Ph. D. Ph.D. Ph .D. Ph.D. Ph.D. &...

DEPARTMENTOF PHYSIOLOGYUNIVERSITYOF KANSASMEDICALCENTER

COLLEGEOF HEALTHSCIENCESANDHOSPITALANNUALREPORT

July 1, 1977 - June 30, 1978

Department Roster

a. AcademicStaff

G. S. Greenwald, Ph.D., Distinguished Professor and ChairmanD. C. Johnson, Ph.D., Professor (Joint appt. Ob-Gyn)F. E. Samson,Ph.D., Professor (and Director of Ralph Smith Center for

Mental Retardation Research)L. P. Sullivan, Ph.D., ProfessorA. M. Thompson,Ph.D., ProfessorR. l. Clancy, Ph.D., Associate ProfessorN. C. Gonzalez,M.D., Associate ProfessorJ. B. Rhodes,M.D., Associate Professor (Joint appt. Medicine)C. r.1.Tarr, Ph.D., Associate ProfessorJ. W. Trank, Ph.D., Associate ProfessorJ. L. Voogt, Associate ProfessorJ. D. Wood,Ph.D., Associate ProfessorJ. S. Connor,Ph.D., Assistant Professor (one year only appointment)H. J. Cooke,Ph.D., Assistant ProfessorW. K. Legler, Ph.D., Assistant ProfessorP. F. Terranova, Ph.D., Assistant ProfessorK. L. Goetz, M.D., Ph.D., Adjunct ProfessorBin C. Wang,Ph.D., Adjunct Instructor

b. Postdoctoral FellowsHector D. Croxatto, M.D.Paul R. Leiffer, Ph.D.Srinivas K. Saidapur, Ph.D.KazuyushiTaya, D.V.M.Archie Vomachka,Ph.D.Harold L. Wilkinson, Ph.D., Instructor

c. Graduate Students Candidate ForPrelims

Oennis C. FaterRobert E. OINeillChon-HwaTsaiDianne L. VermillionMary S. VomachkaDan F. \1atson 10/77

Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.& N.D.

Degree Require-ments Fulfilled

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Notes concerning graduate students:

Danny Watson was named to Who.s WhoAmongGraduate Students in Colleges andUniversities, 1977.

On February 2, 1978 on Medical Student Research Day, ten students presentedpapers, and Danny Watson was the winner of the Russell Haden Medal, the top prizefor medical student research. His paper "Pargyline induces faster components ofaxonal transport in motor neurons" was then presented at the 1978 National StudentResearch Forum in Galveston, Texas which was held May 26-29.

";non-H\AJaTsai presented a paper on "Temporal changes in steroid synthesis bycultured hypophysectomized rat ovaries" on Graduate Student Research Day, March 3.COURSESTAUGHT

101 - Elementary Physiology (F), part of a 1,000 hour course for Emergency Care.Taught by Dr. Thompson, Ms. Linda Gericke and graduate students.Enrollment 19

388 - HumanPhysiology (F), undergraduate physiology course. TaughtLegler, Samson, Terranova and Graduate Student Danny Watson.Enrollment 120.(S) Special session taught by Drs. Samson and Terranova.Enrollment 5.

by Drs. Cooke,

705 - Advanced HumanPhysiology (F).Terranova.Enrollment 33.

Taught by Drs. Clancy, Cooke, Sullivan and

806 - Endocrinology (FO). 3 hours. Taught by Drs. Johnson, Greenwald, Sullivanand Voogt, in conjunction with faculty from Biochemistry.Enrollment 6.

818 - Gastroenterology (SE) 2 hours.Enrollment 6.

Taught by Drs. Rhodes, Woodand Cooke.

825 - Biology of Sex (FO) 2 hours.Enrollment 10.

Taught by Dr. Johnson.

830 - Cardiovascular Physiology (FO) 3 hours.Drs. Goetz and Wang.Enrollment 7.

Taught by Dr. Clancy, assisted by

800 - (770-771) - Medical Physiology. Taught by staff.Fall course enrollment - 122 medical students and 2 graduate students.Spring course - 87 medical students and 3 graduate students.

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DepartmentSeminars

9/26/77 Or. Ralph Adams, Chemistry, KU Electrochemistry techniquesapplied to brain functionsrated to catecho1aminesEffect of exercise on thecardiovascular systemElectrophysiology and computeranalysis of sleept1icrotubule dynamics & gluta-thione metabolism in phago-cytosing human neutrophilsGrowth hormone binding and cor-

relation with growth hormonetherapy

Intracellular recording ofelectrical activity in neuronsof Auerbach's plexusExogenous progesterone: negativeeffects on estrogen secretionMechanisms of platelet aggregation:studies with adenine analogsFSHand cAMPactions on Serto1icells in cultureOverview of the educationalsupport services at KUMCMemory control processes andtheir developmentGenetic studies and hypertension

10/ 3/77

10/1 0/77

10/17/78

10/24/77

10/31/77

11/ 7/77

11/14/77

11/28/77

12/ 5/77

1/23/78

1/30/78

2/ 6/78

2/20/78

2/27/783/13/78

3/20/78

4/24/785/ 8/78

Dr. Wayne Osness, Health, Phys. Ed. &Recreation, KU

Or. E. Othmer, Psychiatry

Or. Brower Burchill, Physiology & CellBiology, KU

Dr. Wayne Moore, Pediatrics

Or. J.D. ~Iood

Or. Gilbert S. Greenwald

Or. Helen Maguire

Dr. John C. Davis, Physiology & CellBiology, KU

Dr. A. J. Yarmat, learning Resources

Or. Earl Butterfield, Pediatrics

Or. Gunther Schlager, Systematics &Ecology, KU

Dr. Michael Si1verglat, Psychiatry Platelet as a model for synapticchemistryFunctional and anatomical aspectsof amphetamine stereotypiaUpdate on the blood-brain barrierThe effect of ouabain on K trans-port in the bullfrog kidneyMechanical properties of thesingle cardiac cellsOvarian steroidogenesisTransport characteristics ofnewborn rabbit intestine

Dr. Stanley Nelson, Pharmacology

Dr. Alan M.ThompsonDr. Harold l. Wilkinson

Or. Merri 11 Tarr

Or. Donald C. JohnsonOr. Helen J. Cooke

Outside Speakers

8/25/77 - Dr. Richard E. TalbottDepartment of PhysiologyUniversity of Oregon Health Sciences Center"In quest of a functional model for postural control in dogs and humansII

9/ 1/77 - Dr. PaulO. CheneyDepartment of Physiology & BiophysicsUniversity of Washington School of Medicine

"Organization and functional properties of the corti co-motor neuronalsystem in the primate"

10/12/77 -

11/ 1/77 -

11/17117 -

12/12/77 -

3/ 3/78 -

3/ 6/78 -

3/31118 -

4/ 3/18-

4/19/78-

5/ 1/78-

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Dr. G. ten BruggencateProfessor and Chairman, Physiological InstituteUniversity of Munich School of Medicine

"Potassium and calcium concentration measured with ion selective micro-electrodes in the extracellular fluid of the cerebellum during quiescenceand stimulus-evoked activity"Dr. Andrew P. EvenDepartment of AnatomyUniversity of NewMexico

