phchha 1

MycotoxinsMycotoxins

Chemical

Aflatoxins

Trichothecenes

Ochratoxin A

Ergot alkaloids

Fumonisins

Patulin

Zearalenone

Aspergillus flavus and A. parasiticus

Mainly Fusarium

Penicillium verrucosum A. ochraceus

Claviceps purpurea

Fusarium moniliforme

P. expansum

Fusarium spp

Corn, peanuts, tree nuts, milk

Cereals and other foods

Wheat, barley, corn

Rye, barley, wheat

Corn

Apples, pears

Cereals, oil, starch

Source Associated Food

phchha 2

0.78

0.79

0.80

0.87

0.94

Minimum Water Activity Mould

Aspergillus ochraceus

Penicillium verrucosum

Aspergillus flavus

Fusarium moniliforme

Stachybotrys atra

Minimum water activity for growthMinimum water activity for growthof toxigenic moulds of toxigenic moulds

phchha 3

Target organs of some mycotoxinsTarget organs of some mycotoxins

Mycotoxin Target

Aflatoxin Liver

Ochratoxin A Kidney

Trichothecenes Mucosa

Ergot alkaloids Peripheral vascularsystem

Zearalenone Uro-genital tract

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Regulatory limitsRegulatory limitsfor mycotoxins in foodsfor mycotoxins in foods

Aflatoxins B+G

Aflatoxin M1

Ochratoxin A

Deoxynivalenol

Patulin

Zearalenone

Mycotoxin

0 - 50

0 - 1000

0.05 - 1.0

1 - 300

1000 - 4000

20 - 50

30 - 1000

Corn, peanuts, other foods

Animal feeds

Milk, dairy

Rice, corn,barley, beans, pork kidney

Wheat

Apple juice

All foods

48

21

17

6

5

10

4

Limit (µg/kg) Commodities No. of Countries

phchha 5

Risk assessment Risk assessment for mycotoxin in foodsfor mycotoxin in foods

Mycotoxin

Aflatoxin B1

Patulin

Ochratoxin A

JECFA Benchmark

0.01 - 3 cancers per yearper 100.000 peopleper g of aflatoxin B1

per kg bw/day

0.4 g/kg bw/day

0.1 g/kg bw/day

phchha 6

Regulatory limits for aflatoxins Regulatory limits for aflatoxins in some Asian and Pacific countriesin some Asian and Pacific countries

CountryAustralia/New Zealand

China

IndiaJapan

MalaysiaPhilippines

SingaporeSri LankaThailand

15 (T) 5 (T)

20 (B1)

30 (B1)

10 (B1) 5 (B1)

35 (T)

20 (B1)

Absence (B1)*30 (T)20 (T)

PeanutsOther foods maize, peanutAllriceother grainsAllCoconuts, peanut products (export)AllAllAll

Limit (µ/kg) Commodity

B1 = Aflatoxin B1

T = Total Aflatoxins*Limit of detection is around 10 g/kg

phchha 7

Chemical hazards in foodChemical hazards in food

Severity

Diseaseand

Death

To

xici

ty

Exposure

phchha 8

Potential physical hazardsPotential physical hazards

Glass Slime or scum Metal Bone Plastic Stones and rocks Capsules or crystals Pits or shell Wood Paper Human and animal hair