Update on the Pharmacological Treatments for Diabetes Mellitus
Pharmacological Treatments for ADHD - February 2010 - CANADA
2
Vyvanse ® Capsules 30 and 50 mg 12-14 h 30 mg Increase to 50 mg after 7 days max. dose /day: Children = 50mg Teens and adults: not indicated in Canada Increments of 10-20 mg/day at weekly intervals max. dose/day: Children = 70 mg Teens and adults = 70 mg 10 15 20 30 40 50 60 80 Illustrations do not reflect real size of pills/capsules. Medications available and illustrations of tablets/capsules Duration of action Starting dose Dose titration as per product monograph Dose titration as per CADDRA www.caddra.ca Dexedrine ® tablets 5 mg Dexedrine ® spansules 10, 15 mg 3-4 h 6 h tablets : 2.5 to 5 mg BID spansules 10 mg a.m. Increments of 5 mg/day at weekly intervals max. dose/day: (die or BID) All ages: 40 mg for ADHD 60 mg for narcolepsia Increments of 5 mg/day at weekly intervals max. dose/day: (die ou BID) Children and Teens = 30 mg Adults = 50 mg AdderallXR ® Capsules 5, 10, 15, 20, 25, 30 mg 12 h 5-10 mg once-daily a.m. Increments of 5-10 mg/day at weekly intervals max. dose/day: Children = 30 mg Teens and adults = 20-30 mg Increments of 5-10 mg/day at weekly intervals max. dose/day: Children = 30 mg Teens and adults = 50 mg Methylphenidate short acting, tablet 5mg (generic) 10, 20 mg (Ritalin ® ) 3-4 h 5 mg BID to TID adult: consider QID Increments of 5-10 mg/day at weekly intervals max. dose/day: Children and adults = 60 mg Increments of 5-10 mg/day at weekly intervals max. dose/day: Children and Teens = 60 mg Adults = 100 mg Biphentin ® Capsules 10, 15, 20, 30, 40, 50, 60, 80 mg 10-12 h 10-20 mg once-daily a.m. Increments of 10 mg/day at weekly intervals max. dose/day: Children and Teens = 60mg Adults = 80 mg Increments of 10 mg/day at weekly intervals max. dose/day: Children = 60 mg Teens and adults = 80 mg Concerta ® Extended Release Tablets 18, 27, 36, 54 mg 12 h 18 mg once-daily a.m. Increments of 18 mg/day at weekly intervals max. dose/day: Children = 54 mg Teens = 54 mg / Adults = 72 mg Increments of 18 mg/day at weekly intervals max. dose/day: Children = 72 mg Teens = 81 mg / Adults = 108 mg Strattera ® Capsules 10, 18, 25, 40, 60, 80, 100 mg Ad 24 h Children : 0.5 mg/kg/day Adult: 40 mg once-daily for 7-14 days Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day 70 kg or Adults: 60 then 80 mg/day max. dose/da : 1.4 mg/kg/D or 100 mg Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day 70 kg or Adults: 60 then 80 mg/day max. dose/day: 1.4 mg/kg/D or 100 mg METHYLPHENIDATE-BASED PSYCHOSTIMULANTS AMPHETAMINE-BASED PSYCHOSTIMULANTS NON PSYCHOSTIMULANT Pharmacological Treatments for ADHD - February 2010 - CANADA 5 10 15 20 25 30 10 20 5 18 27 36 54 10 15 5 www.fmed.ulaval.ca/fmc Trouble déficitaire de l'attention avec/sans hyperactivité
Transcript of Pharmacological Treatments for ADHD - February 2010 - CANADA
Vyvanse®
Capsules 30 and 50 mg 12-14 h 30 mg Increase to 50 mg after 7 days
max. dose /day: Children = 50mgTeens and adults: not indicated in Canada
Increments of 10-20 mg/day at weekly intervals
max. dose/day: Children = 70 mgTeens and adults = 70 mg
10 15 20
30 40 50
60 80
Illustrations do not reflect real size of pills/capsules.
Medications available and illustrations of tablets/capsules
Duration of action
Startingdose
Dose titration as per product monograph
Dose titration as per CADDRA
www.caddra.ca
Dexedrine®
tablets 5 mg
Dexedrine® spansules 10, 15 mg
3-4 h
6 h
tablets : 2.5 to 5 mg BID
spansules10 mg a.m.
Increments of 5 mg/day at weekly intervals
max. dose/day: (die or BID)All ages: 40 mg for ADHD 60 mg for narcolepsia
Increments of 5 mg/day at weekly intervals
max. dose/day: (die ou BID)Children and Teens = 30 mg Adults = 50 mg
AdderallXR®
Capsules5, 10, 15, 20, 25, 30 mg
12 h 5-10 mg once-daily a.m.