"Developmental aspects of proximal tubule and intrarenal vascular systemin puppy kidney"

Dr. Narender P. ReddyCardiovascular Research InstituteUniversity of California, San Francisco

"Lymph propulsion"Dr. J. H. GordonDepartment of AnatomyUniversity of California, Los Angeles

"Alterations of estrogen sensitivity in septal 1esioned rats"Dr. Abba KastinProfessor of Medicine, Tulane University& Chief, Endocrinology Section, VAHospitalNewOrleans, Louisiana

"CNSeffects of hypothalamic-pituitary peptides"

Or. Frank t~oodyProfessor and Chairman, Department of SurgeryUniversity of Utah

"Gastric mucosal barrier"

Dr. Judith A. RamaleyDepartment of PhysiologyUniversity of Nebraska

"Theories of puberty onset"Or. Peretz LavieBehavioral Biology DepartmentIsrael Institute of Technology

"Ninety minute ultradian biorhythmsDr. Howard BernDepartment of ZoologyUniversity of California, Berkeley

"The evolution of prolactin"

Dr. Arnold M. KatzHead, Division of CardiologyUniversity of Connecticut

"Actions of the adrenergic nervous

during sleep and wakefulness"

system on the heart"

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6/ 5/78 - Dr. David DawsonDepartment of PhysiologyUniversity of Iowa

"Cation selectivity of activecolon"

transport pathway in the isolated turtle

Publications

a. Published during year - July July 1, 1977-June 30, 1978.

Brann, l., D. Furtado, C. V. Mig1iazzo, J. Barenda1e and J. D. Wood. Secondaryeffects of aganglionosis in the piebald-lethal mouse model of Hirschsprung1s disease.Journal of laboratory Animal Science 27:946-954.

Carr, l. A., P. M. Conwayand J. l. Voogt. Role of norepinephrine in the releaseof prolactin induced by suckling and estrogen. Brain Research 133:305-314, 1977.

Chiras, D. D. and G. S. Greenwald. An autoradiographic study of long-term folliculardevelopment in the cyclic hamster. Anat. Rec. 188:331-338, 1977.

Chiras, D. D. and G. S. Greenwald. Effects of steroids and gonadotropins onfollicular development in the hypophysectomized hamster. Am. J. Anat. 152:307-320,1978.

Chiras, D. D. and G. S. Greenwald. Acute effects of unilateral ovariectomy onfollicular development in the cyclic hamster. J. Reprod. Fert. 52:221-225, 1978.

Clancy, R. L. and M. Quinlan. Chapter 19, Sex for the Cardiac Patient, in:HumanSexuality for Health Professions, M. W. Barnard, B. J. Clancy, and K. K.Krantz, eds. W. B. Saunders Co., 1978. pp. 249-258.

Cooke, H. J. and D. C. Dawson. Transport characteristics of isolated newbornrabbit ileum. Am. J. Physio1. 234:£257-£261,1978.

Cuppage, F. E., K. Setter, l. P. Sullivan, E. J. Reitzes and A. O. Me1ynkovych.Gentamicin Nephrotoxicity. II. Physiological, Biochemical and MorphologicalEffects of Prolonged Administration to Rats. Virchows Archiv. B. Cell Path. 24:121-138, 1977.

Deeds, D. G., l. P. Sullivan, R. A. Fenton, J. n. Tucker and F. E. Cuppage.Function and Structure of the Perfused Bullfrog Kidney. Am. J. Physio1. 233:481-490, 1977.

Donoso, J. A.,D. F. Watson, I. E. Heller-Bettinger and F. E. Samson. Maytansineaction on fast axop1asmic transport and the ultrastructure of vagal axons.Cancer Res. 38:1633-1637, 1978.

Englert, E., J. W. Freston" O. Y. Graham and J. B. Rhodes. Cimetidine, antacidand hospitalization in the treatment of benign gastric ulcer. A multicenterdouble-blind study. Gastroenterology 74:416-425, 1978.

Erwin, O. N., T. Ninchoji and J. D. Hood. Effects of morphine on electrical activityof single myenteric neurons in cat small bowel. European Journal of Pharmacology41:401-405, 1918.

Fenton, R. A., N. C. Gonzalez and R. l. Clancy. The effect of dibutyryl cyclic AMPand glucagon on the myocardial cell pH. Respir. Physio1. 32:215-227, 1978.

Greenwald, G. S. Recent advances in ovarian endocrinology. Proc. 25th EastCongress of Japan Endocrinological Society, Sendai, pp. 1-9.

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Greenwald, G. S. and J. D. Bast. Hormone patterns in pregnant and pseudopregnanthamsters after unilateral ovariectomy or hysterectomy. Bio1. Reprod. 18:658-662.

Jiminez, A. E., J. l. Voogt and l. A. Carr. Plasma luteinizing hormone andprolactin levels and hypothalamic catecholamine synthesis in steroid-treatedovariectomized rats. Neuroendocrinology 23:341-351,1977.

Jiminez, A. E., J. l. Voogt and l. A. Carr. l-3, 4-dihydroxyphenyla1anine (l-Dopa)as an inhibitor of prolactin release. Endocrinology 102:166-174, 1978.

Johnson, D. C. and H. C. Cheng. Effect of diethylstilbestrol on ovarian responsesto Pregnant Mare's Serum gonadotropin in hypophysectomized immature rats.Endocrinology 102:1563-1569, 1978.

levin, J. I. and J. l. Voogt. Effects of dopamine, norepinephrine and serotoninon plasma prolactin levels in ovariectomized, pituitary-grafted rats. PSEBN157:576-579, 1978.

McCamman,S., P. l. Beyer and J. B. Rhodes. A comparison of three elementaldiets in normal volunteers. Am. J. C1in. Nutr. 30:1655-1660, 1977.

Rhodes, J. B., C. Arvanitakis and J. Folscroft. Intestinal hydrolysis of disac-charides and peptides: Comparison of hydro1ases and perfusion studies. CibaFoundation Symposium50 (new series). Elsevier/Excerta f1edica/North-Ho11and,Amsterdam. pp. 246-263, 1977.

Rhodes, J. B., J. E. Zvargulis, C. H. Williams, G. Gonzales and R. E. Moffat.Oral electrolyte overload to cleanse the colon for co10noscopy. GastrointestinalEndoscopy 24:24-26, 1977.

Rhodes, J. B., F. Holmes and S. Clark. Changing distribution of primary cancersin the large bowel. J. Am. Med. Assoc. 238:1614-16433, 1977.

Rhodes, J. B., J. H. Abrams, R. T. Manning. Controlled clinical trial ofsedative-anticholinergic drugs in patients with the irritable bowel syndrome.J. Clin. Pharm. 18:340-345, 1978.

Rhodes, J. B., J. Engstrom, K. F. Stone. Metoclopramide reduces the distressassociated with colon cleansing by an oral electrolyte overload. GastrointestinalEndoscopy 24:162-163, 1978.

Saidapur, S. and G. S. Greenwald. Sites of steroid synthesis in the hamsterovary. A histochemical study. Am. J. Anat. 151:71-86, 1978.

