PHARMACEUTICAL STANDARDIZATION OF YASTIMADHU …
Transcript of PHARMACEUTICAL STANDARDIZATION OF YASTIMADHU …
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
957
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
PHARMACEUTICAL STANDARDIZATION OF YASTIMADHU
SIDDHA TAILA MATRA BASTI IN THE MANAGEMENT OF
PARIKARTIKA W.S.R. TO ACUTE FISSURE-IN-ANO
1*
Dr. Arif Khan Goran, 2Dr. Pramod Kumar Mishra,
3Dr. Mahesh Kumar,
4Dr. Vijay Jatoliya and
5Dr. Neha Bhanot
1Final Year M.D. Scholar (Swasthavritta & Yoga) Pgdye.
2Professor & H.O.D. (P.G. Dpt. of Swasthavritta & Yoga).
3Assistant Professor (P.G. Dpt. of Swasthavritta & Yoga).
4 Final Year M.D. Scholar (Rasashastra & Bhaishajya Kalpana).
5Bams, Pgdye, Crav (Kayachikitsa), Srf (Ccras- Ahmedabad).
ABSTRACT
Ayurveda is the oldest medical science, based on use of processed
natural products. But for last few centuries the practice of this medical
science become reduced due to allopathic treatment has flourished in
various countries due to quick symptomatic relief, easily availability
and massive production. For drug efficacy and reproducibility of
therapeutic uses, it is essential to standardize the product. The remedy
consists in employing a Piccha-Basti with Yashtimadhu and black
sesamum pasted together and dissolved in clarified butter and honey.
The patient should be laved in cold water and be given his food with
milk. Anuvasana-Basti with the cream of clarified butter or with oil
cooked with Yashtimadhu should be employed. Medicated oil/ghee is one of the important
dosage form widely described in Ayurvedic pharmaceutics. Four types of Snehas (Fatty
preparation) are described in Ayurvedic literature. These are ghrita, taila, vasa and majja.
Among these taila (medicated oil) and ghrita (medicated ghee) are more popular in
therapeutic uses. Preparation of medicated oils and ghee is a bit complicated procedure and
require special care regarding proportion of ingredients, heating pattern and temperature.
Hence in present work an attempt has been made to establish pharmaceutical standardization
of Yastimadhu Siddha Taila as per reference of Sushruta Samhita and in this article an
attempt has been made to review regarding properties of taila, process of method of
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
SJIF Impact Factor 7.632
Volume 10, Issue 9, 957-972 Review Article ISSN 2278 – 4357
*Corresponding Author
Dr. Arif Khan Goran
Final Year M.D. Scholar
(Swasthavritta & Yoga)
Pgdye.
Article Received on
05 July 2021,
Revised on 26 July 2021,
Accepted on 16 August 2021,
DOI: 10.20959/wjpps20219-19813
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
958
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
preparations of drugs, stages of paka (preparation) and its various therapeutic and analytical
indications.
KEYWORDS: Yastimadhu Siddha Taila, Pharmaceutical standardization, Murchhana, Taila
Paka Karma, Matra Basti, Parikartika.
INTRODUCTION
Ayurveda is one of the oldest traditional systems of medicine of India in the world. Its history
of origin started almost from Vedic period. So many types of Ayurvedic formulations are
found in different classical books of Ayurveda, which have been used by the
ancient acharyas for the treatment of diseases. Sneha kalpana (medicated oil) is one of the
important dosage form widely described in Ayurvedic pharmaceutics.
Swarasa (Juice), Kalka (Paste), Kwatha (decoction), hima (cold infusion) and phanta (hot
infusion), are the basic pharmaceutical procedures of Indian system of medicine.
