PHOSPHATE AND MINERAL HOMEOSTASIS

ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY

Editorial Board:

NATHAN BACK, State University of New York at Buffalo

NICHOLAS R. DI LUZIO, Tulane University School of Medicine

EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science

DAVID KRITCHEVSKY, Wistar Institute

ABEL LAJTHA, Rockland Research Institute

RODOLFO PAOLETTI, University of Milan

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PHOSPHATE AND MINERAL HOMEOSTASIS

Edited by

Sha ul G. Massry University of Southern California Los Angeles, California

Michel Olmer University of Aix-Marseille Marseille, France

and

Eberhard Ritz University of Heidelberg Heidelberg, Federal Republic of Germany

PLENUM PRESS • NEW YORK AND LONDON

Library of Congress Cataloging in Publication Data

International Workshop on Phosphate and Other Minerals (7th: 1985: Marseille, France)

Phosphate and mineral homeostasis.

(Advances in experimental medicine and biology; v. 208) "Proceedings of the Seventh International Workshop on Phosphate Metabolism, held

September 1-4, 1985, in Marseille, France"-T.p. verso. Bibliography: p. Includes index. 1. Phosphates-Metabolism-Congresses. 2. Calcium-Metabolism-Congresses. 3.

Magnesium - Membolism - Congresses. 4. Homeostasis - Congresses. I. Massry, Shaul G. 11. Olmer, Michael. III. Ritz, Eberhard. IV. Title. V. Series. QP535.PIIS7 1985 599'.0133 86-30431 ISBN 978-1-4684-5208-2 ISBN 978-1-4684-5206-8 (eBook) DOI 10.1007/978-1-4684-5206-8

Proceedings of the Seventh International Workshop on Phosphate Metabolism, held September 1-4, 1985, in Marseille, France

© 1986 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013

All rights reserved

No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher

Library of Congress Cataloging in Publication Data

International Workshop on Phosphate and Other Minerals (7th: 1985: Marseille, France)

Phosphate and mineral homeostasis.

(Advances in experimental medicine and biology; v. 208) "Proceedings of the Seventh International Workshop on Phosphate Metabolism, held

September 1-4, 1985, in Marseille, France"-T.p. verso. Bibliography: p. Includes index. 1. Phosphates-Metabolism-Congresses. 2. Calcium-Metabolism-Congresses. 3.

Magnesium - Membolism - Congresses. 4. Homeostasis - Congresses. I. Massry, Shaul G. 11. Olmer, Michael. III. Ritz, Eberhard. IV. Title. V. Series. QP535.PIIS7 1985 599'.0133 86-30431 ISBN 978-1-4684-5208-2 ISBN 978-1-4684-5206-8 (eBook) DOI 10.1007/978-1-4684-5206-8

Proceedings of the Seventh International Workshop on Phosphate Metabolism, held September 1-4, 1985, in Marseille, France

© 1986 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013

All rights reserved

No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher

TO OUR WIVES

Meira Massry Helene Olmer Christina Ritz

AND TO OUR CHILDREN

PREFACE

We are pleased to present to our readers the proceedings of the Seventh Internat ional Workshop on Phosphate and other Minerals which was held in Marsielle, France during September 1-4, 1985. It was hosted by Professor Michel Olmer, the Chief of the Divison of Nephrology in Hopital de la Conception of the University of D'Aix­Marsielle II.

The workshop was attended by 250 scientists from 17 countries including Algeria, Austria, Belgium, Canada, Czechoslovakia, Democratic Republic of C'.ermany, Egypt, England, France, Israel, Italy, Japan, Spain, Switzerland and the United States of America. There were 28 invited presentations by leading scientists and 40 oral and 75 poster presentations selected from over 200 abstracts submitted to the Organizing Commi ttee. This meet ing provided an excellent opportuni ty for interested scientists from interrelated disciplines including nephrology, endcrinology, physiology, biochemistry and nutrition to get together and discuss recent advances in the field of phosphate and mineral metabolism.

We would like to express our thanks and gratitude to all those who stimulated, encouraged an~ supported us to hold the Seventh International ~~rkshop in Marsi~lle. This endeavor could not have been possible without the generous financial support of many companies and agencies in France including Bayer Pharma, Boehringer Ingelheim, Ciba, Cobe, Conseil general des Bouches du Rhone, Conseil Regional Provence­Alpes-Cote d'Azur, Eaux Minerales D'Evian, Fournier-Dijon, Gambro, Hemofrance, Hoechst, Hospal, I.C.I. Pharma, LEO, Merck Sharp &: Dohme­Chibret, Municipalite de Marseille, Organon Teknika, Robert Et Carriere, Roussel, Sandoz, Servier Medical, Theraplix, Travenol, Wyeth­Byla and of others in the United States of America including Hoffman LaRoche, Inc., Marion Laboratories, Inc., Plenum Publishing Corp., Proctor and Gamble Company, Salt Institute.

