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    >>PERSPECTIVES_2012THE FUTURE OF CHEMICAL AND PHARMACEUTICALPRODUCTION IN GERMANY

    CMF JUNE 19, 2012 FACILITATED BY DR. MICHAEL REUBOLD, CHEMANAGER

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    >>A BUSINESSPERSPECTIVE.

    THE FUTURE OF VALUE CREATION IN THE GERMAN CHEMICAL & PHARMACEUTICAL INDUSTRY

    Dr. Udo Jung

    The Boston Consulting Group

    ACHEMA PERSPECTIVES 2012

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    The future of value creation in the Germanchemical and pharmaceutical industry

    Frankfurt , June 19, 2012

    Dr. Udo Jung

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    40

    30

    20

    10

    0

    1 year

    32

    30%

    Change in annualTSR (%)1

    Profitable growth: Key lever for sustained valuecreation in the past and in the future

    Sources of value creation of top-quartile performers in S&P 500

    Profitable revenue growthMarginMultipleFree cash flow

    1. TSR= Total return of a stock to an investor (capital gain plus dividends); TSR for top-quartile performers (S&P 500, 19922011)Note: The rolling analysis covers one-, three-, five-, and 10-year time frames from 1992 through 2011. Shows the average of performers in the 75th to 100thpercentile to illustrate approximate for thetop quartile companies (which would be equivalent to the 88 thpercentile); analysis excludes financial institutionsSource: Compustat; BCG Value Science Center

    10 years

    16

    5 years

    19

    3 years

    22

    77%62%49%

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    However: Growth alone does not automatically create value

    Low correlation of growth and TSR1

    (S&P 500, 19922011)

    Why?

    Growth through value-eroding acquisitions

    Growth that degrades margins and ROI

    Growth that requires too much capital

    Growth that increases risk

    Growth that reduces the P/E

    Average annual TSR (%)

    40

    20

    0

    -20

    Average annual revenue growth (%)

    40200-20

    Growth withoutvalue creation

    Growth withvalue creationR2=0,23

    1. TSR: Total return of a stock to an investor (capital gain plus dividends)Source: Compustat; BCG Value Science Center

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    Note: GDP as $ in Purchasing Power Parity (PPP)Source: EIU; BCG analysis

    Capturing profitable growth in Asia drives business model changesof German chemical and pharmaceutical companies

    3.1

    Rest

    ofLatam

    3.4

    World

    3.5

    Russia

    3.7

    MiddleEast

    3.9

    C.E.Europe

    4.0

    China

    20102025, GDP growth (%)

    6

    4

    2

    0

    Japan

    2.0

    EU-15

    2.4

    USA

    2.8

    Brazil

    4.6

    Restof

    Asia

    5.2

    India

    5.5

    MiddleEast

    2.7

    Restof

    Latam

    2.0

    EU-15

    5.4

    USA

    9.3

    0

    World

    4.6

    RoW

    2.9

    Brazil

    1.2

    C.E.Europe

    1.3

    Japan

    Russia

    1.61.4

    7.7

    China

    7.8

    India

    20102025, GDP growth (Trillion US$)

    50 47.9

    40

    20

    10

    30

    Restof

    Asia

    World GDP(K US$)

    201070.6

    2025118.5

    3.5%

    x% CAGR

    Asia

    We are in a two speed world: Asia expected to contribute45% of global GDP growth until 2025

    Asian economies growth compensate for

    OECD countries underperformance

    Asia (ex-Japan) accounts for 45%

    of overall GDP growth until 2025

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    16%

    55%

    6%

    2010

    Asia Pacific

    Western Europe

    North America

    South America

    Rest of World

    17%

    6%

    7%

    2030

    5%

    19%

    21%

    49%

    More than 60% of the total global demand growth inchemicals until 2030 contributed by Asia Pacific

    Source: CEFIC Fact and Figures 2011; various analyst reports; company presentations; BCG analysis

    +1,310

    +224

    +305

    +132

    +180

    9% Rest of World

    6% South America

    14% North America

    10% Western Europe

    61%Asia Pacific

    +2,151

    Global chemicaldemand (B) 2,353

    4,504

    Annualgrowth rate

    4.1%

    1.9%

    2.6%

    3.6%

    4.4%

    3.3%

    Growth contribution

    Backup

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    Rest of World

    North America

    EU5

    Japan

    Pharmerging

    2015

    1,080

    15%

    33%

    13%

    11%

    28%

    2010

    856

    16%

    38%

    17%

    11%

    18%

    "Pharmerging": Huge growth differential vs.established markets starting from a low base

