Pharma R&D 2020 infographic/media/informa-shop-windo… · Cream of the crop for a fourth...
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Sample a veritable banquet of different data points to get a flavor of whereR&D is heading as we move into an exciting new decade.
Pharma R&DAnnual Review 2020
Nearly double-digit growth, as pharma piles on the weight
4,730new drugs added in 2019
Apertif Total Pipeline Size
Will larger portions early in the meal sate pharma’s hunger?
Hors D’oeuvreThe 2020 Pipeline by Phase
Pharma’s gourmands grow leaner,but are they fitter?
Main CourseTop Companies
With 6,504 drugs in R&D, cancer candidates
comprise 36.7% of all of
pharma’s larder,
and the total oncology franchise has grown by 14.2%, outpacing once
again the overall level of pipeline expansion.
Neurologicals post fewer than half as many
candidates, and show a more modest increase,
with a 10.2% growth rate,
while Alimentary/Metabolics is up by a smaller portion
(8.0%).
Anti-infectives was the only therapeutic area to record an actual decline
– shrinking by 1.7%.
And this is at a time where the growth of
antimicrobial resistance means that the need for
new antibacterial drugs is more pressing than ever,
and a zoonotic viral infection is causing
worldwide consternation.
At the top table, the oncology feast continues
Second CourseTop Therapies
In a top 10 which hasn’t changed much this year, immuno-oncology and other related categories again put in a strong showing.
Just outside of the 10 is the first appearance of a newly created category for Gene editing. Although no therapeutics utilizing gene editing have yet
moved beyond Phase II clinical trials, with 117 candidates already under development, this is clearly one hot potato.
New recipes and novel ingredients adding spice to R&D
Third CourseMechanisms and Targets
Biologicals have the sweet taste of success
DessertTypes of Pipeline Drugs
17,737drugs in active development
9.62%growth rate
Preclinical
13.2%increase, over
double last year’s rise of 6%
Phase I
10.3%increase,
outperforming last year’s 7.2% and
3.0% rise in 2018
Phase II
4.4%increase, down
from 2019’s 9.2%
Phase III
1.9%increase, a minor rise as Phase III
remains flat for the past four years
So, there is still considerable failure at Phase II,where there is arguably the biggest productivity challenge
Preclin Phase I Phase II Phase III Pre-reg Registered Launched Suspended
8520
9646
2281
2516
2576
2694 10
09
199
246
152
130 12
73
1324
60 60
N/A
111
10110
20
2019 2020
Dru
g Co
unt
Source: Pharmaprojects® January 2020Note: N/A = Not Applicable and is applied to Companion diagnostics prelaunch
Source: Pharmaprojects® January 2020
Position Company No. of drugs No. of originated 2020 (2019) in pipeline drugs 2020 2020 (2019)
1 (1) Novartis 222 (219) 139
2 (2) Takeda 198 (211) 89
3 (11) Bristol-Myers Squibb 189 (110) 97
4 (3) Johnson & Johnson 182 (208) 91
5 (6) Roche 174 (189) 94
6 (9) Pfizer 170 (163) 108
7 (4) AstraZeneca 164 (194) 93
8 (8) Merck & Co. 157 (176) 84
9 (7) GlaxoSmithKline 144 (177) 77
10 (10) Eli Lilly 143 (124) 85
Top pharma companies by size of pipeline
Cream of the crop for a fourth consecutive year is Novartis, which increases its pipeline size only slightly, but has extended its lead over its nearest rival, Takeda.
In the runner-up position, Takeda’s pipeline shrinks slightly as it continues with its digestion of Shire.
Bulking up this year though is Bristol-Myers Squibb, back into the top 10 after swallowing up Celgene. This was the third biggest pharma deal in history, but will this deal have the right ingredients to serve up a tasty concoction?
260
267
113
113
Hor
mon
al
Antip
aras
itic
Source: Pharmaprojects® January 2020
2019 2020
5697
6504
Antic
ance
r
Bio
tech
nolo
gy54
2261
35
2775
3057
2407
2599
2173
2254
2270
2232
1611
1731
977
1083
962
1036
892
1000
920
972
882
920
665
675
Neu
rolo
gica
l
Alim
enta
ry/M
etab
olic
Refo
rmul
atio
ns
Anti-
Infe
ctiv
e
Mus
culo
skel
etal
Imm
unol
ogic
al
Der
mat
olog
ical
Sens
ory
Card
iova
scul
ar
Resp
irat
ory
Gen
itour
inar
y
Blo
od &
Clo
ttin
g66
467
5
Dru
g Co
unt
Position Mechanism of action (pharmacology) No. of active 2020 (2019) compounds 2020 (2019)
Source: Pharmaprojects® January 2020
1 (1) Immuno-oncology therapy 2,605 (1,875)
2 (2) Immunostimulant 1,293 (1,387)
3 (3) T cell stimulant 718 (404)
4 (4) Immune checkpoint inhibitor 404 (327)
5 (5) Immunosuppressant 191 (199)
6 (6) Angiogenesis inhibitor 191 (186)
7 (7) Gene expression inhibitor 154 (154)
8 (9) Radiopharmaceutical 147 (122)
9 (7) Vascular endothelial growth factor (VEGF) receptor antagonist 140 (149)
10 (10) Apoptosis stimulant 127 (127)
11 (-) Genome editing 117 (-)
12 (10) Opioid mu receptor agonist 114 (116)
13 (14) Immune checkpoint stimulant 113 (99)
14 (21) PD-L1 antagonist 103 (74)
15 (130) CD3 agonist 100 (22)
Source: Pharmaprojects® January 2020
Position Origin No. of active 2020 (2019) products 2020 (2019)
1 (1) Chemical, synthetic 8,921 (8,285)
2 (2) Biological, protein, antibody 2,224 (2,041)
3 (3) Biological, protein, recombinant 795 (840)
4 (10) Biological, cellular, autologous 602 (340)
5 (4) Biological, protein 549 (520)
6 (7) Biological, nucleic acid, viral vector 485 (407)
7 (6) Chemical, synthetic, peptide 478 (428)
8 (5) Biological, cellular 464 (512)
9 (9) Biological, virus particles 405 (373)
10 (8) Chemical, synthetic, nucleic acid 401 (392)
2020 sees the pharma industry looking well fed and in rude health.
It has most of the ingredients it needs to
cook up an exciting menu of new dishes,and, increasingly,
the right recipes too.
While chemical synthesis, the traditional medicinal chemistry way of making drugs, continues to be the industry’s bread and butter,
it has over the past couple of decades acquired a taste for biologicals.
Rising from10th to 4th place,autologous cellular therapies (CAR-T and the like) are the cream in the process of rising to the top.
12 000
0
2 000
6 000
10 000
4 000
8 000
18 000
16 000
14 000
20 000
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
Dru
g Co
unt
Source: Pharmaprojects® January 2020
5995 6198 64166994 7360 7406 7737
9217 9605 9737 971310452 10479
1130712300
13718
14872 1526716181
17737
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