Personalized Treatment of Advanced NSCLC A Coordinated Multidisciplinary Approach
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Transcript of Personalized Treatment of Advanced NSCLC A Coordinated Multidisciplinary Approach
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Personalized Treatment of Advanced NSCLC
A Coordinated Multidisciplinary Approach
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Program Goals
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Treatment of Advanced NSCLC
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Impact of NSCLC-NOS on Treatment Selection in Advanced
NSCLC
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Impact of NSCLC-NOS on Treatment Selection in Advanced
NSCLC (cont)
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IPASS: Study Design
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IPASS: PFS in Patients Positive and Negative for EGFR Mutation
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EGFR TKI Therapy vs Chemotherapy for Patients With EGFR-Mutated Disease
Results From Randomized Clinical Trials
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Crizotinib in Patients With ALK-Positive Advanced NSCLC
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Crizotinib vs ChemotherapyPhase 3 Study Design
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Crizotinib vs ChemotherapyPFS by Independent Radiologic Review
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Case Study 1: 54-Year-Old Woman With Right-Sided Chest Pain and
Cough
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Advanced NSCLC-Biopsy Specimens
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Transthoracic Core Needle Biopsy in
BATTLE Lung Trial
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Case Study 1: 54-Year-Old Woman With Right-Sided Chest Pain and
Cough (cont)
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Stepwise Approach to Classification of NSCLC
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Light Microscopy: NSCLC, Adenocarcinoma Subtype
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Light Microscopy: NSCLC, Squamous Cell Carcinoma Subtype
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Light Microscopy: NSCLC, Subtype Not Identified
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IHC Staining in NSCLCThe Basics
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Histologic Subtyping in NSCLCIHC Staining Arsenal
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Napsin-A Cytoplasmic Staining in NSCLC, Adenocarcinoma Subtype
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p40 Nuclear Staining in NSCLC, Squamous Cell Carcinoma
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Using Clinical Criteria To Select Treatment
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Molecular Testing GuidelineWho Should Be Tested for EGFR and ALK?
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Molecular Testing GuidelineWhen Should EGFR and ALK Testing Be Done?
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Molecular Testing GuidelinePrioritize EGFR and ALK Testing Over Other
Molecular Predictive Tests
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Molecular Testing in Advanced NSCLCKey Principles
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Case Study 1: 54-Year-Old Woman With Right-Sided Chest Pain and
Cough (cont)
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SATURN
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Pemetrexed + Erlotinib vs Pemetrexed or Erlotinib Alone
Phase 2 Trial of Second-Line Treatment
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IHC as a Screening Tool for ALK Detection
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Rebiopsy
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Case Study 2: 41-year-old Woman With Dry Cough
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Case Study 2: 41-year-old Woman With Dry Cough (cont)
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Case Study 2: 41-year-old Woman With Dry Cough (cont)
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Case Study 2: 41-year-old Woman With Dry Cough (cont)
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Rapid Onsite Evaluation (ROSE)
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Cytologic Specimens for Histologic Subtyping and Genotyping
EBUS-TBNA
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Use of Cytologic Material for Molecular Testing in NSCLC
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How Much Cytologic Material Is Needed for Molecular Testing?
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Molecular Testing GuidelinePrimary vs Metastatic Site
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Coordinating Care for Patients With NSCLC
Multidisciplinary Tumor Boards
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Summary
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Abbreviations
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Abbreviations (cont)
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Abbreviations (cont)
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)