Saidapur, S. and G. S. Greenwald. Peripheral blood and ovarian levels of sexsteroids in the cyclic hamster. Biol. Reprod. 18:401,408,1978.

Samson, F. E. Axonal Transport. The mechanisms and their susceptibility toderangement: Anterograde transport in the neurobiologic mechanisms in manipulativetherapy. Ed. I. M. Korr, Plenum Publishing Co., NewYork, 1978. pp. 291-309.

Strome, D. R., R. l. Clancy and N. C. Gonzalez. Determinants of transmembrane HCOjflux during acid-base changes. J. Appl. Physiol. 43:925-930, 1977.

Strome, D. R., R. l. Clancy and N. C. Gonzalez. Contribution of a net transmembraneHC03 flux to intracellular acid-base regulation. J. Appl. Physio1. 43:931-935,1977.

Sullivan, l. P., D. J. Welling, O. G. Oeeds and J. N. Simone. Kinetic analysisof potassium transport in the bullfrog kidney. Am.J. Physiol. 233:464-480,1971.

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Terranova, P. F. and G. S. Greenwald. Steroid and gonadotropin levels during theluteal-follicular shiftof thecyclichamster. Biol. Reprod. 18:170-175,1978.

Wang, B. C., D. D. Bloxhamand K. l. Goetz. Effect of dipivalyl derivatives ofcatecholamines on cardiovascular function in the conscious dog. J. Pharmacol. Exp.Therap. 203:442-443, 1977.

Wang, B. C., N. J. Mueting and K. l. Goetz. Hemodynamicchanges during acutesalicylate intoxication in conscious dogs. Proc. Soc. Exp. Biol. Med. 157:531-535, 1978.

Wantzelius, D. G. and K. l. Goetz. Circuit for automatically zeroing aortic flowbaseline from electromagnetic flowmeter. Am. J. Physio1. 232:H534-536, 1977.

Wantzelius, D. G. and K. l. Goetz. labour-saving 7-channe1 data averager/printerfor cardiovascular and other physiological signals. Med. Bio1. Engr. Computing16:73-77, 1978.

Wood, J. D. Inhibitory neural control of intestinal circular muscle. ProceedingsBulgarian Academy of Sciences, 1977, pp. 91-96.

Wood, J. D. and C. J. Mayer. Intracellular study of electrical activity ofAuerbach's plexus in guinea-pig small intestine. Pf1eugers Archiv 374-265-275, 1978.

Wood, J. D. and C. J. Mayer. Electrical activity of myenteric neurons: Comparisonof results obtained with intracellular and extracellular methods of recording.In: Gastrointestinal Motility in Health and Disease, E. Duthie, ed. ;~TPPressltd., lancaster, England, 1978, pp. 311-321.

b. In press

Chatterjee, S. and G. S. Greenwald. Biochemical changes in the corpora luteaof pregnant and lactating hamsters. J. Endocr., in press.

Chiras, D. D. and G. S. Greenwald. Ovarian follicular development in cyclichamsters treated with a superovulatory dose of pregnant mare's serum. Biol.Reprod., in press.

Cooke, H. J. and A. R. Cooke. Composition of intestinal secretion, in: Handbookof Nutrition and Food, CRCPress, in press.

Dunn, J. D. and D. C. Johnson. Effect of adrenalectomy on temporal patterns ofserum gonadotropin levels. Neuroendocrinology, in press.

Greenwald, G. S. Commentson some aspects of early follicular development.Workshop on Ovarian Follicular Development and Function. Raven Press, in press.

Greenwald, G. S. Follicular development in the mammalian ovary. In: The Verte-brate Ovary, l. E. Jones, ed., Plenum Press, in press.

Greenwald, G. S. Comparative aspects of antral follicular development duringthe menstrual and estrous cycle. In: Animal Models for Research on Contraceptionand Fertility. Harper and Row, in press.

Greenwald, G. S. Introductory remarks: Ruminations on ovarian function. In:Ovarian Follicular and Corpus luteum Formation, C. Channing, ed. Plenum Press,in press.

Greenwald, G. S.injection of lH.

Ovulatory response of hypophysectomized hamsters to deferredJ. Reprod. Fert., in press.

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Greenwald, G. S. Modification by exogenous progesterone of estrogen and gonado-tropin secretion in the cyclic hamster. Endocrinology, in press.

legler, ~~. K. Book chapter, "Telemetry", in Turtles: Perspectives and Research,Marion Harless, ed. John Wiley and Sons, NewYork, in press.

Rhodes, J. B., J. E. Zvargu1is, Hartong, H. H. Right colon loop: A potentialpitfall for total co10noscopy. Endoscopy, in press.

Saidapur, S. and G. W. Greenwald. Ovarian steroidogensis in the proestroushamster. Biol. Reprod., in press.

Saidapur, S. and G. S. Greenwald. Antral follicular and interstitial contributionsto progesterone secretion in the proestrous hamster. In: Ovarian Follicularand Corpus luteum Formation, C. Channing, ed. Plenum Press, in press.

Siegel, H. I. and G. S. Greenwald. The effects of mother-litter separation onlater maternal responsiveness in the hamster. Physiol. Behavior, in press.

Siegel, H. I. and G. S. Greenwald. The temporal pattern of lH, FSHand ovulatoryresponsiveness to luteinizing hormone releasing hormone in the cyclic hamster.Proc. Soc. Exp. Bio1. Med., in press.

Tarr, ~i. and J. W. Trank. Chemically mediated ce11-to-cell contractile activationin isolated frog atrial cardiac cells. Experientia, in press.

Terranova, P. F., Connor, J. S. and G. S. Greenwald. In vitro steroidogenesisin corpora lutea and non-luteal ovarian tissues of the-Cyclic hamster. Bio1.Reprod., in press.

Terranova, P. F. and G. S. Greenwald. The influence of various doses of ergo-cryptine {ECR}on duration of pseudopregnancy in hysterectomized hamsters.Endocrinology, in press.

Vomachka, A. J. and G. S. Greenwald. Acute negative feedback effects of ovariansteroid removal and replacement in the cyclic female hamster. Bio1. Reprod.,in press.

Voogt, J. L. Control of hormone release during lactation. Clinics in Obstetricsand Gynecology 5, in press.

Wood, J. D. The enteric nervous system. In: Autonomic Nervous System, C. Me. Brooks,K. Koizumi and A. Sato, eds. Tokyo University Press, in press.

Wood, J. D., C. J. Mayer, T. Ninchoji and D. N. Erwin. Effects of depletedcalcium on electrical activity of neurons in Auerbach's plexus. Am. J. Physiol.,in press.

c. Abstracts

Clancy, R. L. and C. Branson. effect of norepinephrine and acetylcholine onmyocardial cell pH. Fed. Proc. 37:783, 1978.Clancy, R. L., R. A. Fenton and N. C. Gonzalez. Regulation of myocardial cell pH.Int. Union Physiol. Sciences 13:140, 1977.Connor, J. S. and G. S. Greenwald. Serumendocrine profiles during lactationand the subsequent return to ovulatory activity in the hamster. Fed. Proc. 37:Abst. 395, 1978.

Cooke, H. J., C. Arvanitakis, J. Fo1scroft and J. Bornstein. Effect of aspirin onjejunal alanine and glucose transport in the rat. Fed. Proc. 37:722, 1978.

