(Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic...
Transcript of (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic...
![Page 1: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/1.jpg)
www.entrepreneurindia.co
(Penicillins, Genetics, Solvent Extraction, Aminoglycoside,
Antibiotics, Tylosin, Peptide Antibiotics, Cephalosporins,
Lincomycin, Anticancer Agents, Siderophores, Steroid Fermentations,
Roducts From Recombinant DNA, Cake-Extraction Process, Split
Process, Mycobactin, Hydroxamates, Therapeutic Enzymes,
Fermentation, Metabolic Origins, Cysteine, Bioconversion, Carboxyl
Activation, Biosynthetic Pathway, Metabolic Grid)
![Page 2: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/2.jpg)
www.entrepreneurindia.co
Biotechnology has played an essential role in the
development of the healthcare chemical industries. The
range of product includes diagnostic, prophylactic and
therapeutic agents. The discovery of a potentially active
compound starts a sequence of exhaustive chemical and
biological testing that may culminate in manufacture of
the agent or an improved analog. The role of
biotechnology in this complex path to regulatory approval
and marketing is diverse. Biotechnology is a field of
applied biology that involves the use of living organisms
and bioprocesses in engineering, technology, medicine
and other fields requiring bio products.
![Page 3: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/3.jpg)
Biotechnology also utilizes these products for
manufacturing purpose. Some of the examples of drugs
produced through biotechnology are penicillin,
lincomycin, streptomucin, tylosin, peptide antibiotics,
cephalosporins, etc. Modern use of similar terms includes
genetic engineering as well as cell and tissue culture
technologies. Biotechnology draws on the pure biological
sciences and in many instances is also dependent on
knowledge and methods from outside the sphere of
biology. Conversely, modern biological sciences are
intimately entwined and dependent on the methods
developed through biotechnology and what is commonly
thought of as the life sciences industry. The development
of biotechnology is taking place in almost all fields of
human life.
www.entrepreneurindia.co
![Page 4: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/4.jpg)
www.entrepreneurindia.co
The recent advances in the field of basic genetics have
opened up new vistas, potentials and possibilities.
Some of the fundamentals of the book are the
pharmaceutical industries, marketing strategy, common
features in the evolution of products and processes,
process technology fermentation, product recovery, new
trends in biotechnology, penicillins, biosynthesis and
regulation of thienamycin, olivanic acids and
epithienamycins, aminoglycoside antibiotics, streptidine
and deoxystreptamine, streptomycin, neomycin,
paromomycin, ribostamycin and,butirosin gentamicin,
micronomicin and sisomicin, tylosin, peptide antibiotics,
current applications of peptides, blasticidin S: an
agricultural antibiotic bleomycin and bestatin:
![Page 5: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/5.jpg)
an agricultural antibiotic bleomycin and bestatin:
peptides used in anticancer therapy etc.
The present book contains process of biotechnology
based bulk drugs like penicillin, B lactam antibiotics,
aminoglycoside antibiotics, peptide antibiotics, anti
cancer agents, lincomycin etc. This is very resourceful
book for entrepreneurs, technocrats, research scholars,
libraries etc. The present book contains process of
biotechnology based bulk drugs like penicillin, B lactam
antibiotics, aminoglycoside antibiotics, peptide
antibiotics, anti cancer agents, lincomycin etc. This is
very resourceful book for entrepreneurs, technocrats,
research scholars, libraries etc.
www.entrepreneurindia.co
![Page 6: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/6.jpg)
www.entrepreneurindia.co
Market outlook
The global medical industry is going to experience tremendous
growth in the coming years with a range of development and
investment opportunities for companies looking out to enter in
this industry or to expand within. Healthcare industry is one
of the largest sectors in the country both in terms of revenue
as well as employment.
The global bulk drugs market was valued at around USD122 b
in 2014 and is expected to reach USD175 b by 2019, growing
at a CAGR of 7.5% during 2014–19.
![Page 8: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/8.jpg)
www.entrepreneurindia.co
India's bulk drug exports are likely to grow at a compounded annual
growth rate (CAGR) of 12-14 per cent till 2018-19, driven largely by
exports to regulated markets as well as continued growth in the
semi-regulated markets.
Driven by exports to both regulated and semi-regulated markets,
India’s bulk drug exports are likely to grow at a compound annual
growth rate (CAGR) of 12–14% up to 2018–2019.