The remedy consists in employing a Piccha-Basti with Yashtimadhu and black sesamum
pasted together and dissolved in clarified butter and honey. The patient should be laved in
cold water and be given his food with milk. Anuvasana-Basti with the cream of clarified
butter or with oil cooked with Yashtimadhu should be employed.[1]
Ayurveda is the oldest medical science, based on use of processed natural products. But for
last few centuries the practice of this medical science become reduced due to allopathic
treatment has flourished in various countries due to quick symptomatic relief, easily
availability and massive production. Sneha Kalpana may be defined as - ‘A pharmaceutical
process to prepare oleaginous medicaments from the substances like Kalka, Kwatha and
Drava dravyas, in specific proportions by subjecting to a unique heating pattern and duration
to full-fill certain pharmaceutical parameters, according to the need of therapeutics’. It is one
of the eye-catching techniques in Ayurvedic drug industry to achieve both fat soluble and
water soluble extractives into the oil media which acts on liposomal level. In this study were
prepared Medicated Yastimadhu Siddha Taila and Analyses its Physical parameter and
Chemical parameters.
AMIS AND OBJECTIVE
Pharmaceutical study of Yastimadhu Siddha Taila
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
959
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Analytical study of Yastimadhu Siddha Taila
- To evaluate the organoleptic characters of the test drug.
- To carry out the physicochemical parameters of the Yastimadhu Siddha Taila.
Types of Sneha
Four types of Snehas are described in Ayurvedic literature. These are ghrita, taila, vasa &
majja. Among the four Sneha ghrita is regarded as best one.[2]
Taila[3]
Tail alleviates vata and does not aggravate kapha. It promotes body strength. It is beneficial
for the skin. It is ushna, provide firmness and cleans female genital passage. Taila means oily
portion extracted from the drugs. Acharya Charak mentioned that Tila taila is best one for
strength and unction and considered best for pacification of Vata. Taila assimilates the
properties of other drugs added to it during the paka of Sneha without losing its own
properties. This radical transformation of property is not possible in ghee (Harita).
Madhuka (Yastimadhu)[4]
Yastimadhu being Vata- Pitta Shamaka helped to relieve both these symptoms. In the patients
Yastimadhu also has Vrana Shodhana (wound cleansing) and Vrana Ropana (wound healing)
properties that helped for healing of fissure wound.
Til Taila[5]
Til Taila (Sesamum indicum) similarly has a soothning property. It form a thin film layer on
the fissure bed and that allows early epithelization of wound. It also protects wound from
invasion of any microbes. Taila also reduce the Rukshata of Vayu and maintain the normal
tone of smooth internal sphincters which result into good blood circulations & helped in
healing process.
MATERIAL AND METHOD
Material Use
Yastimadhu Siddha Taila is prepared by Sneha kalpana procedure as per mention in
Shadhandhar Samhita Madhyamkhand.[6]
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
960
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Method of Preparation of Shatpushpa taila
The drug was prepared by Snehapaka method in pharmacy of Dr. S.R. Rajasthan Ayurved
University Pharmacy, Jodhpur by adopting classical method.
Method of Preparation: (Sharangadhar Madhyam Khand 9/1).
Table 1: Ingredients of Yashtimadhu Siddha Taila.
Sr. No. Ingredients Latin Name Part Used Quantity
1. Tila Taila Sesamum Indicum Beeja Taila 6 litters
2. Madhuka
(Yastimadhu) Glycyrrhiza Glabra Moola 1.5 Kg
3. Manjishta Rubia Cordifolia Moola 360 gm
4. Haridra Curcuma Longa Moola Kanda 60 gm
5. Lodhra Symplocos Racemosa Twak 60 gm
6. Musta Cyperus Rotandus Moola Kanda 60 gm
7. Amalaki Emblica Officinalis Phala 60 gm
8. Vibhitka Terminalia Belerica Phala 60 gm
9. Haritaki Terminalia Chebula Phala 60 gm
10. Jal (Water) Aqua - 24 litters
Taila Murchhana
Ingredients
Tila Taila : 1 Part
Madhuka (Yastimadhu) : 1/16th
Part
Manjishta : 1/64th
Part
Haridra : 1/64th
Part
Lodhra : 1/64th
Part
Musta : 1/64th
Part
Amalaki : 1/64th
Part
Vibhitka : 1/64th
Part
Haritaki : 1/64th
Part
Jal (Water) : Four time quantity as Taila
METHOD
Step 1: The uncooked ‘tila taila’ is taken in a vassel which is strong and clean. The vessel is
placed over mild fire and heted until foam starts to appear. Soon the fire is lit off and waited
for nisphena-bhava and saityabhava of the oil.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
961
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Step 2: The oil is now placed again over mild fire and desired quantity of water is added to it.