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Erwin, D. N., T. Ninchoji and J. D. Wood. Effect of morphine on spontaneouslyactive single units of cat myenteric plexus. Society for Neuroscience 3:290, 1977.

Geer, P. G. and K. l. Goetz. Effect of hypotonic and isotonic iv infusions on ADH,renin and renal function in dogs. Physiologist 20:32, 1977.

Goetz, K. l., B. C. Wangand D. C. Fater. Plasma vasopressin levels and urineflow are not altered by application of a local anesthetic to the left atrialsurface. Fed. Proc. 37:704, 1978.

Gonzalez, N. C. and D. R. ~trome. Effects of extracellular HCOjconcentration onextra to intracellular HC03 flux during hypercapnia. Proc. Int. Union of Physiol.Sciences, Paris, 23:272, 1977.

Gonzalez, N. C., H. G. Wemkenand N. Heisler. Buffering properties of normal andhypertrophic myocardium. Pf1ugers Arch. 363:R40, 1978.

Grate, P., J. D. Woodand C. J. Mayer. long duration excitability change inguinea-pig myenteric neurons. Pf1ugers Archiv. (In press).

Johnson, D. C. Adrenal 17a-hydroxy1ase activity in the rat. Abst. 249, EndocrineSociety, 1978.

Levin, J. I. and J. l. Voogt.Fed. Proc. 37:1209, 1978.

Mayer, C. J. and J. D. Wood. Spontaneous activity in neurons of Auerbach's plexusrecorded with intracellular microe1ectrodes. XXVII International Congress ofPhysiological Sciences 13:493, 1977.

Mayer, C. J. and J. D. Wood. Intace11u1ar study of excitatory action of serotonin onneurons of Auerbach's plexus. Pf1ugers Archiv Supp1. 373,R65, 1978.

Mayer, C. J. and J. D. Wood. Intace11ular study of electrical behavior in tonictype myenteric neurons of guinea pig small bowel. Fed. Proc. 37:227, 1978.

Mayer, C. J., J. D. Woodand P. Grafe. Synaptic activation of so-called AH-neurons in guinea-pig myenteric plexus. Pf1ugers Archiv., in press.

Ninchoji, T., D. N. Erwin and J. D. Wood. Effects of depleted calcium on burst-type neurons of cat small intestine. Physiologist 20:68, 1977.

Samson, F. E., D. F. Watson, I. Heller-Bettinger and J. A. Donoso. Effect ofnocodazole on fast axop1asmic transport. Proc. Inter. Soc. Neurochem., 123, 1977.

Shepherd, N., E. A. Johnson, M. Tarr, J. U. Trank and P. leiffer. Sarcomeredynamics in single isolated cells of frog heart. The Physiologist 20:86, 1977.

Strome, D. R., ~. L~ Clancy and N. C. Gonzalez. Myocardial transmembrane HCOjflux: not a HC03-C1 exchange. Physiologist 20:92, 1977.Tarr, M., J. W. Trank, P. Leiffer, N. Shepherd and E. A. Johnson. Sarcomerelength-resting tension relation in single frog atrial cardiac cells. Physiologist20:94, 1977.

Terranova, P. F. and G. S. Greenwald. Anti-LH induced steroid decline, interruptionof pregnancy and superovulation in the hamster. Fed. Proc. 62nd Annual Meeting,No. 839, 1978.

Trank, J. W., P. leiffer and M. Tarr. An integrated instrumentation system for thestudy of isolated single cardiac cells mechanical properties. Fed. Proc. 37:781, 1978.

The effect of biogenic amines on prolactin secretion.

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Watson, D. F., J. A. Don050and F. E. Samson. Pargyline induces changes in axonaltransport in motor neurons. Soc. Neuroscience 111:96, 1977.

Wood, J. D. and C. J. Mayer. Intracellular study of effects of tetrodotoxin andreduced calcium on electrical activity of ganglion cells in Auerbach's plexus ofguinea-pig duodenum. XXVII International Congress of Physiological Sciences 13:819, 1977.

Wood, J. D. and C. J. Mayer. Excitatory action of serotonin on somal membranesof myenteric neurons of guinea pig small bowel. Fed. Proc. 37:227, 1978.

Research Support

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R. l. Clancy: Kansas Heart Association - Effect of Na+-K+ATPase and Ca++ onmyocardial cell pH, July 1,1977 - June 30,1978. Direct Costs $8,961; IndirectCosts $538.

H. J. Cooke: American Heart Association, Kansas Affiliate - Transport character-istics of the newborn rabbit ileum, July 1,1977 - June 30,1978. Direct Costs$9,000; Indirect Costs $540.

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K. l. Goetz: Allan P. and Josephine B. Green Foundation, Blood pressure regulationin free ranging dogs, $32,385, 1977-1979.

Internal grant support from St. luke's Hospital Foundation for Medical Education andResearch.

NIH Grant HL 13623, renewed for 3 years beginning 7/1/78.

N. C. Gonzalez: American Heart Association, Kansas Affiliate - Regulation ofcardiac cell acid base balance, July 1, 1977 - June 30, 1978. Direct Costs $9,000;Indirect $540.

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G. S. Greenwald: NIH- Follicular and luteal regulation in the mammalianovary,June 1, 1978 - December 31, 1978. Direct Costs $69,990; Indirect $19,180.

Ford Foundation - KU Endowment Association - For a program of research and trainingin reproductive biology, Narch 1, 1977 - February 28, 1978. Direct Costs $25,000;Indirect, none.

HEW-NICHO- Research Fellowship Support. Institution allowance $3,000.

D. C. Johnson: National Science Foundation, Biorhythm induced gradients inreproductive functions, 10/1/74-8/30/77, $49,000.

NIH, Aging effects on ovarian tumorigenesis, 9/29/77-8/31/80, $154,441.

J. B. Rhodes: For GI research, J. B. R. Foundation, $15,000; H. H. Robins, $5,000;Nautilus Research $11,000. No direct or indirect costs; 7%administrative costs.

F. E. Samson: NICHHD- Mental Retardation Center Core Grant, Jaunary 1, 1977 -December 31, 1978. Direct Costs $143,046, Indirect $70,218.

Eli Lily Co. - Microtubule involvement in neuropathies, July 1, 1978 - June 30, 1979(with Irene Bettinger). Direct Costs $10,000, no indirect.

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U. S. Army f1edical Research Command- Action of cholinergic poisons on the centralnervous system and effectiveness of potential antidotes, June 1,1978 - May 31,1979.Direct Costs $80,869; Indirect $20,713.

American Cancer Society - Anti-microtubule chemotherapy: relevance of differentialmicrotubule stability, January 1, 1978 - December 31, 1978. Direct Costs $32,144;Indirect $7,661. (Dr. Bettinger is co-investigator.)

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L. P. Sullivan: NIH, Study of factors affecting renal potassium transport,April 1,1977 - Mary 31,1978 (final year). Direct Costs $28,102; Indirect $13,035.

American Heart Association, Kansas Affiliate, Relationship between renal cellularNa and K transport, July 1, 1977 - June 30, 1978. Direct Costs $8,960, Indirect $538.

