Paul M.L. Janssen, Ph.D. Curriculum Vitae, May 2019

Full Name: Paulus Mathias Leonardus Janssen Date of birth: February 9, 1968 Place of birth: Roermond, The Netherlands Nationality: The Netherlands (Birth) and USA (naturalized September 2008) Education: • 1997, Ph.D. in Medical Physiology, Univ. Utrecht (Utrecht, NL, theoretical part), and Johns Hopkins

Univ. (Baltimore, USA), Tohoku Univ. (Sendai, Japan), Wake Forest Univ. (Winston-Salem, USA), and Univ. of Illinois at Chicago (Chicago, USA); practical part. Thesis: ”Determinants of contraction and relaxation in mammalian myocardium: effects of calcium and sarcomere length”.

• 1994, Masters’ Degree in Medial Biology, Univ. Utrecht, Utrecht, NL. Master-Degree-Theses: ”Mechanisms of contra(di)ction” and ”Cardiovascular effects of melanotropins in conscious rats: a structure activity analysis”. Optional courses in animal research, teratology, pathophysiology of the immune-system, psychiatry, virology, microbiology and medical physics and computer-programming. Additional lecture cycle-course in Sportsmedicine, Janus Jongbloed Research Center, Utrecht.

• 1989, Propaedeuse-degree in Medical Biology, Univ. Utrecht, NL. • 1987, Bisschoppelijk College Schöndeln, Roermond, NL (high school). University entrance

diploma. Majors: Dutch, English, physics, chemistry, biology, basic- and applied mathematics. Minors: geography, history, arts, sports, French, German, music, and economics.

Research Experience/Employment: 2015-present Fred A. Hitchcock Professor of Environmental Physiology, The Ohio State University,

Columbus, OH, USA. 2014-present Professor and Vice-Chair, Department of Physiology and Cell Biology, The Ohio State

University, Columbus, OH, USA. 2013-present Professor, Department of Physiology and Cell Biology, and Dept. of Internal Medicine,

Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA. 2008-2013 Associate Professor, Dept. of Physiology and Cell Biology, and Dept. of Internal

Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.

2006-2008 Assistant Professor, Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.

2002-2008 Assistant Professor, Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.

2000-2002 Research Associate, Institute of Molecular Cardiobiology, Dept. of Internal Medicine, Div. of Cardiology, Johns Hopkins Univ., Baltimore, MD, USA.

1999-2000 Research Assistant Professor, Georg-August Univ., Dept. of Cardiology and Pneumology, Göttingen

1997-1999 Post-Doctoral Fellow, Albert-Ludwigs Univ., Dept. of Cardiology, Freiburg ,Germany. Supervisor: Prof. Dr. G. Hasenfuss.

1994-1997 Ph.D. student, Dept. of Internal Medicine, Section on Cardiology, Wake Forest Univ., Bowman Gray School of Medicine, Winston-Salem, NC and Dept. of Physiolo9gy and Biophysics, Univ. of Illinois at Chicago, IL, USA.

1994-1994 Visiting Student Scientist, First Dept. of Internal Medicine, Tohoku Univ., School of Medicine, Sendai, Japan.

1993-1994 Research Trainee, Dept. of Biomedical Engineering, Johns Hopkins Univ., Baltimore, MD, USA.

1992-1993 Research Assistant, Rudolf Magnus Institute for Pharmacology, Univ. Utrecht, Utrecht, NL.

1991-1992 Research Assistant, Dept. of Medical Physiology and Sportsmedicine, Univ. Utrecht, Utrecht, NL and Synchrotron Radiation Source, Daresbury Laboratories, Warrington, U.K.

Teaching: 01-1992: Utrecht University Lab in respiratory physiol. 8 sessions 6 students/session 02-1992: Utrecht University Lab in muscle physiology 8 sessions 5 students/session 10-1992: Utrecht University Lab in muscle physiology 8 sessions 5 students/session 11-1992: Utrecht University Lab in respiratory physiol. 8 sessions 6 students/session 12-1992: Utrecht University Lab in ECG/Cardiology 16 sessions 6 students/session 05-1993: Utrecht University Cardiovascular pharmacol. 3 lectures 80 students 05-2001: Johns Hopkins U. Cardiac physiology MED I 2 lectures 110 students 05-2003: OSU Cardiac physiology IBGP 3 lectures 30 students 08-2003: OSU Cardiac biophysics BPG 1 lecture 9 students 10-2003: OSU Cardiac metablosim Med II 2 lectures 120 students 01-2004: OSU Cardiac biophysics BPG 3 lectures 20 students 02-2004: OSU Gastro-intestinal physiol. 6 lectures 200 students 05-2004: OSU Cardiac physiology IBGP 3 lectures 30 students 10-2004: OSU Cardiac metablosim Med II 2 lectures 120 students 02-2005: OSU Gastro-intestinal physiol. 6 lectures 200 students 05-2005: OSU Cardiac physiology IBGP 3 lectures 30 students 08-2005: OSU Cardiac biophysics BPG 2 lectures 15 students 01-2006: OSU Cardiac physiology 911.27 3 lectures 8 students 02-2006: OSU Gastro-intestinal physiol. 6 lectures 200 students 05-2006: OSU Cardiac physiology IBGP 3 lectures 30 students 05-2007: OSU Cardiac physiology IBGP 4 lectures 30 students 01-2008: OSU Cardiac physiology 911.27 3 lectures 8 students 05-2008: OSU Cardiac physiology IBGP 3 lectures 27 students 10-2008: OSU Cardiovascular physiol. 1 lecture 10 students 01-2009: OSU Cardiac physiology 911.27 3 lectures 9 students 05-2009: OSU Cardiac physiology IBGP 4 lectures 21 students 05-2009: OSU Freshman Seminar Series 6 lect/10 labs 11 students 10-2009: OSU Cardiovascular physiol. 1 lecture 23 students 10-2009: OSU Freshman Seminar Series 6 lect/10 labs 17 students 05-2010: OSU Cardiac physiology IBGP 4 lectures 24 students 11-2010: OSU Cardiac physiology 911.27 2 lectures 14 students 02-2011: OSU Cardiac developm. 911.28 2 lectures 8 students 04-2011: OSU Freshman Seminar Series 6 lect/10 labs 19 students 05-2011: OSU Cardiac physiology IBGP 4 lectures 22 students 05-2011: OSU Principles of Grant Writing 2 lectures 20 students 10-2011: OSU Striated Muscle Physiology 6 lectures 250 students 04-2012: OSU Freshman Seminar Series 6 lect/10 labs 18 students 05-2012: OSU Cardiac physiology IBGP 4 lectures 28 students 05-2012: OSU MVIMG747 1 lecture 23 students 10-2012: OSU Striated Muscle Physiology 6 lectures 270 students 01-2013: OSU Freshman Seminar Series 6 lect/10 labs 11 students 02-2013: OSU Biomedical Sciences 2 hours discussion 15 students 08-2013: OSU Myology Course 1 lecture 19 students 10-2013: OSU Striated Muscle Physiology 6 lectures 270 students 01-2014: OSU Biomedical Sciences 2 hours discussion 15 students 01-2014: OSU MVIMG 7470 1 lecture 25 students

08-2014: OSU Myology Course 1 lecture 14 students 03-2015: OSU Cardiac Physiology 8101 3 lectures 9 students 08-2015: OSU Myology Course 1 lecture 9 students 10-2015: OSU Human Physiology 3200 4 lectures 180 students 02-2016: OSU Human Physiology 3200 4 lectures 190 students 08-2016: OSU Myology Course 1 lecture 8 students 09-2016: OSU Physiology 6101 4 Lectures 45 students 10-2016: OSU Human Physiology 3200 4 lectures 190 students 01-2017: OSU Cardiac Physiology 8101 3 lectures 7 students 03-2017: OSU Human Physiology 3200 4 lectures 190 students 10-2017: OSU Physiology 6101 4 Lectures 45 students 10-2017: OSU Human Physiology 3200 4 lectures 220 students 02-2018: OSU Human Physiology 3100 3 lectures 67 students 02-2018: OSU Human Physiology 3200 4 lectures 250 students 08-2018: OSU Myology Course 1 lecture 6 students 09-2018: OSU Physiology 6101 1 Lecture 60 students 10-2018: OSU Human Physiology 3200 4 lectures 250 students 01-2019: OSU Cardiac Physiology 8101 3 lectures 22 students 02-2019: OSU Human Physiology 3100 3 lectures 75 students 02-2019: OSU Human Physiology 3200 4 lectures 250 students Course Development: 2006: OSU 911.27 (now 8101): Advanced Cardiac Physiology (new course) 2009: OSU Freshman Seminar Series: The Art and Science of LEGO (with B. Coifman, new course) 2010: OSU 911.28: Advanced Cardiac Development (With P. Lucchesi and T. Elton) 2010: OSU 911.29: Advanced Cardiac Pathophysiology (With P. Lucchesi and T. Elton) 2017: OSU 3100: Human Physiology and Pathophysiology (new course) Academic Service, Department: PCB Faculty Search Committee: Member, 2002-2005, 2007-present Graduate Recruitment Committee: Chair, 2004-2007; Member, 2007-2009 Merit committee: Member, 2010; Chair, 2011-2012, Member 2012-2015, Chair, 2015-2016, Member, 2016-2018. AP&T committee: Chair, 2010-2011; Member, 2011-2013; Chair, 2015 Space Committee: Member, 2009-present; Chair, 2013-present Teaching Committee: Member, 2004-2007, Chair, 2017-present Department Vice-Chair, 2014-present Academic Service, College: IBGP Admission Committee: Member, 2003-2007 IBGP Graduate Studies Committee: Member, 2003-2007 COM Graduate Education Committee: Member, 2006-2010 MD/PhD Program Admission Committee: Member 2009-present COM Faculty Council: Member, 2010-2015 COM College Coucil: Member, 2016-present Shared Services Advisory Committee: Member, 2011-2013 Ohio State Cardiac Tissue Resourse: Director, 2009-present DHLRI Executive Board: Member, 2013-present COM AP&T committee (tenure track): Member, 2014-2016, Chair, 2017-present COM Faculty Council: Interim Secretary, 2015

