REACH EVERY CHILD

Reach every child

October 2014

PENTAVALENT VACCINE

1 vaccine to stop 5 diseases in 73 countries

1 FIVE DISEASES

threaten millions of people,

especially in the lowest-income countries

5diseases

threaten the lives

and health of millions

Hepatitis BCan cause liver cancer and cirrhosis

~ 600,000 deaths/year

Haemophilus influenzae type b (Hib)Can cause bacterial meningitis, pneumonia

~ 200,000 child deaths/year

PertussisWhooping cough

~ 200,000 child deaths/year

TetanusCauses seizures, fatal without treatment

2,000 child deaths/year*

DiphtheriaRespiratory illness, can affect other organs

2,000–3,000 deaths/year

* Non-neonatal tetanus only.

Sources: www.who.int/immunization/monitoring_surveillance/burden/estimates/en/. www.who.int/immunization/monitoring_surveillance/burden/vpd/surveillance_type/passive/en/

Pertussis photo credit: Janice Haney Carr l Hepatitis photo courtesy World Health Organization (WHO) l Other pictures courtesy of Centers for Disease Control and Prevention

5diseases

threaten the lives

and health of millions

Bad health means:• Higher healthcare costs

• Less money for children’s education

• More time spent caring for sick children

• Lower productivity

• Weaker economy

THE PENTAVALENT VACCINE

1 vaccine

with unique advantages

• Protects against 5 diseases

• 3 jabs instead of 9

• Easy to introduce:

• 2 new antigens – hepatitis B and Hib –

combined with diptheria-tetanus-

pertussis vaccine in the same vial

• Saves time and money

A HIGHLY EFFECTIVE VACCINE

Pentavalent vaccine helped to eliminate Hib meningitis in Kenya (Kilifi district)

Hib incidence (per 100,000)

Source: Anthony Scott, Wellcome Trust Senior Research Fellow in Clinical Science

KEMRI-Wellcome Trust Research Programme , Kilifi, Kenya, January 2014

A HIGHLY EFFECTIVE VACCINE

Hepatitis B prevalence before and after immunisation

0

2

4

6

8

10

12

14

16

Taiwan Shanghai Rural China Gambia

Before After

%

Source: Dr Mark Kane. Compilation of data from several years found in:

Mast E, Mahoney F, Kane M, Margolis H. Hepatitis B vaccines In: Plotkin SA,

Orenstein WA, eds. Vaccines. 4th ed. Orlando, FL: WB Saunders Co.: 2003:299-337.

2 THE JOURNEY

A compelling story that began in 2001

TOGETHER WE ARE STRONGER

Success involves all Vaccine Alliance partners

Implementing

countries

Donors

UNICEF

WHO

World

Bank

Civil

society

Pharmaceutical

industry

Research

institutes

PENTAVALENT INTRODUCTIONS: A PROMISE DELIVERED

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

Gavi-supported countries that introduced pentavalent independently of Gavi funding

193million

children

vaccinated

3million

future deaths

prevented

73rd Gavi country,

South Sudan

Kenya first country

to introduce with

Gavi support

Vaccine access in high- and low-income countries

% of countries

INCREASING EQUITY, 2000–2014

Source: The International Vaccine Access Center (IVAC) VIMS database. *As of 31 July 2014.

Note: only countries with universal national introduction are included.

Hepatitis B Haemophilus influenzae type b (Hib)

0

20

40

60

80

100

2000 2014*

High-income countries Low-income countries

0

20

40

60

80

100

2000 2014*

High-income countries Low-income countries

MARKET POWER

In 2013, Gavi shipped

160 million doses

of pentavalent vaccine

~85%of world demand

in 2013

> 1 billion since 2001

Note: refers to the diphtheria-tetanus-whole-cell pertussis-Hib-hepatitis B

pentavalent vaccine. Number of doses shipped since 2001 includes

monovalent and tetravalent vaccines that contain the same antigens.

Source: UNICEF Supply Division

A HEALTHIER PENTAVALENT VACCINE MARKET

Increasing volumes, growing number of suppliers, reducing prices

Sources: UNICEF Supply Division 2014; country annual

progress reports 2012 (requested doses)

A SHARED RESPONSIBILITY

180million US$

country co-financing

for pentavalent vaccine

2008–2013

10%

of the total cost of the vaccine

Developing countries contribute to the cost of their pentavalent vaccines

Source: Gavi data as of September 2014

3 THE ROAD AHEAD

Reaching every child

SUCCESS TO DATE – AMBITIOUS GOALS

0

10

20

30

40

50

60

70

80

1999 2001 2003 2005 2007 2009 2011 2013 2015

%

Pentavalent coverage in GAVI-supported countries increasing. But much more to be done.

53% coverage in 2013

Target: 77% by the

end of 2015

Source: WHO/UNICEF Estimates of National Immunization Coverage, 2014

Reach every child

“It is unacceptable to die of something that a vaccine can prevent.

Dr Maryan Qasim, Minister of Human Development and Public Services, Somalia

“As a government, we can’t rest until we reach all Somali children and stop the death of children who die from the lack of a simple vaccine.”

A woman closes her eyes as her baby is inoculated with the new pentavalent vaccine at Medina Mother

and Child Health Centre in Mogadishu, Somalia.

© UNICEF/NYHQ2013-0198/Holt