We would 1 ike to express our deepest appreciation to Ms. Lilian Neel for her tremendous and valuable contribution to the organization of the Workshop and to Ms. Haidi Samouha for her important organizational assistance during the workshop.

Shaul G. Massry Mi che 1 Olmer Eberhard Ri tz

vii

CONTENTS

I. SPECIAL PRESENTATIONS

High Energy Phosphate, Phospholipids and Calcium in Ischemic Renal Tubular Cell Injury .

H.D. Humes, V.D. Nguyen, and D.A. Hunt

Calcium, Cell Function and Cell Death L. V. Avioli

Primary Hyperparathyroidism (PHP) Revisited C.R. Kleeman, S. Salehmoghaddam, and G. Hertz

II. RENAL HANDLING OF PHOSPHATE

Mechanisms of Ion Transport Regulation by Parathyroid Hormone: cAMP/Ca2+/Calmodulin and Phospholipid Dependent Phosphorylation .................. .

K. Hruska, J. ScobIe, D. Moskowitz, and M. Goligorsky

Mechanisms of NAD Action in Regulation of Renal Brush Border Membrane Transport of Phosphate . . . . .

S.A. Kempson and T.P. Dousa

Interactions between Inorganic Phosphate and Energy Metabolism in Renal Cortical Tubules . . . . .

V.W. Dennis and P.C. Brazy

Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways . . .

H. Murer, J. Biber, K. Malmstrom, I. Mohrmann, and M. Coady

Phosphorin, A Phosphate-Binding Hydrophobic Protein Isolated from Renal Brush Border Membranes . . . . . . .

R.J. Kessler, D.A. Vaughn, C. Schali, and D.D. Fanestil

3

9

17

49

59

67

73

83

Intrarenal Phosphate Reabsorption: Role of Nephron Heterogeneity. 93 A. Haramati

Resistance to the Phosphaturic Effects of Parathyroid Hormone during Phosphate Conservation is Due to Enhanced Phosphate Reabsorption by the Pars Recta .

F.G. Knox, T.J. Berndt, and J.A. Haas . .. 101

ix

Brush Border Membrane Phosphate Transport Effects of Volume Expansion . • . • . . . . • . . . .. •.•.•.... 109

J.B. Puschett, J. Liput, and C. Galya

The Direct Effect of l,25-Dihydroxycholecalciferol on Membrane Phospholipid Composition and Phosphate Transport ... 115

B.R.C.Kurnik, M. Huskey, and K.A. Hruska

Possible Role of Calcium in Parathyroid Hormone Action on Phosphate Transport in Rabbit Renal Proximal Tubules • . . • 125

N. Yanagawa and O.D. Jo

Calcium Stimulates Sodium-Dependent Phosphate Absorption in Rabbit Proximal Convoluted Tubules Perfused In Vitro • . . • • • 133

D. Rouse and W. Suki

Characteristics of Phosphate Transport Across the Basolateral Membrane of the Proximal Tubule: An In Vivo Study . • . . • • • 137

T.S. Yan and G.A. Quamme

Renal Proximal Tubular Brush-Border Membrane Transport of Phosphate with Acute Acidosis . . • • . . . . . . • . • . • • 145

B.S. Levine, J.A. Kraut, and D.R. Mishler

Effects of Glucagon on Renal and Extrarenal Handling of Pi in Rodents: Evidence for Pi Mobilizing Activity •...•. 155

R.C. MUhlbauer, J.P. Bonjour, and H. Fleisch

III. RENAL HANDLING OF CALCIUM AND MAGNESIUM

Calcium Transport by the Proximal Tubule • . . . . •.•. 165 F.S. Wright and K. Bomsztyk

Mechanisms of Calcium Transport in the Thick Ascending Limb of the Loop Henle ..•••••.•••.......... 171

Z.S. Agus, F.N. Ziyadeh, and E. Kelepouris

Calcium Transport in the Distal Convoluted Tubule ••...•..•. 177 L.S. Costanzo

Renal Membrane Transport of Calcium . . • • . . . . . . . • . • . • • 183 Y. Tsukamoto and W.N. Suki

Renal Tubular Disorders Associated with Hypocalciuria • • • . • • • . 187 R.A.L. Sutton

Renal ~1agnesium Wasting Disorders •. • • • • . . . • • • • . • . • • 193 J.H. Dirks and N.L.M. Wong

Role of PTH, Vitamin D and Bone Metabolism in Low Protein-Induced Hypercalciuria • • . • • . • . • . • • • • . • • 199