    Pharmerging countries: China, India, Brazil, Russia, Mexico, Turkey, Poland, Venezuela, Argentina, Indonesia, South Africa, Thailand, Romania, Egypt, Ukraine, Pakistan and VietnamEU5 countries: Germany, France, Italy, Spain, UKNorth America: USA, CanadaSource: IMS; analyst reports; BCG analysis

    +148

    +25

    -5

    +30

    +26

    12% Rest of World

    10% Japan

    13% North America 65% Pharmerging

    +224

    Global pharmaceuticalsdemand (B)

    Annualgrowth rate

    14.4%

    4.8%

    - 0.7%

    1.8%

    3.6%

    4.8%

    Growth contribution

    Backup

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    Divergence in demographics: In mature markets 55+segment drives consumer spending growth until 2030

    1. Data of Japan excludes expenditure for households with a single person, due to data availability 2. Data of Germany refers to 2007 (instead of 2008) due to data availability issuesNote: spending power evolution forecasted based on historic correlation with GDP, not corrected with potential higher relative savingsSource: Consumer Expenditure Survey Commissioned by AARP, 2008; Consumer Expenditure Survey, 2008; Japan Statistics Bureau & Statistics Center; Statistische Bundesamt

    US Japan1 Germany2

    2030

    10.1

    6.1

    4.0

    Growth200830

    4.0

    2.0

    2.0

    2008

    6.1

    4.1

    2.0

    Consumer spending ($K)

    15

    10

    5

    0

    < 55

    55+

    Consumer spending ($K)

    3

    2

    1

    0

    < 55

    55+

    2030

    1.8

    0.8

    1.0

    Growth200830

    0.6

    0.2

    0.4

    2008

    1.3

    0.6

    0.70.1

    0.3

    2008

    1.2

    0.7

    0.6

    Growth200830

    0.4

    2

    1

    0

    < 55

    55+

    2030

    1.6

    0.7

    0.9

    3

    Consumer spending ($K)

    What is the implication for German chemical andpharmaceutical companies?

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    5 Year value creation by industry sector

    69

    51 54 56

    35

    4551

    54

    36

    54

    83

    29

    48

    31

    93

    35

    57

    33 35

    1610 10 8 7 6 6 5 5 5 5 4 4 3 3 2 2 1 1

    -10 -5 -5

    -15 -13 -14

    -27

    -15-21

    -7

    -15-19 -21

    -14 -16 -12

    -8

    -18

    -49

    -60

    -40

    -20

    0

    20

    40

    60

    80

    100

    120

    Average annual TSR, 2006-2010 (%) High

    Low

    Industry weighted average

    Chemicals

    Machinery

    Non-Durables

    Mining

    Media &Publishing

    Travel &Tourism

    Pharma-ceuticals

    Telecom-munication

    UtilitiesRetail Pulp andPaper

    Multibusiness

    Automotive

    Sources: Thomson Reuters Datastream; BCG analysis

    Technology Components

    Durables &Apparels

    MedicalTechnology

    Transport.&

    Logistics

    Constr. &Build Mat.

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    annual TSR1

    Rank (n=164) Quartile TSR (p.a. in %)

    20 years (19922011)

    Rank (n=318)

    annual TSR1

    5 years (20062010)

    Quartile TSR (p.a. in %)

    5 years (20072011)

    annual TSR1

    Rank (n=269)

    10 years (20022011)

    Quartile TSR (p.a. in %)

    Fuchs Petrolub

    K + S

    Honam Petrochemical

    LG Chem

    6040200%-20-40

    H & RClariant

    Wacker Chemie

    Givaudan

    Lanxess Symrise

    Syngenta

    EMS-Chemie

    Linde BASF

    -40

    Clariant

    BayerGivaudan

    EMS-Chemie

    6040200%-20

    Linde

    BASF

    Syngenta

    H & R

    K + S

    Fuchs PetrolubLG Chem

    Honam Petrochemical

    1. TSR derived from calendar year data in local currencyNote: Worldwide industry sample based on Thomson Reuters DataStream supersector segment excluding firms not continually listed within the respective timeframeSource: Thomson Reuters DataStream; BCG analysis