COM Faculty Council: Vice-President, 2015-2017 COM Agenda Committee: Member, 2015, 2017-present Dept. Emergeny Medicine P&T commmittee: Ad Hoc Member, 2016-2017 COM Faculty Council President, 2017-present Dept. Biomedical engineering P&T commmittee: Ad Hoc Member, 2017 COM Investigation Committee: Member, 2018 (2 cases) COM Faculty Experience Initiatives Committee: Member, 2018-present COM Bridge and Innovation Grant Committee: Member, 2018-present COM Investigation Committee: Chair, 2019 (1 case) Academic Service, University: Freshman Seminar Transition Committee, Member, 2009 Advising Graduate Students: Name Dates Program Current Position Oliver Zeitz, MD 1997-2000 Med. School, Germany Assoc. Prof. Sripriya Raman 2003-2005 IBGP, OSU Pediatric Ongologist Kenneth Varian 2004-2008 MSTP / IBGP, OSU Cardiologist Nitisha Hiranandani 2004-2009 IBGP, OSU Physician Carlos Torres, MD 2005-2014 Biophysics Grad. Prog. Clin. Assist. Prof. Michelle M. Monasky 2005-2010 Biophysics Grad. Prog. Research Scientist Ying Xu 2007-2011 MCDB, OSU Physician Kaylan Haizlip 2008-2012 IBGP, OSU Post-Doc Jessica Abraham 2008-2012 IBGP, OSU Scientific Writer, Abbott Nima Milani-Nejad 2010-2014 MSTP / IBGP Resident Mohammad Elnakish 2011-2013 MCDB, OSU Res. Assist. Professor Brit L. Martin 2013-2017 MCDB, OSU Scientific Writer Jae-Hoon Chung 2014-2018 MSTP / BSGP MD Student Nancy Saad 2014-2018 Egyptian exchange program Research Associate Amanda Huang 2018-present MSTP / BSGP Graduate Student Kyra Peczkowski 2018-present BSGP Graduate Student Farbod Fazlollahi 2018-present MSTP / BSGP Graduate Student Undergraduate Students and Volunteers: Name Dates Program Current Position Alice Jacobson 2010-2011 Nishikawara Fellowship Respiration Technologist Jennifer Conkle 2012-2015 Undergraduate Undergraduate Tallib Karaze 2013-2015 Undergradaute Research Technician G. Thaddeus Billman 2013 Undergradaute Accountant Kyle T. Floyd 2014-2015 Undergradaute Research Technician Amy L. Eisenberg 2014-2015 Undergraduate Undergraduate Will Crecelius 2015-2017 Undergraduate Undergraduate Steven Repas 2016-2018 Undergraduate MD student Jorge Santini 2017-2018 Undergraduate Graduate student Nathan Meyer 2018-2019 Undergraduate Undergraduate Austin Hare 2018-present Undergraduate Undergraduate Mohammed Mashali 2018-present Post-graduate Volunteer

Caroline Wright 2018-present Undergraduate Undergraduate Divyaam Satiya 2018-present Undergraduate Undergraduate Mason Mangapora 2019-present Undergraduate Undergraduate Post-Doctoral Fellows: Name Dates Current Position Tepmanas Bupha-Intr 2005-2007 Associate Prof., Dept Physiol., Mahidol Univ., Thailand Qing Lou 2011-2012 Post Doctorlal fellow, Ohio State University Mohammad Elnakish 2013-2017 Research Assistant Professor, Ohio State University Mei-Pian (Peggy) Chen 2014-2018 Post Doctoral fellow, Ohio State University Honors and Awards: 1991 Medical Biology Student Honor Society. 1992 Conference-supportship of the Utrecht University Foundation (U-fonds). 1993/94 Research Award/Scholarship of the Netherlands Heart Foundation (NHS). 1993/94 Scholarship Award of the United Savings Bank Foundation (VSB-fonds). 1998 Sagawa Young Investigator Award, Cardiovascular System Dynamics Society. 2002 Best-Poster Award, XVth meeting, Cardiovascular System Dynamics Society. 2004-present Secratary/Treasurer of the Cardiovascular System Dynamics Society. 2006 Established Investigator, American Heart Association. 2008 Elected as Fellow of the American Heart Association (FAHA). 2008 President, The Ohio Physiological Society, Chapter of APS. 2010 54th Bowditch Award, American Physiological Society. 2013 Elected as Fellow of the Cardiovascular Section of the American Physiological Society (FAPS). 2019 Distinguished Diversity Enhancement Award, The Ohio state University Outreach Activities: 2006-present Presented science posters and oral presentations in support of the local AHA chapter. 2008-present Presented several science lessons and math presentations at elementary/middle schools. 2010 Performed a cardiac anatomy laboratory (dissection of a cow heart) for 5th grade

science students at Bluffview Elementary. 2010-present Represented scientist point-of-view regarding musclular dystrophy disease for patient support groups and individual patients. 2011-2012 Contributed to several television segments featuing team science at OSU. 2012 Represented basic science faculty for patient group “Mended Little Hearts“. 2012-present Started fundraising initiative LEGO Ohio stadium, OSU development fund to raise funds and awareness for heart failure and muscular dystrophy research (>$80,000) 2012 Presented at TEDxOhioStateUniversity. 2013 Guest Lecture at Columbus Museum of Art and Humanities Department at OSU. Grants, Active: 08/15/2012-07/31/2020, Janssen (PI) Frequency-dependent modulation of cardiac myofilament function in health/disease NIH R01 HL113084 07/01/2016-06/30/2019, Janssen (PI)

AWRP Mentor-Mentee Award American Heart Association 16MM32110000 07/01/2019-06/30/2023, Gyorke (PI), Janssen (Co-I) Controlled and uncontrollable calcium release in heart NIH R01 (NHLBI) HL063043 04/01/2018-03/31/2022, Fedorov (PI), Janssen (Co-I) Integration of structure and signaling in cardiac pacemaker function NIH R01 (NHLBI) HL11580 04/01/2018-03/31/2023, Rafael-Fortney (PI), Janssen (Co-I) Functions of skeletal muscle mineralocorticoid receptor signaling in chronic and acute injury NIH R01 AR072574 06/01/2018-05/31/2022, Biesiadecki (PI), Janssen (Co-I) Integrated crosstalk of thin filament post-translational modifications NIH R01 (NHLBI) HL114940 09/15/2017-08/31/2021, Mohler/Wold (MPI), Janssen (Co-I) Defining the impact of E-cigarettes on cardiac pathophysiology NIH R01 HL139348 07/01/2017-06/30/2021, Fedorov (PI), Janssen (Co-I) Targeting the arrhythmogenic sources of human atrial fibrillation NIH R01HL135109 12/15/2016-11/30/2021, Khan (PI), Janssen (Co-I) Biomimetic cardiac patch capable of rapid angiogenesis NIH R01 HL136232 12/15/2016-11/30/2020, Davis (PI), Janssen (Co-I) Role of Cardiac Troponin in Health and Disease NIH R01 HL132213 07/10/2017-04/30/2022, Burghes (PI), Janssen (Co-I) Biomarkers and additive therapies to enhance symptomatic treatment of spinal muscular atrophy. NIH R01 HD060586 Grants, Completed: 07/01/2013-04/30/2019, Janssen and Rafael-Fortney (Dual-PI) Mechanisms and synergies of therapeutic drug treatments in muscular dystrophy NIH R01 NS082868 08/01/2018-12/31/2018, Rafael-Fortney (PI), Janssen (Co-PI) Testing novel drugs in mouse models of Duchenne muscular dystrophy Bayer Pharma AG 01/01/2017-12/31/2018, Chung (Pre-Doc-PI), Janssen (Mentor) Effect of Frequency Modulation on Cross-bridge Cycling Kinetics and Calcium Sensitivity in Heart Failure American Heart Association Pre-Doctoral Fellowship 16PRE33410549

06/01/2013-05/31/2018, Biesiadecki (PI), Janssen (Co-I) Integrated crosstalk of thin filament post-translational modifications R01 HL114940 01/01/2016-12/31/2017, Elnakish (Post-Doc-PI), Janssen (Mentor) Desynchronization of Intracellular Ca2+ Release by IK1 Activation: A New Antiarrhythmic Approach in Human Hearts at Risk American Heart Association Post-Doctoral Fellowship 16POST27760155 09/30/2013-09/29/2017, Rafael-Fortney (PI), Janssen (Qualified Collaborator) Optimization of renin-angiotensin-aldosterone inhibitors as a treatment for Duchenne muscular dystrophy Army Medical Res & Materiel Command/DOD W81XWH-13-1-0378 04/01/2016-10/31/2017, Rafael-Fortney (PI), Janssen (Co-PI) Testing novel drugs in mouse models of Duchenne muscular dystrophy Bayer Pharma AG 07/01/2013-06/30/2017, Guttridge (PI), Janssen (Co-I) Muscle stem cells and cancer cachexia R01 CA180057 08/01/2013-05/31/2017, Mohler (PI), Janssen (Co-I) EHD proteins in cardiac membrane protein targeting and remodeling NIH R01 HL114383 12/1/2010-12/31/2017, Beattie (PD), Janssen (Core-D PI) Ohio State Neuroscience Core Grant NIH NINDS P30 NS045758-06 06/01/2013-05/31/2017, Raman and Rafael-Fortney (Dual-PI), Janssen (Co-I) Therapeutic potential for aldosterone inhibition in Duchenne muscular dystrophy NIH R01 HL116533 04/01/2012-03/31/2017, Guttridge (PI), Janssen (Co-I) NF-kB/IKK signaling in myogenesis and disease NIH R01 AR052787 09/01/2015-08/31/2016, Davis (PI), Janssen (Co-I) Role of Cardiac Troponin in Health and Disease NIH R56HL091986 04/15/2012-02/29/2016, Gyorke (PI), Janssen (Co-I) Abnormal intracellular calcium release in heart failure NIH R01 HL074045 09/01/2012-08/31/2015, Martin (PI), Janssen (Site-PI, Co-I) Translational studies of GALGT2 gene therapy for Duchenne muscular dystrophy Army Medical Res & Materiel Command/DOD 08/01/2010-06/30/2015, Davis (PI), Janssen (Co-I) Role of Cardiac Troponin in Health and Disease NIH R01HL091986

07/01/2012-06/30/2014, Milani-Nejad (Student-PI), Janssen (Mentor) Regulation of Cardiac Cross-Bridge Cycling Rate via Length-Dependent Post-Translational Modifications in Health/Disease American Heart Association Predoctoral Fellowship 12PRE11480008 08/01/2011-09/31/2012, Janssen (PI) Prevention of eccentric stress damage and contractile dysfunction by glycoprotein-based membrane strengthening in cardiac muscle Parent Project Muscular Dystrophy 01/01/2010-12/31/2012, Rafael-Fortney (PI), Janssen (Collaborator) Investigation of a new treatment target for heart failure in muscular dystrophy Muscular Dystrophy Association RG157566 09/30/2010-08/31/2012, Janssen (PI) Electrical and mechanical behavior of live human myocardium in health and disease NIH (NHLBI) RC1 HL099538 05/01/2009-04/30/2012, Haizlip (Student), Janssen (mentor) Functional and Molecular Changes During Development of Compensatory Hypertrophy NIH National Research Service Award Fellowship, 1F31HL096397 08/01/2011-01/31/2012, Rafael-Fortney (PI), Janssen (Co-I, 5% effort) Optimization of renin-angiotensin-aldosterone inhibitors as a treatment for dystrophin-deficient skeletal muscles and heart Parent Project Muscular Dystrophy 01/01/2007-12/31/2011, Janssen (PI) AHA National Center, Established Investigator Award 0740040N Cardiac relaxation; frequency dependent relaxation and load induced remodeling 09/01/2007-08/31/2011, Mendell (PI), Janssen (Co-PI) Diverse strategies to correct the dystrophin gene using vascular delivery NIH (NINDS) U54 NS055958 07/01/2006-06/30/2011, Ziolo (PI), Janssen (Co-PI) Functional effects NOS1/NOS3 on cardiac myocyte function NIH NHLBI RO1 HL079283 07/01/2009-06/30/2011, Abraham (Student), Janssen (Mentor) Frequency-Dependent Modulation of Myofilament Calcium Sensitivity in Health and Disease Pre-doctoral award, American Heart Association Great Rivers Affiliate 04/01/2004-03/31/2011, Janssen (PI) Cardiac Contraction-Relaxation coupling NIH (NHLBI) R01 HL073816 04/01/2006-03/31/2011, Janssen (PI) Myofilament calcium sensitivity in health and disease NIH (NHLBI) KO2 HL083957, Career development award 01/12/2007-02/28/2011, Guttridge (PI), Janssen (Co-PI) NF-B inhibition therapy for Duchenne Muscular Dystrophy NIH UO1 NS058451