Meanwhile the fine power of manjistha and other ausadha dravyas is mixed with little
quantity of water to prepare kalka.
Step 3: This kalka is added to vessel and the boiling is continued with frequent stirring.
Boiling is continued until all snehasiddha lakshana are attained. The oil retains (Aruna Varna)
reddish colour after the process.
Step 4: Yashtimadhu kalka (paste) was made into a small bolus and poured into the Taila and
fried for few minutes. 16 parts of water was then added into the mixture for preparation of the
Yashtimadhu Siddha Taila by Sneha Paka procedure.
Step 5: The whole content was heated for three days consecutively to evaporate the whole
water content and leave behind only the Oil (Taila) portion. As soon as all the ‘Sneha siddha
lakshana’ are attained.
Step 6: The received Oil was then filtered by a thin cotton cloth and the final Yashtimadhu
Siddha Taila was obtained. The prepared Taila was stored in clean air tight container for
further therapeutic use.
Taila Paka Karma
Yashtimadhu
Siddha Taila
rsy
Murchhana Drvyas
mix with Ushna
Taila
Tila Taila
Ushna Karma
Tila Taila, Yastimadhu
Yava Churna and
Murchhana Drvyas Yava
Churna
Prepared Yashtimadhu
Siddha Taila
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
962
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Figure 1: Yashtimadhu Siddha Taila (Medicine) Preparation Procedure.
Table 2: Sneha Siddha Lakshana.[7]
1. ofrZor~ LusgdYd% Sneha kalka attains ‘perfect wick shape’ when rolled
between thumb and index finger.
2. ;nkaxqY;k foefnZr% If a part of Sneha kalka is put into the fire no sound is
produced indicating the loss of moisture in it.
3. Qsuksn~xeLrSys
Qsu’kkfUr’p lfiZ”k%
Foam appears in ‘taila paka’ and it disappears in ‘ghrta
paka’ during completion of preparation.
4. xU/ko.kZjlksRifÙk% Desired colour, odor and taste of the ingredients become
appreciable as the preparation is properly done.
Preservation
Tailas are preserved in glass, or Plastic containers.
Shelf Life Period of Taila
According to Govt. of India notification life period of Taila is three years.
ANALYTICAL STUDY
Introduction
Pharmaceutical analysis helps to confirm the quality of finished drug forms. Though
principles of drug standardization at different stages of pharmaceutics (process and finished
Yashtimadhu Yava Churna
Kalka mix with Taila
Prepared Yashtimadhu
Siddha Taila Chhanan kriya Four time Water mix
for Taila Paka Karma
Taila Paka Karma Second and Third day
Taila Paka Karma
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
963
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
product) have been highlighted at many instances in Ayurvedic treatises it is well known fact
that there has been unprecedented technological advancement. It becomes our duty to utilize
the same and bring more objectivity to the standardization of Ayurvedic formulations. In
present study certain parameters of finished drug that is Yastimadhu Siddha Taila was studied
to ascertain the qualities.
AIMS AND OBJECTIVES
- To evaluate the organoleptic characters of the test drug.
- To carry out the physic-chemical parameters of the Yastimadhu Siddha Taila.
MATERIALS AND METHODS
1. The drug was prepared by Snehapaka method in pharmacy of Dr. S.R. Rajasthan Ayurved
University Pharmacy, Jodhpur by adopting classical method.
2. Complete study was carried out in the Pharmaceutical Chemistry Lab, Dr. S.R. Rajasthan
Ayurved University, Jodhpur. Suitable method was adopted for the study of following
parameters as per CCRAS recommendation.
