Pink Science Spring 2013

BREAST CANCER CAMPAIGN MAGAZINE / SPRING 2013

PINKSCIENCE

THE FUNDS YOU RAISE ARE HELPING

US WITH OUR GROUND-BREAKING

BREAST CANCER RESEARCH

Every step I take brings us

closer to the cure

A LOOK TO THE FUTURE

Our researchers have been having their say on the future of breast cancer treatment

ACTION PACKEDFind out what a fantastic job you did during Breast Cancer Action Month

BREAST OF MATES Our regional groups are about more than fundraising, they’re about friendship too

PLUS All the latest news from the charity, pink products and important dates for your diary

GET TO KNOW US

OUR MISSION

Everything we do at Breast Cancer

Campaign is focused on one thing:

beating breast cancer. The charity

is bringing its unique community

of supporters, scientists and those

touched by breast cancer closer

through a new way of thinking:

Pink Science. It sums up the charity’s

pioneering approach to breast

cancer research, which identifies

and funds the research projects

with the greatest potential to save

and improve lives – and, ultimately,

find a cure for breast cancer.

HOW WE SPEND YOUR MONEY

Today, the charity supports 95

research projects, with combined

funding of more than £16 million, in

34 centres of excellence across the

UK and Ireland. All our donations

come from the fundraising efforts of

people like you – thank you. Over

the past 16 years, the charity has

awarded 386 grants worth a total of

over £40 million to universities,

medical schools and research

institutes. And the figures are rising.

UNDERSTANDING PINK SCIENCE

We chose a jigsaw piece as our logo

because it symbolises the missing

piece of the puzzle that is the cure

for breast cancer. Everyone can be

part of Pink Science; not just the

scientists whose work we fund but

also our supporters and, of course,

those touched by breast cancer.

47,700women diagnosed

with breast cancer

every year

12,000women who die

from breast cancer

every year

80%of women diagnosed

with breast cancer

today will still be

DOLYH�LQ�¿YH�\HDUV

1 in 8chance a woman will

get breast cancer in

her lifetime

3years between

screening invitations

for women aged

50 to 70

340men diagnosed with

breast cancer every

year – it proves fatal

for around 80

£40million

TOTAL WE HAVE AWARDED

IN GRANTS TO FUND

BREAST CANCER

RESEARCH IN THE

PAST 16 YEARS

TO FIND OUT MORE PLEASE VISIT OUR WEBSITE

BREASTCANCERCAMPAIGN.ORG OR CALL OUR

SUPPORTER CARE TEAM ON 020 7749 4114

JOIN OUR FACEBOOK GROUP

OR FOLLOW US ON TWITTER

@BCCAMPAIGN

BREAST

CANCER

FACTS

Pink Science

covers every

aspect of breast

cancer research.

Its eight themes

mirror the cancer

journey, making

Pink Science

accessible and

relevant to all.

Prevention

Treatment

Emotional

Education

Biology

Genetics

Diagnosis

Growth

WHAT DO THE PINK ICONS MEAN?F

igure

s r

ela

te to U

K a

nd a

re c

orr

ect at tim

e o

f goin

g to p

ress

TOGETHER, WE

CAN FIND A CURE Welcome to the spring issue of Pink Science. Before we

venture into our exciting goals for the New Year, I would

like to look back at some of our latest achievements.

Thanks to your support, we have invested more than

£40 million in vital breast cancer research projects across

the UK and Ireland. Our scientists are spearheading research

developments, finding ways to treat breast cancer and

gaining a better understanding of how to diagnose breast

cancer earlier. We select Campaign’s top 10 achievements of

2012 on page 26, which give us hope for the future and will

help bring us closer to finding a cure for breast cancer.

Hope is definitely a theme of this issue. I hope you enjoy

the inspiring story of long-term supporter Jan Casson on

pages 20-25, and gain some insight into our second

pioneering Gap Analysis meeting on pages 16 and 17.

Without your support we would not be where we are

today, offering hope through research to those affected

by breast cancer. Together we can BE PART OF THE CURE.

Baroness Delyth Morgan Chief Executive, Breast Cancer Campaign

PINK SCIENCE is produced by Northstar (thisisnorthstar.com) for Breast Cancer Campaign. Project Editor Emma Barlow Deputy Project Editor Lisa Paul Designer Pippa Hester Group Project Editor Robin Swithinbank Group Art Director Matt Warner Group Production Editor Andy Tidball Production Manager Helen Craig Managing Director Mark Beazleigh. For Breast Cancer Campaign: 0HGLD�5HODWLRQV�2I¿FHU�Isabel Monk

04-09Notebook

A round-up of Breast Cancer

Action Month, including wear it

pink and the Pink Ribbon Ball.

Plus, three ways you showed

your support in 2012

10-11Policy

We celebrate the Government’s

Cancer Radiotherapy

Innovation Fund, and introduce

our new online breast cancer

awareness quiz

12-15Fundraising friends

Meet the supporters who are

putting the fun into fundraising

and making a difference to

Campaign with their friends

16-19Research

Dr Sue Eccles explains why

Gap Analysis is vital for breast

cancer research. And we

present three Campaign-funded

VFLHQWLVWV¶�QHZ�¿QGLQJV

20-25Every step counts

Read the inspiring story of Jan

Casson, who has dedicated her

time to raising money for

Campaign and is determined

to continue, despite her own

battle with breast cancer

26-31Pink pages

See our top 10 achievements,

and browse our fab Pink Picks.

Plus, gallery and your letters

Inside this issue

[ W E LC O M E ] 03

BREASTCANCERCAMPAIGN.ORG

BREAST CANCER CAMPAIGN NEWS FROM AROUND THE UK

NOTEBOOK

From taking part in wear it

pink, to painting the town

pink, you took action across

the nation to raise funds so we

can continue to fund ground-

breaking breast cancer research.

A huge thank you to all of our

‘superheroes’ who got involved

– with your support we can all

BE PART OF THE CURE.

Last October was especially

important as we celebrated the

10th anniversary of wear it pink.

Hundreds of thousands of you wore

pink on October 26, and to date we

have received £1.7 million, so we’re

on track to achieve our target of

£25 million raised over 10 years.