07/01/2005-06/30/2010, Yates (PI), Janssen (Co-PI) NIH Systems in Integrated Biology Training Grant 07/01/2008-06/30/2010, Monasky (Student), Janssen (Mentor) Myofilament properties as determinants of myocardial relaxation Pre-doctoral award, American Heart Association Great Rivers Affiliate 01/07/2006-06/30/2008 Varian (PI), Janssen (Mentor) Myofilament Calcium Sensitivity under Physiologic Conditions in Health and Disease Pre-doctoral award, American Heart Association Ohio Valley Affiliate 07/01/2007-06/30/2009, Hiranandani (PI), Janssen (Mentor) Role of myofilament and calcium in oxidative stress injury in heart Pre-doctoral award, American Heart Association Great Rivers Affiliate 07/1/2007-06/30/2008, Torres (Student-PI), Janssen (Mentor) Emergency Medicine Foundation, Career development award Unraveling the inotropic effect of pyruvate 07/1/2007-06/30/2008, Janssen (PI) Davis Heart & Lung Research Institute, Program Project Initiative Grant PPIG-PJ Cardiac Diastolic Dysfunction 07/1/2007-06/30/2008, Ziolo (PI), Janssen (Co-PI) Davis Heart & Lung Research Institute, Research Development Grant NOS2 Signaling and Functional Effects on Cardiac Contractility 07/1/2007-06/30/2008, Rafael-Fortney (PI), Janssen (Co-PI) Davis Heart & Lung Research Institute, Research Development Grant RDG-JRF The role of Claudin-5 in Cardiomyopathy 7/1/2006-6/31/2008, Janssen and Martin (Dual-PI) CCRI/OSUCOM Research Collaboration Award Humanizing glycosylation to humanize disease progression in mdx mouse model of Duchenne’s. 01/01/2004-12/31/2007, Periasamy (PI), Janssen (Co-PI) Serca, a determinant of cardiac contractility NIH NHLBI RO1 HL064140-06 11/01/2006-10/31/2007, Janssen (PI) Time-dependent contribution of calcium handling and myofilament properties to ischemia-reperfusion injury. Davis Heart & Lung Research Institute, Research Development Grant 1/1/07-12/31/07, Torres (PI), Janssen (Co-PI/Mentor) Unraveling the Inotropic Effect of Pyruvate Strategic Investment Grant, OSU College of Medicine 01/07/2005-06/30/2006, Raman (PI), Janssen (Mentor) Role of Persistent versus Periodic Stress on Cardiac Contractility, Cell Remodeling. Pre-doctoral award, American Heart Association Ohio Valley Affiliate 07/01/2002-06/30/2006, Janssen (PI)

Load Dependent Changes in Myocyte Dimensions and Properties of Myocytes in Culture SDG 0235045N, American Heart Association National Center 10/01/2003-09/30/2004, Janssen (PI) Economy of Force Generation in Murine Myocardium NIH P&F MMPC DK59630 06/01/2003-05/31/2004, Janssen (PI) Inotropic effects of ATI-101 Artesian Therapeutics 07/01/2003-09/30/2003, Maringer (PI), Janssen (Mentor) Effect of Pyruvate on Cardiac contractility American Physiological Society, Frontiers in Physiology Summer Research Program 2000-2002 American Heart Association, Mid-Atlantic Affiliate, Post-Doctoral Fellowship. 1999-2000 Research Grant: Apoptosis in myocardium, impact of Nebivolol, Berlin-Chemie, Berlin

Germany. 1999-2000 Research support award, University of Göttingen, Germany. 1998-1999 Research Grant „Beta-blockers and calcium sensitivity“, Berlin-Chemie, Berlin Germany. 1996-1997 Affiliate Fellowship Grant of the American Heart Association, North Carolina Affiliate. 1992 Tohoku University International Studentsupportship. Membership in Scientific Societies (since): • American Physiological Society (1994) • Biophysical Society (1995) • Cardiac Muscle Society (1996) • Cardiovascular Systems Dynamics Society (1998) • American Heart Association (1999) • International Society for Heart Research (2000) • Ohio Physiological Society (2008) Editorships 2009-present Editorial board member, Open Journal of Cardiology 2010-present Editorial board member, ISRN Cardiology 2010-2012 Editor-in-Chief, Frontiers in Cardiac Muscle Physiology 2012-present Co-Editor-in-Chief, Frontiers in Striated Muscle Physiology In my role as founding (co-)edtior-in-chief of Frontierts in Striated Muscle Physiology, this Nature Publishing Group on-line journal reeached an ISI impact factor of 4.43, ranking among the top journals in Physiology, within only several years. Duties include population and maintenance of the editorial and review boards, conflict management, and the final manscript acceptance/rejection decisions. 2017-present Editorial Board Member, Circulation: Heart Failure Reviewing, Journals (since): • J. Moll. Cell. Cardiol. (1997) • Circ. Res. (1998) • Circulation (1998) • Am. J. Physiol. (1998) • Eur. J. Physiol. (1998)

• Acta Physiol. Scan. (1999) • J. Exp. Clin. Pharmacol. (1999) • J. Physiol. (2000) • Cardiovasc. Res. (2000) • Exp. Op. Pharmacother. (2001) • Drug Discovery Today (2001) • Experimental Biology and Medicine (2001) • Faseb J. (2002) • Drug Development (2004) • Physiological Genomics (2005) • Aging Cell (2006) • Muscle and Nerve (2007) • Heart and Vessels (2007) • Medical Science Monitor (2007) • J. Biol. Chem. (2008) • International Journal of Cardiology (2008) • J. Gen. Physiology (2009) • Experimental Lung Research (2009) • Annals of Neurology (2009) • Women’s Health (2009) • J. Appl. Phys. (2010) • Mol. Ther. (2010) • Can. J. Physiol. Pharmacol. (2010) • ISRN Cardiology (2011) • J Transl Med (2011) • J Biol. Med. Model. (2011) • Mol. Med. (2011) • Exp. Physiology (2011) • Physiol. Res. (2011) • Biochem. Res. Int. (2012) • Am. J. Pathol. (2012) • PLoS One (2013) • J. Anatomy (2013) • Archives Biochem. Biophys. (2013) • BBA general Subjects (2013) • J. Res. Cell motil. (2014) • Biomaterials (2015) • Biomarker Insights (2018) Reviewing, Grants: • AHA National, Member, study section Cardiac Biology and Regulation (2004-2006) • AHA National, Member, study section Cardiac Biology and Regulation 2 (2007) • AHA, Great Rivers Affiliate, Member, Cardiac Biology 1 (2008-2010) • AHA National, Member, study section Bio BCT 1 (2011-2014) • AHA National, Co-chair, study section Bio BCT 4 (2015-present) • National Science Foundation (2009-present) • National Institutes of Health (Ad Hoc/member, 2009-present) • Prinses Beatrix Fonds, Netherlands (2011-present) • Muscular Dystrophy Association (2011-present) • Cure CMD (2011-present)

• Israel Science Foundation (2013-present) • Auckland Medical Research Foundation (2013) • Michigan Diabetes Research Center (2018) • Irish Research Council (2018) • Florida Department of Health (2018-present) Full peer-reviewed papers:

1. Schiereck P, de Beer EL, van Heijst BGV, Janssen PML, van Andel AJ, Jennekens FGI, Sontrop MATA, Bavinck A. Calcium-channel blockers enhance tension in skinned skeletal and heart muscle fibers. Eur J Pharmacol. 1993;249:317-324. PMID: 8287918

2. Van Bergen P, Janssen PML, Hoogerhout P, de Wildt DJ, Versteeg DHG. Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship. Eur J Pharmacol. 1995;294:795-803. PMID: 8750747

3. Janssen PML, Hunter WC. Force, not sarcomere length, correlates with prolongation of isosarcometric contraction. Am J Physiol Heart Circ Physiol. 1995;269:H676-H685. PMID: 7653632

4. Janssen PML, Honda H, Koiwa Y, Shirato K. The effect of diastolic vibration on the relaxation of rat papillary muscle. Cardiovascular Res. 1996;32:344-350. PMID: 8796122

5. Janssen PML, de Tombe PP. Uncontrolled sarcomere length shortening increases the intracellular calcium transient in rat cardiac trabeculae. Am J Physiol Heart Circ Physiol. 1997;272:H1892-H1897. PMID: 9139976

6. Janssen PML, Schiereck P, Honda H, Naya T, Koiwa Y. The effect of applied mechanical vibration on two different phases of rat papillary muscle relaxation. Eur J Physiol (Pflügers Archiv). 1997;434:795-800. PMID: 9306014

7. Wannenburg T, Janssen PML, Fan DS, de Tombe PP. The Frank-Starling mechanism is not mediated by changes in the rate of cross-bridge detachment. Am J Physiol Heart Circ Physiol. 1997;273:H2428-H2435. PMID: 9374781

8. Janssen PML, de Tombe PP. Protein Kinase A does not alter unloaded velocity of sarcomere shortening in cardiac muscle. Am J Physiol Heart Circ Physiol. 1997;273:H2415-H2422. PMID: 9374779

9. Janssen PML, Lehnart SE, Prestle J, Lynker JC, Salfeld P, Just H, Hasenfuss G. The trabeculae culture system: A novel technique to study contractile parameters over a multi-day time period. Am J Physiol Heart Circ Physiol. 1998;274:H1481-1488. PMID: 9612353

10. Schiereck P, van Heijst BGV, Janssen PML, Schiereck J, van der Leun M, Bras W, de Beer EL. Force generation and shift of transfer between myosin and actin in skinned striated muscle fibers at low calcium concentrations. Eur Biophys J. 1998;27:575-581. PMID: 9791940

11. Janssen PML, Zeitz O, Hasenfuss G. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol. Eur J Pharmacol. 1999;366:223-232. PMID: 10082203

12. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Preservation of contractile parameters of human myocardium in multi-day cell culture. J Mol Cell Cardiol. 1999;31:1419-1427. PMID: 10423340

13. Zeitz O, Rahman A, Hasenfuss G, Janssen PML. Impact of -adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium. J Cardiovasc Pharmacol. 2000;36:126-131. PMID: 10892670