National Science Founcation, Study of factors affecting renal potassium transport,May 15, 1978 - May 16, 1980. Prorated per year, Direct Costs $26,159, Indirect$11,791.

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t C. M. Tarr: NHLI, Contractile activity of single cardiac cells, April 1, 1977 -March 31, 1978. Direct Costs $30,207; Indirect $12,698.

P. F. Terranova: KUMCResearch grant, Delayed ovulation: its influence on thesteroidogenic capability of the preovulatory follicle, March 1,1978 - r1arch 31,1979. Direct Costs $4,451, no Indirect.

J. l. Voogt: NIH, Pituitary hormones and brain amines during reproduction,September 30,1977 - August 31,1978. Direct Costs $64,832; Indirect $9,210.

J. D. Wood: NIH, Function of the enteric nervous system, May 1,1977 - April 30,1978. Direct Costs $40,538; Indirect $1,700.

NIH, Research Career Development Award, June 1,1977 - May 31,1978. Direct Costs$31,900; Indirect $2,552.

Co-investigator with Dr. Joe R. Kimmelon NIH grant, Structure-function relation-ships in proteins, for 4 years. Total amount $215,634. First year $51,580 DirectCosts, $21,417 Indirect. Dr. Kimmel is principal investigator.

ACTIVITIES OF STAFF

Richard L. Clancy, Ph.D., Associate Professor

July 17-23, 1977 - Attended the International Physiological Congress, Paris.

July 25-27, 1977 - Attended the Symposiumon Acid Base Regulation, Strasbourg, France.

April 7, 1978 - Attended the meeting of the Kansas Heart Association ResearchCommittee.

April 10-14, 1978 - Attended the meetings of the Federation of American Societiesfor Experimental Biology in Atlantic City, NewJersey.

Memberof the Kansas Heart Association Research Committee.

Memberof the HumanExperimentation Committee, St. Luke's Hospital, Kansas City, No.

Memberof the Faculty Assembly and Chairman of the Medical Faculty Steering Committee.

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Memberof the Faculty Student Affairs Committee.

Chairman of the Graduate Adminissions Committee of the Department.

Serves as an ad hoc referee for Proceedings of the Society for Experimental Biologyand Medicine and the American Journal of Physiology.

Directed research work of Carol Branson, medical student, who submitted a paper onthis work on Medical Student Research Day.

Teaching activities:

Physiology 705 - 26 hours - General, neuro, and cardiovascular physiology.

Cardiovascular Physiology 830 - 48 hours.

Medical Physiology - 14 hours per class (2 classes during year).

Was promoted to Professor effective July 1, 1978.

Helen J. Cooke, Ph.D., Assistant Professor

September 12-16, 1977 - Attended the International GI Motility meetings at theRoyal College of Physicians in Edinburgh, Scotland.

November 2-4, 1977 - Attended meeting of the American Federation for ClinicalResearch in Chicago.

April 10-14, 1978 - Attended the meetings of the Federation of American Societiesfor Experimental Biology in Atlantic City, NewJersey.

Is serving on the committees of graduate students Dianne Vermillion and Robert O'Neill.

Memberof the Graduate Admissions Committee of the department.

Teaching Activities:

Physiology 3885 hours gastrointestinal, 4 hours renal, and 2 hours metabolism

Physiology 7058 hours gastrointestinal

Medical Physiology12 hours conferences and 9 hours labs

Kenneth L. Goetz, Ph.D., M.D., Adjunct Professor

July 18-22, 1977 - Attended the International Congress of Physiology, Paris, France.

October 9-14, 1977 - Attended the American Physiological Society fall meetings, Miami.

November 28-December 1,1977- Attended the American Heart Association meetings, Dallas.

April 9-14, 1978 - Attended the F.A.S.E.B. meetings in Atlantic City.

Chairman, Human Investigation Committee, St. Luke's Hospital.

Chairman, Animal Care Committee, St. Luke's Hospital.

Member, Radioisotope Committee, St. Luke's Hospital.

Reviews articles for the American Jounral of Physiology on ad hoc basis.

Is directing research of graduate student Dennis Fater.


Medical Physiology4 hours lecture each course

Physiology 8304 hours lecture

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Norberto C. Gonzalez, Ph.D., Associate Professor

On sabbatical leave at the Department of Physiology, Max Planck Institute forExperimental Medicine, Gottingen, West Germany.

July 17-23, 1977 - Attended the 27th International Physiological Congress, Paris,France.

July 25-27, 1977 - Attended

March, 1978 - Attended theGottingen, Germany.

Outside lectures:

October, 1977 - Cardiothoracic Institute, University of London. "Contributionof extracellular bicarbonate to the regulation of myocardial cell pH".

February, 1978 - Department of Zoophysiology, University of Aarhus, Aarhus,Denmark. "Role of a H+or HC03transmembrane flux on the regulation ofskeletal and cardiac muscle pH".

April, 1978 - Laboratoire de Physio1ogie Respiratoire, CNRS,Strasbourg,France. "f\1echanisms of regulation of myocardial cell pH during hypercapnia".

April, 1978 - Department of Biology, Zoological Station, Vil1e Franche-Sur-~1er, France. "Relative contribution of passive chemical buffering and oftransmembrane fluxes on the regulation of cell pH of normal and hypertrophichearts" .

Reviewed grant applications for the National Science Foundation.

the Symposium on Acid Base Regulation, Strasbourg, France.

annual meeting of the German Physiology Society,

Gilbert S. Greenwald, Ph.D., Distinguished Professor and Chairman

August 13-17, 1977 - Attended meeting of the Society for the Study of Reproduction atAustin, Texas.

September 9, 1977 - Attended meeting of the Committee on Animal Models of Fertilityand Contraception for the National Research Council in Washington, D.C.

October 7-9, 1977 - Presented a major address on "Recent Advances in ReproductiveEndocrinology" to the 25th Japanese Congress of Endocrinology in Sendai, Japan.

May 6-10, 1978 - Chaired a Symposium on Animal Models for Research on Contraceptionand Fertility in Washington, D.C.

June 11-13, 1978 - Attended a Workshop on Ovarian Follicular/Corpus Luteum in MiamiBeach, Flori da .

June 14-15, 1978 - Attended the annual meeting of the Endocrine Society.

Consultant, National Research Council Committee on Animal Models of Fertilityand Contraception, 1977-1978.

Member, Organizing Committee, Workshop on Ovarian Function, NIH, Miami.Committees - local:

Promotions and Tenure CommitteeChairman, lecture series "The Scientific Basis of Medical Practice"Committee on Distinguished and NamedProfessorsMember, Interinstitutional Executive Committee

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Member, Editorial Board of Endocrinology.

Reviewed manuscripts for Biology of Reproduction, Science, Proceedings of theSociety of Experimental Medicine, American Journal of Anatomy, Life Sciences.

Reviewed grant applications for National Science Foundation.


Physiology 806 (Endocrinology)8 hours lecture

Medical Physiology5 hours lecture on Endocrinology Fall course5 hours lecture on Endocrinology Spring courseConducted conference group Spring course

Post-doctoral Fellows:

Archie Vomachka, Ph.D.Srinivas K. Saidapur, Ph.D.