Most of this growth is expected to come from generics, with exports of
bulk drugs used for manufacturing off-patent drugs expected to
continue to grow at a 12–14% CAGR in the next five years till 2018–
2019. Demand for active pharmaceutical ingredients from on-patent
drugs, on the other hand, is expected to grow at a slower pace.
![Page 9: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/9.jpg)
www.entrepreneurindia.co
Global Drug Market
2012-13 2016-17
%Growth
Global pharma market (in $
bn)962 1200 24.7%
Global generic market (in $
bn)274 432 57.7%
Global generic market (in $
bn)28.5% 36%
2012-13 2014-15 %Growth
Indian pharma generic drug
exports (in $ bn)15 25
66.7%
![Page 10: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/10.jpg)
www.entrepreneurindia.co
The generic drug market is expected to grow at nearly at 60 percent
by the year 2016-2017 and contribute nearly 36 percent of the total
market in the year 2016-2017.
The Indian pharmaceuticals market increased at a CAGR of 17.46
per cent in 2015 from USD6 billion in 2005 and is expected to
expand at a CAGR of 15.92 per cent to USD55 billion by 2020.
![Page 11: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/11.jpg)
www.entrepreneurindia.co
Revenue of Indian Pharmaceutical Sector(US$ Billion)
![Page 12: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/12.jpg)
www.entrepreneurindia.co
Growing per capita sales of pharmaceuticals in India
offers ample opportunities for players in this market Per
capita sales of pharmaceuticals is expected to expand at
a CAGR of 19.4 per cent to USD33 by 2016.
![Page 14: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/14.jpg)
www.entrepreneurindia.co
The Indian pharmaceuticals market increased at a
CAGR of 17.46 per cent during 2005-16 with the
market increasing from US$ 6 billion in 2005 to US$
36.7 billion in 2016 and is expected to expand at a
CAGR of 15.92 per cent to US$ 55 billion by 2020.
![Page 15: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/15.jpg)
www.entrepreneurindia.co
Table of Contents
INTRODUCTION
• The Pharmaceutical Industries
• Marketing Strategy
• Common Features in the Evolution of Products
and Processes
• Process Technology
• Fermentation
• Product Recovery
• New Trends in Biotechnology
![Page 16: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/16.jpg)
www.entrepreneurindia.co
PENICILLINS
• Historical Perspective History
• Biosynthetic Penicillins
• Process Overview
• Fermentation Technology
• The Culture: Strain Development
• Mutation
• Selection
• Genetics
• Fermetation Process : Flow Sheet
• Facilities
• Inoculum Development
• Fermentation Stage: Medium
• Process Control
![Page 17: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/17.jpg)
www.entrepreneurindia.co
• Physiological Variables and Their Effect on
Product Formation
• Duration of the Fermentation
• Recovery of Penicillin
• Carbon Process ( Obsolete)
• Solvent Extraction Process (Industry Standard)
• Process Overview
• Filtration
• Solvent Extraction
• Carbon Treatment
• Further Extraction
• Crystallization
• Drying
• Further Processing
![Page 18: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/18.jpg)
www.entrepreneurindia.co
• Penicillin Acid Process (State of the Art)
• Semisynthetic Penicillins
• 6-Aminopenicillanic Acid
• Enzymic Cleavage of Penicillins to Yield 6-
Aminopenicillanic Acid
• Chemical Preparation of 6-Aminopenicillinic Acid
• Synthesis of Clinically Useful Penicillins and Closely
Related Congeners
• Automation
• Process Economics
• Costs
![Page 19: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/19.jpg)
www.entrepreneurindia.co
NOVEL-LACTAM ANTIBIOTICS
• Thienamycin
• Discovery
• Chemistry
• Pharmacological Activity
• Chemical Synthesis
• Biosynthesis and Regulation of Thienamycin
• Biosynthesis
• Regulation
• Classical Fermentation Process
• Introduction
• Seed Stages
• Production Stage
• Fermentation Process Development
![Page 20: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/20.jpg)
www.entrepreneurindia.co
• Fed-Batch Techniques
• Synthetic Media
• Novel Fermentation Processes
• Ultrafiltration Coupled Fermenter
• Immobilized Cells
• Thienamycin Purification
• Future Prospects
• Market Projections
• Clavulanic Acid
• Introduction
• Production