Leading beauty brand nails inc.

helped us spread the word with its

Paint Your Pinkie Pink campaign

and special-edition Pinkie Pink

polish. Plus, the world’s largest bra,

which we unveiled during Breast

Cancer Awareness Month 2011,

sold to GoldenPalace.com in an

auction on eBay and raised £3,601

for breast cancer research.

We have loved seeing pictures of

how you got involved – like Paulet High

School in Burton on Trent (above).

If you still have money to send in,

visit wearitpink.co.uk or call us on

0800 107 3104. However you got

involved, thank you!

We called on you to take action during Breast Cancer Action Month to help us

raise vital funds and awareness. And you didn’t disappoint!

YOUDID IT!

IFE SERVICES DO THEIR BIT. THANK YOU!

[ N O T E B O O K ] 0 5


A huge thank you to staff at Veolia

Environmental Services, Jigsaw,

RBS/Natwest, Ladbrokes, Curves,

Bonmarché and nails inc. for helping

us to make this the most successful

Breast Cancer Action Month yet. Staff

at Debenhams held dance events

nationwide and took part in a fundraiser

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THANKS TO OUR PARTNERS

IN THE PINK

Sugababe Heidi

Range and Dr

James Flanagan

(below left) m

any of our scientists took part

in wear it pink, but some took

it to a whole new level. Dr James

Flanagan, a Breast Cancer

Campaign Fellow at Imperial

College London, and his team

Kirsty Flower, Kevin Brennan

and Angela Wilson dyed their

hair pink after raising £1,705.

Elsewhere, our scientists at

the University of Birmingham

helped turn the university’s

iconic clock tower pink in

support of Campaign.

PINK SCIENTISTS!

YOUR WEAR

IT PINK

PICTURES Check out some of our amazing supporters who took part in wear it pink

YOU’RE OUR HEROES! COLLETT TRANSPORT SERVICES

CLIFFORD JONES TIMBER LTD GET INTO THE SPIRIT

KLH ARCHITECTS REALLY LEAP INTO ACTION

PINK SUPERHEROES TO THE RESCUE AT IFE SERVICES

PINK IS SO YOUR COLOUR! LYMINGTON YACHT CLUB


we kicked off Breast Cancer

Action Month in style on

October 1, when many of London’s

most famous landmarks turned pink

for Breast Cancer Campaign.

Among the iconic buildings in

the pink were Buckingham Palace,

Somerset House, the Tower of

London, BT Tower, and Tower 42,

where the launch party was held.

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pink cocktails specially created by

Levi Roots as they watched the

skyline change colour.

Supporters and passers-by also

helped boost awareness by posting

photos on Twitter, Facebook and

Instagram. Check out our pick of the

best photos on our Pinterest page

(pinterest.com/bccampaign). Other

places in the UK that turned pink

were the Isle of Wight, Reading,

North Tyneside, Newcastle-under-

Lyme, Falmouth, Birstall and York.

A huge thank you to our volunteer

teams for their hard work, and

everyone that took part in pink

activities. Together you raised over

£80,000! If you’d like to turn your

town or city pink this October, visit

breastcancercampaign.org

LONDON GOES PINK TO LAUNCH

BREAST CANCER ACTION MONTHAll over the capital, buildings, towers and other famous landmarks were turned pink to kick-start the beginning of Breast Cancer Action Month for Campaign

06 [ N O T E B O O K ]

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Pink Ribbon Ball at London’s

Dorchester was the most

successful yet! The event raised

more than £300,000, which

will help us continue funding

pioneering breast cancer

research and bring us closer

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Guests at the event

were treated to a special

performance by singer Paloma

Faith (right). Breast cancer is

a cause very close to Paloma’s

heart after her mother beat the

disease following a diagnosis

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Actress and writer Morwenna

Banks was the host for an

evening of spectacular

circus-themed entertainment,

featuring magician Pete

Firman, Chicks ’n’ Tricks, who

performed magic at people’s

tables, Cirque du Cabaret’s

high-kicking can-can dancing

troupe, Kittie Kittie Kan Kan,

and the fantastic hand-balancing

act Vladimir Khan.

PINK RIBBON GETS

THE BALL ROLLING

Annual celebrations

[ N O T E B O O K ] 07


LIGHT IT UP

Blushing landmarks included (from

top) Northwood House in the Isle

of Wight, Buckingham Palace,

Trafalgar Square, the Tower of

London and HMS Belfast

There’s still plenty of time to help add to our fundraising success.

If you’d like to hold your own event for Breast Cancer Campaign, or

attend the next Pink Ribbon Ball, visit breastcancercampaign.org

BE PART OF THE CURE

HAVING A BALL

The Pink Ribbon Ball

Committee organised

another great night

08 [ N O T E B O O K ]


3 WAYS TO FUNDRAISE

FOR CAMPAIGNLast year you showed your support in so many ways – including holding collections and buying our pink products (page 30). Are you ready to do it all again this year?

YOU WALKED

On Sunday, September 9 more than

200 of you donned your best pink

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Hampstead Heath to take part in the

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STARTGENERATION WALKS

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John Bottomley says: ‘Our

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DAMART

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LONDON MEGA RAID

3


Asda’s Tickled Pink campaign

had another huge year in 2012,

and since it launched in 1996 it has

raised a whopping £30 million for

Breast Cancer Campaign and

Breast Cancer Care, with every

penny going towards supporting

people across the UK affected

by breast cancer.

Tickled Pink started 2012 with

a bang as pop stars including

Alexandra Burke and The

Saturdays took to the stage

at London’s Shepherd’s Bush

Empire to entertain the crowds at a

fabulous Girls’ Night Out concert.

Asda staff and customers also

backed the 16th Tickled Pink

campaign, including the Tamworth

store which hosted a ‘Carve a

Pumpkin’ fundraising class, and an

Asda colleague in Ulster who

shaved her head to raise vital funds.

Breast Cancer Awareness Month

also saw brands such as Walkers,

Jaffa Cakes, Mr Kipling and

Lucozade turn pink. All products

were available in Asda stores, with

proceeds going to both charities.

Meanwhile, George at Asda

created a dedicated clothing range

which included T-shirts, umbrellas

and shoes. Fashion designer Julien

Macdonald also designed a special

limited-edition reusable bag – all in

support of Tickled Pink.

Glamorous celebrities Alexandra

Burke, Danielle Lineker, Lacey

Turner, Zoe Hardman and Heidi

Range (above, from left) took part

in the 1950s-inspired Tickled Pink

Ladies photoshoot to show

their support for the campaign.

