PHYSIOLOGY: Digestion , Absorption & Defecation

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PHYSIOLOGY: Digestion, Absorption & Defecation

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PHYSIOLOGY: Digestion , Absorption & Defecation. Reference. Guyton A., and Hall, J. Textbook of Medical Physiology. 12 th ed. Seeley, R., Stephens, T., and Tate, P., Anatomy & Physiology. 8 th ed. McGraw Hill Company Inc., (2008). Functions of the Digestive System. Motility Functions - PowerPoint PPT Presentation

Transcript of PHYSIOLOGY: Digestion , Absorption & Defecation

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PHYSIOLOGY: Digestion, Absorption &

Defecation

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Reference Guyton A., and Hall, J. Textbook of Medical

Physiology. 12th ed.

Seeley, R., Stephens, T., and Tate, P., Anatomy & Physiology. 8th ed. McGraw Hill Company Inc., (2008)

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Functions of the Digestive System

• Motility Functions• Propulsion• Mechanical Digestion

• Secretory Functions• Chemical Digestion• Regulation

• Absorptive Functions

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Six basic processes are involved: ingestion, secretion, propulsion, digestion, absorption and defecation.

Ingestion is taking food into the mouth.

Secretion is the act of expelling a liquid. The cells lining the GI tract secrete about 9 liters (9.5 quarts) of water, acid, buffers, and enzymes each day to lubricate the canal and aid in the process of digestion.

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Propulsion consists of alternating contraction and relaxation of smooth muscle in the walls of the GI tract to squeeze food downwards.

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Digestion has two parts, mechanical and chemical.

Mechanical digestion is chewing up the food and your stomach and smooth intestine churning the food

Chemical digestion is the work the enzymes do when breaking large carbohydrate, lipid, protein and nucleic acid molecules down into their subcomponents -these and others are the nutrients.

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Absorption occurs in the digestive system when the nutrients move from the gastrointestinal tract to the blood or lymph.

Defecation the act or process by which solid or semisolid waste material (feces) from the digestive tract are eliminated via the anus.

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Digestion in the Mouth Mechanical Digestion

Mastication reflex

Food enters mouth Relaxation of muscles of

mastication Stretch reflex causes contraction

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Digestion in the Mouth• Chemical Digestion by Saliva• Serous secretion for digestion

of starches: amylase• Mucous secretion for

lubrication

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Swallowing• Oral

• Pharyngeal

• Esophageal

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DEGLUTITION (SWALLOWING) accomplishes the propulsion of ingested food the mouth to the stomach.

Three stages:Buccal

PharyngealEsophageal

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BUCCAL STAGEtongue moves upward and backward to push the food toward the pharynx. PHARYNGEAL STAGE coordinated involuntary actions which direct food to the esophagus closing the airway passages

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ESOPHAGEAL STAGE peristaltic waves propel food from the esophagus to the stomach

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NO Digestion in the Esophagus

• No actual digestion• Propulsion via peristalsis• Mucous secretion for lubrication

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Digestion in the Stomach• Food storage in the fundus• LES prevent reflux of stomach

contents• Mechanical Digestion via

segmental contractions• No absorption

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Digestion in the Stomach• Chemical digestion by Oxyntic cell

secretionCELL SECRETION FUNCTION

Mucous Neck Cells

Mucus Lubrication & protection

Peptic Chief cells

Pepsinogen + HCl to produce a proteolytic enzyme Pepsin

for protein digestionParietal Cells

HClIntrinsic Factor

B12 Absorption

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Chemical Digestion by Pancreas

• Acini cells secrete pancreatic digestive enzymes into the hepatopancreatic duct to empty into the small intestine

• Enzymes are not activated until they are mixed with acidic chyme

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Chemical Digestion by the Pancreas

Trypsin Split proteins into peptidesChymotrypsin

Carboxypolypeptidase Split proteins into AAPancreatic Amylase Carbohydrate

breakdownPancreatic Lipase Fat digestionCholesterolesterasePhospholipase

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Biliary Secretions by the Liver & Gall Bladder

• For fat digestion & absorption• Emulsify large particles for more

efficient lipase action• Ease of absorption

• Means of excretion of waste• bilirubin

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Biliary Secretions by the Liver & Gall Bladder

• Liver constantly produces bile and is concentrated in the gall bladder

• Biliary secretions include HCO3- to neutralize the acidic chyme

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Digestion & Absorption in the Small Intestine

• Dominating chemical digestion via• Pancreatic secretions• Biliary secretions• Intestinal secretions

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Digestion & Absorption in the Small Intestine

Mucus Protection & Lubrication

Peptidase Split peptides into individual amino acids

Maltase Split maltose glucose + glucoseLactase Split lactose glucose + galactoseSucrase Split sucrose fructose + glucoseLipase Split fats into glycerol + free fatty

acids

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Digestion & Absorption in the Small Intestine

• Absorption via transport processes• Water: diffusion through tight

junctions

• Carbohydrates: Na-Glucose cotransport; fructose via facilitated diffusion

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Digestion & Absorption in the Small Intestine