Kazuyushi Taya, D.V.M.

Dept. Physiology, KUMCDepartment of ZoologyKarnatak UniversityDharwas 580 003, India

Laboratory of Veterinary PhysiologyTokyo University of Agricultural TechnologyTokyo, Japan

Department of PathologyCatholic University of ChileSantiago, Chile

II (Anatomy)

Hector D. Croxatto, M.D.

Pre-doctoral student: Charles H. Bill

Ph.D., Professor of Gynecology & Obstetrics and Physiology

- Attended meeting of the Society for the Study of Reproduction,

Donald C. Johnson,

August 14-17, 1977Austin, Texas.

March 15-18, 1978 - Attended meeting of the Society for Gynecologic Investigationin Atlanta, Georgia.

June 14-16, 1978 - Attended meeting of the Endocrine Society, Miami Beach, Florida.

NamedResearch Professor in HumanReproduction.

Directs the research programs of 3 graduate students: Chon-HwaTsai and NaryVomachka, Physiology and Claude Powers, Pharmacology.


Physiology 806 - EndocrinologyCoordinator and gave 8 lectures, Fall 1977

Physiology 825 - Biology of SexIn charge of course, Fall 1977

Medical PhysiologyIn charge of Endocrinology sectionConference and Laboratory Section, Fall semester

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Warren K. Legler, Ph.D., Assistant Professor

November 28 - December 9 - Attended a RSXll-M class at the Digital EquipmentCorporation.

Director of Ralph L. Smith Mental Retardation Research Center Computing Laboratory.

{-iemberof I'JRRCComputer Committee.


Medical PhysiologySchedule coordinator for both courses.Had conference and lab section in Fall semester course.

James B. Rhodes, M.D., Associate Professorfvleeti ngs:

October 3-4, 1977 - Clinical Trials Methodology, NIH, Bethesda, Md.

October 17-20, 1977 - Internal Medical Postgraduate course., KUMC.

February 17-18, 1978 - Internal Medicine, Kansas American College of Physicians,March 4, 1978 - Midwest Gut Club, Omaha, Nebraska.

May 21-26, 1978 - American Gastroenterological Association, Las Vegas, Nevada.

June 5-9, 1978 - 4th International Congress of Gastroenterology, Madrid, Spain.Outside lectures:

"Oral/Parentral Nutrition in Infl ammatory Bowel Disease", Internal f.'iedicinePostgraduate Course, Kansas City, Kansas, 10/19/77.

"GI Physiology for Clinical Dieticians", KUMC,11/14/77.

"Metoclopramide for placement of small bowel biopsy instruments", FDA, ~Jashington,D.C., 1/16178.

Topeka.

"Meet the Professor", Kansas American College of Physicians, Topeka, 2/17/78.

"GI Physiology for Clinical Dieticians", KUMC,3/6/78."Inflammatory Bowel Disease - Recent Concepts", Stormont-Vail Hospital, Topeka,

4/8/78.

"Geriatric GI Disorders", Family Practice Postgraduate Course, KUMC,4/27/78.

"Cl inical Probl ems of Delayed Gastric Emptying", Nedicine Grand Rounds, KU~iC,

"Malabsorption Syndromes", St. Joseph Hospital, Wichita, 5/18/78.

Committees:

f'iember of committee to Review the Bylaws of the Faculty AssemblyMember, Long Range Planning Committee.

Member, Advisory Committee of the Department of Dietetics and Nutrition.

Member, Post Graduate Education Committee of the Department of Medicine.

Reviews articles on an ad hoc basis for the American Journal of Physiology,Journal of Laboratory and Clinical Medicine, and the Journal of CanadianMedical Association.

5/3178.

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Graduate students:

Rose Bondy- Dietetics & NutritionSusan Knopp - Dietetics & NutritionMary Ellen Clark - Nursing


Medical Physiology - 12 lectures on Gl Physiology,

PHSL 818 - Gastroenterology - 4 lectures

November 177 and March '78

Frederi~k E. Samson.. Ph.D., Professor

Meetings attended:August 13-19. 1977 - Max Planck Neuropsychiatry Institute, Munich.

August20-26, 1977 - International Society for Neurochemistry, Copenhagen.October 13-14,1977- National Leadership Conference, University of Chicago.October 23-26. 1977 - Conference on I\ianipulative Therapy, Michigan StateUniversity.October 31-November1,1977 - Mental Retardation Research Centers Directorsmeeting, Boston, Massachusetts.

November6-10, 1977 - Society for Neuroscience National Meeting, Anaheim,California.

March 1-2, 1978 - Association for Children with learning DisabilitiesNational Conference. Kansas City.

r\~arch13-16. 1978 - American Society of Neurochemistry National meeting,Washington, D.C.May15-17.1978 -June 5-30, 1978 -Program. Boston.

Outside lectures given:

September 6, 1977 - Dept of Neurology. KUMC.August 22 - "Effect of Nocodazole on Fast Axoplasmic Transport", InternationalSociety for Neurochemistry meeting (poster session).October 23-26 - IIAxoplasmicTransport Derangementll; also chaired session on"Trophic Action of Nerves", Michigan State University.

November 16 - Lecture IIBrain Research" to Electrical Engineering class inBioengineering, KU.f.1arch1, 1978 - IIBrain Functional t'!jappingll,Association for Children withlearning Disabilities National Conference, Kansas City.March6 - IIf'lental Retardation Researchll. University of Kansas DiscussionGroup. KU.

Mental Retardation Research Center Directors meeting. Denver.

Massachusetts Institute of Technology. Neurosciences Research

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Committees

Outside KUNCChairman, University of Chicago Alumni Fund, Greater Kansas City area.Chairman, Program Committee, American Society of Neurochemistry for 1980

meeting, Houston, Texas.Served on Ph.D. thesis committees at KU, Lawrence for:

Young Lee, Dept. of BiochemistryDaniel Cawley, Department of BiochemistryMary Hedbloom, Department of BiochemistryMary Lou Michaelis, Department of HumanDevelopment

Chairman, Planning Committee for encouraging research collaboration betweenMental Retardation Research Centers.

Loca1Director, Ralph L. Smith Research CenterChairman, Research Committee of the Ralph L. Smith Research Center

President, Sigma Xi, Kansas City ClubMember, Kansas City Chapter, Society for Neurosciences (Sec-Treas,

President, 1978-79)Memberof Ph.D. Thesis committees for:

George Kemper, Department of AnatomyRobert Stephens, Department of AnatomyBernard Schnieder, Department of PharmacologyJ. Alexander Donoso, Department of PharmacologyDanny Watson, Department of PhysiologyRobert OINeill, Department of Physiology

I';~:ii::erof Hiniccmputer Committee, Ralph l. Smith Research CenterChairman, Judging Committee for Graduate Student Research Day

Memberof Inter-campus LiaisonChairman, Visiting Lecturers Committee, Department of PhysiologyIn charge of Seminar Series, Department of PhysiologyScrivencr-Scrib8, Department of Physiology

1977-78;

Editorial Service

Edits manuscripts on an ad hoc basis for: Neurosciences Research ProgramBulletin, Journal of Neurobiology, Proceedings of the National Academy ofSciences, and other journals in neurobiology.