Breast Cancer Campaign

supporter Heidi says: ‘Tickled Pink

has raised £30 million, which has

gone towards supporting those

affected by breast cancer and

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Pink items you know your money is

helping to save lives.’

Our patron

Linda Nolan

joined Breast

Cancer

Campaign at

two annual

Rotary Club

conferences in

Bournemouth

and Galway recently, to

encourage Rotary Clubs to

take on the £100 Challenge.

The Challenge is open to

groups and clubs of all types

and could not be simpler – we

ask you to set a fundraising

target of £100 or more and

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groups and clubs taking part

in the Challenge over the past

eight years have raised an

amazing £1 million. Linda

says: ‘I was honoured to

speak at such prestigious

events. Research into breast

cancer is so important, so I

really hope Rotary Clubs

take on the challenge and

support Campaign.’

ROTARY CLUBS JOIN THE £100 CHALLENGE...

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involved in the £100

Challenge, call 020 7749 4114

or email 100challenge@


BE PART OF

THE CURE

TICKLED PINKAsda’s campaign has raised £30 million for breast cancer charities

[ N O T E B O O K ] 09

10 [ P O L I C Y ]


ADD GIFT AID TO GIVE MORE

Wear it pink raises millions for

Breast Cancer Campaign, but

half a million pounds each year is

lost because of Gift Aid red tape.

Campaign is taking action to change

this and calling on the Government

to simplify requirements for small

workplace donations.

In 2011, wear it pink raised over

£2.2 million for Campaign but the

charity only managed to reclaim

£40,000 in Gift Aid. As more than

75 per cent of money raised through

wear it pink comes from people

giving money in the workplace, this

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than £400,000 – assuming the

maximum amount of Gift Aid

was reclaimed on all donations.

Under current legislation, charities

can claim Gift Aid on donations

by UK taxpayers when donors

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their name and address, and that

they pay more tax in a year than

they donate to charity. However,

a survey completed for Campaign

by Ipsos Mori revealed that 45 per

cent of employees who have made

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out a Gift Aid declaration. The

survey also revealed that 33 per

cent of UK workers don’t know

anything about Gift Aid.

Campaign is now calling for the

Government to make changes to

raise awareness of the Gift Aid

scheme, and also to amend the

law to make it easier for charities

to access Gift Aid.

Breast Cancer Campaigncalls for changes to improve access to essential Gift Aid funds

[ P O L I C Y ] 11


Policy news: spring 2013

An independent review into screening reveals risk of over-diagnosis

If you’d like to know more about

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BE PART OF THE CURE

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that if left untreated would

grow so slowly they would

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This ‘over-diagnosis’ is

estimated to be in the region

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Care and Breakthrough

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women to attend their

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The information given

to women when they are

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knowledge and understanding

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know more about how and

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of this review serves as

a reminder of just how

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Breast Cancer Campaign has

welcomed the announcement by

the Government that they plan to

establish the Cancer Radiotherapy

Innovation Fund, worth £15 million.

The fund is designed to speed

up the use of Intensity Modulated

Radiotherapy (IMRT), an advanced

form of radiotherapy, across the

NHS so that more cancer patients can

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IMRT for breast cancer, and we have

been calling for better access to IMRT

for a number of years. It’s great that

extra money has been made available

for its use.

According to the Government,

designated radiotherapy centres

will be providing IMRT from April.

IMRT Radiotherapy

Campaign has developed a brand

new breast cancer awareness quiz

(above) to help women recognise the

signs and symptoms of breast cancer

and to get into the habit of checking

their breasts on a regular basis.

We know that the earlier breast

cancer is detected, the better the

chances of survival, so please

check out the quiz and share it with

family and friends by visiting breast

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Test yourself

Policy update

SCREENING REVIEW RESULTS

12 [ F U N D R A I S I N G ]


12 [ F U N D R A I S I N G ]

From bake sales to climbing mountains – there are lots of ways to support Campaign but it’s always easier when you’ve got a little help from your friends

BOSOM BUDDIESFriendship through fundraising

“ It helps that we’re close. We’re also blessed with very supportive friends and family”

[ F U N D R A I S I N G] 13


Supporting Breast Cancer

Campaign is not just about

raising essential funds and

awareness. It’s also a great way of

having fun with your friends, whether

you get together to form one of our

regional volunteer groups, or team

up to do your bit with friends at work.

Here, we meet four groups of pals

who are fundraising together to

BE PART OF THE CURE...

Judy Baskett and Terry Groom wanted

to raise money for Breast Cancer

Campaign in memory of their close

friend Carol Southgate, who lost her

battle with breast cancer aged just 40.

Judy (second left) had already been

fundraising for Campaign by taking part

in the adidas Women’s 5k Challenge in

London’s Hyde Park, as well as

organising garden parties and holding

her popular Tea at Three event in her

beach hut in Felixstowe, Suffolk.

‘It was at one of my beach hut

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a volunteer group,’ says Judy. ‘We are

all good friends and many of us know

someone who has been touched by

breast cancer so we were all really

enthusiastic about the idea.’

Breast Mates was launched in

Stowmarket in 2012, and the group set

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year. They have smashed that target

– raising £4,000 by holding quiz nights,

tea parties and a handbag-swapping

event, inspired by the Colchester

regional volunteer group, Up Front.

‘It helps that we’re close,’ says Judy.

‘Both Terry [far right] and myself have

a sister in the group, as well as

Terry’s daughter Amy and my best

friend Jane. We’re also blessed

with supportive friends and family.

‘We meet up each month to

discuss events over a glass of wine

– and this year our plans include a

Frock Swap, a Sixties Dance and a Pink

Dinner,’ says Judy. ‘Being in a regional

volunteer group is so rewarding – it’s

lovely that we make a difference together.

We really are the breast of mates.’

Breast Mates

RAISE VITAL

FUNDS

Emma Allard had always wanted

to do something for charity. So

when her employer, CAA, a small

company based in Ipswich, decided

to organise a trip to Peru to trek the

Inca Trail for charity in 2012, she

jumped at the chance. And she

encouraged her friend at work, Lori

Dunne, to go along too.

Together, Emma and Lori were

part of a select group chosen to take

part in the company trek in support

of Breast Cancer Campaign.