• Market
• Olivanic Acids and Epithienamycins
• Nocardicins
![Page 21: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/21.jpg)
www.entrepreneurindia.co
• Introduction
• Production of Nocardicin A
• Market Projections
• Monobactams
AMINOGLYCOSIDE ANTIBIOTIC
• Streptidine and Deoxystreptamine
• Streptomycin
• Neomycin, Paromomycin, Ribostamycin and
Butirosin
• Gentamicin, Micronomicin and Sisomicin
• Fortamine and Fortimicins
• Mutasynthesis
• A-Factor
![Page 22: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/22.jpg)
www.entrepreneurindia.co
• Metabolic Grid
• Manufacture
• Fermentation
• Microorganisms
• Equipment
• Inoculum Development
• Media
• Procedures
• Isolation
• Strain Improvement
TYLOSIN
• Production Technology
• Structure of Tylosin and Related Compounds
![Page 23: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/23.jpg)
www.entrepreneurindia.co
• Biosynthetic Pathway
• Growth of Producer Microorganisms
• Product Recovery and Purification
• Product Development
• Development in the Genetic Improvement of
Producing Strains
• Developments in Fermentation Technology
PEPTIDE ANTIBIOTICS
• Current Applications of Peptides
• Blasticidin S : an Agricultural Antibiotic
• Bleomycin and Bestatin: Peptides used in Anticancer
Therapy
• Cyclosporin: an Immunosuppressor
![Page 24: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/24.jpg)
www.entrepreneurindia.co
• Structural Types of Peptides
• Biosynthesis of Peptide Antibiotics
• Ribosomal and Nonribosomal Mechanisms
• Reactions Involved in Enzymatic Peptide Formation
• Carboxyl Activation
• Peptide Bond Formation
• Modification Reactions
• Production of Peptides
• Screening Methods
• Biotechnological Production Methods
• Improvements and Modification Procedures
• Compilation of Peptides
• Abbreviations Used in the Table Alternative Names
and Synonyms Compounds Listed in the Table
• Appendix
![Page 25: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/25.jpg)
www.entrepreneurindia.co
STREPTOMYCIN AND COMMERCIALLY
IMPORTANT AMINOGLYCOSIDE ANTIBIOTICS
• Generalities on Aminoglycoside Antibiotics
• Historical Background
• Structure of Different Classes of Aminoglycoside
Antibiotics
• Microbiological Activity and Clinical use
• Mode of Action
• Problems with Toxicity and Bacterial Resistance
• Toxicity
• Bacterial Resistance
• Streptomycin
![Page 26: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/26.jpg)
www.entrepreneurindia.co
• Generalities
• Physicochemical Properties
• Assay and Identification Methods
• Assay Methods
• Identification Methods
• Biosynthesis
• Production Technology
• Fermentation
• Product Recovery
• Other Major Aminoglycoside Antibiotics
• Screening and Genetic Engineering of Strains for
New Aminosides
• Screening of new strains
• Use of Idiotrophic Mutants
• Structural Modification of Known Aminosides
![Page 27: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/27.jpg)
www.entrepreneurindia.co
• Hemisynthesis
• Bioconversion
• Chemical Synthesis of New Aminosides
• Streptothricins, Aminoglycoside-like Antibiotics
• Structure
• Physicochemical and Biological Properties
• Production by Fermentation and Isolation
• Uses
• Marketing Prospects
CEPHALOSPORINS
• Mode of Action of Cephalosporins
• Structure and Biosynthesis of Bacterial Cell Wall
![Page 28: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/28.jpg)
www.entrepreneurindia.co
• Sensitivity and Resistance
• Structure/Activity Relationships
• Cephalosporin Market
• Biosynthesis of Cephalosporins
• Biosynthesis Pathway
• Regulation of Cephalosporin Biosynthesis
• ï•¡-Aminoadipic Acid
• Valine
• Cysteine
• Effect of Oxygen Tension
• Catabolite Repression Specific Growth Rate
• Fermentation Process
• The Fermenter-Its Design and Instrumentation
• Fermentation Microbiology
• Production Kinetics
• Strain Development
![Page 29: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/29.jpg)
www.entrepreneurindia.co
• Fermentation Development
• Alternative Process-DAC Process
• Recovery Process
• Purification of Cephalosporin C
• Cleavage of Cephalosporin C to 7-ACA
COMMERCIAL PRODUCTION OF CEPHAMYCIN
ANTIBIOTICS
• Cephamycin Product Description
• Discovery
• Mode of Action
• Cefoxitin
• Physicochemical Characteristics