PARAMETERS STUDIED
Organoleptic parameters
The organoleptic character of Ayurvedic drug is very important and give the general idea
regarding the genuineness of the sample.
Besides quality control measures Rupa (colour), Rasa (taste), Gandha (odour) and Sparsha
(texture) pertaining to Panchagyanendriya Pariksha are noted. These primary parameters are
important, the verification of which generates confidence in patient as well as in the
physician.
Table 3: Organoleptic Parameters of Yashtimadhu.
Sr. No. Parameters Yashtimadhu
1. Roop (Colour) Brownish Yellow
2. Rasa (Taste) Sweet
3. Gandha (Smell) Aromatic
4. Sparsha (Touch) Rough
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
964
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Table 4: Organoleptic Parameters of Yashtimadhu Siddha Taila.
Sr. No. Parameters Yastimadhu Siddha Taila
1. Colour Reddish
2. Odour Like Taila
3. Taste Tasteless
4. Texture Liquid
5. Touch Smooth, Oily
Physico-chemical Parameters
Following parameters were required to develop standards for the reproducibility of
Yastimadhu Siddha Taila. The sample was analysed with appropriate protocols for standard
physicochemical parameters such as.
1. Weight / ml
2. Viscosity (at room Temperature)
3. Saponification Value
4. Acid Value
5. Peroxide Value
6. Detection of Mineral Oil (Holde’s Test)
7. Rancidity Test (Kreis Test)
1. Uniformity of Weight[8]
This test is applicable to tablets that contain less than 10 mg or less than 10% w/w of active
ingredient. For tablets containing more than one active ingredient carry out the test for each
active ingredient that corresponds to the aforementioned conditions.
The test for Uniformity of content should be carried out only after the content of active
ingredient (s) in pooled sample of the tablets has been shown to be within accepted limits of
the stated content.
The test for Uniformity of content is not applicable to tablets containing trace elements.
2. Determination of Viscosity[9]
Viscosity is a property of a liquid, which is closely related to the resistance to flow.
In C.G.S. system, the dynamic viscosity (n) of a liquid is the tangential force in dryness per
square centimeter exerted in either of the two parallel planes placed, 1 cm apart when the
space between them is filled with the fluid and one of the plane is moving in its own plane
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
965
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
with a velocity of 1 cm per second relatively to the other. The unit of dynamic viscosity is the
poise (abbreviated p). The centi. poise (abbreviated cp) is 1/100th of one poise.
While on the absolute scale, viscosity is measured in poise or centi poise, it is most
convenient to use the kinematic scale in which the units are stokes (abbreviated S) and centi-
stokes (abbreviated CS). The centistokes is 1/100th of one stoke. The kinematic viscosity of a
liquid is equal to the quotient of the dynamic viscosity and the density of the liquid at the
same temperature, thus.
Dynamic Viscosity
Kinematic Viscosity = ——————————
Density
Viscosity of liquid may be determined by any method that will measure the resistance to
shear offered by the liquid.
Absolute viscosity can be measured directly if accurate dimensions of the measuring
instruments are known but it is more common practice to calibrate the instrument with a
liquid of known viscosity and to determine the viscosity of the unknown fluid by comparison
with that of the known.
3. Determination Of Saponification Value[10]
The saponification value is the number of mg of potassium hydroxide required to neutralize
the fatty acids, resulting from the complete hydrolysis of 1 g of the oil or fat, when
determined by the following method.
Dissolve 35 to 40 g of potassium hydroxide in 20 ml water, and add sufficient alcohol to
make 1,000 ml. Allow it to stand overnight, and pour off the clear liquor. Weigh accurately
about 2 g of the substance in a tared 250 ml flask, add 25 ml of the alcoholic solution of
potassium hydroxide, attach a reflux condenser and boil on a water-bath for one hour,
frequently rotating the contents of the flask cool and add 1 ml of solution of phenolphthalein
and titrate the excess of alkali with 0.5 N hydrochloric acid. Note the number of ml required
(a) Repeat the experiment with the same quantities of the same reagents in the manner
omitting the substance. Note the number of ml required (b) Calculate the saponification value
from the following formula.
