Peter Kjäll

Business Area Manager – Life Science Acreo Swedish ICT

BioCom LabBioelectronics and printed electronics for future eHealth

How we work - Industry

Technical Expertise

Distributed diagnostics and eHealth solutions will increase

resources for the individual meeting

1970 2016

2016

Functions: • Adaption • Safety systems • Emergency call • Remote Diagnostics • Remote service • Connectivity Conditions: • Regulatory • Reliability • Harsh environment

LET US COMPARE… with the dramatic development of the

automotiveFunctions: • Adaption • Safety systems • Emergency call • Remote Diagnostics • Remote service • Connectivity Conditions: • Regulatory • Reliability • Harsh environment

2030

Printed Biosensor

BioCom Lab - Towards the intra body network

Sensors on /in the body

E-TreatmentCommunication

Sensors in the ambidient

Vision of a Smart intra-body network together with connection to the cloud or a doctor would make possible functions like remote diagnostics, remote emergency calls, remote therapy etc.

BioCom Lab - A first venture - 4 M EUR

Smart system for prognosis, diagnostics and treatment of epilepsy

Epilepsy is the most common serious neurological condition, affecting almost 60 million people and 2.5 million new cases are each year.

Not possible to intervene with oral medication. Would benefit from very fast and on-demand treatment.

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Sensoring – EEG (ElectroEncephaloGraphy) and more

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Sensoring – Vital parameters, holistic approach

Pulse Blood pressure

Oxygen saturation

Respiratory rate

Temperature

Sweat

Electrolyte

Homeostasis

ECG

MovementMotoric functions

Balance

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Ionpump – E-treatment

drug / neurotransmitter

electron

SUBSTANCE DELIVERY

e–

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Ionpump – E-treatmentLow Mg2+

4-AP

CA3

CA1

CA3 CA1

pumpon

pumpon

pumpon

pumpon

activity stopped

activity stopped

50 µV

50 ms

recording electrode

(CA3)

50 µV 1 min

50 µV 1 min

50 µV 20 s

10 µV 20

s

10 µV

100 ms

recording electrode

(CA1)

ion pump outlets

CONTROLLING EPILEPTIFORM ACTIVITY EX VIVO

induced hypersensitivity

first organic electronic therapeutic

…in an awake animal

direct delivery to spinal nerves

low dose, no side effects

DELIVERY TO THE SPINAL CORD

DELIVERY TO THE SPINAL CORD

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Communication InterfacesDatatransmission with the human body as conductor

BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy

Big-Data Analysis

Eco-system for Innovation

Research Prototype Development Commercialization

Industry

PEA Manufacturing

PRINTED ELECTRONICS IS ALL ABOUT ……produce electronics in the same way as we produce newspaper so we can provide

• Packages with built in quality control, logistic trackers and tempearture sensors

• Simple disposable tests for home diagnostics • Smart cards with skimming control • Food containers with allergy warning

and much much more……

PROPERTIES: • Electrochemically

and electrolyte gated OFET

• 0.5 – 3 V • Switch time:1E-6 to

1E-2 s

Transistors, resistors

PROPERTIES: • Hybrid material • Up to 2 GHz

Diodes Displays

TECHNOLOGY PLATFORM

PROPERTIES: • Monochrome • Emissive • Paper or plastic • 1-3 V (reflective)

PROPERTIES: Electrolyte based sensor capacitors or transistors. Piezo and Pyroelectrical

Analyte parameters: humidity,

heat ,pressure, vibrations, bio, etc

(www.3-plast.com)

Sensors

• “Printed instrument” • Low cost • Disposable • Generic sensor

technology platform • Multiple sensors

Printed Sensors and Biosensors

Point of Care • Glucose • Personalized medicine • Blood coagulation • Creatinine • Medication safety Printed Biosensors on band aid

• Temperature • EEG/ECG • Oxygen • Glucose • Inflammation • Active wound healing

Printed Biosensor

Formfactors Printed Sensors on Packages • Temperature • Time • Humidity • Security and Safety • Food Quality

Home Care • Glucose • Fall detection • Blood coagulation • Medication safety • Pressure Long Term Care

• Pressure Ulcer • Venous Thromboembolism • Temperature / Fever • Humidity / Wetting • Inflammation • Active wound healing

Healthcare situationsAcute Care and Interactive implants • Temperature • Positioning • Wireless sensor patches • Wound Hemorrhage • Fiber optic Sensors

Smart clothes for diagnosis and treatment

Problem Epilepsy and Parkinson are common chronic neurological diseases. Solution Comfortable, smart garments with built-in sensor systems for monitoring movements, heart rate etc

Goal To improve the diagnosis, treatment and quality of life for the patients. Already tested in Clinic by collaboration with Sahlgrenska Akademien.

Temperature label for vaccines22 million children below the age of one not receiving their full dose of vaccinations each year.”

• “Currently, the requirement for a vaccine to be transported and stored in a constant cold chain, from the time it leaves the manufacturer until it is used at a vaccination point, places huge logistical challenges on vaccination providers who must ensure that the cold chain is maintained each step of the way. Although this is not a significant challenge in wealthy countries, it is a considerable obstacle in developing countries, particularly in areas that are hot, isolated, and which lack reliable electricity for refrigeration. This difficulty in getting vaccines to some places is a significant cause of low immunization rates in some countries, leading to more than22 million children below the age of one not receiving their full dose of vaccinations each year.”

An MSF staff member vaccinates a young patient in South Sudan

Possible Effects• More accurate diagnosis • Early warning eg. heart

failure, stress, burnout, ... • Automatic, person specific

and situation based medication

• Patients can be mobile • Automatic control systems

(Parkinson, Epilepsy..) • etc…

Inspiring environment and close collaboration

Develop your next innovation at BioCom Lab