PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on...
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Transcript of PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on...
![Page 1: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/1.jpg)
PET in Colorectal Cancer
![Page 2: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/2.jpg)
Indications for FDG PET
• Rising marker, (-) CT/MRI• Nonspecific findings on CT/MRI, recurrence or post treatment changes?• Known metastases; evaluate extent or disease or identify other sites of recurrence• Evaluate response to chemotherapy
![Page 3: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/3.jpg)
LV
12/09/9304/23/9608/22/96
PET-FDG SCAN IN RECTAL CA
191642
![Page 4: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/4.jpg)
Coronal
MSKCC AL361200
![Page 5: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/5.jpg)
Case 1Case 1Case 1
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Comparison of PET and CT
N=40 pts. (93 biopsies)
WCT=0.73+/-.06*
WPET=0.97/-.02*
*P<.001
![Page 7: PET in Colorectal Cancer. Indications for FDG PET Rising marker, (-) CT/MRI Nonspecific findings on CT/MRI, recurrence or post treatment changes? Known.](https://reader035.fdocuments.in/reader035/viewer/2022081418/56649e9e5503460f94ba04c4/html5/thumbnails/7.jpg)
Biopsy Correlated Finding SUV in Colon Cancer
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PET-FDG SUV
Fra
cti
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FPF
TPF
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PET in Colorectal Cancer
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Prevalence of Disease
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ease
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lity
T+/D+
T-/D+
Change: post vs pre
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Diagnostic Imaging in Oncology• Detection
• Differential Diagnosis
• Tumor biology relevant to therapy
• Staging
• Recurrence
• Response
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PET in Colorectal Cancer• PET accuracy between 88 - 92% > CT (75%)• Among pt.s with suspected recurrence, SUV > 3.5
has a 90% probability of tumor, and a 10% prob of being a benign lesion
• Most common reasons for missing lesions is size (< 1 cm in diameter), location (peritoneum), and artifact (lesion near high count area)
• PET >> CT for Rx response in rectal Ca