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children = 30 mg Teens and adults = 20-30 mg
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children = 30 mg Teens and adults = 50 mg
Methylphenidate short acting, tablet5mg (generic)
10, 20 mg (Ritalin®)
3-4 h 5 mg BID to TID
adult: consider QID
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children and adults = 60 mg
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children and Teens = 60 mgAdults = 100 mg
Biphentin®
Capsules10, 15, 20, 30, 40, 50, 60, 80 mg
10-12 h 10-20 mg once-daily a.m. Increments of 10 mg/day at weekly intervals
max. dose/day: Children and Teens = 60mgAdults = 80 mg
Increments of 10 mg/day at weekly intervals
max. dose/day: Children = 60 mgTeens and adults = 80 mg
Concerta®
Extended Release Tablets 18, 27, 36, 54 mg12 h 18 mg once-daily a.m. Increments of 18 mg/day at weekly
intervalsmax. dose/day: Children = 54 mgTeens = 54 mg / Adults = 72 mg
Increments of 18 mg/day at weekly intervalsmax. dose/day: Children = 72 mgTeens = 81 mg / Adults = 108 mg
Strattera®
Capsules 10, 18, 25, 40, 60, 80, 100 mgAd 24 h Children :
0.5 mg/kg/day
Adult: 40 mg once-daily for 7-14 days
Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day70 kg or Adults: 60 then 80 mg/day
max. dose/da : 1.4 mg/kg/D or 100 mg
Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day70 kg or Adults: 60 then 80 mg/day
max. dose/day: 1.4 mg/kg/D or 100 mg
METHYLPHENIDATE-BASED PSYCHOSTIMULANTS
AMPHETAMINE-BASED PSYCHOSTIMULANTS
NON PSYCHOSTIMULANT
Pharmacological Treatments for ADHD - February 2010 - CANADA
5 10 15
20 25 30
10 20
5
18 27 36 54
10 15
5
www.fmed.ulaval.ca/fmcTrouble déficitaire de l'attention avec/sans hyperactivité
ADDERALL XR ®
BIPHENTIN ®
CONCERTA ®
VYVANSE ®
Delivery system of long acting psychostimulants
Illustrations from : MY BRAIN STILL NEEDS GLASSES, Annick Vincent, Impact! Éditions, 2007www.attentiondeficit-info.com
ILLUSTRATION OF A SYNAPSE
MESSAGE
MESSAGE
NEURONE A
SYNAPSE
NEURONE B
Neurotransmitter
Reuptake pump
Receptor
www.fmed.ulaval.ca/fmcTrouble déficitaire de l'attention avec/sans hyperactivité
Vyvanse®
Capsules 30 and 50 mg 12-14 h 30 mg Increase to 50 mg after 7 days
max. dose /day: Children = 50mgTeens and adults: not indicated in Canada
Increments of 10-20 mg/day at weekly intervals
max. dose/day: Children = 70 mgTeens and adults = 70 mg
10 15 20
30 40 50
60 80
Illustrations do not reflect real size of pills/capsules.
Medications available and illustrations of tablets/capsules
Duration of action
Startingdose
Dose titration as per product monograph
Dose titration as per CADDRA
www.caddra.ca
Dexedrine®
tablets 5 mg
Dexedrine® spansules 10, 15 mg
3-4 h
6 h
tablets : 2.5 to 5 mg BID
spansules10 mg a.m.
Increments of 5 mg/day at weekly intervals
max. dose/day: (die or BID)All ages: 40 mg for ADHD 60 mg for narcolepsia
Increments of 5 mg/day at weekly intervals
max. dose/day: (die ou BID)Children and Teens = 30 mg Adults = 50 mg
AdderallXR®
Capsules5, 10, 15, 20, 25, 30 mg
12 h 5-10 mg once-daily a.m.
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children = 30 mg Teens and adults = 20-30 mg
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children = 30 mg Teens and adults = 50 mg
Methylphenidate short acting, tablet5mg (generic)
10, 20 mg (Ritalin®)
3-4 h 5 mg BID to TID
adult: consider QID
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children and adults = 60 mg
Increments of 5-10 mg/day at weekly intervals
max. dose/day: Children and Teens = 60 mgAdults = 100 mg
Biphentin®
Capsules10, 15, 20, 30, 40, 50, 60, 80 mg
10-12 h 10-20 mg once-daily a.m. Increments of 10 mg/day at weekly intervals
max. dose/day: Children and Teens = 60mgAdults = 80 mg
Increments of 10 mg/day at weekly intervals
max. dose/day: Children = 60 mgTeens and adults = 80 mg
Concerta®
Extended Release Tablets 18, 27, 36, 54 mg12 h 18 mg once-daily a.m. Increments of 18 mg/day at weekly
intervalsmax. dose/day: Children = 54 mgTeens = 54 mg / Adults = 72 mg
Increments of 18 mg/day at weekly intervalsmax. dose/day: Children = 72 mgTeens = 81 mg / Adults = 108 mg
Strattera®
Capsules 10, 18, 25, 40, 60, 80, 100 mgAd 24 h Children :
0.5 mg/kg/day
Adult: 40 mg once-daily for 7-14 days
Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day70 kg or Adults: 60 then 80 mg/day
max. dose/da : 1.4 mg/kg/D or 100 mg
Maintain dose for a minimum of 7-10 days before adjusting Children: 0.8 then 1.2 mg/kg/day70 kg or Adults: 60 then 80 mg/day
max. dose/day: 1.4 mg/kg/D or 100 mg
METHYLPHENIDATE-BASED PSYCHOSTIMULANTS
AMPHETAMINE-BASED PSYCHOSTIMULANTS
NON PSYCHOSTIMULANT
Pharmacological Treatments for ADHD - February 2010 - CANADA
5 10 15
20 25 30
10 20
5
18 27 36 54
10 15
5
www.fmed.ulaval.ca/fmcTrouble déficitaire de l'attention avec/sans hyperactivité
ADDERALL XR ®
BIPHENTIN ®
CONCERTA ®
VYVANSE ®
Delivery system of long acting psychostimulants
Illustrations from : MY BRAIN STILL NEEDS GLASSES, Annick Vincent, Impact! Éditions, 2007www.attentiondeficit-info.com
ILLUSTRATION OF A SYNAPSE
MESSAGE
MESSAGE
NEURONE A
SYNAPSE
NEURONE B
Neurotransmitter
Reuptake pump
Receptor
www.fmed.ulaval.ca/fmcTrouble déficitaire de l'attention avec/sans hyperactivité