(b–a) × 0.02805 × 1.000
Saponification Value = ——————————————
W
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
966
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Where ‘W’ is the weight in g of the substance taken.
4. Determination of Acid Value[11]
The acid value is the number of mg potassium hydroxide required to neutralize the free acid
in 1 g of the substance, when determined by the following method.
Weigh accurately about 10 g of the substance (1 to 5) in the case of a resin into a 250 ml flask
and add 50 ml of a mixture of equal volumes of alcohol and solvent ether, which has been
neutralized after the addition of 1 ml of solution of phenolphthalein. Heat gently on a water-
bath, if necessary until the substance has completely melted, titrate with 0.1 N potassium
hydroxide, shaking constantly until a pink color which persists for fifteen seconds is
obtained. Note the number of ml required.
Calculate the acid value from the following formula.
a × 0.00561 × 1000
Acid Value = ———————————
W
Where ‘a’ is the number of ml. of 0.1 N potassium hydroxide required and ‘w’ is the weight
in g of the substance taken.
5. Determination of Peroxide Value[12]
The peroxide value is the number of milliequivalents of active oxygen that expresses the
amount of peroxide contained in 1000 g of the substance.
METHOD
Unless otherwise specified in the individual monograph, weigh 5 g of the substance being
examined, accurately weighed, into a 250-ml glass-stoppered conical flask, add 30 ml of a
mixture of 3 volumes of glacial acetic acid and 2 volumes of chloroform, swirl until dissolved
and add 0.5ml volumes of saturated potassium iodide soluton. Allow to stand for exactly 1
minute, with occasional shaking, add 30 ml of water and titrate gradually, with continuous
and vigorous shaking, with 0.01M sodium thiosulphate until the yellow colour almost
disappears. Add 0.5 ml of starch solution and continue the titration, shaking vigorously until
the blue colour just disappears (a ml). Repeat the operation omitting the substance being
examined (b ml). The volume of 0.01M sodium thiosulphate in the blank determination must
not exceed 0.1 ml.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
967
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Calculate the peroxide value from the expression
Peroxide value = 10 (a – b)/w
Where w = weight, in g, of the substance.
6. Detection Of Mineral Oil (Holde’s Test)[13]
Take 22ml of the Alcoholic KOH solution in a conical flask and add 1ml of the sample of oil
to be tested. Boil in a water bath using an air or water cooled condenser till the solution
becomes clear and no oily drops are found on the sides of the flask. Take out the flask from
the water bath, transfer the contents to a wide mouthed warm test tube and carefully add 25ml
of boiling distilled water along the side of the test tube. Continue shaking the tube lightly
from side to side during the addition. The turbidity indicates presence of mineral oil, the
depth of turbidity depends on the percentage of mineral oil present
7. Rancidity Test (Kreis Test)[14]
The test depends upon the formation of a red colour when oxidized fat is treated with conc.
HCl and a solution of phloroglucinol in ether.
The compound in rancid fats responsible for the colour reaction is epihydrin aldehyde. All
oxidized fats respond to the Kreis test and the intensity of the colour produced is roughly
proportional to the degree of oxidative rancidity.
Procedure
Mix 1 ml of melted fat and 1 ml of conc. HCl in a test tube. Add 1 ml of a 1 % solution of
phloroglucinol in diethyl ether and mix thoroughly with the fat-acid mixture. A pink colour
formation indicates that the fat is slightly oxidized while a red colour indicates that the fat is
definitely oxidized.
Table 5: Physico-chemical Parameters.
Sr.No. Tests (Method as per API & CCRAS Guidelines) OBSERVATION
1. Weight / ml 0.885 gm / ml
2. Viscosity (at room Temperature) 37.503 centipoise
3. Saponification Value 178.117
4. Acid Value 9.368
5. Peroxide Value 5.421
6. Detection of Mineral Oil (Holde’s Test) Negative
7. Rancidity Test (Kreis Test) Negative
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
968
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Figure 2 : Report of Physico - Chemical Parameters by Quality Control Laboratory,
P.G. Dept. of RSBK, UCA, DSRRAU, Jodhpur.