14. Janssen PML, Zeitz O, Keweloh B, Siegel U, Maier LS, Barckhausen P, Pieske B, Prestle J, Lehnart SE, Hasenfuss G. Influence of Cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium. Cardiovasc Res. 2000;47:99-107. PMID: 10869535

15. Hermann HP, Zeitz O, Keweloh B, Hasenfuss G, Janssen PML. Pyruvate potentiates the positive inotropic effects of isoproterenol and calcium in rabbit cardiac muscle preparations. Am J Physiol Heart Circ Physiol. 2000;279:H702-H708. PMID: 10924069

16. Wannenburg T, Heijne GH, Geerdink JH, van den Dool HW, Janssen PML, de Tombe PP. Crossbridge kinetics in rat myocardium: Effect of sarcomere length and calcium activation. Am J Physiol Heart Circ Physiol. 2000;279:H779-H790. PMID: 10924078

17. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PML, Blanz J, von Figura K, Saftig P. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2 deficient mice. Nature. 2000;406:902-906. PMID: 10972293

18. Janssen PML, Datz N, Zeitz O, Hasenfuss G. Levosimendan improves diastolic and systolic function of failing human myocardium. Eur J Pharmacol. 2000;404:191-199. PMID: 10980279

19. Lehnart SE, Janssen PML, Franz WM, Donahue JK, Lawrence JH, Marban E, Prestle J, Hasenfuss G. Preservation of myocardial function after adenoviral gene transfer in isolated myocardium. Am J Physiol Heart Circ. Physiol. 2000;279:H986-H991. PMID: 10993759

20. Schillinger W, Janssen PML, Emami S, Henderson SA, Ross RS, Teucher N, Zeitz O, Philipson KD, Prestle J, Hasenfuss G. Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na+-Ca2+ exchanger. Circ Res. 2000;87:581-587. PMID: 11009563

21. Prestle J, Janssen PML, Janssen AP, Zeitz O, Lehnart SE, Bruce L, Smith GL, Hasenfuss G. Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+-leak from the sarcoplasmic reticulum and increases contractility. Circ Res. 2001;88:188-194. PMID: 11157671

22. Baudet S, Weisser J, Janssen AP, Beulich K, Bieligk U, Pieske B, Noireaud J, Janssen PML, Hasenfuss G, Prestle J. Increased basal contractility of cardiomyocytes overexpressing protein kinase C and blunted positive inotropic response to endothelin-1. Cardiovasc Res. 2001;50:486-494. PMID: 11376624

23. Milting H, Janssen PML, Wangemann T, Kogler H, Domeier E, Seidler T, Hakim K, Grapow M, Zeitz O, Prestle J, Zerkowski HR. FK506 does not affect human cardiac contractility and adrenergic response in vitro. Eur J Pharmacol., 2001;430:299-304. PMID: 11711047

24. Most P, Bernotat J, Ehlermann P, Pleger ST, Reppel M, Boerries M, Niroomand F, Pieske B, Janssen PML, Eschenhagen T, Karczewiski P, Smith GL, Koch WJ, Katus HA, Remppis A. S100A1: a novel regulator of myocardial contractility. PNAS. 2001;98:13889-13894. PMID: 11717446

25. Janssen PML, Zeitz O, Rahman A, Hasenfuss G. Protective role of Nebivolol in hydroxyl radical induced injury. J Cardiovasc Pharmacol. 2001;38;Suppl 3;S-17-23. PMID: 11811388

26. Hermann HP, Zeitz O, Lehnart SE, Keweloh B, Datz N, Hasenfuss G, Janssen PML. Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. Cardiovasc Res. 2002;53:116-123. PMID: 11744019

27. Janssen PML, Hasenfuss G, Zeitz O, Lehnart SE, Prestle J, Darmer D, Holtz J, Schumann H. Load dependent induction of apoptosis in multicellular myocardial preparations. Am J Physiol Heart Circ. Physiol. 2002;282:349-356. PMID: 11748081

28. Hasenfuss G, Maier LS, Hermann HP, Lüers C, Hünlich M, Munk S, Zeitz O, Janssen PML, Pieske B. Influence of pyruvate on contractile performance and Ca2+-cycling in Isolated failing human myocardium. Circulation, 2002;105:194-199. PMID: 11790700

29. Janssen PML, Stull LB, Marban E. Myofilament properties comprise the rate-limiting step for cardiac relaxation at physiological temperature in rat myocardium. Am J Physiol Heart Circ. Physiol. 2002;282:499-507. PMID: 11788397

30. Zeitz O, Maass AE, Van Nguyen P, Hensmann G, Koegler H, Moeller K, Hasenfuss G, Janssen PML. Hydroxyl radical induced acute diastolic dysfunction is due to calcium overload via reverse mode Na+/Ca2+ exchange. Circ. Res., 2002;90:988-995. PMID: 12016265

31. Janssen PML, Schillinger W, Donahue JK, Zeitz O, Emami S, Lehnart SE, Weil J, Eschenhagen T, Hasenfuss G, Prestle J. Intracellular β-blockade; overexpression of Gi2 depresses the -adrenergic response in intact myocardium. Cardiovasc. Res. 2002;55;300-308. PMID: 12123769

32. Stull LB, Leppo MK, Marban E, Janssen PML. Physiological determinants of contractile force generation and calcium handling in mouse myocardium. J Mol Cell Cardiol. 2002;34:1367-1376. PMID: 12392997

33. van der Velden J, Papp Z, Boontje NM, Zaremba R, de Jong JW, Janssen PML, Hasenfuss G, Stienen GJM. The effect of myosin light chain 2 dephosphorylation on Ca2+-sensitivity of force is enhanced in failing human hearts. Cardiovasc Res. 2002;57:505-514. PMID: 12566123

34. van der Velden J, Papp Z, Boontje NM, Zaremba R, de Jong JW, Janssen PML, Hasenfuss G, Stienen GJ. Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium. Adv Exp Med Biol. 2003;538:3-16 (review). PMID: 15098650

35. Janssen PML, Stull LB, Leppo MK, Altschuld RA, Marbán E. Selective contractile dysfunction of left, not right, ventricular myocardium in the spontaneous hypertensive heart failure (SHHF) rat. Am J Physiol Heart Circ. Physiol. 2003;284:772-778. PMID: 12424099

36. Schillinger W, Ohler A, Emami S, Mueller F, Christians C, Janssen PML, Teucher N, Pieske B, Seidler T, Hasenfuss G. The functional effect of adenoviral Na+-Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+ ATPase. Cardiovasc. Res. 2003;57:996-1003. PMID: 12650877

37. Rossman EI, Petre RE, Chaudhary KW, Piacentino III V, Janssen PML, Gaughan JP, Houser SR, Margulies KB. Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. JMCC. 2004;36:33-42. PMID: 14734045

38. Hermann HP, Arp J, Pieske B, Kogler H, Baron S, Janssen PML, Hasenfuss G. Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure. Eur. J. Heart Failure 2004, 6;213-218. PMID: 14984729

39. Takimoto E, Soergel DG, Janssen PML, Stull LB, Kass DA, Murphy AM. Frequency- and Afterload Dependent Cardiac Modulation In Vivo by Troponin I with Constitutively Active Protein Kinase A Phosphorylation Sites. Circ. Res. 2004;94:496-504. PMID: 14726477

40. Palmer BM, Georgakopoulos D, Janssen PM, Wang Y, Alpert NR, Belardi DF, Harris SP, Moss RL, Burgon PG, Seidman CE, Seidman JG, Maughan DW, Kass DA. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res. 2004;94(9):1249-55. PMID: 15059932

41. Most P, Pleger S, Volkers M, Heidt B, Boerries M, Weichenhan D, Loffler E, Janssen PML, Williams ML, Katus HA, Remppis A, Koch WJ. Cardiac adenoviral S1001A gene delivery rescues contractile function of failing myocardium. J Clin Invest. 2004;114:1550-1563. PMID: 15578088

42. Babu GJ, Zheng Z, Natarajan P, Wheeler D, Janssen PML, Periasamy M. Overexpression of sarcolipin decreases myocyte contractility and calcium transient. Cardiovasc Res.2005;65:177-186. PMID: 15621045

43. Weisser-Thomas J, Dieterich E, Prestle J, Schmidt-Schweda S, Maier LS, Sumbilla C, Janssen PML, Pieske B. Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes. J Pharmacol Toxicol Methods. 2005;51:91-103. PMID: 15767202

44. Janssen PML, Hiranandani N, Mays T, Rafael-Fortney JA. Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice Am. J. Physiol. Heart Circ. Physiol., 2005;289:H2373-2378. PMID: 16024571

45. Raman S, Kelley MA, Janssen PML. Effect of muscle dimensions on trabecular contractile performance under physiological conditions. Eur. J. Physiol. 2006;451:625-630. PMID: 16082545

46. Babu GJ, Bhupathy P, Petrashevskaya NN, Wang H, Raman S, Wheeler D, Jagatheesan G, Wieczorek D, Schwartz A, Janssen PML, Ziolo MT, and Periasamy M. Targeted over expression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. J. Biochem. 2006;281:3972-3979. PMID: 16365042

47. Stull LB, Hiranandani N, Kelley MA, Kelley MK, Marban E, Janssen PML. Murine strain differences in contractile function are temperature- and frequency-dependent. Eur J Physiol. 2006;452:140-145. PMID: 16397793

48. Hiranadani N, Varian KD, Monasky MM, Janssen PML. Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyper-thermic conditions. J. Appl. Physiol. 2006;100:1723-1732. PMID: 16410377

49. Varian KD, Raman S, Janssen PML. Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae. Am. J. Physiol. Heart Circ. Physiol., 2006;290:H2092-2097. PMID: 16603708

50. Stypmann J*, Janssen PML*, Prestle J, Engelen MA, Kögler H, Lüllmann-Rauch R, Eckardt L, von Figura K, Landgrebe J, Mleczko A, Saftig P. LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling. Basic Res. Cardiol. 2006;101:281-291. PMID: 16604439

51. Hiranandani N, Bupha-Intr T, Janssen PML. SERCA overexpression reduces hydroxyl radical injury in murine myocardium. Am. J. Physiol. Heart. Circ. Physiol. 2006;291:H3130-3135. PMID: 16798816

52. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PML, Carathers M, Li Z, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. IKK/NF-kB Signaling interplay in macrophages and myofibers promotes muscle generation in Duchenne muscular dystrophy. J. Clin. Invest. 2007;117:889-901. PMID: 17380205

53. Varian KD, Janssen PML. Frequency dependent acceleration of relaxation involves decreased myofilament calcium sensitivity. Am. J. Physiol. Heart. Circ. Physiol. 2007;292:H2212-2219. PMID: 17209002

54. Hiranandani N, Raman S, Kalyanasundaram A, Periasamy M, Janssen PML. Frequency-dependent contractile strength in mice over- and under-expressing the sarcoplasmic reticulum calcium ATPase. Am. J. of Physiol. Reg. Integr. Comp. Physiol. 2007;293:R30-R36. PMID: 17255213