    Value creation of German chemical companiesin the global context

    17.9%

    6.6%

    -4.6%

    18.9%

    8.7%

    2.5%

    14.1%

    6.8%

    1.9%

    6040200%-20-40

    Mitsui Chemicals

    Asahi Kasei

    Kuraray

    IFF

    H & R

    Linde Bayer

    Fuchs PetrolubBASF

    Honam PetrochemicalK + S

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    Observations in value creation patterns in theglobal chemical industry in the past 5 years

    Observation

    Overall Asian chemical companies lead in value creationespecially in base chemicals

    Agro related chemical businesses with superior value creation

    Japan with specific challenges in value creation

    German & European chemical companies with a good track record in diversified and specialtychemicals business modelsdriven by the ability to manage differentiated business models

    1

    2

    3

    4

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    Global energy and geopolitical trends create challenges forthe European and German based chemical industry

    Feedstock advantaged countries will continue investing in a scenario of lower gas prices vs. higher

    naphtha prices No great expectations for cheap unconventional gas in Europe

    Shale gas revolution in the US reduces European competitiveness in Chemicals

    Countries will growing Chemicals demand and advantaged feedstock will increasingly drive theirown economic development agenda, which includes localization of chemicals supply sources

    Increase value added to local economies

    Reduce imports and increase self sustainability

    For specialty chemicals customer proximity (in emerging markets) provides competitive advantage,thus favoring new capacity in demand centerssuccessful European chemical companies will haveto "localize" their global business models

    Regulatory pressure on the chemical and adjacent sectors (e.g., power) will lead to increased costs inEurope and a potential reduction of European industry competitiveness

    Larger and integrated new "megasites" in the Middle East and in Asia copy successful Europeanexamples

    Are there unique advantages for European based value addin production, innovation and business management?

    1

    2

    3

    4

    5

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    Asian and Middle East chemical companies gain importanceGlobal top 10 chemical companies 19802011

    Note: Asian and Middle East companies in orange boxesSource: Chemical and Engineering News, ICIS Top 100, Chemical Week; Company websites; BCG analysis

    Several new leader are part of national economic agendas"decision making beyond IIR and quarterly reporting"

    Rank 1980Chemicalsales (B$) 1995

    Chemicalsales (B$) 2011

    Chemicalsales (B$)

    79.6

    60.0

    58.1

    57.9

    50.6

    50.6

    38.0

    37.3

    33.0

    29.6

    14.1

    14.1

    13.8

    13.7

    13.7

    10.6

    10.0

    8.4

    7,6

    7.0

    24.2

    22.1

    21.2

    18.0

    17.9

    15.9

    15.3

    15.1

    14.5

    13.3

    6.3

    PetroChina

    1

    2

    3

    4

    5

    6

    7

    8

    9

    10

    26

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    Many factors influencing the future of theEuropean chemical production base

    Overview of most relevant system dynamics

    Changes in theEuropean chemical

    production base

    Assetinvests

    Innovationinvests

    Relocationof decision

    centers

    Investmentdecisions of the

    chemical industry/companies

    Public andpolitical sentiment

    Industrystructure

    End-industryproduction and

    innovationnetworks

    Relocation ofnetworkstowardsgrowth regions

    Share of newinvest intogrowth regions

    Europeanchemical demand

    GDP-driven

    Growth ofsegment

    "55+"

    Self-sufficiencypolicies in growth

    regions

    Perception shaping

    Share ofSMEs

    Global market positionof European-basedChemCos in spec.segments

    Share offoreign assetownership

    Clustercompetitiveness

    New advantagedcapacities in

    growth regions

    Rawmaterial

    differentials

    Europeancompetitiveness

    in specificsegments

    Invest focuson competitiveclusters

    Exit hurdles

    non-compe-titive clusters

    Changes intrade balances

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    European Advantage (I): The competiveness of chemical sitesand clusters in Europe will become even more decisive

    Large

    Small to medium size

    Region

    Rheinland-Pfalz (Mainz), DE

    Dsseldorf, DE

    Vlaams Gewest (Antwerpen), BE

    Rhne-Alpes (Lyon), FR

    Istanbul, TR

    Darmstadt (Frankfurt am Main), DE

    Kln, DE

    Ege (izmir), TR

    Mnster, DE

    Cheshire (Chester), UK

    Nordwestschweiz (Basel), CH

    Size(employees)

    40,075

    25,284

    21,937

    20,361

    18,133

    16,250

    15,928

    10,587

    9,590

    9,108

    8,549

    Source: The role of clusters in the chemical industry; BCG analysis

    Value added provided by industrial

    parks and industry cluster

    Better access to raw materials(for chemical industries)

    Easier movement of final outputsasinputs to other downstream sectors

    Reduction in energy footprintandincreased efficiency

    Common investment in required

    infrastructures(rail, ports, pipe-lines, ) reduce investmentrequirements and minimizesenvironmental footprint

    Opportunities to coordinate andcooperatein key fields (distribution,R&D, purchasing, )

    Option to leverage larger scaleprojectsthough associations

    .......