‘It was very emotional when we

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so it was great to have Lori’s

support,’ says Emma. ‘We’ve been

good friends ever since we met

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it that bit easier knowing that I had

a friend I could always turn to.

We helped pull each other through

the tough parts of the trek.’

Emma and Lori enjoyed the

experience so much that they have

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together, and to date they have

raised over £7,000 for Campaign.

A bake sale and auction raised

£200, and their company directors

even auctioned their old iPhones

to help raise another £400.

‘It was a blessing doing the trek

for Campaign,’ says Emma. ‘Lori

and I had so much fun fundraising

together, and it felt special that we

got to do something for the inspiring

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every day with courage and dignity.’

14 [ FUNDRA IS ING]


“ It made it that bit easier knowing that I had a friend I could always turn to”

Ain’t no mountain high enough…

PEAK

PERFORMANCE

Lori (left) and

Emma at Machu

Picchu in Peru

TAKE A

CLOSE

FRIEND

[ F U N D R A I S I N G ] 15


If you and your friends would

like to do something together to

support Campaign, please visit


BE PART OF

THE CURE

Working together

MITIE Group, the strategic

outsourcing and energy

services company, was already

backing the Breast Cancer

Campaign Tissue Bank Appeal

when Rob Earnshaw from the

company decided to sign up 29 of

his work friends to go the extra mile

and raise vital funds for the charity.

After looking at Campaign’s

website for fundraising ideas, the

colleagues decided to sign up for the

Major Series obstacle course, which

had all the elements they wanted.

It was a physical challenge but they

knew it would also be a laugh.

And they were right. On October

21, 2012, the group (above) got wet

and muddy while smashing their

initial fundraising target of £1,450

to raise over £5,000 for Campaign.

Rob says: ‘It was so much fun and

a great team-building event – and

at the same time we raised vital

money for an excellent charity

and a very worthy cause.’

KEEP ON RUNNING

(and cycling and

swimming). From left:

Sarah, Jane and Anna

GET

YOUR

HANDS

DIRTY

Sarah Lewis-James had been

working as Day Visitor Manager

at Hever Castle and Gardens in

Kent for seven years when she was

diagnosed with breast cancer

on September 26, 2011. Only the

day before she got the news, Sarah

had been at the Hever Castle

Triathlon, a popular annual event

that she helped to organise.

‘I went through two rounds of

surgery, followed by radiotherapy,’

recalls Sarah. ‘It was while I was

travelling to hospital one morning for

my daily treatments that I decided to

set myself a goal to work towards.

,�ZRXOG�PDUN�WKH�¿UVW�DQQLYHUVDU\�RI�

my diagnosis by taking part in the

2012 Hever Castle Triathlon.

‘I talked to my friends at work,

Jane Bradley, Head of Finance, and

Anna Spender, Castle Co-ordinator,

and they were keen to form a team,

with me running and Anna and Jane

swimming and cycling respectively.’

And so the Hever Castle Princesses

was formed.

Sarah completed her radiotherapy

course at the end of January and

VWDUWHG�WR�VORZO\�UHEXLOG�KHU�¿WQHVV�

until she could run 4km.

Then, on September 29 last year,

Sarah crossed the line of the Anne

Boleyn Relay Sprint – part of the

Hever Castle Triathlon series – with

Anna and Jane at her side and their

colleagues cheering them on.

The Hever Castle Princesses

raised more than £3,700 for

Campaign, and not only did they

enjoy fundraising together but

the experience has made their

friendship even stronger.

‘It was such an amazing,

emotional day, and I felt a fantastic

sense of achievement to complete

the course and achieve my goal. But

I couldn’t have done it without my

wonderful friends who trained so

hard with me and were so

supportive,’ says Sarah.

‘We wanted to give something

back to the women who are dealing

with the challenge of breast cancer.’

Hever Castle Princesses

SHARE THE

WORK

16 [ R E S E A RC H ]


F ive years ago Breast Cancer

Campaign organised a series of

pioneering meetings with the aim of

identifying gaps in our understanding

of breast cancer. These Gap Analysis

meetings brought together some of the UK and

Ireland’s leading breast cancer researchers.

The most important outcome of their

ground-breaking talks was the Tissue Bank,

a unique, innovative and vital tool in the search

for cures. Scientists now know more about

breast cancer subtypes than ever before, but

there’s still a long way to go. So last autumn

Campaign carried out a second Gap Analysis,

and once again gathered a group of experts to

discuss what more needs to be done.

‘The last Gap Analysis was a huge success,

but it’s important that we carry on highlighting

any new gaps so that we can keep breast

cancer research moving forward,’ says Dr Sue

Eccles, a Campaign Trustee based at The

Institute of Cancer Research in Sutton who

led the latest round of meetings alongside

Professor Alastair Thompson, Chair of the

Tissue Bank Management Board.

Whatever the new Gap Analysis pinpoints

in 2013, tissue banking will remain a priority

for Breast Cancer Campaign.

μ:H�XVHG�WR�GH¿QH�EUHDVW�FDQFHU�VLPSO\�DV�

oestrogen receptor positive or negative,’ she

says. ‘And the former can be treated effectively

with drugs such as tamoxifen. Then we

LGHQWL¿HG�WKH�+(5��H[SUHVVLQJ�VXEW\SH�IRU�

ZKLFK�ZH�KDYH�WUDVWX]XPDE��+RZHYHU��WKHUH�

are many cancers which don’t express these

therapeutic targets, and rarer subtypes that

remain elusive. We need more types of breast

FDQFHU�WLVVXH�LQ�WKH�%DQN�WR�¿QG�RXW�ZKDW�

drives them and work out how to treat them.’

Access to more tissue samples could also

improve our knowledge of therapy-resistant

disease and cancers that have spread

(metastases), which are responsible for

up to 90 per cent of cancer deaths.

‘We still can’t effectively control metastases

as they may respond differently from the

primary cancer. Treating them is like shooting

at an enemy in the dark,’ Dr Eccles explains.

‘Relapse of disease in the liver, bones or

brain is a major challenge to achieving cures.

My main wish is to be able to collect more

samples of metastatic/drug-resistant cancer

for the Tissue Bank.’

7KH�VXFFHVV�RI�¿JKWLQJ�FDQFHU�UHOLHV�RQ�

patients agreeing to donate tissue samples,

and if that happens Dr Eccles believes that

in 10 years’ time breast cancer treatment will

become more personalised.

