IPEA - Estado, Instituições e Democracia - Vol 1_República - 2010
Pesquisas durante e pós epidemia do virus Zika - IPEA · Microcephaly-definition TORCH Infections:...
Transcript of Pesquisas durante e pós epidemia do virus Zika - IPEA · Microcephaly-definition TORCH Infections:...
Pesquisas durante e pós epidemia do virus Zika
Celina Turchi Martelli
Public Health Emergency of International Concern
Notification of microcephaly cases Brazil 2015 – Feb 2016
Emergence and evolution of Zika virus vector-borne transmission
Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019
Zika virus vector-borne transmission
Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019
Microcephaly-definition
TORCH Infections: Toxoplasmosis Other (Syphilis, Varicella-zoster) Rubella, Cytomegalovirus Herpes infections
Rare neurodevelopmental disorder
Causes Genetic Environmental Toxic exposures Foetal alcohol S. Radiation Clinical/Infections
Cases series studies
DOI:10.2105/ Miranda et al. American Journal of Public Health - 2016
Modeoftransmission
Microcephaly Intracranialcalcification
s
Oculardisease
Hearingdeficits
Cytomegalovirus Persontoperson ++ + + ++
Toxoplasmosis Food + + + -
Rubella Persontoperson + - + ++
Herpessimplesvirus Persontoperson + - + +
ZikavirusVector-borneSexualTransfusion
++ + + +
DOI:10.2105/Mirandaetal.AmericanJournalofPublicHealth-2016
DOI10.1002/ajmg.a.38170
Case-control study
Arboviroses Laboratory LaboratoryofVaccinologyandExperimentalTherapeutics
Ø Isolation of ZIKV: Recife 2015 Ø Detection of Positive IgM for Zika virus
30 neonates with microcephaly in Brazil Cordeiro,et al. The Lancet 387, 2016)
Ø Reference laboratory for ZIKV
Funded by the Horizon 2020 Framework Programme of the European Union
CongenitalZikaSyndrome
NEURO-Zika
Non-VectorTransmission
NEURO-Zika:Pathogenesis
DiseaseBurdenRiskAssessment
WEAR
COMMUNICATIONLatin-American
NETWORKConsortiumCoordination
DiagnosticsEvaluation
MODELLING
VaccinesinADE
ViralFitness
Source: Blog NE10. https://blogs.ne10.uol.com.br/social1/2019/03/14/premio-tacaruna-mulher/ Acesso em 18 de Março de 2019.
International Classification of Diseases The global standard for diagnostic health information
KA62ViralinfectioninthefoetusornewbornKA62.0CongenitalZikavirusinfection
https://icd.who.int/
June2018
PubMed Search
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"Zika Virus Infection"
1954-2015 2016 2017 2018
“Congenital Zika Syndrome"
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Prioritizing Severe Emerging Diseases for Research and Development
EpidemicthreatPrioritypathogens
1.Humantransmission2.Medicalcountermeasures3.Severityorcasefatalityrate4.Thehuman/animalinterface5.Thepublichealthcontext6.Potentialsocietalimpacts7.Evolutionarypotential
• Zika• Crimean-CongoHemorrhagicFever• EbolaViralDisease-MarburgViral• LassaFever• MERSandSARS• Nipahandhenipaviraldiseases• RiftValleyFever• DiseaseX
Feb.2018http://www.who.int/blueprint/priority-diseases/en/
UFPE
www.cpqam.fiocruz.br/merg/
RicardoXimenes
LauraRodrigues
CelinaTurchi
ThaliaAraujo
WaynerSouza
FátimaMilitão
ErnestoMarques
MarliTenório
EnriqueVazquez
CynthiaBraga
RafaelDhalia
SinvalBrandão