    A unique "German advantage": cross-industry production, innovationand supply chain clustersdriven by the "Mittelstand champions"

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    CO2as newbuilding block

    Noble earthsubstitution inindustrialapplication

    Key issue thermodynamics CO2utilization only with

    limited potential to solveclimate challenge

    Rapidly taken up, since keythreat across all industries

    No alternative solutionsdeveloped yet

    New feed-

    stocks basedon biomass

    New feed-stocks basedon gas/coal

    Biomass may becomemore important, but stillunlikely to match 'traditional'capacities by 2020

    Boosted by direct publicfunding on global level

    Several technologies withlimited yield established

    Water scarcityand means ofalternativeenergy input

    Global key challenge, drivenby climate change/regulation

    Proven technology avail. Next gener. to be developed

    Processintensification

    Methanecoupling

    Energy and raw materialefficiency major driver

    Continuous focus resultingin new process technologies

    Key driver abundant globalgas resources

    Still unmatured topic, due tothermodynamic challenge

    3

    Bio-processing unlikelyto substantially matchtraditional chemical pro-cesses in terms of volume

    Resource efficiency driven Selected systems in differ.

    development stages Limited commercializ. yet

    1

    2

    5

    4

    Boosted by demographics Broad R&D topic landscape Different maturity of multiple

    applications in food and feed

    Driven by demographics Multiple existing substances Crop industry leaders foster

    R&D to sustain AI-pipelines

    HC availabilty pattern shift New gen. of perf. chemicals

    beyond classical surfactantsabout to be commercialized

    3

    Boosted by new energyinitiative

    Multiple systems, but noproven technology available

    Driven by enhanced energyefficiency in transportation

    New high efficient polymersto be commercialized

    1

    2

    5

    4

    Boosted by CE trends andPV thinfilm application

    First conducting polymerscommerz.in selected applic.

    White bio-technology

    Improving bio-processingwith GMO

    Biomimetriccatalysts

    Organo-electronics

    Leight

    weightedmaterials

    Active agroingredients

    Chemicals forenhanced oilrecovery

    Source:

    Energystorages

    European Advantage (II): Innovation andorchestration of chemical value chains

    ProductsFeedstock

    Chemical reactionsEnergy efficiency

    Organic/inorganic feedstock

    Energy

    Energy efficiencyLow carbon intense products

    Enabling precursors/products

    Energy efficiencyProven technologies

    New process technologies

    Technologies

    3

    1

    2

    5

    4

    Selected key topics

    Key R&D topic

    Driver and maturity

    Germany has a unique value propositionin cross industry innovation

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    6040200%-20-40

    Immunogen

    Kyowa Hakko

    Astellas

    Biotest

    Pfizer

    BayerNovartis

    Roche

    Sanofi

    Novo NordiskBiogen Idec

    6040200%-20-40

    Evotec

    Qiagen

    PfizerMorphosys Sanofi

    Novartis Stada

    AstraZeneca

    Biogen IdecBayer

    Merck KGaABiotest

    Novo Nordisk

    6040200%-20-40

    Stada

    Evotec

    Novartis Qiagen

    MorphosysSanofi

    PfizerMerck KGaA

    AstraZeneca Bayer

    Biotest

    Biogen Idec

    Novo Nordisk

    Value creation of German pharmaceuticalcompanies in the global context

    annual TSR1

    Rank (n=90) Quartile TSR (p.a. in %)

    20 years (19922011)

    Rank (n=306)

    annual TSR1

    5 years (20062010)

    Quartile TSR (p.a. in %)

    5 years (20072011)

    annual TSR1

    Rank (n=248)

    10 years (20022011)

    Quartile TSR (p.a. in %)

    1. TSR derived from calendar year data in local currencyNote: Worldwide industry sample based on Thomson Reuters DataStream supersector segment excluding firms not continually listed within the respective timeframeSource: Thomson Reuters DataStream; BCG analysis

    18.5%

    5.9%

    -4.0%

    13.2%

    4.2%

    -2.4%

    14.1%

    6.8%

    1.9%

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    Leading pharma companies emerged from M&A