55. Keweloh B, Janssen PML, Siegel U, Datz N, Zeitz O, Hermann HP. Influence of pyruvate on economy of contraction in isolated rabbit myocardium. Eur. J. Heart Fail. 2007;9:754-761. PMID: 17532261

56. Carnes CC, Janssen PML, Ruehr ML, Nakayama H, Nakayama T, Haase H, Bauer JA, Chung MK, Fearon IM, Gillinov MA, Hamlin RL, Von Wagoner DR. Atrial Glutathione Content, Calcium Currents and contractility. J. Biol. Chem. 2007;282:28063-28073. PMID: 17656369

57. Rodino-Klapac LR, Janssen PML, Montgomery CL, Coley BD, Chicoine LG, Clark KR, Mendell JR. A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure treatment. J. Translational Medicine 2007;5:45. PMID: 17892583

58. Janssen PML, Periasamy P. Determinants of Frequency Dependent Contraction and Relaxation of Mammalian Myocardium. J Mol Cell Cardiol. 2007;43:523-531 (review). PMID: 17919652

59. Guterl KA, Haggart CR, Janssen PML, Holmes JW. Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles. Am. J. Physiol. Heart Circ. Physiol. 2007;293:H3707-H3712. PMID: 17921334

60. Bupha-Intr T, Holmes JW, Janssen PML. Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. Am J. Physiol. Heart Circ. Physiol. 2007;293:H3759-H3767. PMID: 17933962

61. Periasamy M, Janssen PML. Molecular basis of diastolic dysfunction. Heart Failure Clinics. 2008:4;13-21 (review). PMID: 18313621

62. Monasky MM, Varian KD, Janssen PML. Gender comparison of contractile performance and beta-adrenergic response in isolated rat cardiac trabeculae. J. Comp. Physiol. Biochem. 2008;178:307-313. PMID: 18030479

63. Monasky MM, Varian KD, Davis JP, Janssen PML. Dissociation of Force Decline from Calcium Decline by Preload in Isolated Rabbit Myocardium. Eur J Physiol. 2008;178:267-276. PMID: 18057959

64. Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PML, Ziolo MT. Neuronal Nitric Oxide Synthase Signaling within Cardiac Myocytes Targets Phospholamban. Am. J. Physiol. Cell Physiol. 2008;294:C1566-1575. PMID: 18400986

65. Mays TA, Binkley PF, Lesinski A, Doshi AA, Quaile MP, Margulies KB, Janssen PML, Rafael-Fortney JA. Claudin-5 levels are reduced in human end-stage cardiomyopathy. J. Mol. Cell. Cardiol. 2008;45:81-87. PMID: 18513742

66. Sanford JL, Mays TA, Varian KD, Wilson JB, Janssen PML, Rafael-Fortney JA. Truncated CASK does not alter skeletal muscle or proteins interactions. Muscle and Nerve. 2008;38:1116-1127. PMID: 18642383

67. Torres CAA, Varian KD, Janssen PML. Variability in interbeat duration influences myocardial contractility in rat cardiac trabeculae. Open Cardiovascular Medicine Journal, 2008;2:100-104. PMID: 19440237

68. Janssen PML, Zeitz O, Schumann H, Holtz J, Hasenfuss G. Load-induced apoptosis in cultured multicellular preparations is unaltered in presence of the β-adrenoceptor antagonist nebivolol. Pharmacology, 2009;83:141-147. PMID: 2085204

69. Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine LG, Clark KR, Sahenk Z, Mendell JR, Janssen PML. Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild type mice. Am J Physiol Cell Physiol. 2009;296:C476-488. PMID: 19109526

70. Bupha-Intr T, Haizlip KM, Janssen PML. Temporal changes in expression of connexin-43 after load-induced hypertrophy in vitro. Am J Physiol Heart Circ Physiol. 2009;296:H806-814. PMID: 2085204

71. Monasky MM, and Janssen PML. The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium J. Comp. Physiol. B. 2009;179:469-479. PMID: 2085204

72. Gupta SC, Varian KD, Bal NC, Abraham JL, Periasamy M, Janssen PML. Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits. Am J Physiol Heart Circ Physiol. 2009;296:H1933-1939. PMID: 2085204

73. Varian KD, Xu Y, Torres CAA, Monasky MM, Janssen PML. A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium. Am J Physiol Heart Circ Physiol. 2009; 297:H1940-H1948. PMID: 2085204

74. Varian KD, Kijtawornrat A, Gupta SC, Torres CAA, Monasky MM, Hiranandani N, Delfin DA, Rafael-Fortney JA, Periasamy M, Hamlin RL, Janssen PML. Impairment of Diastolic Function by Lack of Frequency-Dependent Myofilament Desensitization in Rabbit Right Ventricular Hypertrophy. Circulation: Heart Failure, 2009;2:472-481. PMID: 2085204

75. Kota J, Handy C, Haidet A, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall WR, Walker CM, Weisbrode SE, Janssen PML, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Science Translational Medicine, 2009;1:6ra15. PMID: 2085204

76. Kohr MJ, Kaludercic N, Tocchetti CG, Gao WD, Kass DA, Janssen PML, Paolocci N, Ziolo MT. Nitroxyl enhances cardiomyocyte systolic Ca2+ by exclusively targeting sarcoplasmic reticulum Ca2+-cycling. Frontiers in Bioscience, 2010;2:614-26. PMID: 2085204

77. Billman GE, Nishijima Y, Belevych AE, Terentyev D, Xu Y, Haizlip KM, Monasky MM, Hiranandani N, Harris WS, Gyorke S, Carnes CA, Janssen PML. Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies. Am J Physiol Heart Circ Physiol, 2010;298:H1219-H1228. PMID: 2085204

78. Janssen PML. Challenges in cardiac muscle physiology. Front Physiol. 2010;1:2. PMID: 21423345 79. Monasky MM, Biesiadecki BJ, Janssen PML. Increased phosphorylation of tropomyosin,

troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions. JMCC, 2010;48:1023-1028. PMID: 2085204

80. Chandrasekharan K, Yoon JH, Xu Y, deVries S, Camboni M, Janssen PML, Varki A, Martin PT. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Science Translational Medicine. 2010;2:42ra54. PMID: 2085204

81. Ramesh T, Lyon AN, Pineda RH, Wang C, Janssen PML, Canan BD, Burghes AHM, Beattie CE. A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease. Disease Models & Mechanisms, 2010;9-10:652-662. PMID: 2085204

82. Hiranandani N, Billman GE. Janssen PML. Effects of hydroxyl radical induced-Injury in atrial versus ventricular myocardium of dog and rabbit. Frontiers in Physiology, 2010;1:25. PMID 21423367

83. Janssen PML. Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere. Am J Physiol Heart Circ Physiol, 2010;299:H1092-1099. PMID: 2085204

84. Janssen PML. 54th Bowditch Lecture: Myocardial Contraction-Relaxation Coupling. Am J Physiol Heart Circ Physiol, 2010;299:H1741-1749. PMID: 20852049

85. Xu Y, Delfín DA, Rafael-Fortney JA, Janssen PML. Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy. J Appl Physiol, 2011;110:512-519. PMID: 21127205

86. Peterson JM, Kline W, Canan BD, Ricca DJ, Kaspar B, Delfín DA, DiRienzo K, Clemens PR, Robbins PD, Baldwin AS, Flood P, Kaumaya P, Freitas M, Kornegay JN, Mendell JR, Rafael-Fortney JA, Guttridge DC, Janssen PML. Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med, 2011;17:508-515. PMID: 21267511

87. Delfín DA, Xu Y, Peterson JM, Guttridge DC, Rafael-Fortney JA, Janssen PML. Improvement of cardiac contractile function by peptide-based inhibition of NF-kappaB in the utrophin/dystrophin-deficient murine model of muscular dystrophy. J Transl Med 2011, 9:68. PMID: 21586145

88. Haizlip KM, Janssen PML. In vitro studies of early cardiac remodeling: impact on contraction and calcium handling. Frontiers in Bioscience, 2011:3:1047-1057. PMID: 21622254

89. Rafael-Fortney JA*, Chimanji NS, Schill KE, Martin CD, Murray JD, Ganguly R, Stangland JE, Tran T, Xu Y, Canan BD, Mays TA, Delfín DA, Janssen PML*, Raman SV*. Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation 2011;124-582-588. PMID: 21768452 *contributed equally.

90. Roof SR, Shannon TR, Janssen PML*, Ziolo MT*. Effects of increased systolic Ca2+ and phospholamban phosphorylation during β-adrenergic stimulation on Ca2+ transient kinetics in cardiac myocytes. Am J Physiol Heart Circ Physiol, 2011;124:582-588, *contributed equally. PMID 21765055

91. Xu Y, Monasky MM, Hiranandani N, Haizlip KM, Billman GE, Janssen PML. Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions. J Appl Physiol., 2011;111:1159-1167. PMID 21778421

92. Torres CAA, Janssen PML. Contractile strength during variable heart duration is species and pre-load dependent. J Biomed Biotech, 2011;294204, PMID 22131801

93. Beastrom N, Lu H, Macke A, Canan BD, Johnson EK, Penton CM, Kaspar BK, Rodino-Klapac LR, Zhou L, Janssen PML, Montanaro F. Mdx5cv mice manifest more severe muscle dysfunction and diaphragm force deficits than mdx mice. Am J Pathology, 2011;179:2464-2474. PMID 21893021.

94. Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PML, Guttridge DC. IKKα and Alternative NF-κB Regulate PGC-1β to Promote Oxidative Muscle Metabolism J Cell Biol., 2012;196:497-511, PMID 22351927

95. Varian KD, Biesiadecki BJ, Ziolo MT, Davis JP, Janssen PML. Staurosporine Inhibits Frequency Dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae. Biochem. Res. Int., 2012;290971, PMID 22649731

96. Slabaugh JL, Brunello L, Gyorke S, Janssen PML. Contractile parameters and occurrence of alternans of isolated rat myocardium at supra-physiological stimulation frequency. Am J Physiol Heart Circ Physiol., 2012;302:2267-2275. PMID: 22467303

97. Grose WE, Clark KR, Griffin D, Malik V, Shontz KM, Montgomery CL, Lewis S, Brown Jr. RH, Janssen PML, Mendell JR and Rodino-Klapac LR. Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency Following AAV5 Gene Transfer. PLoS ONE 2012;7:e39233, 2012. PMID: 22720081

98. Haizlip KM, Bupha-Intr T, Biesiadecki BJ, Janssen PML. Effects of increased preload on the force frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy. Am J Physiol Heart Circ Physiol. 2012;302:H2509-2517. PMID: 22467304

99. Delfín DA, Xu Y, Schill KE, Mays TA, Canan BD, Zang KE, Barnum JA, Janssen PML*, Rafael-Fortney JA*. Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model. Mol Ther. 2012;20:1378-1383. *contributed equally. PMID: 22547149

100. Little SC, Biesiadecki BJ, Kilic A, Higgins RSD, Janssen PML, Davis JP. The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac Troponin C. J Biol Chem. 2012;287:27930-27940. PMID: 22718768

101. Bupha-Intr T, Haizlip KM, Janssen PML. Role of endothelin in the induction of cardiac hypertrophy in vitro. PLoS ONE, 2012;7:e43179. PMID: 22912821.