DISCUSSION
Taila kalpana may be defined as a process, where ingredients like-Taila, Kalka, Kwatha
dravyas are used for the preparation of medicaments.
Fat / water soluble active principles of drugs are extracted into Taila in this method.
During the preparation extra benefits of Taila are added in formulations as their qualities
are also mixed in drugs.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
969
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
Cooking should be done on medium temperature. Special emphasis should be given on
Stage detection during preparation as therapeutic indications changes with the stages.
Medicated Taila are having more extra power and shelf life than unmediated one.
The organoleptic character of Ayurvedic drug is very important and give the general idea
regarding the genuineness of the sample.
Besides quality control measures Rupa (colour), Rasa (taste), Gandha (odour) and
Sparsha (texture) pertaining to Panchagyanendriya Pariksha are noted. These primary
parameters are important, the verification of which generates confidence in patient as well
as in the physician.
There is cutting and burning pain in ano predominantly present in a pattern in Parikartika
as the disease is Vata- Pitta predominant. Yastimadhu being Vata- Pitta Shamaka helped
to relieve both these symptoms. In the patients Yastimadhu also has Vrana Shodhana
(wound cleansing) and Vrana Ropana (wound healing) properties that helped for healing
of fissure wound.
Til Taila (Sesamum indicum) similarly has a soothning property. It form a thin film layer
on the fissure bed and that allows early epithelization of wound. It also protects wound
from invasion of any microbes. Taila also reduce the Rukshata of Vayu and maintain the
normal tone of smooth internal sphincters which result into good blood circulations &
helped in healing process.
In fissure in ano, the ulcer is at muco-cutaneous junction and it heals as Yastimadhu
Siddha Taila having healing potency in mucosal inflammation and ulcer.
The underlying pathology in Parikartika is spasm of the sphincter muscle and slight
narrowing of the anal canal. This phenomenon is due to the formation of ulceration in
anal mucosa. During the act of defecation when the anal canal is stretched the pain will
aggravate which will in turn cause spasm of the sphincter muscle. Thus the vicious cycle
is formed.
The Yastimadhu Siddha Taila will break this vicious cycle. The gradual process of
analgesia gradually relaxes the anal canal. The relaxed anal canal will reduce the
sphincter spasm, which will in turn allow the ulcer to heal. Relaxed anal canal will
accommodate hard stools minimizing trauma over the anal canal and allows the ulcer to
heal.
One research study shows the Post-radiation mucosal complications were reduced with
Yashtimadhu[15]
has Madhura Rasa, Sheeta Virya, Madhura Vipaka.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
970
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
It is Vata-Pitta Shamaka. Moreover, studies conducted on modern scientific parameters
have proved the healing, anti-ulcer, anti-inflammatory and skin regeneration activity of
Yashtimadhu.[16]
Sodium, glycyrrhizate possessed anti-ulcer activity and stimulation of
regeneration of skin.
Yashtimadhu contains glycyrrhizin acid and ammonium salt [GA] which has proven
activity of ulcer healing according to some pharmacological articles[17]
it reduces number
of inflammatory cells, and enhanced fibroblasts maturation and tissue alignment and on
ulcer healing show increase in the percentage of ulcer contraction and epithelization.[18]
CONCLUSION
Formulations prepared from the Taila enhance life, complexion, strength and anabolism
of body.
The water soluble as well as fat soluble active principles can be transformed into Taila
media and this addition of properties of material made the formulation more potent and
effective.
Shelf life period of Taila kalpana is three years.
Formulations should be analysed with all the parameters laid down in ancient and modern
texts to standardize them.
This Taila Kalpana is Madhyam Paka Process, a part of Sneha kalka is put into the fire
no sound is produced indicating the loss of moisture in it.
The organoleptic character of Ayurvedic drug is very important and give the general idea
regarding the genuineness of the sample.
Medicated Taila are having more extra power and shelf life than unmediated one.