E. Fernandez-Repo11et and M. Martinez-Maldonado

IV. INTESTINAL ABSORPTION OF PHOSPHATE AND CALCIUM

Mechanism and Regulation of Intestinal Phosphate Transport D.B.N. Lee

x

• 207

Intestinal Absorption of Phosphate in Man: Effect of Drugs .. . . . 213 C. Gennari, R. Nardi, and L. Fusi

Mechanism of Phosphate Transport Adaptation in Rat Intestinal and Renal Brush Border Membranes ...•.••. 223

G. Danisi, J. Caverzasio, J-Ph. Bonjour, H. Murer, and R.W. Straub

Analysis of Calcium Transport in Rat Intestine . . • . • . . • . . • . 227 F. Bronner, D. Pansu, and W.D. Stein

Calcium Absorption in the Rat Colon Measured In Vivo • . . • . . . . . 235 P. Ammann, R. Rizzo1i, and H. Fleisch

Impaired Intestinal Calcium Transport in the Spontaneously Hypertensi ve Rat . . • . . .. ............... 239

P.A. Lucas, T. Drueke, B. Lacour, R.C. Brown, and D.A. McCarron

V. BONE METABOLISM

Cellular Mechanisms of Bone Remodeling Evaluated at the Intermediary Level of Organization of Bone . . . . . . . . . . . 247

P.J. Meunier

The Local Regulation of Bone Remodeling . . . . . . . . . . . . 255 W.A. Peck, L. Rifas, S. Cheng, and V. Shen

Immune Cells and Bone Resorption . • . . . . . . . . . . . 261 ~I. Gowen, B.R. MacDonald, D.E. Hughes, H. Skjodt,

and R.G.G. Russell

Bisphosphonates Can Reduce Osteoclastic Bone Resorption by Two Different Mechanisms . . . . . . . . " ....... 275

C.W.G.M. Lowik, P.M. Bonnekamp, G. van de Pluym, L. van de Wee-Pals, H.B. van Treslong-de Groot, and O.L.H. Bijvoet

Comparison of Aluminum Related with Vitamin D Related Osteomalacia by Tetracycline Based Bone Histomorphometry . . . . 283

A.M. Parfitt, D. Rao, J. Stanciu, and A.R. Villanueva

Parathyroid Hormone and 1.25 Vitamin D3 Exert Opposite Effects on Bone . • . . ..•..... 289

H.H. Mulluche, C. Matthews, ~1. Faugere, P. Fanti, and R.M. Friedler

Serunl Bone GLA-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients . . . . . . . . . . . ., ..... 291

S.A. Charhon, P.D. Delmas, L. Malaval, P.M. Chavassieux, M.C. Chapuy, and P.J. Meunier

Effects of l,25(OH)2D3 Administration on Serum Bone GLA Protein in Predia1ysis Chronic Renal Failure . .•..... 297

G. Coen, S. 1.lazzaferro, G. Donato, C. Massimetti, P. Ballanti, F. Bondatti, C. Della Rocca, A. Smacchi, F. Mantazzoli, and G.A. Cinotti

xi

Skeletal Mass in Long Term Hemodialysis Patients . . . . • • . • • . . 305 J. Letteri, P. Nagwani, and S. Cohn

VI. PARATHYROID HORMONE

Parathyroid Hormone Antagonists Effective In Vivo . . . . • . . . . • 315 L.H. Caporale and M. Rosenblatt

Solubilization of a Guanine Nucleotide-Sensitive Parathyroid Hormone-Receptor Complex from Canine Renal Cortex • • • . . 329

R.A. Nissenson, E. Mann, J. Winer, A. Teitelbaum, and C. D. Arnaud

Parathyroid Hormone Secretory Responses to Peroral Phosphate and Stimulability of Serum Levels of Carboxyl-Terminal Flanking Peptide (PDN-2l) of the Human Calcitonin Gene by Calcium in NOrmal and Osteoporotic Patients •. .••.. 345

M.A. Dambacher, J. Ittner, R. Muff, and J.A. Fischer

Renal Adenylate Cyclase Stimulating Action of Normal and Oxidized Parathyroid Hormone (1-34). . . . . ....•. 351

J.J. Helwig, N. Burgmeier, A. Gairard, M.C.M. Yang, and P.K.T. Pang

Hypercalcemia of Malignancy ..............•....• 357 J.W. Jacobs and E. Simpson

Mechanism of the Hypocalcemic Agent WR-272l and Its Acute and Chronic Application in Eu- and Hyperparathyroidism . • • • . 367

S. Hirschel-Scholz, J. Caverzasio, and J.P. Bonjour

Determinants of Circulating Levels of 1.25(OH)2D3 (Calcitriol) in Primary Hyperparathyroidism (PHPT) .•..•..•..•.• 371

M. Paillard. P. Patron, and J.P. Gardin

Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism • . • . . 379 Ph. Jaeger, W. Jones, M. Kashgarian, G.V. Segre, and