‘Every patient’s cancer will be genotyped

and they will be offered a cocktail of drugs

WDLORUHG�VSHFL¿FDOO\�WR�WKHP��ZKLFK�VKRXOG�OHDG�

to fewer side effects. Biomarkers will allow us

to manage their progress so this targeted

treatment can be altered quickly if it’s

ineffective,’ she continues.

‘The hope is that we’ll have found strategic

ways to address the gaps in breast cancer

research – current and emerging – such as

how to deal with the disease in a diverse and

multicultural society where there could be key

genetic differences.’

This important

initiative enables

&DPSDLJQ�WR�UH¿QH�

its cutting-edge

research

programmes, which

we fund with your

donations. ‘This

new Gap Analysis

is a vision for the

future,’ says Dr

Eccles. ‘That’s

why it’s so

important for

us to continue

fundraising.’

IN 10 YEARS

CANCER

PATIENTS

WILL BE

OFFERED

DRUGS

TAILORED

SPECIFICALLY

TO SUIT THEM

“

”

A vision for the futureDR SUE ECCLES TELLS US

WHY CAMPAIGN’S GAP

ANALYSIS IS SO IMPORTANT

FOR THE FUTURE OF BREAST

CANCER RESEARCH

[ R E S E A RC H ] 17


2011Breast Cancer

Campaign brings

together four

leading NHS trusts

and breast cancer

research institutions

WR�FUHDWH�WKH�¿UVW�

UK Breast Cancer

Tissue Bank

2012The Tissue Bank

is opened to

all breast cancer

scientists in the

UK and Ireland. The

¿UVW�WLVVXHV�DUH�VHQW�

out in April

2013/14Tissue banks will

begin to collect

secondary and rarer

types of breast cancer

samples, which will

have a huge impact

on research and

could lead to

VSHFL¿FDOO\�WDLORUHG�

treatments

TISSUE

BANK

MILESTONES

Dr Jean-Christophe Bourdon is

D�VFLHQWL¿F�IHOORZ�DW�1LQHZHOOV�

+RVSLWDO��8QLYHUVLW\�RI�'XQGHH��

+LV�ZRUN�IRFXVHV�RQ�WKH�NH\�UROH�

WKDW�S��LVRIRUPV��SURWHLQ�

YDULDQWV��SOD\�LQ�EUHDVW�FDQFHU

What inspired you to pursue

a career in science?

During a visit to a hospital for a

cancer conference in Paris, I met a

doctor, a mother and her terminally

ill child in a lift. It was the despair

and tears of the dedicated doctor

and the most wonderful smile of this

very frail child that inspired me to

dedicate my life to cancer research,

rather than to general medicine.

Your work focuses on a protein

called p53. Why is it so important?

It’s the keystone of our defence

system against cancer forming

and is inactivated either partially,

or totally, in every kind of tumour,

including breast cancer. It can be

inactivated by mutation or by a virus

protein and when p53 stops working,

our defence system against cancer

formation collapses, so cancer cells

are able to grow and spread.

How will your work benefit people

with breast cancer in the future?

I hope we’ll be able to predict the

PRVW�HI¿FLHQW�WUHDWPHQW�IRU�SDWLHQWV�

by determining the type of breast

cancer they have, the p53 mutation

status and which p53 isoforms are

expressed in the patient’s breast

tumour after they have a biopsy or

surgery. So we should be able to

improve treatment, as well as avoid

unnecessary treatment. We are

winning battles against breast

cancer and results indicate that we

are not far from winning the war.

18 [ R E S E A RC H ]


Breast Cancer Campaign funds some of the UK and Ireland’s leading breast cancer research. Here are some of the latest projects that could save lives one day

WE ARE FUNDING THE CURE

Research update

[ R E S E A RC H ] 19


How has Breast Cancer Campaign

supported your work?

Breast Cancer Campaign has

played an essential role in my

work. In 2006, the charity decided

to fund three years of my research

project into p53 – it was a unique

opportunity so I seized it. Then in

2012, Campaign awarded me its

prestigious Fellowship, which will

support my research on p53 over

WKH�QH[W�¿YH�\HDUV��,W¶V�YHU\�

reassuring to know that my work

will be allowed to develop over

that time, despite the current

¿QDQFLDO�GLI¿FXOWLHV�DQG�WKH�

Government’s cuts in the science

budget. I am so grateful to

Campaign and everyone who

supports this fantastic cause.

Dundee has a strong tradition

of breast cancer research – what

is it like being part of that?

I moved from Paris to Dundee

LQ��MXVW�DIWHU�,�¿QLVKHG�

my PhD, to join the research

laboratory of eminent cancer

scientist Professor Sir David

Lane, who actually discovered

p53. Although I promised my wife

that it would only be for two years,

we’re still in Dundee 15 years

later! I recently established my

own research group on p53 in

breast cancer and joined the

prestigious Breast Cancer

Research team, headed up by

Professor Alastair Thompson,

Chair of the Tissue Bank

Management Board.

What is your ultimate goal?

I want to provide clinicians with

the tools they need to identify and

treat each type of breast cancer

with minimal side effects, so that

in the future our children and

grandchildren will not suffer from

this terrible disease. We can all

do something to help beat breast

cancer, so it’s crucial that people

continue to fund research.

For more on Jean-Christophe,

visit breastcancercampaign.org

When the cells in a patient’s breast

tumour overproduce oestrogen

receptors (ER) they are

diagnosed with ER-positive

breast cancer. This type of

cancer is treated with anti-

hormone therapies such as

tamoxifen and fulvestrant. Sadly,

about 30 to 40 per cent of patients

with ER-positive cancer will become

resistant to these drugs, so it’s crucial

scientists develop alternatives.

At Cardiff University, Dr Richard

Clarkson has found a way to kill the

cells that have become resistant to

anti-hormone therapies using drugs

to activate a protein called the ‘TRAIL’

receptor on the cell’s surface.

Dr Clarkson will use his

Campaign grant to look at

how tumours taken from anti-

hormone resistant patients

respond to TRAIL receptor

drugs, and will also investigate

how a protein called ‘cFlip’

controls the way breast cancer cells

respond to these drugs. His research

could provide patients with ER-positive

breast cancer with further options if

their anti-hormone drugs stop working.