Yastimadhu being Vata- Pitta Shamaka helped to relieve both these symptoms. In the
patients Yastimadhu also has Vrana Shodhana (wound cleansing) and Vrana Ropana
(wound healing) properties that helped for healing of fissure wound.
Tila Taila (Sesamum indicum) similarly has a soothning property. It form a thin film
layer on the fissure bed and that allows early epithelization of wound. It also protects
wound from invasion of any microbes. Taila also reduce the Rukshata of Vayu and
maintain the normal tone of smooth internal sphincters which result into good blood
circulations & helped in healing process.
In fissure in ano, the ulcer is at muco-cutaneous junction and it heals as Yastimadhu
Siddha Taila having healing potency in mucosal inflammation and ulcer.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
971
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
REFERENCES
1. Bhaisajya Kalpana Vijnanam, Chaukhambha Sanskrit Bhawan publication Varanasi,
Edition: Reprint 2009, Writer Dr. K. Rama Chandra Reddy, 246
2. Krisna Murthy MS etall, M.D. thesis, RSBK, IPGT&R, Jamnagar, 2002.
3. Pt. Kashinath Shastri, Acharya Charaka’s Charaka Samhita, Part I,Chaukhamba Sanskrit
Samsthana, 8th Edition Page No. 258.
4. Kaiyadeva Nighantu, edited and translated by Prof P V Sharma, Choukhamba oriental, 1st
edition, pp 696, pg 373.
5. P V Sharma, Dravya guna Vigyana Vol-2, 17th
Edition, Varanasi, Chaukhambha Bharati
Academy, 1996; 873: No-253.
6. Sharangadhar Samhita Madhyam Khand 9/1 jeevanprada vyakhya by Shaileja
Shrivastava,Chaukhambha orientalia,Varanasi, 2009.
7. Bhaisajya Kalpana Vijnanam, Chaukhambha Sanskrit Bhawan publication Varanasi,
Edition: Reprint 2009, Writer Dr. K. Rama Chandra Reddy, 246.
8. UNIFORMITY OF WEIGHT, PROTOCOL FOR TESTING FOR AYURVEDIC,
SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director; Govt. of India
Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines, Ghaziabad.
9. DETERMINATION OF VISCOSITY, PROTOCOL FOR TESTING FOR
AYURVEDIC, SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director;
Govt. of India Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines,
Ghaziabad.
10. DETERMINATION OF SAPONIFICATION VALUE, PROTOCOL FOR TESTING
FOR AYURVEDIC, SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director;
Govt. of India Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines,
Ghaziabad.
11. DETERMINATION OF ACID VALUE, PROTOCOL FOR TESTING FOR
AYURVEDIC, SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director;
Govt. of India Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines,
Ghaziabad.
12. DETERMINATION OF PEROXIDE VALUE, PROTOCOL FOR TESTING FOR
AYURVEDIC, SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director;
Govt. of India Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines,
Ghaziabad.
www.wjpps.com │ Vol 10, Issue 9, 2021. │ ISO 9001:2015 Certified Journal │
972
Goran et al. World Journal of Pharmacy and Pharmaceutical Sciences
13. DETECTION OF MINERAL OIL(Holde’s Test), PROTOCOL FOR TESTING FOR
AYURVEDIC, SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director;
Govt. of India Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines,
Ghaziabad.
14. RANCIDITY TEST (Kreis Test), PROTOCOL FOR TESTING FOR AYURVEDIC,
SIDDHA & UNANI MEDICINES BY DR. D.R. LOHAR, Director; Govt. of India
Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines, Ghaziabad.
15. Ministry of Health & Family Welfare. Vol. 3. New Delhi: Department of AYUSH,; Data
base of Indian Medicinal Plants –Government of India; p. 562. (e book).
16. http://www.energy.sk/info/menu_x2055x.asp.
17. International journal of pharmaceutical and biological archiveves, 2013; 4(5): 833-841
18. Physico-chemical evaluation of Yashthimadhu ghrita ijmhs, july 2014; I(1).