• Cephamycin C Assay Techniques
![Page 30: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/30.jpg)
www.entrepreneurindia.co
• Fermentation Microbiology
• Introduction
• Metabolic Origins
• Carbon Metabolism
• Nitrogen Metabolism
• Sulfur Metabolism
• Phosphate Metabolism
• Cephamycin Production Technology
• Inoculum Development Stage
• Antibiotic Production Stage
• Isolation and Purification Stage
• Conclusions and Implications
• LINCOMYCIN
• Discovery
• Chemistry
• Spectrum
![Page 31: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/31.jpg)
www.entrepreneurindia.co
• Mode of Action
• Lincomycin Assays for Fermentation Development
and Production
• Production Technology
• Lincomycin Biosynthesis
• Fermentation
• Lincomycin Production by Other Actinomyces
Species
• Fermentation Power Requirements
• Isolation
• Chemical Derivatives of Lincomycin
• Commercial Markets
• Current Manufacturers
• Product Outlook
![Page 32: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/32.jpg)
www.entrepreneurindia.co
• Pharmacologically Active and Related Marine
Microbial Products
• Pharmocologically Active Compounds From Marine
Microorganisms
• Products From the Culture of Microalgae in Coastal
Ponds
• Agricultural Applications
• Conclusions
ANTICANCER-AGENTS
• The Drug Development Process
• Market Information
• Containment Technology for Cytotoxic Agents
• Containment of Process Equipment
![Page 33: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/33.jpg)
www.entrepreneurindia.co
• Personnel Protection
• Decontamination of Waste Streams
• Microbial Process Examples
• Fermentation Processes for Production of
Anthracyclines
• Strain Improvement
• Batch Fermentation Processes
• Isolation and Purification
• Fermentation Processes for Production of Nucleosides
• Strain Improvement
• Batch Production Process
• Therapeutic Enzymes
• Batch and Continuous Fermentation Processes
• Isolation and Purification
• Examples of Products of Mammalian Cells in Culture
![Page 34: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/34.jpg)
www.entrepreneurindia.co
• Interferon Production
• Fibroblast Processes (HuIFN-ï•¢)
• Leukocyte Processes (HulFN-a )
• Lymphoblastoid Processes (Hu Ly, IFN)
• Immune Interferon Processes (HulFN-Y)
• Future Technologies: Lymphokines and Monoclonal
Antibodies
• Summary
• Appendix
SIDEROPHORES
• The Need for Iron-Solubilizing Agents
• The Role of Siderophores
• Uptake and Release of Iron from the Siderophore
Complex
![Page 35: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/35.jpg)
• Production of Siderophores Extraction
• Adsorption
• Ion-exchange Chromatography
• Restricted Growth
• Protein Binding of Contaminant Iron
• Range of Molecular Structures
• Hydroxamates
• Catecholates (sometimes referred to as phenolates)
• Siderophores with Antibiotic Activity
• Sideromycins
• Interference with Iron Uptake
• Siderophore Analogues
• Sideromycins
• Extraction and Purification of Siderophores
• Mycobactin
www.entrepreneurindia.co
![Page 36: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/36.jpg)
• Enterochelin
• Ferrichrome
• Commercial Production of Desferrioxamine B (Desferal)
• Uses of Siderophores
• Iron Metabolism in the Body
• Iron Poisoning and Chelation Therapy
• Haemochromatosis and Chelation Therapy
• Chelation Therapy
• Other Medical Application for Siderophores
• Applications for Siderophores Outside Medicin
• Future Trends
www.entrepreneurindia.co
![Page 37: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/37.jpg)
STEROID FERMENTATIONS
• Bioconversions of Practical Importance
• Bioconversions of Limited or Potential Practical
Importance
• Progesterone Side Chain Cleavage
• Ring A Aromatization
• 17 and 21-Hydroxylations
• Alternative Bioconversion Methods
• Sterol Degradation
• Steroid Solubility
• Methods of Steroid Addition
• Steroid Conversion in Organic Solvents
• Future Trends in Steroid Bioconversions
• Recovery of Steroids
www.entrepreneurindia.co
![Page 38: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/38.jpg)
• Split Process
• Whole-beer Process
• Cake-extraction Process
• Products of Commercial Importance Summary
• Roducts from Recombinant DNA
• Production Technology
• Methods for Cloning and Expression
• Range and Relative Advantages of Host