    Note: Only a selection is shown on this slideSource: Company webpage; BCG analysis

    Legend:

    Target

    Buyer

    Year when it happened

    GSK

    Merck &Co

    NovartisSandoz

    Ciba

    Glaxo

    Wellcome

    MarionMerrel

    Hoechst

    RousselUclaf

    Fisons

    RhonePoulenc

    Upjohn

    Pharmacia

    Pfizer

    J&J

    Sanofi-Aventis

    Bayer

    RocheRoche

    Genentech

    Pfizer

    J&J

    Aventis

    Pfizer

    WarnerLambert

    GlaxoWellcomeSmithKlineBeecham

    Zeneca

    Astra AB

    J&J

    Centocor

    Rhone

    Poulenc

    H MRoussel

    Merck&Co

    Rosetta

    Pharmacia

    Pharmacia& Upjohn

    Monsanto

    Alza

    Sanofi

    Synthlabo

    Sanofi-Synthlabo

    Astra-ZenecaMed-

    Immune

    Bayer

    ScheringAG

    Chugai

    Chiron

    AstraZeneca

    Wyeth

    Schering-

    Plough

    1995 1996 1997 2005 2006 2007 2008 20091998 1999 2000 2001 2002 2003 2004 2010 2011

    KingPharma

    Inspire

    Guangdong

    BeiKang

    Anadys

    Crucell

    Alcon

    Zentiva

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    Pharmaceutical market still dominated by US and EU playersGlobal top 10 pharmaceutical companies 19802011

    Source: IMS Health; BCG analysis

    Rank 1980

    Pharma

    sales (B$) 1995

    Pharma

    sales (B$) 2011

    Pharma

    sales (B$)

    56.3

    51.5

    40.1

    39.3

    37.0

    34.5

    34.3

    27.6

    25.8

    23.9

    1.6

    1.4

    1.4

    1.2

    1.2

    1.1

    1.0

    1.0

    1.0

    0.9

    9.7

    9.6

    7.8

    7.7

    6.8

    6.5

    6.2

    6.1

    5.7

    5.5

    1

    2

    3

    4

    5

    6

    7

    8

    9

    10

    Smith Kline

    Bristol-Myers

    Th f t f l ti i th G h i l d

    http://de.wikipedia.org/w/index.php?title=Datei:Pfizer_Logo.svg&filetimestamp=20080319105413http://../Downloads///upload.wikimedia.org/wikipedia/de/4/43/Sanofi_2011_logo.svghttp://../Downloads///upload.wikimedia.org/wikipedia/de/4/43/Sanofi_2011_logo.svghttp://en.wikipedia.org/wiki/File:Merck_Logo.svghttp://de.wikipedia.org/w/index.php?title=Datei:Novartis-Logo.svg&filetimestamp=20061224154146http://de.wikipedia.org/w/index.php?title=Datei:Pfizer_Logo.svg&filetimestamp=20080319105413http://../Downloads///upload.wikimedia.org/wikipedia/de/8/8d/GlaxoSmithKline-Logo.svghttp://en.wikipedia.org/wiki/File:Merck_Logo.svghttp://de.wikipedia.org/w/index.php?title=Datei:Novartis-Logo.svg&filetimestamp=20061224154146http://en.wikipedia.org/wiki/File:Bilogo_new.jpghttp://../Downloads///upload.wikimedia.org/wikipedia/de/9/92/Abbott_A_Promise_For_Life_Logo.svghttp://../Downloads///upload.wikimedia.org/wikipedia/en/4/4f/AstraZeneca.svghttp://de.wikipedia.org/w/index.php?title=Datei:Pfizer_Logo.svg&filetimestamp=20080319105413
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    The future of value creation in the German chemical andpharmaceutical industry

    Obviously the global context matters

    2-speed global economy, the rise of state owned enterprises in chemicals, self-sustainabilityagenda in pharma and in chemicals in many growth regions

    Company perspective

    To grow profitably and to create value European and German based chemical andpharmaceutical companies will continue to globalize their business modelsand invest in

    "localization" in the growth regions (production, R&D, decision center relocation)

    Location perspective

    European chemical and pharmaceutical company have proven their ability to create value withdifferentiated and diverse business model (management of complexity)

    The attractiveness of Europe and Germany as a location for innovation and production is

    driven by the "integrated attractiveness" (infrastructure, logistics, resource efficiency) of sitesand clusters

    Cross-industry innovation and production cluster are largely a unique German advantagedriven by the unmatched density of "Mittelstand-champions"