102. Elnakish MT, Hassona MDH, Alhaj MA, Moldovan L, Janssen PML, Khan M, Hassanain HH. Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis. PLoS ONE, 2012;7:e42500. PMID: 22936985

103. Haizlip KM, Hiranandani N, Biesiadecki BJ, Janssen PML. Impact of Hydroxyl Radical-Induced Injury on Calcium Handling and Myofilament sensitivity in Isolated Myocardium. J Appl. Physiol., 2012;113:766-774. PMID: 22773772

104. Delfín DA, Zang KE, Schill KE, Patel NT, Janssen PML, Rafael-Fortney JA. Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases. Neuromuscular Disorders. 2012;22:1006-1014. PMID: 22749475

105. Murray JD, Canan BD, Martin CD, Stangland JE, Rastogi N, Rafael-Fortney JA, Janssen PML. The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design. Frontiers in striated muscle physiology. 2012;3:422. PMID: 23162469

106. Roof SR, Biesiadecki BJ, Davis JP, Janssen PML, Ziolo MT. Effects of increased systolic Ca2+ and β-adrenergic stimulation on Ca2+ transient decline in NOS1 knockout cardiac myocytes. Nitric Oxide, 2012;27:242-247. PMID: 22960389

107. Elnakish MT, Hassanain HH, Janssen PML. Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice. J. Cardiovasc. Pharmacol., 2012;60:544-552. PMID: 22967989

108. Milani-Nejad N, Xu Y, Davis JP, Campbell KS, Janssen PML. Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature. J Gen Physiol. 2013;141:133-139. PMID: 23277479.

109. Heller KN, Montgomery CL, Janssen PML, Clark KR, Mendell JR, Rodino-Klapac LR. AAV-mediated Overexpression of Human α7 Integrin Leads to Histological and Functional Improvement in Dystrophic Mice. Molecular Ther. 2013;21:520-525. PMID: 23319059

110. Kalyanasundaram A, Lacombe VA, Belevych A, Brunello L, Janssen PML, Kranias EG, Knollmann BC, Periasamy M, Gyӧrke S. Upregulation of sarcoplasmic reticulum calcium uptake leads to heart failure and early mortality in mice deficient in expression of cardiac Calsequestrin. Cardiovasc. Res. 2013:98:297-306. PMID: 23135969

111. Torres CAA, Varian KD, Canan CH, Davis JP, Janssen PML. The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity. PloS ONE. 2013;8:e63608. PMID 23691074

112. Elnakish MT, Moldovan L, Khan M, Hassanain HH, Janssen PML. Myocardial Rac1 Exhibits Partial Involvement in Thyroxin-Induced Cardiomyocyte Hypertrophy and its Inhibition is Not Sufficient to Improve Cardiac Dysfunction or Contractile Abnormalities in Mouse Papillary Muscles. J. Cardiovasc. Pharmacol., 2013;61:536-544. PMID: 23429587

113. Brunello L, Slabaugh JL, Radwański PB, Ho HT, Belevych AE, Lou Q, Chen H, Napolitano C, Lodola F, Priori SG, Fedorov VV, Volpe P, Fill M, Janssen PML*, Györke S*. Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia. Proc Nat Acad Sci., 2013;110:13212-10317. *co-corresponding authors. PMID 23733959

114. Nixon BR, Liu B, Scellini B, Tesi C, Piroddi N, Ogut O, Solaro RJ, Ziolo MT, Janssen PML, Davis JP, Poggesi C, Biesiadecki BJ. Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Arch Biochem Biophys. 2013;535:30-38. PMID: 23232082

115. Monasky MM, Taglieri DM, Jacobson AK, Haizlip KM, Solaro RJ, Janssen PML. Post-Translational Modifications of Myofilament Proteins Involved in Length-Dependent Prolongation of Relaxation in Rabbit Right Ventricular Myocardium. Arch Biochem Biophys. 2013;535:22-29. PMID: 23085150

116. Martin PT, Camboni M, Xu R, Golden B, Chandrasekharan K, Wang C, Varki A, Janssen PML. N-glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in alpha sarcoglycan-deficient mice. Glycobiology. 2013;23:833-843. PMID: 23514716

117. Aeffner F, Abdulrahman B, Hickman-Davis JM, Janssen PML, Amer A, Bedwell DM, Sorscher EJ, Davis IC. Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity. J Infect Dis. 2013;208:780-789. PMID 23749967

118. Elnakish MT, Hassanain HH, Janssen PML, Angelos MG, Khan M. Emerging Role of Oxidative Stress in Metabolic Syndrome and Cardiovascular Diseases: Important Role of Rac/NADPH Oxidase. Am J Path., 2013;231:290-300. PMID 24037780

119. Rodino-Klapac LR, Janssen PML, Shontz KM, Canan B, Montgomery CL, Griffin D, Heller K, Schmelzer L, Handy C, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. Micro-dystrophin and Follistatin Co-Delivery Restores Muscle Function in Aged DMD Model. Hum Mol Gen. 2013;22:4929-4937. PMID 23863459

120. Janssen PML*, Murray JD, Schill KE, Rastogi N, Schultz JE, Tran T, Raman SV, Rafael-Fortney JA*. Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy. PLoS ONE 2014;9:e88360. PMID 24551095 *equal contribution.

121. Milani-Nejad N, Janssen PML. Small and Large Animal Models in Cardiac Contraction Research: Advantages and Disadvantages. Pharmacology and Therapeutics. 2014;141:235-249. PMID 24140081

122. Meng H, Janssen PML, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW. Tissue triage and freezing for models of skeletal muscle disease. JoVE. 2014;89:doi10.3791. PMID 25078247

123. Milani-Nejad N, Brunello L, Gyorke S, Janssen PML. Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae. J. Mus. Res. Cell Motil. 2014;35:225-234. PMID 25051095

124. Bonilla I, Long VP, Vargas-Pinto P, Wright P, Belevych A, Lou Q, Mowrey ,Yoo J, Binkley PF, Fedorov VV, Gyorke S, Janssen PML, Kilic A, Mohler PJ, Carnes CA. Calcium-activated Potassium Current Modulates Ventricular Repolarization in Chronic Heart Failure. Plos One. 2014;9:e108824. PMID 25271970

125. Salhi HE, Walton SD, Hassel NC, Brundage EA, Tombe PP, Janssen PML, Davis JP, Biesiadecki BJ. Cardiac Troponin I Tyrosine 26 Phosphorylation Decreases Myofilament Ca2+ Sensitivity and Accelerates Deactivation. JMCC. 2014;76C:257-264. PMID 25252176

126. Biesiadecki BJ, Davis JP, Ziolo MT, Janssen PML. Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics. Biophysical Reviews. 2014;6:273-289. PMID 25484996

127. Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wie Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PML, Kilic A, Higgins RSD, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ. Dysfunction in the betaII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015;131:695-708. PMID 25632041

128. Radwański PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PML, Mohler PJ, Bridge JHB, Poelzing S, Györke S. Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release. Cardiovasc. Res. 2015;106:143-152. PMID 25538156

129. Haizlip KM, Milani-Nejad N, Brunello L, Varian KD, Slabaugh JL, Walton SD, Gyorke S, Davis JP, Biesiadecki BJ, Janssen PML. Dissociation of calcium transients and force development

following a change in stimulation frequency in isolated rabbit myocardium. Biomed. Res. Int. 2015:468548. PMID 25961020

130. Swager SA, Delfín DA, Rastogi N, Wang H, Canan BD, Fedorov VV, Mohler PJ, Kilic A, Higgins RSD, Ziolo MT, Janssen PML, Rafael-Fortney JA. Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1. Cardiovasc. Pathol. 2015;24:160-167. PMID 25440958

131. Khan M, Xu Y, Hua S, Johnson J, Belevych A, Janssen PML, Gyorke S, Guan J, Angelos MG. Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (hiPSC-CMs) cultured on an Aligned-Nanofiber Cardiac Patch. Plos ONE. 2015;10:e0126338. PMID 25993466

132. Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RSD, Binkley PF, Janssen PML, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ. Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy. Journal of the American Heart Association. 2015;4:e001762. PMID 26015324

133. Elnakish MT, Schultz EJ, Gearinger RL, Saad NS, Rastogi N, Ahmed AAE, Mohler PJ, Janssen PML. Differential involvement of various sources of reactive oxygen species in thyroxin-induced hemodynamic changes and contractile dysfunction of the heart and diaphragm muscles. Free Radicals in Biology and Medicine. 2015;83:252-261. PMID 25795514

134. Elnakish MT, Ahmed AAE, Mohler PJ, Janssen PML. Role of oxidative stress in thyroid hormone-induced cardiomyocyte hypertrophy and associated cardiac dysfunction: an undisclosed story. Oxidative Medicine and Cellular Longevity. 2015;854265. PMID 26146529

135. Lowe J, Wodarcyk AJ, Floyd KT, Rastogi N, Schultz EJ, Swager SA, Chadwick JA, Tran T, Raman SV, Janssen PML*, Rafael-Fortney JA*. The angiotensin converting enzyme inhibitor lisinopril improves muscle histopathology but not contractile function in a mouse model of Duchenne muscular dystrophy. J. Neuromusc. Diseases. 2015;2:257-268. *contributed equally.