~aviews app~oxio.ately 6 grant application per year for the National ScienceFoundation.

Medical students working with him: Valerie Chowand George Pierson.


Physiology 388, Spring semester - 5 lectures; Fall semester - By specialarrangement made for 4 anesthesiology nursing students, Drs. Terranova andSa~son handled the course, sharing the lectures equally.

Medical Physiology - Handled a conference section for the Fall class(approximately 12 2-hour conferences)

Physiology 850 (Research)Fall semester - 1 student, 3 hoursSpring semester - 2 students, 5 and 4 hours respectively

Physiology 860 (Thesis)Spring semester - 2 students, 3 and 2 hours respectively

Physiology 782 (Advanced Topics)Fall semester - 1 student, 3 hours.

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LawrenceP. Sullivan, Ph.D., Professor

October 10-14, 1977 - Attended the Fall meeting of the American PhysiologicalSociety in Hollywood, Florida.

November 21-22, 1977 - Attended meeting of the American Society of Nephrology inWashington, D.C.; participated in selection of free communications forpresentation at meeting and chaired free communication session on Acid-Basef~echanisms.

April 9-12, 1978 - Attended the FASEBmeetings in Atlantic City, NewJersey.

June 18-23 - Attended the International Congress of Nephrology in Montreal, Canada.

November 1, 1977 - Lectured on "Glomerular Function in Health and Disease" atMenorah Hospital.

January 16, 1978 - Gave a talk at the County Heart Society at Garden City, Kansasand also gave TV and radio interviews for the Heart Association in severaltowns in southwest Kansas.

t.lay 10,1978 - Lectured on "Renal Acid-Base t'Jechanisms" at St. Luke's Hospital.

Member, Program Advisory Committee of the American Physiological Society.

Research Publicity Director, member, Research Committee and Member, Board ofDirectors, American Heart Association, Kansas Affiliate.

Member, Research Committee of the Great Plains Region of the American Heart Association.

Member,Student Evaluation Committee, KUMC.

Organized and chaired Sigma Xi panel discussion on "Role and support of research atKU~1C".

Reviewed on ad hoc basis for the American Journal of Physiology, Kidney International,Journal of Clinical Investigation, and the Journal of Pharmacology andExperimental Therapeutics.

Reviewed on ad hoc basis grant applications for the National Science Foundation.


Physiology 705 - 8 hours lecture

Physiology 806 - 2 hours lecture

Medical Physiology9 hours lecture + 6 2-hour problem sessions in Fall course9 hours lecture + 6 2-hour problem sessions + lab and conference section in

Spring course.

Medical Pharmacology course - 2 hours lecture on Diuretic Agents

Merrill Tarr, Ph.D., Associate Professor

July 15-16, 1977 - Was an invited participant in a Symposium on Voltage Clamp andStriated Muscle in Poitiers, France.

July 17-23 - Attended the International Physiological Congress in Paris, France.

September, 1977 - Lectured on Cardiac Electrophysiology to a graduate courseclass at the University of Missouri at Columbia.

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October, 1977 - Attended the fall meetings of the American Physiological Societyin Hollywood Beach, Florida. Presented a paper entitled "Sarcomere 1ength~resting tension relation in single frog atrial cardiac cells". Co-authoreda paper presented by N. Shepherd entitled "Sarcomere dynamics in singleisolated cells of frog heart".

February, 1978 - Lectured on Muscle Physiology in the Department of Physiologyat the Emory University School of Medicine and presented a seminar on"Mechanical properties of single cardiac cells".

April, 1978 - Attended the spring meetings of the Federation of Societies forExperimental Biology in Atlantic City, NewJersey and co-authored a paperpresented by J. t~. Trank entit1 ed "An instrumentation system for the studyof isolated single cardiac cells mechanical properties".

Memberof Editorial Board of Circulation Research.


Post-doctoral fellow: Paul Leiffer (10/1/76 to present)


Medical Physiology (Fall semester)6 hours lecture on nerve electrophysiology1 hour lecture on cardiac electrophysiology4 hours problem and review sessions on electrophysiology2 hours lecture on muscle physiology2 hours problem and review sessions on muscle physiology6 hours conference sessions9 laboratory sessions (2-6 hours each)

Medical Physiology (Spring 1978)6 hours lecture on nerve electrophysiology2 hours lecture on cardiac electrophysiology4 hours problem and review sessions on electrophysiology2 hours lecture on muscle physiology2 hours problem and review sessions on muscle physiology

Paul F. Terranova, Ph.D., Assistant Professor

August 14-20, 1977 - Attended the meeting of the Society for the Study of Reproductionin Austin, Texas and the ~Jorkshop on "Ontogeny of Receptors and Moleculart,jechanisms of Reproductive Hormone Action" sponsored by the Center forPopulation Research, National Institutes of Health.

April 10-14, 1978 - Attended the FASEBmeetings in Atlantic City, NewJersey.

George Parker worked with him the Summerof 1978 as part of the KawValleyMedical Society program.


Physiology 388, Spring semester - 11 lectures (5 on Cell Physiology and6 on Neurophysiology).

Fall semester - With Dr. Samson handled the course for 4 anesthesiologynursing students, sharing the lectures equally.

Physiology 705 - Gave 4 2-hour lectures on Endocrinology.

Medical Physiology - Shared the duties for a conference section inthe Fall course and was in charge of a full lab and conference sectionfor the Spring course.

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AlanM. Thompson~_Ph.D.tProfessor andAssociate Deanfor GraduateStudies

July 17-23, 1977 - Attended the International Physiological Congress, Paris.

November 29-0ecember 2 - Attended the meeting of the Council of Graduate Schools inNewOrleans, louisiana.

February 21-24, 1978 - Participated on the Associateship Panel of the NationalResearch Council in Washington, D.C., including the Final ranking panel

March 7-8 - Attended Career Placement Day of the Associated Colleges of CentralKansas in Bethel, Kansas.

March 29 - Presented a one-day seminar on various aspects of the blood-brainbarrier at Brooks Air Force Base, at their invitation.

April 10-14 - Attended the F.A.S.E.B. meetings in Atlantic City.

June 29-30 - Participated on the National Research Council (NASA) panel in Washington,D. C.

Member, Planning Committee for Health Service Administration Program

Memberof Faculty Assembly Bylaws Committee.

Memberof Calendar and Catalog Committee, KUMC.

Memberof Graduate School Bylaws Committee.

In June read Associateship applications for National Research Council.

May 25-26 - Assisted with the visit of Dr. Stanley Rapoport of NIH who gave twolectures on the Blood-Brain Barrier to the Society for Neuroscience.


Physiology 101 (Fall, 1977)In charge of class; also gave 17 lectures and reviews out of the 39 total.Was in charge of and/or participated in 3 lab days out of the 6.

Medical Physiology - in charge of Transport and Body Fluids section;gave 6 lectures to both courses plus review sessions and special help tostudents - was in charge of a full lab and conference section for thefall course.

John W. Trank, Ph.D., Associate Professor

October 9-14, 1977 - Attended the Fall meetings of the American PhysiologicalSociety in Hollywood, Florida.

February 20-24, 1978 - Attended the meeting of the Great Plains Region of theAmerican Heart Research Review Committee.