J.P. Hayslett

Changes in Serum Calcium and Phosphorus Induced by Chronic Renal Failure in the Absence of Parathyroid Hormone . . . • . . 383

M. Rodriguez, V. Lorenzo, A.J. Felsenfeld, and F. Llach

VII. MINERALS AND BLOOD PRESSURE

Theoretical Mechanisms of Dietary Calcium's Antihypertensive Action. . • .. . .•.................... 389

R. Bukoski, P. Lucas, T. Drueke, and D. McCarron

Calcium as a Mediator of Salt Sensitive Hypertension . • • • . . • . . 397 L.M. Resnick

The Effect of Calcium on Renin, Aldosterone and Prostaglandin Release . • . . . . . . . . . . . . . . . . 405

J.L. Nadler and I. Antonipillai

Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats •.•...•.•.•......••..• 417

R.J.M. Bindels and C.H. van Os

xii

Participation of Various Brain Nuclei in the Altered Time Course of Genetic Hypertension in SHR Dependent on Changes in Calcium Metabolism . . . . . . • • • . • • . • . • 423

H. Geiger, M. Palkovits, U. Bahner, G. Schmid, and A. Heidland

Dissociation Between the Hypotensive Effect of Thiazides and Plasma Divalent Cations. . • . . . . . . . ..... 433

D.C. Batlle, W-C. Yang, A. Von Riotte, and S.K. Mujais

VIII. NEPHROLITHIASIS

Urine Citrate and Calcium in Calcium Nephrolithiasis . . . . . . . • • 445 J .H. Parks and F. L. Coe

Influence of Oxalate on Calcium Oxalate Crystals Formation in Urine Oversaturation . . . . . . . • 451

M. Olmer, Y. Berland, ~I. Grandvuil1emin, L. Madsen, and R. Boistel1e

Therapeutic Hodalities for the Prevention of Nephrolithiasis . • . • . 459 I\'. Tschope, R. Horsch, and E. Ritz

IX. MISCELLANEOUS

Factors Controlling the Intracellular Concentration of Orthophosphate (Pi) in Mammalian Cells . . . . • . . . • • . . . 469

A. Bevington, G.J. Kemp, and R.G.G. Russell

Phosphate Transfer and 3lp Nuclear Magnetic Resonance (NMR) Spectroscopy Pre and Post Hemofiltration (HF) ....... 479

T. Haas, Ph. Jehenson, D. Hillion, S. Tran Dinh, E. de Vie1, J. Verrier, and A. Syrota

Effects of Aldosterone Regulation of Renal Na-K-ATPase: in Phosphate Depletion

S.K. Mujais •.•.•.. 485

Effects of the Impairment of Renal Function and of the pH of Gastric Secretion on the Efficacy of AI(OH)3 to Reduce Serum Inorganic Phosphorus . . • . . . . • . . . . • . . . . • . 493

G. Barsotti, ~1. Lazzeri, A. Polloni, E. Morelli, E. Giovannetti, S. Lupetti, A. Cupisti, L. Dani, and S. Giovannetti

Effects of Different Insulin Administration Modalities on Vitamin D ~Ietabolism of Insulin-Dependent Diabetic Patients . . 501

C. Colette, L. Monnier, J. Arnal, J-L. Selam, and J. Mirouze

Influence of Inorganic Phosphate on Glucose-Induced Insulin Release In Vitro . . • • . . . . . . . . . . . .• •.•.. 509

J.I. Osuna, M. Castillo, E. Rodriguez. J.E. Campil10, and C. Osorio

Mechanist! of Inhibition of Glycolysis by Vanadate . • . . • . • • . • 517 J.E. Benabe, L.A. Echegoyen, and M. Martinez-Maldonado

Regulation of Na+/H+ Antiport in the Intact Renal Proximal Tubular Cell ..••.........•.•.••. 529

E.P. Nord, D. Goldfarb, and L.G. Fine

xiii

Interaction of Vitamin D-Metabolites with Adenylate Cyclase/ Cyclic AMP System: A Biological Model of Controlled Regulation . . . . . . . . . . . . . .. ......... 533

M.M. Popovtzer, H. Wald, M.M. Friedlaender, and D. Rubinger

Dibutryladenosine 3 1 ,5 1 -Cyclic Monophosphate (dBcAMP) Does Not Mimic the Action of Parathyroid Hormone (PTH) on Canine Proximal Tubular Basolateral Membrane Na+:Ca2+ ..... 537

J.E. ScobIe, D. Moskowitz, and K.A. Hruska

Phosphate Transport Through Placenta Brush Border Membrane . . . • . . 543 M.G. Brunette, S. Letendre, and S. Allard

INDEX •••••••••.••••..•••.••••.••••••• 549

xiv