PGS INfographic copy
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A small sample of cells are removed from the outside layer of a blastocyst embryo.
The cells that have been removed from each embryo are loaded into a small tube and sent to the reference laboratory for Next Generation Sequenc-
The cells are analyzed to verify that all 23 sets of chromosome pairs are identified to confirm the embryo is genetically normal.
Based on the genetic results, you and your medical team will select which embryo will be transferred.
How
PG
S/N
GS
Wor
ks
% NORMAL EMBRYOBY AGE GROUP
AGE
<35 years
35-37 years
38-40 years
41-42 years
> 42 years
Egg Donors
% Normal Blastocyst
48%
44%
33%
17%
11%
61%
2 Weeks Monitoring
Day 3Menstrual CycleBegin Monitoring
ER RetrievalInsemination
Day
Fertilization Day 22-4 Cells
Day 36-8 CellsBiopsy
Preparation Begins(Assisted Hatching)
Biopsy Process & Blastocyst
Freezing Occurs
D0 D1 D2 D3 D4 D5 D6 D7
Confirmation of sending biopsy samples out for
testing
Completion of IVF Cycle 7-10 days
PGS Test Results
Next Cycle Day 3
Frozen Embryo Transfer (FET)
Cycle preparation
IVF TIMELINE FOR PGS/NGS
<35 35-37 38-40 41-42 >42
MATERNAL AGE
PREG
NA
NC
Y R
ATE
S
WITHOUTPGS*
WITH PGS*
66%68% 69%
76%
66%
4.5%
10.2%
19%
30%
39.5%
PGD (Preimplantation Genetic Diagnosis) diagnoses embryos for known genetic disorders that
both the patient and partner are carriers of including: Sickle cell,
Cystic Fibrosis, SMA1, Tay Sachs, Fragile X, etc.
PGS (Preimplantation Genetic Screening) screens embryos to
ensure 23 pairs of chromosomes (22 autosomes and the sex chromosomes X and Y) are
present and there is no aneuploidy.
PGSVS
PGDNext Generation Sequencing or NGS
is a form of preimplantation genetic screening that can be performed on embryos. -Ensures 23 pairs of genetic chromosomes are present
-Ensure no aneuploidy* is occurring-Detect mosaicism (fragmented
chromosomes)
*ANEUPLOIDY IS THE MAIN CAUSE OF FAILED IMPLANTATION AND RECURRING PREGNANCY LOSS.
WHAT IS NGS?
Reduce chance of miscarriageReduce # of IVF cycles
Reduce risk of multiple pregnancyIncreased live birth rates
Increased ongoing pregancy rates
NGSBENEFITS
GENETIC SCREENING 101
For more information please contact us:Email: [email protected]: (212) 969-7430
4 Columbus CircleFloor 4
New York City, NY 10012www.newhopefertility.com
*Pro
vide
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