Pedigree Charts - Mrs. Meadows Sciencemeadowsscience.weebly.com/.../pedigree_charts_ppt.pdfPedigree...
Transcript of Pedigree Charts - Mrs. Meadows Sciencemeadowsscience.weebly.com/.../pedigree_charts_ppt.pdfPedigree...
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Pedigree Charts
The family tree of genetics
Created by Lauren Almaguer, CDC Science Ambassador, 2004
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Overview
I. What is a pedigree?
a. Definition
b. Uses
II. Constructing a pedigree
a. Symbols
b. Connecting the symbols
III. Interpreting a pedigree
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What is a Pedigree?
A pedigree is a chart of the genetic history of family over several generations.
Scientists or a genetic counselor would find out about your family history and make this chart to analyze.
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Constructing a Pedigree
Male
Female
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Connecting Pedigree Symbols
Married Couple
Children
Examples of connected symbols:
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Example
What does a pedigree chart look like?
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Symbols in a Pedigree Chart
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Affected
X-linked
Autosomal carrier
Deceased
Symbols in a Pedigree Chart
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Interpreting a Pedigree Chart
1. Determine if the pedigree chart shows an
autosomal or X-linked disease.
– If most of the males in the pedigree are
affected the disorder is X-linked
– If it is a 50/50 ratio between men and
women the disorder is autosomal.
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Example of Pedigree Charts
Is it Autosomal or X-linked?
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Answer
Autosomal
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Interpreting a Pedigree Chart
2. Determine whether the disorder is
dominant or recessive.
– If the disorder is dominant, one of the
parents must have the disorder.
– If the disorder is recessive, neither
parent has to have the disorder because
they can be heterozygous.
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Example of Pedigree Charts
Dominant or Recessive?
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Answer
Dominant
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Example of Pedigree Charts
Dominant or Recessive?
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Answer
Recessive
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Summary
Pedigrees are family trees that explain your
genetic history.
Pedigrees are used to find out the
probability of a child having a disorder in a
particular family.
To begin to interpret a pedigree, determine if
the disease or condition is autosomal or X-
linked and dominant or recessive.