monica HarbellPrincipal InvestigatorMt Zion Health Fund, 5/1/2017–9/30/2018Point-Of-Care Ultrasound (POCUS) Training for MZ Anesthesia Providers$9,630

Judith HellmanPrincipal InvestigatorMassachusetts General Hospital, 8/8/2016–8/8/2019Species Inspired Research for Innovative Treatments (SPIRIT)$541,000

Principal InvestigatorNIH/NIGMS, 7/1/2017–6/30/2022Comprehensive Anesthesia Research Training / $1,413,361

San Francisco Foundation, 1/1/2015 – ongoing, San Francisco Foundation Award / $200,000

Christina Inglis-ArkellPrincipal Investigator; Co-Investigator: Anjali Dixit, MDMt Zion Health Fund, 8/1/2018–7/31/2019Preventing Opioid Over-Prescription in Post-Surgical Patients / $21,835

Irfan KathiriyaPrincipal InvestigatorHellman Family Award, 7/1/2017–6/30/2019Developmental Origins of Congenital Heart Disease / $50,000

Principal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $60,000

Helen KimPrincipal InvestigatorNIH/NINDS, 7/1/2013–6/30/2019Predictors of spontaneous cerebral AVM hemorrhage / $2,297,210

Principal InvestigatorNIH/NINDS, 5/15/2017–4/30/2022Long-term Outcomes in Unruptured Brain Arteriovenous Malformation Patients / $3,076,884

Co-InvestigatorUniversity of Pennsylvania, 7/1/2017–4/30/2022TLR4 and the Microbiome in CCM Disease / $757,685

Principal InvestigatorUCSF REAC, 7/1/2017–6/30/2019PET Characterization of Inflammation in Patients with Cerebral Cavernous Malformations / $50,000

Principal InvestigatorThe University of Chicago, 12/1/2017–11/30/2018Trial Readiness in Cavernous Angiomas with Symptomatic Hemorrhage / $78,103

Co-LeaderNIH/NINDS, 9/30/2014–7/31/2019Brain Vascular Malformation Consortium-Project 1: Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformation$561,268

DirectorNIH/NINDS, 9/30/2014–7/31/2019Brain Vascular Malformation Consortium-Administrative Unit$521,313

Sakura KinjoPrincipal InvestigatorAnesthesia Dept, 7/1/2017–6/30/2019Anesthesia Department Clinical Research Award / $34,702

Jens KrombachPrincipal InvestigatorUCSF-ZSFG Risk Reduction Award, 7/1/2016–6/30/2019Improvement & Expansion of an Integrated Electronic Checklist System for Routine and Emergency Anesthesia Procedures / $125,000

Philip KurienPrincipal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $38,000

Alain LartiguePrincipal InvestigatorAnesthesia Dept, 1/1/2018–12/31/2019Anesthesia Department Clinical Research Award / $39,982

Michael LawtonPrincipal InvestigatorNIH/NINDS, 9/30/2014–7/31/2019Brain Vascular Malformation Consortium: Predictors of Clinical Course / $6,179,248

Chanhung LeeMerck, 7/1/2017–2/13/2023A Double-Blind, Randomized, Crossover Design Study to Compare the Rocuronium Reversal by Sugammadex to Succinylcholine for Electroconvulsive Therapy (ECT)$359,809

Jae-Woo LeePrincipal InvestigatorNIH/NHLBI, 5/1/2017–1/31/2021Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung Injury / $2,219,549

ACTIVE RESEARCH GRANTS /

32 YEAR in REVIEW 2018

Jacqueline LeungPrincipal InvestigatorNIH/NIA, 3/1/2017–2/28/2019Acute Preoperative Sleep Disruption and Postoperative Delirium$438,536

Michael LipnickUCSF REAC, 1/1/2017–12/31/2018Novel Methods for Accurately Measuring Blood Oxygen Saturation in Patients with Severe Anemia$39,588

Hellman Foundation, 8/1/18–ongoingUCSF Global Anesthesia Workforce Project / $200,000

Bin LiuPrincipal InvestigatorUniversity of Virginia, 6/1/2018–5/31/2023Novel Radioimmunocongugates for Targeted Alpha-Particle Therapy of Metastatic Prostatic Cancer$1,320,422

Principal InvestigatorNIH/NCI, 8/6/2012–7/31/2019Internalizing human antibody-targeted nanosized siRNA therapeutics / $1,607,090

Principal InvestigatorUCSF-Pfizer CTI, 11/16/2016–11/15/2018Site-Specific Immune Activation by Novel Antibody / $550,750.28

Principal InvestigatorUCSF Parker Institute for Cancer Immunotherapy, 7/1/2017–6/1/2019Synthetic Notch T Cells / $518,000

Principal InvestigatorVivace Therapeutic, 12/1/2017–11/30/2019Bispecific Antibody for Cancer Immunotherapy / $791,646

Martin LondonPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2019Anesthesia Department Research Award / $5,500

James MarksPrincipal InvestigatorNIH/NIAID, 2/1/2013–9/30/2018Generation of therapeutic antibodies for serotype F botulism / $5,448,316

Principal InvestigatorNIH/NCI, 9/24/2014–8/31/2019Antibody Technology Research Center / $5,779,613

Principal InvestigatorCA Dept of Health, 7/1/2018–6/30/2021Development of Monoclonal Antibody-based Ultrasensitive Assays for Diagnosis of Infant Botulism / $1,470,907