Microorganisms
• Stability of Strains and Plasmids
• Product Recovery and Purification
• Commercial Markets
• Markets for Recombinant
www.entrepreneurindia.co
![Page 39: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/39.jpg)
Tags
www.entrepreneurindia.co
Process for Production of Penicillin, Biotechnology in Bulk Drug Production,
Manufacturing of Bulk Drugs, Bulk Drugs Production, Manufacturing
Process of Penicillins, Fermentation Process, Novel Fermentation Process,
Manufacture Aminoglycoside, Manufacturing Process of Tylosin, Production
of Peptides, Production of Streptomycin, Fermentation Process of
Cephalosporins, Cephamycin Production, Production of Lincomycin, Drug
Development Process, Fermentation Process for Production of Anthracylines,
Batch Fermentation Process, Fermentation Process for Production of
Nucleosides, Batch Production Process, Interferon Production, Leukocyte
Process, Lymphoblastoid Process, Immune Interferon Process, Production of
Siderophores, Production of Cloning and Expression, Production of
Penicillin, Process of Fermentation, Production of Fermentation, Novel
Fermentation Processes for Manufacturing, Novel Fermentation Production,
Manufacture of Aminoglycoside, Production of Tylosin, Manufacturing of
Peptides, Production of Peptides, Process for Production of Streptomycin,
Production of Cephalosporin, Fermentation for Cephalosporin Production,
Production of Cephamycin, Lincomycin Production, Anthracycline
Production, Process for Production of Anthracycline, Producing Nucleotide
by Fermentation, Production of Nucleotides, Batch Production, Production
of Interferon, Cloning And Expression of Antibiotic Production,
![Page 40: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/40.jpg)
www.entrepreneurindia.co
How to Start Anthracycline Processing Industry, Production Of Cephamycin Industry,
Most Profitable Novel Fermentation Production Ideas, Cloning and Expression
Processing Projects, Small Scale Nucleosides Production Projects, Starting Penicillin
Production Business, How to Start Anthracylines Production Business, Bulk Drugs
Based Small Scale Industries Projects, , NPCS, Niir, Process Technology Books,
Business Consultancy, Business Consultant, Project Identification and Selection,
Preparation of Project Profiles, Startup, Business Guidance, Business Guidance to
Clients, Startup Project for Aminoglycoside Manufacture, Startup Project, Startup
Ideas, Project for Startups, Startup Project Plan, Business Start-Up, Business Plan for
Startup Business, Great Opportunity for Startup, Small Start-Up Business Project,
Start-Up Business Plan for Peptides Production, Start Up India, Stand Up India,
Modern Small and Cottage Scale Industries, Profitable Small and Cottage Scale
Industries, Setting Up and Opening Your Bulk Drugs Business, How To Start
Production of Nucleosides ?, Best Small and Cottage Scale Industries, Bulk Based
Business, Profitable Small Scale Manufacturing,
Tags
![Page 41: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/41.jpg)
www.entrepreneurindia.co
Niir Project Consultancy Services (NPCS) can provide Technology Book on
(Penicillins, Genetics, Solvent Extraction, Aminoglycoside, Antibiotics,
Tylosin, Peptide Antibiotics, Cephalosporins, Lincomycin, Anticancer Agents,
Siderophores, Steroid Fermentations, Roducts From Recombinant DNA,
Cake-Extraction Process, Split Process, Mycobactin, Hydroxamates,
Therapeutic Enzymes, Fermentation, Metabolic Origins, Cysteine,
Bioconversion, Carboxyl Activation, Biosynthetic Pathway, Metabolic Grid)
See More https://goo.gl/6qPgpk
https://goo.gl/t2QFiI
https://goo.gl/zdlNLq
![Page 43: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/43.jpg)
Take a look at
Niir Project Consultancy Services
on #Street View
https://goo.gl/VstWkd
www.entrepreneurindia.co
Locate us on
Google Mapshttps://goo.gl/maps/BKkUtq9gevT2
![Page 44: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/44.jpg)
www.entrepreneurindia.co
Our inexhaustible Client list includes public-
sector companies, Corporate Houses, Government
undertaking, individual entrepreneurs, NRI,
Foreign investors, non-profit organizations and
educational institutions from all parts of the
World. The list is just a glimpse of our esteemed
& satisfied Clients.