Treating drug- resistant breast cancerDR RICHARD CLARKSON

A third of breast cancer cases in the

UK are diagnosed in women over

the age of 70. However, doctors

can currently only make

subjective decisions about

which treatments to use for

older patients, who might

have other health problems.

Dr Alistair Ring believes

that decisions about treatments

for older patients could be made

more objectively by assessing

their ‘biological age’.

Using his pilot grant from

Campaign, he will take blood from

140 healthy volunteers of various

ages and 20 breast cancer patients

over 70, and measure a variety of

indicators – all believed to correlate

with age. The indicators include

the length of a piece of DNA

called the telomere, the

amount of a protein called

p16INK4a in blood cells, and

the levels of proteins called

cytokines. From this study, Dr

Ring hopes to develop ways to

determine a person’s ‘biological

DJH¶�WR�¿QG�WKH�PRVW�DSSURSULDWH�

treatment for older patients.

Treating breast cancer in older patientsDr Alistair Ring

Radiotherapy and chemotherapy

can often result in severe side

HIIHFWV��VR�LW¶V�YLWDO�ZH�¿QG�

new and effective treatments

that will improve the quality

of life for patients. One

solution could be cancer

immunotherapy, a treatment

that uses the body’s immune system

WR�QDWXUDOO\�¿JKW�FDQFHU�FHOOV��

Professor Andy Sewell, who is

based at Cardiff University, believes

the key lies in a protein found in

breast cancer cells called MAGE-A3.

Fragments from this protein, called

peptides, would normally cause our

immune system’s killer T-cells to

attack the cancer cells. However,

T-cells have been taught not

to attack the body’s cells,

including breast cancer.

Supported by his

Campaign grant, Professor

Sewell aims to avoid such

‘self-tolerance’ by stimulating

killer T-cells in the lab with ‘super

peptides’ made from MAGE-A3.

This research could eventually

lead to an effective breast cancer

immunotherapy.

Cancer immunotherapyPROFESSOR ANDY SEWELL

Supporting science Three new projects you have helped us fund...


00 [ X X X X X X ]

WORDS Emma Barlow

PHOTOGRAPHY Charlie Campbell

“

”

I know that fundraising will be a part of my life forever. Every step I take brings us closer to finding a cure

[ FA M I LY M AT T E R S ] 21


22 [ FA M I LY M AT T E R S ]


Within a matter of weeks, Jan lost her stepmother

Rose to advanced breast cancer, received the

news that she too had the disease, and then

her older sister Cathy was diagnosed with a

rare form of leukaemia, which was the result

of breast cancer treatment she received seven years ago. For

lots of women, this would be too much to bear. But not for Jan.

‘In many other ways 2012 was a good year – with the

Olympics and the Queen’s Jubilee celebrations. I just felt so

proud to be British!’ Jan says, grinning. It’s this ability to see

the positives among the negatives, plus her incredible

determination, that has enabled Jan to raise a vast amount for

Breast Cancer Campaign over the years. These qualities have

also made her a true inspiration for others.

Jan, who lives in North Tyneside with her husband Ian and

daughter Lori, says she’s lived with breast cancer all her life.

6KH�ZDV��ZKHQ�KHU�PXP�ZDV�¿UVW�GLDJQRVHG�ZLWK�WKH�GLVHDVH��

and just 23 when she died. ‘Mum was only 52 and her death left

a huge void in my life,’ she says.

While Jan eventually came to terms with her loss, the

hereditary nature of the disease was always in the back of her

mind, and when her older sister Cathy was diagnosed aged 51,

Jan thought that one day it would ‘come

knocking’ on her door. She decided that if she

was going to get the disease, she needed some

kind of game plan to prepare herself for it.

��μ,�ZDQWHG�WR�EH�¿W�¶�VKH�VD\V��μ$QG�LW�ZDV�DOVR�

about giving myself and Cathy something to

focus on. She lives in Holland, so I visited her

over there and said: “When you’re sorted, we’ll

do some fundraising together.”’

It was Cathy who decided they should raise

money for Breast Cancer Campaign. Both

sisters passionately believe that research

holds the key to beating breast cancer.

7KH\�UDQ�WKHLU�¿UVW�*UHDW�1RUWK�5XQ�IRU�WKH�

FKDULW\�LQ��D�\HDU�DIWHU�&DWK\�¿QLVKHG�KHU�

WUHDWPHQW��μ,�SXOOHG�KHU�WR�WKH�¿QLVK�OLQH�RQ�WKDW�

¿UVW�UDFH��%XW�ZH�ZHQW�IURP�RQH�HYHQW�WR�WKH�

next and we did really well,’ says Jan.

$IWHU�¿YH�\HDUV�DQG�QXPHURXV�UDFHV��&DWK\�

decided to hang up her trainers, so Jan was

on the lookout for her next challenge.

‘I thought I’d just up the bar a bit,’ she says.

‘Upping the bar’ meant entering the London

Marathon in 2011, and despite developing a

stress fracture in her leg – a massive setback

to her training – Jan completed the marathon

and raised yet more vital funds for Campaign.

After going it alone for the marathon, Jan

decided it would be nice to get together

with other Campaign supporters to

fundraise. So last summer she helped put

together Pink on the Tyne, a regional volunteer

group dedicated to raising money for Campaign.

In the short time the group has been together,

the members have raised a phenomenal

£18,000 through events, including walking

Hadrian’s Wall and hosting regular Pink

Curry Nights – which are a huge hit!

In fact, over the seven years since Cathy’s

diagnosis, fundraising has become an integral

SDUW�RI�-DQ¶V�JDPH�SODQ�±�DQG�KHU�OLIH��$QG�WKH�

cause became pertinent again when Jan’s

Jan Casson has had a tough 12 months but she’s still fighting for women with breast cancer


[ X X X X X X ] 0 0

stepmother Rose was diagnosed with breast

cancer in 2006 and sadly passed away in 2012.

Unbelievably, just two weeks after Rose’s

death, Jan spotted a dint in her left breast.

‘I went to the GP that day and I said: “I’ve got

this problem…” As soon as I said it I realised

that I had breast cancer. It was logical that it

was going to happen at some stage,’ says Jan.

