Pharmanex

Product Training

Cortitrol:Dietary Supplement

Cortitrol is a supplement that assists you in dealing with difficult situations.

Take Control!

What is Cortitrol?

Introducing Cortitrol

Cortitrol is a unique dietary supplement that addresses the symptoms of a fast-paced lifestyle.

Cortitrol’s ingredients balance the level of cortisol in the body.

Background

Cortisol is a hormone produced by your body in response to difficult events.

The occasional release of cortisol is essential to respond to emergency situations. Too frequent release of cortisol can lead to health problems.

What is Cortisol?

Cortisol

The role of Cortisol in

Health and Longevity.

What is Cortisol?

Today’s Health Demons

• 1980’s = Cholesterol• Early 1990’s = Free Radicals / Antioxidants• Later 1990’s = Insulin / Blood Sugar

• 2000’s = Cortisol

What is Cortisol?

Cortisol in the Media• More Than 1,000 News Articles Over the Past Year!

• Time, Washington Post, Reader’s Digest, etc

• 1st International Symposium on Cortisol, Stress and Health

• May 2002

• New Book: The Cortisol Connection...Why Stress Makes You Fat & Ruins Your Health…And What You Can Do About It

• Published September 2002

What is Cortisol?

• The body’s primary stress hormone:– “Fight-or-Flight” response– Required by the body for survival– Regulates inflammation, carbohydrate metabolism,

cardiovascular function, etc…

• BUT too much of cortisol for too long leads to problems:– Repeated exposure to stressful situations (personal, family,

work)– Modern stressors do not permit “fight-or-flight”– Stress hormones do not dissipate– Stress can lead to degenerative health consequences

What is Cortisol?

STRESS

• ACUTE STRESS• brief• normal circadian

rhythm• adaptive

CHRONIC STRESS• prolonged & repeated• disrupted circadian

rhythm• maladaptive

What is Cortisol?

Repeated Stress Elevates CortisolCortisol Levels Throughout the Day

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What is Cortisol?

The Relationship Between Elevated Cortisol and Stress Related Conditions

Scientific Evidence

What is Cortisol?

• Obesity & Metabolic Syndrome– High cortisol secretion = abdominal fat =

illness

• Suppressed Immunity– Associated with low counts of white blood cells– Acute psycholsocial and sleep deprivation

stress disrupts skin barrier homeostasis• Changes due in part from increased cortisol levels.

What is Cortisol?

Impact of Elevated Cortisol in:

• Appetite– People who diet have high cortisol secretion

• Bone Metabolism– High cortisol secretion = dietary restraint =

implications for bone health

What is Cortisol?

Impact of Elevated Cortisol in:

Other Research

Additional research has also identified many other health issues associated with elevated cortisol levels.

What is Cortisol?

Work Demands

Job Control

CortisolReactivit

y

Increased Health

Care Costs$$$

Ganster et al. Journal of Applied Psychology, 2001, 86, 954-964.

Stress and Health Care Costs

Cortisol Levels are Elevated in…• Chronic Stress• Sleep Deprivation• Dieting / Restrained Eating

Adults who need to control cortisol levels:– Get less than 8 hours sleep– Feel run-down, lack of mental focus– Limit caloric intake to lose weight– Often in difficult situations

What is Cortisol?

• 80% of workers report feeling stress on the job

• Stress contributes to half of all illnesses in the US

• 70-80% of all doctor visits are stress-related

• >50% all deaths between the ages of 1 and 65 result from stress

Sources: U.S. Center for Disease Control; World Health Organization; www.whmc.af.mil; 2000 Gallup Poll “Attitudes in the American Workplace”

The Market: Prevalence of Chronic Stress

• Generalised anxiety disorder affects an estimated 183 million people worldwide

• People who live in a high state of anxiety are 4.5 times more likely to die prematurely

Sources: U.S. Center for Disease Control; World Health Organization; www.whmc.af.mil; 2000 Gallup Poll “Attitudes in the American Workplace”

The Market: Prevalence of Chronic Stress

• You can control cortisol levels via:– Stress Management Techniques

• Meditation, coping strategies, etc…

– Exercise– Optimal Nutrition

• LifePak and Tegreen 97

– Dietary Supplements• Cortitrol, LifePak and Tegreen 97

The Solution: Cortisol Management

• Valerian

• Kava Kava

• Melatonin

• Tyrosine

None of these supplements directly address cortisol control

Common Anti-Stress Solutions

Cortitrol• Enhances feelings of well-being and control

in response to difficult situations

• Improves performance and increased vigour throughout the day

• Generates better mental concentration and focus

• Supports weight maintenance efforts

What is Cortitrol?