Click here to take a look
https://goo.gl/G3ICjV
OUR CLIENTS
![Page 45: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/45.jpg)
Free Instant Online Project Identification & Selection Search Facility
Selection process starts with the generation of a product idea. In order
to select the most promising project, the entrepreneur needs to
generate a few ideas about the possible projects.
Here’s we offer a best and easiest way for every entrepreneur to
searching criteria of projects on our website
www.entrepreneurindia.co that is “Instant Online Project
Identification and Selection”
www.entrepreneurindia.co
![Page 46: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/46.jpg)
NPCS Team has simplified the process for you by providing
a "Free Instant Online Project Identification & Selection"
search facility to identify projects based on multiple search
parameters related to project costs namely: Plant &
Machinery Cost, Total Capital Investment, Cost of the
project, Rate of Return% (ROR) and Break Even Point %
(BEP). You can sort the projects on the basis of mentioned
pointers and identify a suitable project matching your
investment requisites.
Click here to go
http://www.entrepreneurindia.co/project-identification
www.entrepreneurindia.co
![Page 47: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/47.jpg)
Contact us
Niir Project Consultancy Services
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: [email protected] , [email protected]
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Fax: +91-11-23845886
Website : www.entrepreneurindia.co , www.niir.org
Take a look at NIIR PROJECT CONSULTANCY SERVICES on
#StreetView
https://goo.gl/VstWkd
![Page 49: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/49.jpg)
o One of the leading reliable names in industrial world for
providing the most comprehensive technical consulting services
o We adopt a systematic approach to provide the strong
fundamental support needed for the effective delivery of services
to our Clients’ in India & abroad
Who are we?
www.entrepreneurindia.co
![Page 50: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/50.jpg)
We at NPCS want to grow with you by providing solutions scale
to suit your new operations and help you reduce risk and give a
high return on application investments. We have successfully
achieved top-notch quality standards with a high level of
customer appreciation resulting in long lasting relation and
large amount of referral work through technological
breakthrough and innovative concepts. A large number of our
Indian, Overseas and NRI Clients have appreciated our
expertise for excellence which speaks volumes about our
commitment and dedication to every client's success.
www.entrepreneurindia.co
![Page 51: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/51.jpg)
We bring deep, functional expertise, but are known for
our holistic perspective: we capture value across
boundaries and between the silos of any organization.
We have proven a multiplier effect from optimizing the
sum of the parts, not just the individual pieces. We
actively encourage a culture of innovation, which
facilitates the development of new technologies and
ensures a high quality product.
www.entrepreneurindia.co
![Page 52: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/52.jpg)
o Project Identification
o Detailed Project Reports/Pre-feasibility Reports
o Business Plan
o Industry Trends
o Market Research Reports
o Technology Books and Directory
o Databases on CD-ROM
o Laboratory Testing Services
o Turnkey Project Consultancy/Solutions
o Entrepreneur India (An Industrial Monthly Journal)
What do we offer?
www.entrepreneurindia.co
![Page 53: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/53.jpg)
o We have two decades long experience in project consultancy and
market research field
o We empower our customers with the prerequisite know-how to
take sound business decisions
o We help catalyze business growth by providing distinctive and
profound market analysis
o We serve a wide array of customers , from individual
entrepreneurs to Corporations and Foreign Investors
o We use authentic & reliable sources to ensure business precision
How are we different ?
www.entrepreneurindia.co
![Page 54: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/54.jpg)
Our Approach
Requirement collection
Thorough analysis of the project
Economic feasibility study of the Project
Market potential survey/research
Report Compilation
www.entrepreneurindia.co
![Page 55: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/55.jpg)
Who do we serve?
