24 hr darksensitizer 3,24 hr dark

sensitizer 3,4 hr h @ 625 nm

+20 hr dark

Fluorescence microscope images of acridine orange (AO) and propidium iodide (PI) stained K562 cells, incubated in full medium with 500 nM sensitizer 3 in dark (the middle panel); irradiated with red LED at 625 for 4 hours followed by 20 hr incubation in dark at 37 oC in the presence of 500 nM sensitizer 3 (right panel); and incubated in dark for 24 hr (left panel). Live cells were preferentially stained with AO (green) and dead cells with PI (red) due to increased cellular permeability.

Photoinduced cytotoxicityBilkent Üniversitesi

CNT-derivatizationBilkent University

SWCNTs as carries for PDT reagentsBilkent University

SWCNTs as carriers for PDT reagentsBilkent University

(A) AFM image of compound 1-SWNT. (B) AFM 3D topographic view.

(B) PSIA XE-100E AFM and Multi75AI tip was used in noncontact mode with resonance frequency 75 KHz and force constant 3.0 N/m.

SWCNTs as carriers for PDT reagentsBilkent University

500 550 600 650 700 7500.0

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Abso

rban

ce

Wavelength (nm)

670 nmdye DPSB

dye DPSB + H+

PDT reagents with pH-modulated activity

Bilkent University

 

  Gordon Moore made his famous observation in 1965, just four years after the first planar integrated circuit was discovered. The press called it "Moore's Law" and the name has stuck. In his original paper, Moore observed an exponential growth in the number of transistors per integrated circuit and predicted that this trend would continue. Through Intel's relentless technology advances, Moore's Law, the doubling of transistors every couple of years, has been maintained, and still holds true today. Intel expects that it will continue at least through the end of this decade.

                                    

Gordon Moore

Moore’s LawBilkent University