Jan hasn’t been screened for a BRCA

mutation – the gene mutation that increases the

risk of breast cancer – and Cathy’s test was

negative, but she’s convinced that the disease

UXQV�LQ�KHU�IDPLO\��$QG�KHU�IHDUV�ZHUH�FRQ¿UPHG�

10 days later when -DQ�ZDV�RI¿FLDOO\�GLDJQRVHG�

with breast cancer. ‘It wasn’t a shock,’ says Jan,

‘because I had been preparing myself for breast

cancer. I think my husband, my daughter and

my friends got the biggest shock.’

Jan’s cancer was classed as invasive but

not aggressive and was contained within

the breast tissue. A lumpectomy would have

been enough to remove the cancer but Jan

elected to have a mastectomy.

‘I was intent on having a mastectomy and I

was given a little bit of time to go down another

route, which included reconstruction at the

same time,’ she explains.

The surgeons took away the tumour from

within the breast tissue and fortunately found

that the lymph nodes were clear of cancer. Then

they also inserted an implant. Jan did have

to go back into hospital for a further procedure

DIWHU�D�ÀXLG�EXLOG�XS��EXW�RWKHUZLVH�WKH�VXUJHU\�

was a great success.

IT WASN’T A SHOCK BECAUSE I

HAD BEEN PREPARING MYSELF

FOR BREAST CANCER

“

”

24 [ FA M I LY M AT T E R S ]


I CAN’T CONTROL

THE DRUGS

I TAKE AND I CAN’T

CONTROL THE

SURGERY I’VE HAD.

THE THING I WAS IN

CONTROL OF WAS

MY HAIR, SO

I SHAVED IT OFF

“

”

DR JAMES FLANAGAN

discovered strong evidence that

epigenetic changes in genes

can be an indicator of breast

cancer risk – many years

in advance of breast

cancer developing.

DR STEWART MARTIN

found that the protein calpain-2

could help predict survival

outcomes for women with triple

negative breast cancer and

basal-like breast cancer – the

two most aggressive types

of breast cancer and the two

PRVW�GLI¿FXOW�WR�WUHDW�

DR FIONA KENNEDY

published research exploring

how women’s perceptions of

a DCIS diagnosis change

over time, and made

recommendations for

information and communication

needed in clinical care.

PROFESSOR ROS CORNEY

carried out a study which

revealed that young women

with breast cancer needed more

information and support

on fertility issues.

RECORD SUPPORT

for wear it pink from MPs,

MSPs and AMs, including video

messages of support

from Nick Clegg MP, Ian

Duncan-Smith MP, Ed Miliband

MP and Ed Balls MP.

REPLACEMENT IMPLANTS

were granted for all breast

cancer patients with PIP

implants (as appropriate) after

Campaign called on the

Department of Health to clarify

the rights of breast cancer

patients.

DR JO MORRIS

learnt more about how the

BRCA1 gene interacts with

other proteins, bringing us

closer to the bigger picture of

how cancer develops from

mutated BRCA1 genes.

DR OLIVIA FLETCHER

DQG�KHU�WHDP�IRXQG�WKH�¿UVW�

direct link between breast

cancer risk and genetically

determined levels of oestrogen

in younger women.

BREAST CANCER CAMPAIGN

and wear it pink were mentioned

in Prime Minister’s Questions

in September, which led to

the Prime Minister agreeing to

meet with the Chairs of the

All-Party Parliamentary Group on

Breast Cancer and the leading

breast cancer charities.

SEVEN SCIENTIFIC AWARDS

or prizes won by our scientists for

their pioneering work in breast

cancer research for 2012.

26 [ P I N K PA G E S ]


Thanks to your support we have made some incredible achievements in 2012. As we move into the New Year we take a look back at some of them...

Campaign’s 2012 achievements

EYE-OPENING

Dr Fiona Kennedy

shed light on DCIS

GUIDING LIGHTS

Professor Ros Corney

studied young women with

breast cancer.Below: our supporters

[ P I N K PA G E S ] 27


Q I’m really keen to support

your charity but I don’t want

to run a marathon or do a trek. Is

there anything else I can do?

Eva Karlsson-Blyth, Wembley

AThere are lots of ways you can

get involved with and support

Breast Cancer Campaign. Maybe

you feel inspired to organise your

own event with your family, friends

or colleagues? Start with something

small such as a bake sale or clothes

swap, or organise a big event such

as a black-tie ball! With Valentine’s

Day around the corner, why not

link your fundraising event to this.

For more ideas and inspiration,

please visit our website, or call our

Supporter Care team (details below).

I’M NOT A RUNNER!

HOW CAN I HELP?

WHAT IS MINIMUM

SPONSORSHIP?

YOUR POINT OF VIEWWe love it when you get in touch with your letters and questions, or to share your experiences. So here’s a few of our favourites...

I’D LIKE TO BE

ON YOUR TEAM

Q I’ve secured a place for

this year’s Virgin London

Marathon and I’d like to run

for you and raise sponsorship

to fund breast cancer research.

Can I get a pink vest?

Stephanie Smith, north London

ACongratulations on securing

your own place! We would

really love to have you on our

team, and by running for us you

will be helping Campaign to beat

breast cancer. If you contact our

Supporter Care team they will

send you a free running and

fundraising pack, which includes

sponsorship forms and a vest.

Q I want to take part in your

Grand Canyon Trek this

October. What’s the minimum

sponsorship I need to raise?

Isabel Good, Cardiff

AThe Grand Canyon Trek

is a fantastic and unique

challenge and we’d love for you

to join us. The registration fee

is £399, which goes towards

DFFRPPRGDWLRQ��IRRG��ÀLJKWV�DQG�

transfers, and we ask that you

raise a minimum sponsorship

of £3,350. Our Fundraising Team

is here to help and support you.

Call them on 020 7749 4114 for

more information and advice.

Your spare change can make a real difference, so save it up for Breast Cancer Campaign with a fantastic new

moneybox for your home. Instead of having piles of small change lying around, why not pop it in a moneybox

instead. Over time, the pennies will add up and you’ll raise vital cash to help us fund world-class and pioneering

breast cancer research. To request your moneybox today, please contact us on 020 7749 4114. Raising money

for Breast Cancer Campaign has never been simpler!

Request your Campaign moneybox

GET IN TOUCH

WRITE TO US AT:

Breast Cancer Campaign,

Clifton Centre, 110 Clifton Street,

London EC2A 4HT

CALL SUPPORTER CARE:

020 7749 4114

EMAIL US AT:

[email protected]

VISIT OUR WEBSITE:

breastcancercampaign.org/aboutus

JOIN IN

Share your

photos

with us on

Facebook

today!