o Public-sector Companies
o Corporates
o Government Undertakings
o Individual Entrepreneurs
o NRI’s
o Foreign Investors
o Non-profit Organizations, NBFC’s
o Educational Institutions
o Embassies & Consulates
o Consultancies
o Industry / trade associations
www.entrepreneurindia.co
![Page 56: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/56.jpg)
Sectors We Cover
o Ayurvedic And Herbal Medicines, Herbal Cosmetics
o Alcoholic And Non Alcoholic Beverages, Drinks
o Adhesives, Industrial Adhesive, Sealants, Glues, Gum & Resin
o Activated Carbon & Activated Charcoal
o Aluminium And Aluminium Extrusion Profiles & Sections,
o Bio-fertilizers And Biotechnology
o Breakfast Snacks And Cereal Food
o Bicycle Tyres & Tubes, Bicycle Parts, Bicycle Assembling
www.entrepreneurindia.co
![Page 57: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/57.jpg)
Sectors We Cover Cont…
o Bamboo And Cane Based Projects
o Building Materials And Construction Projects
o Biodegradable & Bioplastic Based Projects
o Chemicals (Organic And Inorganic)
o Confectionery, Bakery/Baking And Other Food
o Cereal Processing
o Coconut And Coconut Based Products
o Cold Storage For Fruits & Vegetables
o Coal & Coal Byproduct
www.entrepreneurindia.co
![Page 58: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/58.jpg)
Sectors We Cover Cont…
o Copper & Copper Based Projects
o Dairy/Milk Processing
o Disinfectants, Pesticides, Insecticides, Mosquito Repellents,
o Electrical, Electronic And Computer based Projects
o Essential Oils, Oils & Fats And Allied
o Engineering Goods
o Fibre Glass & Float Glass
o Fast Moving Consumer Goods
o Food, Bakery, Agro Processing
www.entrepreneurindia.co
![Page 59: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/59.jpg)
Sectors We Cover Cont…
o Fruits & Vegetables Processing
o Ferro Alloys Based Projects
o Fertilizers & Biofertilizers
o Ginger & Ginger Based Projects
o Herbs And Medicinal Cultivation And Jatropha (Biofuel)
o Hotel & Hospitability Projects
o Hospital Based Projects
o Herbal Based Projects
o Inks, Stationery And Export Industries
www.entrepreneurindia.co
![Page 60: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/60.jpg)
Sectors We Cover Cont…
o Infrastructure Projects
o Jute & Jute Based Products
o Leather And Leather Based Projects
o Leisure & Entertainment Based Projects
o Livestock Farming Of Birds & Animals
o Minerals And Minerals
o Maize Processing(Wet Milling) & Maize Based Projects
o Medical Plastics, Disposables Plastic Syringe, Blood Bags
o Organic Farming, Neem Products Etc.
www.entrepreneurindia.co
![Page 61: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/61.jpg)
Sectors We Cover Cont…
o Paints, Pigments, Varnish & Lacquer
o Paper And Paper Board, Paper Recycling Projects
o Printing Inks
o Packaging Based Projects
o Perfumes, Cosmetics And Flavours
o Power Generation Based Projects & Renewable Energy Based Projects
o Pharmaceuticals And Drugs
o Plantations, Farming And Cultivations
o Plastic Film, Plastic Waste And Plastic Compounds
o Plastic, PVC, PET, HDPE, LDPE Etc.
www.entrepreneurindia.co
![Page 62: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/62.jpg)
Sectors We Cover Cont…
o Potato And Potato Based Projects
o Printing And Packaging
o Real Estate, Leisure And Hospitality
o Rubber And Rubber Products
o Soaps And Detergents
o Stationary Products
o Spices And Snacks Food
o Steel & Steel Products
o Textile Auxiliary And Chemicals
www.entrepreneurindia.co
![Page 63: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/63.jpg)
Sectors We Cover Cont…
o Township & Residential Complex
o Textiles And Readymade Garments
o Waste Management & Recycling
o Wood & Wood Products
o Water Industry(Packaged Drinking Water & Mineral
Water)
o Wire & Cable
www.entrepreneurindia.co
![Page 64: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/64.jpg)
Contact us
Niir Project Consultancy Services
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: [email protected] , [email protected]
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Fax: +91-11-2385886
Website : www.entrepreneurindia.co , www.niir.org
Take a look at NIIR PROJECT CONSULTANCY SERVICES on
#StreetView
https://goo.gl/VstWkd
![Page 65: (Penicillins, Genetics, Solvent Extraction, Aminoglycoside ... · an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains](https://reader034.fdocuments.in/reader034/viewer/2022042104/5e82cb42562f8f0e852b931e/html5/thumbnails/65.jpg)
www.niir.org
Follow Us
www.entrepreneurindia.co