136. Hansen BJ, Zhao J, Csepe TA, Moore B, Li N, Jayne LA, Kalyanasundaram A, Nguyen PH, Lim P, Bratasz A, Powell KA, Simonetti O, Higgins RSD, Ahmet A, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov VV. Atrial Fibrillation Driven by Microanatomic Intramural Reentry Revealed by Simultaneous Sub-Epicardial and Sub-Endocardial Optical Mapping in Explanted Human Hearts. Eur. Heart J. 2015;36:2390-2401. PMID 26059724

137. Li N, Csepe T, Hansen B, Dobrzynski H, Higgins RSD, Kilic A, Mohler P, Janssen PML, Rosen M, Biesiadecki B, Fedorov VV. Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. Circ Arrthyth. and Electrophys. 2015;8:1219-1227. PMID 26304511

138. Martin BL, Gallagher TL, Rastogi N, Davis JP, Beattie CE, Amacher SL, Janssen PML. In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae. J. Applied Physiol. 2015;119:799-806. PMID 26251513

139. Xu R, Singhal N, Serinagaoglu Y, Chandrasekharan K, Joshi M, Bauer J, Janssen PML, Martin PT. Deletion of Galgt2 (B4galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice. Am. J. Pathol. 2015;185:2668-2684. PMID 26435413

140. Musa H, Kline CF, Sturm AC, Murphy N, Adelman S, Wang C, Yan H, Johnson BL, Csepe TA, Kilic A, Higgins RSD, Janssen PML, Fedorov VV, Wiess R, Salazar C, Hund TJ, Pitt GS, Mohler PJ. SCN5A variant that blocks Fibroblast Growth Factor Homologous Factor regulation causes human arrhythmia. PNAS. 2015;112:12528-12533. PMID 26392562

141. Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PML, Hund TJ, Knollmann BC, Kranias EG, Györke S. Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT. Cardiovasc. Res. 2015;108:299-311. PMID 26410369

142. Iyer CC, McGovern VL, Murray JD, Gombash SE, Zaworski PG, Foust KD, Janssen PML, Burghes AH. Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA. Hum Mol Gen. 2015;24:6160-6173. PMID 26273812

143. Zhao J, Hanse BJ, Csepe TA, Lim P, Wang Y, Williams M, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov VV. Integration of Panoramic Optical Mapping and 3D Micro-CT Imaging to Resolve the Structural Basis of Atrial Conduction in the Human Heart. Circ: Arrhyth Electrophys. 2015;8:1514-1517. PMID 26671938

144. Milani-Nejad N, Canan BD, Elnakish MT, Davis JP, Chung JH, Fedorov VV, Binkley PF, Higgins RSD, Kilic A, Mohler PJ, Janssen PML. The Frank-Starling Mechanism Involves Deceleration of Cross-Bridge Kinetics and is Preserved in Failing Human Right Ventricular Myocardium. Am J Physiol, Heart Circ Physiol. 2015;309:H2077-2086. PMID 26453335

145. Xu J, El Refaey M, Xu L, Zhao L, Floyd K, Karaze T, Janssen PML, Han R. Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy. Skeletal Muscle 2015;5:43. PMID 26693275

146. Csepe TA, Zhao J, Hansen BJ, Li N, Sul LV, Lim P, Wang Y, Simonetti OP, Kilic A, Mohler PJ, Janssen PML, Fedorov VV. Human Sinoatrial Node Structure: 3D Microanatomy of Sinoatrial Conduction Pathways. Progress in Biophysics & Molecular Biology 2015;120:164-178. PMID 26743207

147. Lowe J, Floyd KT, Rastogi N, Schultz EJ, Chadwick JA, Swager SA, Zins JG, Kadakia FK, Smart S, Gomez-Sanchez EP, Gomez-Sanchez CE, Raman SV, Janssen PML*, Rafael-Fortney JA*. Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice. J. Neuromusc. Diseases, 2016;3:395-404, *contributed equally. PMID 27822449

148. Shettigar V, Zhang B, Little S, Salhi H, Hansen BJ, Li N, Zhang J, Roof SR, Ho H, Brunello L, Lerch J, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PML, Biesiadecki B, Ziolo MT, Davis JP. Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease. Nature Communications 2016;7:10794.

149. Canan BD, Haizlip KM, Xu Y, Monasky MM, Hiranandani N, Milani-Nejad N, Varian KD, Slabaugh JL, Schultz EJ, Fedorov VV, Billman GE, Janssen PML. Effect of exercise training and myocardial infarction on force development and contractile kinetics in isolated canine myocardium. J Appl Physiol, 2016;120:817-824. PMID 26823341

150. Saad NS, Floyd K, Ahmed AAE, Mohler PJ, Janssen PML*, Elnakish MT*. The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities. PLoS One 2016;11:e0153694. *contributed equally. PMID 27082116

151. Tewari SG, Bugenhagen SM, Vinnakota KC, Rice JJ, Janssen PML, Beard DA. Influence of metabolic dysfunction on cardaic mechanics in decompensated hypertrophy and heart failure. J. Mol. Cell. Cardiol. 2016;94:162-175. PMID 27085901

152. Smith S, Hughes L, Kline C, Kempton A, Dorn L, Curran J, Makara M, Webb T, Wright P, Voigt N, Binkley PF, Janssen PML, Kilic A, Carnes CA, Dobrev D, Rasband M, Hund TJ, Mohler PJ. Dysfunction of the βII spectrin-based pathway in human heart failure. Am. J. Physiol, Heart Circ. Physiol. 2016;310:H1583-1591. PMID 27106045

153. Milani-Nejad N, Chung JH, Canan BD, Davis JP, Fedorov VV, Higgins SD, Kilic A, Mohler PJ, Janssen PML. Insights into Length-Dependent Regulation of Cardiac Cross-Bridge Cycling kinetics in Human Myocardium. Archives of Biochemistry and Biophysics, 2016;601:48-55. PMID 26854725

154. Davis JP, Shettigar S, Tikunova ST, Little SC, Liu B, Siddiqui JK, Janssen PML, Ziolo MT, Walton, SD. Designing Proteins to Combat Disease: Cardiac Troponin C as an Example. Archives of Biochemistry and Biophysics, 2016;601:4-10. PMID 26901433

155. Janssen PML, Biesiadecki BJ, Ziolo MT, Davis JP. The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve. Circ. Res. 2016;119:418-422. PMID 27458197

156. Li N, Csepe TA, Hansen BJ, Sul LV, Kalyanasundaram A, Zakharkin SO, Zhao J, Guha A, Van Wagoner DR, Kilic A, Mohler PJ, Janssen PML, Biesiadecki BJ, Hummel JD, Weiss R, Fedorov VV. Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart. Circulation, 2016;134:486-498. PMID 2746069

157. Milani-Nejad N, Schultz EJ, Slabaugh JL, Janssen PML*, Rafael-Fortney JA*. Myocardial Contractile Dysfunction is Present Without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and is Prevented after Claudin-5 Virotherapy, Frontiers in Physiology, 2016;7:539. PMID 27999547, *contributed equally.

158. Salhi HE, Hassel NC, Siddiqui JK, Brundage EA, Ziolo MT, Janssen PML, Davis JP, Biesiadecki BJ. Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration. Frontiers in Physiology, 2016;7:567. PMID 28018230

159. Chung JH, Biesiadecki BJ, Ziolo MT, Davis JP, Janssen PML. Myofilament calcium sensitivity: Role in regulation of in vivo cardiac contraction and relaxation. Frontiers in Physiology, 2016;7:562. PMID 28018228

160. Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PML, Biesiadecki BJ, Davis JP. Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I. Frontiers in Physiology, 2016;7:632. PMID 28066265

161. DeAguero JL, McKown EN, Zhang L, Keirsey J, Fischer EG, Samedi VG, Canan BD, Kilic A, Janssen PML, Delfín DA. Altered protein levels in the isolated extracellular matrix of failing human hearts with dilated cardiomyopathy. Cardiovascular Pathology. 2016;26:12-20. PMID 27837684

162. Elnakish MT, Canan BD, Kilic A, Mohler PJ, Janssen PML. Effects of Zacopride, a Moderate IK1 channel agonist, on Triggered Arrhythmia and Contractility in Human Ventricular Myocardium. Pharmacological Research, 2017;115:309-318. PMID 27914945

163. Csepe TA, Zhao J, Sul LV, Wang Y, Hansen BJ, Li N, Ignozzi AJ, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Hummel J, Simonetti OP, Fedorov VV. Novel Application of 3D Contrast Enhanced CMR to Define Fibrotic Structure of the Human Sinoatrial Node In-vivo. Eur Heart J, Cardiovasc Imag 2017; 10.1093/ehjci/jew304. PMID 28087602

164. Zygmunt D, Singhal N, Kim ML, Cramer M, Crowe K, Xu R, Jia Y, Adair J, PenaI, Akaaboune M, White P, Janssen PML, Martin PT. Deletion of Pofut1 in mouse skeletal myofibers induces muscle aging-related phenotypes in cis and in trans. Mol Cel Biol. 2017;37:e00426-16. PMID: 28265002

165. Saad NS, Repas SJ, Floyd K, Janssen PML, Elnakish MT. Recovery Following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In-Vivo and Ex-Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice. BioMed Res. Int. 2017:6071031. PMID: 28791308

166. Li N, Hansen BJ, Ignozzi AJ, Sul LV, Csepe TA, Zhao J, Zakharki SO, Kalyanasundaram A, Davis JP, Biesiadecki BJ, Kilic A, Janssen PML, Mohler PJ, Weiss R, Hummel JD, Fedorov VV. Integrated Mapping Revealed Robustness of Human Sinoatrial Rhythm Regulation By Multiple Intranodal Pacemakers and Conduction Pathways. Sci. Transl. Med. 2017;9. PMID: 28747516

167. Zhao J, Hansen BJ, Wang Y, Csepe TA, Sul LV, Tang A, Yuan Y, Li N, Bratasz A, Powell KA, Kilic, A, Mohler PJ, Janssen PML, Weiss R, Simonetti OP, Hummel JD, Fedorov VV. Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex-Vivo. JAHA. 2017:6. PMID: 28862969.

168. El Refaey M, Xu L, Gao Y, Canan B, Ayodele Adesanya TN, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R. In vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice. Circ Res. 2017;121:923-929. PMID: 28790199.

169. Ackermann MA, Petrosino JM, Mannin H, Wright P, Shettigar V, Kilic A, Janssen PML, Ziolo MT, Accornero F. TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism. J Mol Cell Cardiol. 2017;112:49-57. PMID: 28870505.

170. Repas SJ, Saad NS, Janssen PML, Elnakish MT. Memantine, an NMDA Receptor Antagonist, Prevents Thyroxin-Induced Hypertension but Not Cardiac Remodeling. J. Cardiovasc Pharmacol. 2017:70:305-313. PMID: 29112047

171. Koenig SN, LaHaye S, Feller JD, Rowland P, Hor K, Trask AJ, Janssen PML, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017:2. PMID: 29093270

172. Monasky MM, Torres CAA, Janssen PML. Length-Dependent Prolongation of Force Relaxation is Unaltered by Delay of Intracellular Calcium Decline in Early-Stage Rabbit Right Ventricular Hypertrophy. Frontiers in Striated Muscle Physiology. 2017;8:945. PMID: 29255420

173. Milani-Nejad N, Chung JH, Canan BD, Fedorov VV, Whitson BA, Kilic A, Mohler PJ, Janssen PML. Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium. J Mol Cell Cardiol. 2017:114;116-123. PMID: 29141185

174. Kempton A, Justice C, Guo A, Cefalu M, Makara M, Janssen PML, Ho TH, Smith SA. Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model. Clin Exp Hypertens. 2017:1-10. PMID: 29172746

175. Lowe J, Kadakia FK, Zins JG, Haupt M, Peczkowski KK, Rastogi N, Floyd KT, Gomez-Sanchez EP, Gomez-Sanchez CE, Elnakish MT, Rafael-Fortney JA*, Janssen PML*. Mineralocorticoid receptor antagonists in muscular dystrophy mice during aging and exercise. J. Neuromusc. Diseases 2018;5:295-306. *contributed equally. PMID 30010143

176. Kempton A, Cefalu M, Justice C, Baich T, Derbala M, Canan B, Janssen PML, Mohler PJ, Smith SA. Altered regulation of cardiac ankyrin repeat protein in heart failure. Heliyon. 2018;4:e00514. PMID 29560432

177. Williams JL, Loccoh EC, Daugherty JC, Smith, SA, Canan BC, Janssen PML, Koenig S, Kline FC, Mohler PJ, Bradley EA. Defining the Molecular Signatures of Human Right Heart Failure. Life Sciences. 2018;196:118-126. PMID: 29366750