Mervyn MazeUCSF School of Medicine, 2/1/2018–1/31/2019Translating Preclinical Pathophysiologic Mechanisms into Therapies for Postoperative Cognitive Decline / $100,000

Claus NiemannPrincipal InvestigatorOregon Health & Science University, 1/1/2016–12/31/2018Donor Management Research Institute / $1,969,200

Principal InvestigatorStanford University, 1/13/2017–12/31/2021Storage and Recall of Human B Cell Memory of Influenza Over Tissues and Time / $158,387

Jonathan PanPrincipal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $80,000

Ludmila PawlikowskaPrincipal InvestigatorBe Brave for Life, 4/18/2018–4/17/2019Circulating Exosomal MicroRNA as a Potential Biomarker of Cerebral Cavernous Malformation Severity$20,000

Co-LeaderNIH/NINDS, 9/30/2014–7/31/2019Brain Vascular Malformation Consortium-Genetic and Statistical Analysis Core (GSAC) / $416,197

Lawrence PoreePrincipal InvestigatorSt. Jude Medical Inc., 3/1/2017–3/9/2019A Post-Approval Study to Evaluate Targeted SCS (DRG) Stimulation for the Management of Moderate to Severe Chronic, Intractable, Pain of the Lower Limbs due to CRPS types I and II (TARGET) / $272,325

Arun Prakash BuddePrincipal InvestigatorNIH/NIGMS, 2/1/2015–1/31/2019Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion / $790,560

Principal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $80,000

Jeffrey SallPrincipal InvestigatorNIH/NIGMS, 3/1/2015–2/29/2020Testosterone’s role in sex-specific outcomes after early anesthesia$1,524,496

Principal InvestigatorUC Davis, 1/1/2017–12/31/2019Prevention of Cerebral Injury in Pediatric Diabetic Ketoacidosis$28,600

Principal InvestigatorTasly Pharmaceuticals, Inc, 8/17/2017–5/23/2023A Double-blind, Randomized and Placebo-controlled Study to Evaluate the Safety and Efficacy of T89 in Preventing Acute Mountain Sickness (AMS) During Rapid Ascent$3,451,755

Andrew SchoberPrincipal InvestigatorAnesthesia Dept, 7/1/2017–6/30/2019Anesthesia Department Clinical Research Award / $40,000

Mark SchumacherPrincipal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $80,000

Una SrejicPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2019Anesthesia Department Clinical Research Award / $20,000

Hua SuPrincipal InvestigatorNIH/NINDS, 1/1/2014–12/31/2018Hemodynamics of Cerebral Arteriovenous Malformations$1,633,785.65

Principal InvestigatorNIH/NHLBI, 1/16/2015–12/31/2018Cell Type-Specific Influences on HHT Pathogenesis / $1,582,037

Arthur WallacePrincipal InvestigatorNCIRE, 3/1/2012–3/1/2019Perioperative Outcomes Epidemiologic Consortium$150,000

Principal InvestigatorSponsor VA National Anesthesia Office, 1/2/2014–1/1/2019VA_AnesQIP / $100,000

Principal InvestigatorECOM Medical, 8/1/2016–7/31/2019Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM) / $10,000

Principal InvestigatorObelab, 8/1/2016–7/31/2019Clinical Testing of NIRS for Quantitative Assessment of Depression and PTSD / $100,000

Elizabeth WhitlockPrincipal InvestigatorNIH/NIA, 8/1/2018–7/31/2020Impact of Coronary Revascularization on Longitudinal Cognitive Change in the Elderly$240,469

Principal InvestigatorFAER, 8/1/2018–7/31/2020Impact of Coronary Revascularization on Longitudinal Cognitive Change in the Elderly$50,000

Xiaobing YuPrincipal InvestigatorAnesthesia Dept, 7/1/2013–6/30/2019Anesthesia Department Research Award / $50,000

Principal InvestigatorAnesthesia Dept, 7/1/2016–6/30/2019Anesthesia Department Clinical Research Award / $17,996

Eunice ZhouPrincipal InvestigatorImmunogen, Inc., 4/1/2018–3/31/2019Internalizing and Cross-Reactive Human mAbs to Tumor Associated Antigen NaPi2b / $50,000

Wei ZhouPrincipal InvestigatorAnesthesia Dept, 7/1/2018–6/30/2019Anesthesia Department Research Award / $57,624

Principal InvestigatorInternational Anesthesia Research Society, 7/1/2016–6/30/2019The Roles and Applications of Orexin/Hypocretin System in Anesthesia / $150,000 ■

YEAR in REVIEW 2018 33

ALUMNI

Connecting with Friends and Colleagues – The 2018 ASA Alumni ReceptionThe 2018 Department of Anesthesia and Perioperative Care Alumni Reception at the American Society of Anesthesiologists’ Meeting was well attended, bringing both old and new friends together. Held at Perbacco in San Francisco, the event was a wonderful chance for more senior department members to connect with current trainees, for old colleagues to reconnect, and for all attendees to enjoy a taste of San Francisco’s vibrant food and wine culture.

Photos courtesy Martin Backhauss. See more photos at tinyurl.com/Anesth18ARasa

34 YEAR in REVIEW 2018

Upcoming Department Events:https://anesthesia.ucsf.edu/events/upcoming

YEAR in REVIEW

2018

Department of Anesthesia and Perioperative Care

Pioneers in Perioperative Medicine

Dedicated to healing, teaching, and discovering for sixty years.