TWEET US:

@BCCampaign

FACEBOOK AT:

facebook/breast

cancercampaign

28 [ G A L L E RY ]


CHARITY STARSA heartfelt thank you to everyone who has been busy fundraising for

Campaign. Here is just a selection of what you’ve all been up to

Breast Cancer Campaign’s latest...

1

2

4

3

6

5

[ G A L L E RY ] 29


1 Supporter Alison Brown completed her sixth Great North Run for Campaign – she has raised over £8,000 to date. 2 Soroptimist

members took part in a sponsored walk, with personalised pink Mini in tow. 3 At just 19 days old, Sophia Morris was our youngest

wear it pink participant. 4 Helen and Eric Sorrell raised almost £8,000 at their second Bridge Champ event. 5 TOPS held a coffee

morning and quiz, raising £650. 6 John from Damart and Ikram from Campaign celebrated 10 years of Damart support. 7 34 of our

wonderful supporters took part in the Three Peaks Challenge to raise funds for Campaign. 8 Supporter Catherine Drage held a dinner

and dance, raising over £4,000. 9 The Breast of Bromley regional volunteer group kicked off their fundraising campaign with a party.

10 Dean, a butcher from Birstall, endured a chest, leg and eyebrow wax to raise £420 for Campaign. 11 Stella Carter trekked the Great

Wall of China to raise funds. 12 Amanda Hyde hosted a glamorous ball at Studley Castle, raising over £5,000 for Campaign.

7

98

11

10

12

30 [ P I N K P I C K S ]


If you’re looking for the perfect Mother’s Day gift, or simply treating yourself, why not choose one of our fab ‘pink picks’ and a contribution

from your purchase will help Campaign fund life-saving research

Pink Picks

HELPING HAND

Protect yourself while

baking with this pretty oven

mitt by Ethos* – pair it with

the matching apron for

top-to-toe pink hearts

£4.99, call 01268 505 090

UP-TO-DATE

Keep track of your social

engagements with this

cute pink personal organiser

from Filofax

£30, filofax.co.uk

£2 donation to Campaign

TEA FOR TWO

Ideal for a his and hers

morning brew, these pretty

mugs by Ethos* will ensure

you wake up with a smile –

and the perfect cuppa

£2.99, call 01268 505 090

TICK TOCK

You’ll never have to worry

about burnt cakes and

over-cooked dinners again

with this handy 60-minute

egg-shaped timer by Ethos*

£4.99, call 01268 505 090

FOUR SEASONS

$GG�D�OLWWOH�,WDOLDQ�ÀDLU�

to your spaghetti bolognese

with this pink pepper

grinder from Ethos*.

Buon appetito!

£12.99, call 01268 505 090

CHOCOHOLIC

This chocolate fountain is

perfect for a party and will

impress your guests

£23.99, call 01268 505 090

Ethos* is donating £10,000

to Campaign this year

PEN PAL

A splendid partner to the

pink Filofax, this liquid gel

pen by Pentel is perfect for

scribbling in your diary

£2.99, pentel.co.uk

25p donation to Campaign

EASY SQUEEZY

Looking for a stylish

yet practical addition to

your kitchen? This vintage-

look citrus juicer by Ethos*

ticks both boxes

£22.99, call 01268 505 090

BAKING QUEEN

You too can be a domestic

goddess and give Nigella

and Delia a run for their

money in this heart-print

apron by Ethos*

£9.99, call 01268 505 090

* Ethos is donating £30,000 to Campaign over three years

IT’S A DATE

Buy this beautiful diary

to keep track of all your

important dates and events

and support research

£10.29, letts.co.uk

£1 donation to Campaign

[ D I A RY ] 31


We’re keeping busy

Get stuck in,

military-style, at

the wet and muddy

Major Series North

Take on the

challenge of a

lifetime and trek the

Great Wall of China

Scale the highest

mountain in Britain

on the Summer

Ben Nevis Trek

Join our epic

Sisters To The

Summit Kilimanjaro

Trek this spring

Get your running

gear ready for the

adidas Silverstone

Half Marathon

Join Nightrider,

a 100km moonlit

cycle through the

streets of London

Slip on your

trainers for the

Mizuno Reading

Half Marathon

Enjoy the historic

sights as you run

the Bath Half

Marathon

Join the masses for

the Virgin London

Marathon – it’s the

world’s largest!

Take on the famous

trio and join us for

the Three Peaks

Challenge

Head to the Kent

countryside for the

challenging Major

Series South

Swim, cycle and

run in the Virgin

Active London

Triathlon

14-24

3Pound the streets

and take in the

sights at the

Brighton Marathon

14

2 6-14

8-9

7-9

3

219 12-15

DATES FOR THE DIARY Exciting fundraising events, key dates to note, and a look at what’s ahead

MARCH APRIL MAY JUNE/JULY

JULY

APRIL 6-14

MARCH 9

APRIL 21

JUNE 8-9

27-28

8 SEPT

Run to the Beat powered

by Nike+

15 SEPT

Bupa Great North Run

6 OCT

Royal Parks Foundation

Half Marathon

5-12 OCT

Grand Canyon Trek

NOV

ING New York City

Marathon

15-22 NOV

Britain v Cancer Jordan

Desert Trek

Coming soon

SHOW YOUR

SUPPORT

Run for Campaign and you’ll get a big cheer on race

day (right)

17

20Brave the bogs and

hills at the Major

Series Midlands

obstacle race

Get involved in

the rewarding

Yorkshire Three

Peaks Challenge

Run or even walk

the 100km

London 2 Brighton

Challenge

Spot the capital’s

landmarks as

you run the Bupa

London 10,000

24-26

25-26

27

11Hit the streets of

London for the

annual Moonwalk –

every step counts!

9Our annual Breast

Cancer Campaign

awards at the

House of Lords

5-12 OCTOBEr 2013

TREK THE GRAND CANYON

AND BE PART OF THE CURE

Join Breast Cancer Campaign and trek

the Grand Canyon to raise funds for

vital, life-saving research.

To receive your information pack now, call 020 7749 4114

or email [email protected]

Registered Charity No: 299758


Pink Science Spring 2013

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Transcript of Pink Science Spring 2013