Cortitrol: Advantage• Unique patent-pending dietary supplement that

supports healthy cortisol levels• Proprietary (company owned) blend &

comprehensive ingredients– Balances cortisol levels

• Contains a proprietary, all-natural form of theanine extract

• Manufactured according to the highest TGA standards and the Pharmanex 6S Quality Process

• Comprehensive, proprietary formula that addresses direct cortisol modulation

• Scientifically validated ingredients in clinically significant dosages– Magnolia Bark– Phosphatidylserine– Epimedium– L-Theanine

Cortitrol: Proprietary Formula

LifePakJungamals LifePak for KidsGeneral Health & Well-Being

Joint FormulaJoint Health

Optimum OmegaHeart Health

Tegreen 97Antioxidant Protection

CordyMax Cs-4Vitality & StaminaFatigue

BioGinkgo 27/7Memory & Concentration

FibreNetDigestive HealthWeight Management

OverDriveSports Nutrition

FibreNet PlusDigestive Health

Cortitrol

Cortitrol: Product Positioning

OPTIMAL HEALTH

FibreNet  

Optimum Omega

Joint Formula

BioGinkgo 27/7

LifePak/Cortitrol

Tegreen 97

OPTIMAL HEALTH FOUNDATION BLOCKS

Inner Health Memory

Protection

JungamalsLifePak for

Kids

 

• Take two (2) tablets with your evening meal. For optimal results take an additional one (1) tablet with your morning meal

Cortitrol: Recommended Usage

• Promote Cortitrol to be taken with LifePak.

• Why?– Optimal nutritional health which

includes vitamin C, B1, B2, Calcium, Magnesium, Pantothenic acid, and Pyridoxine, combined with cortisol modulation.

Cortitrol: And LifePak

• Magnolia Bark

• Phosphatidylserine

• Epimedium

• Theanine

Cortitrol: Ingredients

• Clinical Studies & references on individual ingredients in the formula– Pharmanex Web Site – www.pharmanex.com.au or

www.pharmanex.co.nz– PubMed Web Site -

www.ncbi.nlm.nih.gov/entrez/query.fcgi

• Also on our web site:– Product Information– Q&As– Training Material– General Health Facts

Cortitrol: Product Support

• Why does Cortitrol come in tablet form?– Better cost value

• Is there a difference b/w Epimedium brevicornum and koreanum?– No. Both are from two similar plants but have

the same efficacy, the same active component. TGA preferred we use brevicornum.

Cortitrol: Q&A

• Are there any known drug interactions?– If you are pregnant or lactating, have a known medical

condition or are taking a prescription medication, or are allergic to any component of this product, consult a physician prior to use.

• Will coffee or caffeine negate the effectiveness of Cortitrol?– No, coffee or caffeine will not "negate" the effects of Cortitrol;

rather, Cortitrol would be expected to permit the "energy" benefits of coffee but without the "jittery" side effects.

Cortitrol: Q&A

• There are several hormones regarding stress besides cortisol. Why is Pharmanex focusing on cortisol and not the others?– Cortisol is the primary stress hormone. When we

experience stress, cortisol is the stress hormone that remains elevated the longest.

• Will Cortitrol make it hard for me to sleep at night?– In some cases, Cortitrol users have experienced

increases in energy levels and makes them feel more alert. We suggest taking Cortitrol in the morning, rather than the evening, which seems to help.

Cortitrol: Q&A

• What is the normal range of cortisol levels?– The "normal" range for blood cortisol levels is fairly

wide, 6-23 mcg/dl, but these levels can vary tremendously in response to stress, illness, and even following meals.

Cortitrol: Q&A

• Any drug or medical interactions?– We have found that people are able to take Cortitrol with most

medications. Just like all of our products, however, we do not know all the potential interactions with Cortitrol. As always, we must recommend that they discuss this product with their doctor or pharmacist who knows their prescription history.

– If you are pregnant or lactating, or taking a prescription medication, have a known medical condition, or allergic to any component of this product, please consult a physician prior to use. Consult a physician if you are taking prescription "anti-stress" medications such as anxiolytics, sedatives, or hypnotics. Consult a physician if you are taking other CNS depressants, tricyclic antidepressants, anti-epileptics, muscle relaxants, anticoagulants, corticosteroids and quinalone antibiotics. Use of l-theanine concomitantly with chemotherapeutic agents must be done under medical supervision. L-theanine may enhance the effects of doxorubicin, idarubicin, adriamycin, and picarubicin and may ameliorate some of their side effects (PDR for Nutritional Supplements 2001, Sadzuka 1996, Sugiyma 1998, 1999). This supplement should be discontinued two weeks prior to surgery.

Cortitrol: Q&A

Cortitrol: Marketing Material

• Pharmanex Brochure (5 pk) $8.00• Pharmanex Cap (ea) $12.95• Power of Wisdom & Knowledge Video (ea) $7.50• Pharmanex Pill Box (ea) $3.00• Cortitrol Brochure (5 pk) $4.50• The Cortisol Story Brochure (5 pk) $9.50• Stress Test Card (5 pk) $11.00

• Summary– Balances cortisol levels– Proprietary blend of ingredients shown to have

direct effects on cortisol levels– Proprietary l-theanine ingredient– Today’s answer to the fastest growing health

demon!

Cortitrol

Cortitrol

• Next Steps– Order Today!– Spread the word– Ensure all Distributors and Customers benefit

from purchasing through ADP.