• Absorption via transport processes • Lipids: diffusion with bile salts

• Proteins: Na-Glucose cotransport or endocytosis

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Digestion & Absorption in the Small Intestine

• Absorption via transport processes • Na: diffusion down a electrical

gradient• Cl: diffusion via solvent drag• HCO3

-: indirectly by secretion of H+

• *Other ions & vitamins are also absorbed

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Absorption in the Large Intestine

• Absorption of electrolytes occur but backflow is prevented by tight junctions

• Water follows as result of osmotic gradient

• Secretion of mucus for lubrication

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Mouth -chewing & lubrication (saliva) Esophagus -conduit Stomach -digestion takes place

-secretes pepsin + HCl Small intestine -duodenum

jejunum ileum (functional reserve)

Large intestine -stores and concentrates undigested material

- colon: 3 limbs -ascending

transversedescending

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Rectum ampulla - temporary storage for waste.

As the rectal walls expand, stretch receptors from the nervous system located in the rectal walls stimulate the desire to defecate.

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Colon innervation:Intrinsic1. Auerbach plexus- segmentation and

peristalsis2. Plexus of Meissner- secretions and

sensationExtrinsic3. Parasympathetic increases and

relaxes sphincters4. Sympathetic decreases motility and

contracts sphincters

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The muscular wall of the cecum and colon is innervated by:

Vagus nerve- cranial nerve X in PNSSuperior mesenteric plexus – SNS

cord segment T9-L2

The rectum and anal canal innervation:Pelvic splanchnic nerves-

parasympathetic S2-4Hypogastric nerve- sympathetic T11-

L2

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Anal sphincters innervation:Internal anal sphincter- pelvic splanchnic

nerves and hypogastric nervesExternal anal sphincter – pudendal

nerve

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Defecation Reflex• Integrated in the sacral region of

the spinal cord

• Stimulated by distention of the rectal wall• Weak contractions of rectal wall• Relaxation of anal sphincter

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Defecation Reflex

• May be inhibited by voluntary constriction of external anal sphincter

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If the urge is not acted upon, the material in the rectum is often returned to the colon where more water is absorbed.

If defecation is delayed for a prolonged period the fecal matter may harden, resulting in constipation.

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During defecation the chest muscles, diaphragm, abdominal wall muscles, and pelvic diaphragm all exert pressure on the digestive tract and ventilation temporarily ceases as the lungs push the chest diaphragm down in order to exert pressure.

Blood pressure rises. Not good for high- risk cardiac

patients.

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For defecation external anal sphincter must relax.

Sphincter ani externus muscle for anal and urethral are both closely linked by the same nerves

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Fecal incontinence is the inability to control one's bowels.

When one feels the urge to have a bowel movement, they may not be able to hold it until they can get to a toilet, or stool may leak from the rectum unexpectedly.

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Fecal incontinence may be caused by physical injury

(such as damage to the anal sphincter that may result from an episiotomy)

intense fright, inflammatory bowel disease, impaired water absorption (diarrhea), and psychological or neurological factors.

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BEFORE DEFECATIONFecal material passes to rectum by the

longitudinal muscular contraction. When there is distension in the sigmoid

colon and rectum, the internal sphincter relaxes at the same time as the external sphincter contracts.

This allows some of the fecal contents to enter the anal canal and be sampled by its sensitive epithelium to determine if its solid, liquid or gas.

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If the individual decides to continue with defecation, the intrarectal pressure increases on straining. Added pressure from abdominal straining or Valsalva maneuver aids defecation. Straining requires intact innervation of the lower thoracic cord T6-T12.

The pressure should be sufficient to overcome the external sphincter which relaxes with the pelvic floor that causing the rectum to straighten up reducing the rectal angle.

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This increase in intraabdominal pressure forces stool into the rectum with relaxation of the extenal anal sphincter allowing defecation.

Fecal matter stimulate the anal canal further relaxing the external anal sphincter.

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If the individual decides not to continue with defecation, the rectum relaxes further to allow accommodation of the contents which further stimulates the external sphincter to contract.

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Upper motor neuron lesion- damage above the defecation reflex center in the sacral cordResults to:

1. Abnormal storage of feces2. Inability to recognize urge and

distinguish contents3. External sphincter dyssynergia

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Lower motor neuron lesion – damage within the reflex defecation centerResults to:

1. Fecal retention2. Oozing of stool through the flaccid

sphincter3. Sensory and motor pathways are

disrupted so the patient is unaware of urge to defecate and unable to exercise voluntary external anal sphincter

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Assessment is through the bulbocavernosus reflex and the anal relfex

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The bulbocavernosus reflex is a palpable or visible contraction of the anal sphincter when pressure is applied to the glans penis or clitoris.

When contraction is present, (+) result. This indicates that the reflex activity of the sacral cord is intact and therefore the SCI is an UMN lesion.

Should be tested soon after SCI, before the spinal shock passes.

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The anal reflex is a visible contraction of the anal sphincter in response to a pinprick. A positive response indicates an UMN lesion.

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