March 8-12 - Was in Galveston, Texas consulting about biomedical engineering.

April 7 - Attended the meeting of the Kansas Heart Association Research Committeein Topeka.

April 10-14 - Attended the FASEBmeetings in Atlantic City, NewJersey.

January 12, 1978 - Was the program speaker for the Kansas City Region of theInstitute of Electrical and Electronic Engineers and Biomedical Engineering.

February 14 - lectured on IIElectrical Safetyll at Pediatric Cardiology seminar.

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~~mberof a joint KUMC - School of Engineering Biomedical Engineering CurriculumCommittee.

Memberof the Board of Directors of the Kansas Heart Association.

Memberof the Kansas Heart Association Research Committee.

Memberof the American Heart Association Regional Research Review Board.

rlember of the Biomedical Engineering Technician Advisory Committee of JohnsonCounty Junior College.

Memberof the Kansas Heart Association Community Program Committee.

Shares in the post-doctoral training of Paul Leiffer.

Supervisor of the Physiology Electronics Shop.

Consultant to University of Texas Medical Branch in Galveston - biomedical engineeringresearch and development and service.

Consultant to Burnett Instruments, Lawrence, Kansas - physiological monitoringelectrodes.


Medical Physiology (each course)12 hours Hemodynamicsand Cardiovascular Control Systems14 two-hour conferences8 laboratory sessions

Physiology 827-827 - Physiological Instrumentation I and II(covers basic electronics as well as specific instrumentation)40 hours lecture24 hours lab

Critical Care Nursing24 hours lecture on the physiology and reality of hospital-patient electrical

hazards

EE 236 Medical Instrumentation, KU, Lawrence2 lectures

James L. Voogt, Ph.D., Associate Professor

April 10-14, 1978 - Attended meetings of the Federation for Societies of ExperimentalBiology in Atlantic City~ NewJersey.

September 28, 1977 - Gave a seminar on "The Brain and Prolactin" to the NeuroscienceClub of Kansas City.

October 12, 1977 - Gave seminar for the Department of Anatomy and Physiology atKansas State University on "Recent studies on the control of prolactin secretion".

Gave 8 lectures at St. Luke's Hospital, Kansas City, Missouri on Endocrinology ofReproduction.

Chairman, Physiology Department Library Committee.

Editorial services: Did 5 ad hoc reviews for Endocrinology and 1 for Science.


Physiology 806 - 2 lectures

Medical Physiology11 hours lecture on Endocrinology (5 Fall and 6 Spring)In charge of one full conference and laboratory section in the Spring course

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Jack D. Wood, Ph.D., Associate Professor

Spent June 30-September 23, 1977 as Visiting Professor at the Physiological InstituteIn Munich, West Germany on a von Humboldt fellowship.

July 17-23, 1977 - Attended the 27th International Physiological Congress in Paris.Presented two papers on Neurophysiology of Auerbach's Plexus.

September 12-17, 1977 - Attended the Sixth International Symposium on GastrointestinalMotility in Edinburgh, Scotland; presented paper on Neurophysiology ofAuerbach's Plexus.

October 23-26, 1977 - Invited guest at workshop of the American GastroenterologicalAssociation on Smooth Muscle Physiology at Hyannis, Massachusetts.

October 27, 1977 - Visited Columbia University in NewYork City.

March 3-6, 1978 - Attended and presented a paper on Action of Serotonin onEnteric Neurons at meeting of the Midwest Gut Club in Omaha, Nebraska.

March 14-19, 1978 - Invited lecture at the U.S.-Japan Joint Symposium on theAutonomic Nervous System in NewYork City.

filarch 20, 1978 - Gave seminar on "Slow Excitatory Postsynaptic Potentials" atNational Institutes of Mental Health, St. Elizabeth's Hospital, Washington, D.C.

May 22-26, 1978 - Attended meeting of the American Gastroenterological Association atLas Vegas, Nevada, and was one of three principal speakers at a symposium onPathophysiological and Clinical Aspects of Achalasia, speaking on "Inhibitoryneuronal control of intestinal musculature".

Lectured on "Binocular Vision and Stereopsis" at Baptist Hospital in Kansas City, Mo.

Memberof Editorial Board of the American Journal of Physiology: Metabolism,Endocrinology and Gastrointestinal Physiology Section.


Member, Graduate Student Admission Committee of Department of Physiology.

Promoted to Professor effective July 1,1978.

Teachings Activities:

Physiology 818 - shared teaching duties with Drs. Rhodes and Cooke.

Medical Physiology (each course)16 lectures in Neurophysiology (in charge of section)3 lectures in GI Physiology (shared duties of section with Dr. Rhodes)

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Chairman's Rep~

It was predicted in last year's report that all threevatiint facliltypositions would be filled in the coming academit yea'r. This indeed has come truewith the addition to the staff of Dr. Paul Cherley, assistant professor of Physiology;Dr. Paul Terranova, assistant professor of Physiology; and Dr. JamesVoogt"associate professor of Physiology. They are all heartily welcom~d to the "family"and we look forward to a long and productive relationship as they add to theteaching and research objectives of the department.

It is axiomatic that there are three requirements for a first rate academi-cian: teaching, research and service, and it is expected (or at least hoped!)that the faculty will excel in all of them. Progress continues to be made butthere is room for improvement in all of the areas. As a newcomerto the depart-ment, I was unaware of the heavy teaching load in paramedical courses. InSeptember, 1978 there are about 220 students enrolled in courses involving alliedhealth and nursing personnel. This is equal to the number of students involvedin Medical Physiology in the Winter and Spring semesters. If the load of para-medical teaching continues to proliferate, additional staff may be needed if thedepartment is to meet all of its assignments.

I believe the department is committed to quality in teaching and is con-scientious in carrying out its assignments. A recurring theme at faculty meetingsis whether we are really getting across in the Medical Physiology course. Is the"t" score system removing the incentive of students to work hard? Would a lettergrade system be preferable to our current pass-fail? Whydon't our students dobetter on Part 1 of the National Board exam? Has the student note-taking servicebecome too much of a crutch and a bad habit for students? Perhaps one of ourproblems is that we overteach? (My own simplistic theory!) These are all healthysigns of disagreement and evidence that the faculty has not become complacent inits teaching responsibilities.

The list of publications during the past year and "in press" attests to theresearch activity of the department; but even here, there is room for improvement.The amount of teaching hours assigned to a medical faculty is ridiculously smallwith the majority of time available for scholarly activity. There is thereforeno excuse for faculty not to be vigorously engaged in research. In a universitysetting, research is as natural as eating and breathing, and the department'sreputation at the national level is judged by its research performance. Thegrant situation is admittedly bleak in comparison to the golden age of the 50sand 60s, but evidence of ingenuity, continued productivity and novel approachesand problems still pay off in the art of grantsmanship.

A numberof the staff are involved in service activites on the nationallevel but this will be further enhanced as our reputation as a research orienteddepartment increases.

All in all, it has been a good year, but each one should be better than theone before. All that is needed is that everyone works to their capacity, notbecause they are being prodded but because of the pleasure derived from a jobwell done.

Ph. D. Ph.D. Ph .D. Ph.D. Ph.D. &...

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