178. Macri, V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitzv SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorovv VV, Janssen PML, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani, CM, Cupples A, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van DR, Chung MK, Vlahakes GJ, O’Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT. Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction. Circ. Gen. Prescis. Med. 2018;11:e001663. PMID 29752399

179. Slabaugh JL, Brunello L, Elnakish ME, Milani-Nejad N, Gyorke S, Janssen PML. Synchronization of Intracellular Ca2+ Release in Multicellular Cardiac Preparations. Frontiers in Physiology. 2018;9:968. PMID 30079034

180. Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas, SJ, Schultz EJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, Crecelius W, Peczkowski KK, Ziolo MT, Fedorov VV, Kilic A, Whitson BA, Higgins RSD, Smith SA, Mohler PJ, Binkley PF, Janssen PML. Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium. J. Mol Cell Cardiol. 2018;121:81-93. PMID 29923888

181. Campbell KS, Janssen PML, Campbell SG. Force-dependent recruitment from the myosin OFF state contributes to length-dependent activation. Biophys. J. 2018;115:543-553. PMID 30054031

182. Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, Shintaku J, Gu J, Little SC, Ratnam NM, Londhe P, Lu L, Gaw CE, Petrosino JM, Liyanarachchi S, Wang H, Janssen PML, Davis JP, Ziolo MT, Sharma SM, Guttridge DC. NF-κB inhibition rescues cardiac function through chromatin remodeling of calcium genes in a model of Duchenne muscular dystrophy. Nature Commun. 2018;9:3431. PMID 30143619

183. Janssen PML, Canan BD, Kilic A, Whitson BA, Baker AJ. Human Myocardium Has Robust α1A-Subtype Adrenergic Receptor Inotropic Responses. J. Cardiovasc. Pharmacol. 2018;72:136-142. PMID 29923888

184. Chung JH, Canan BD, Whitson BA, Kilic A, Janssen PML. Force-frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium. Physiological Reports. 2018 (in press). PMID 30350481

185. McKown EN, DeAguero J, Canan BC, Zhu Y, McKown E, Janssen PML, Kilic A, Delfin DA. Adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to

isolated extracellular matrix from failing hearts is impaired. Heliyon. 2018 (in press). PMID 30364772

186. Abbaszadeh S, Javidmehr A, Askari B, Janssen PML, Soraya H. Memantine, an NMDA receptor antagonist, attenuates cardiac remodeling, lipid peroxidation and neutrophil recruitment in heart failure: A cardioprotective agent? Biomedicine and Pharmacotherapy. 2018;108:1237-1243. PMID 30372825

187. Saad NS, Elnakish MT, Brundage EA, Biesiadecki BJ, Kilic A, Ahmed AAE, Mohler PJ, Janssen PML. Assessment of PKA and PKC Inhibitors on Force and Kinetics of Non-failing and Failing Human Myocardium. Life Sciences. 2018:215;119-127. PMID 30399377

188. Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden AP, Bradley EA, Hund TJ, Mohler PJ. Novel mechanistic roles for ankyrin-G in cardiac remodeling and heart failure. JACC BTS. 2018;3:675-689. PMID 30456339

189. Hansen BJ, Zhao J, Li N, Zolotarev A, Zakharkin S, Wang Y, Atwalc J, Kalyanasundaram A, Abudulwaheda SH, Helfrich KM, Bratasz A, Powell KA, Whitson B, Mohler PJ, Janssen PML, Simonetti OP, Hummel JD, Fedorov VV. Human Atrial Fibrillation Drivers Correlated with Integrated Functional and Structural Imaging to Benefit Clinical Mapping. JACC Clin Electrophys. 2018;4:1501-1515. PMID 30573112

190. Janssen PML. Myocardial relaxation in human heart failure: Why sarcomere kinetics should be center-stage. Arch Biochem Biophys, 2019;661:145-148. PMID 30447209

191. Saad NS, Elnakish MT, Ahmed AAE, Janssen PML. Protein Kinase A as a Promising Target for Heart Failure Drug Development. Arch. Med. Res. 2019;49:530-537. PMID 30642654

192. Adesanya TMA, Russell M; Park KH, Zhou X, Sermersheim MA, Gumpper K, Koenig SN, Tan T, Whitson BA, Janssen PML, Lincoln J, Zhu H, Ma J. MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling. JAHA. 2019 (in press). PMID 30741589

193. Hauck JS, Lowe J, Rastogi N, McElhanon KE, Petrosino JM, Peczkowski KK, Chadwick AN, Zins JG, Accornero F, Janssen PML, Weisleder NL, Rafael-Fortney JA. Mineralocorticoid Receptor Drugs Improve Membrane Integrity Independent of Muscle Force in Dystrophy. Hum. Mol Gen. 2019 (in press). PMID 30759207

194. Janssen PML, Elnakish MT. Modeling heart failure in animal models for novel drug discovery and development. EODD. 2019;14:355-363. PMID 30861352

195. Chen MP, Kiduko SA, Saad NS, Canan BD, Kilic A, Mohler PJ, and Janssen PML. Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin’s Role in Blunting Cardiac Kinetic Reserve. Cardiovasc. Res. 2019 (in press). PMID 30778519

196. Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther P, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones

WK, Gilbert RJ, Sadayappan S. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. JMCC. 2019;129:236-246. PMID 30862451

197. Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud GE, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ. Defining new mechanistic roles for αII spectrin in cardiac function. J. Biol. Chem. 2019 (in press). PMID: 31064843

198. Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaev M, Koenig S, Astrom Aneq M, Hoorntje ET, Graw SL, Aafaqi S, Davies RW, Fatah M, Rafiq MA, Chiasson DA, Koopmann TT, Taylor MRG, Simmons SL, Han M, van Opbergen CJM, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TAB, Wilde AAM, Healey JS, Janssen PML, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B Dysfunction Predisposes to Arrhythmogenic Cardiomyopathy and is Amenable to Therapy. J. Clin. Invest. 2019 (in press).

199. Ng R, Manring HR, Papoutsidakis N, Albertelli T, Tsai N, See C, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PML, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG. Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation. JCI Insight 2019 (in press). PMID 31194698

Invited book chapters: 1. Prestle J, Janssen PML, Janssen A, Hasenfuss G. Overexpression of FKBP12.6 to influence

SR function. Molecular approaches to the therapy of heart failure. Eds. G. Hasenfuss and E. Marbán. Chapter 7, pp 89-99, 2000.

2. Janssen PML, Lehnart SE, Donahue JK, Prestle J, Marban E, Hasenfuss G. Adenovirus-mediated transfection of multicellular cardiac preparations. In: Molecular approaches to the therapy of heart failure. Eds. G. Hasenfuss and E. Marbán. Chapter 9, pp 112-125, 2000.

3. Janssen PML, Davis JP. An overview of muscle biology and physiology for muscle gene therapy. In “Muscle Gene Therapy”, edited by Dongsheng Duan and Jerry Mendell. Chapter 1 (of 45), pages 3-12, 2019.

4. Davis JP, Tikunova S, Janssen PML. Mechanism of muscle contraction and relaxation. In ”Muscle and Exercise Physiology“, edited by Jerzy Zoladz. Elsevier, 2019.

Abstracts: 1. van Andel AJ, Janssen PML, van Heijst BGV, de Beer EL, Schiereck P. Verapamil and

Diltiazem enhance maximal tension of skinned single skeletal muscle fibers. Pflügers Arch. 1992;420:R92.

2. Janssen PML, van Andel AJ, Sontrop MATA, de Beer EL, Schiereck P. Modeling of the frequency characteristics of striated muscle. Pflügers Arch. 1992;420:R94.

3. Janssen PML, van Andel AJ, Sontrop MATA, de Beer EL, Schiereck P. Force development beyond actin-myosin overlap: excluding an artifact. Pflügers Arch. 1992;420:R95.

4. van Andel AJ, Gerrits JM, Janssen PML, de Beer EL, Schiereck P. Mechanism of two Mg-ATP-ase blockers in skinned single skeletal muscle fibers. Pflügers Arch. 1992;421:R35.

5. Gerrits JM, van Heijst, BGV, Janssen PML, Schiereck P, de Beer EL. Calcium activation and cooperativity in force development in skinned smooth muscle of rat aorta. Pflügers Arch. 1992;421:R37.

6. Janssen PML, van Heijst BGV, Sontrop MATA, de Beer EL, Schiereck P. Feasibility of the length clamp: a mathematical model study. Pflügers Arch. 1992;421:R39.

7. Janssen PML, van Andel AJ, Schiereck P, de Beer EL. Intracellular effects of calcium antagonists on the contractile system in skinned heart tissue. J Mus Res Cell Motil. 1993;14:263.

8. Gerrits JM, van Heijst BGV, Janssen PML, Schiereck P, de Beer EL. Calcium activation and cooperativity in force development in skinned smooth muscle of rat aorta. J Mus Res Cell Motil. 1993;14:264.

9. van Andel AJ, Gerrits JM, van Heijst BGV, Janssen PML, Schiereck P, de Beer EL. Intracellular effects of calcium antagonist and Mg-ATPase blockers on the contractile system in skinned skeletal muscle fibers. J Mus Res Cell Motil. 1993;14:265.

10. Schiereck P, van Heijst BGV, Janssen PML, Schiereck J, de Beer EL, Crowe A. Cross-bridge formation at sub-threshold calcium concentrations in skinned skeletal muscle cells. J Mus Res Cell Motil. 1993.

11. Sontrop MATA, Janssen PML, van Heijst BGV, de Beer EL, Schiereck P. The segment-clamp technique induces erroneous length tension relations: a mathematical model study. Biophys J. 1993;64:A25.

12. van Bergen P, Janssen PML, van der Vaart JGM, Kasbergen CM, Versteeg DHG, de Wildt DJ. Structure activity relationship of MSH/ACTH-like peptides with respect to the effects on blood pressure in the rat. Pharmacol Toxicol. 1993;72(Suppl II):52,.

13. van Bergen P, Kleijne JA, Janssen PML, van der Vaart JGM, Casbergen CM, Versteeg DHG, de Wildt DJ. Effects of MSH/ACTH-like peptides on hemodynamic parameters in the rat. Pharmacy World & Science 1993;15:I12.

14. Janssen PML, Hunter WC. Early relaxation of myocardial contraction depends on twitch force. Proceedings of the Second world congress of biomechanics, 1994.

15. Janssen PML, Honda H, Kamada E, Naya T, Koiwa Y. The effect of diastolic vibration on the relaxation of rat papillary muscle. J Cardiovascular Diag & Proced. 1994;12:110.

16. Hunter WC, Janssen PML. Force, not sarcomere length, correlated with prolongation of isosarcometric contraction in isolated rat trabeculae. J Cardiovascular Diag & Proced. 1994;12:122.

17. Schiereck P, Janssen PML, Honda H, Koiwa Y. Early onset of relaxation in isolated left ventricles induced by small volume perturbations. J Cardiovascular Diag & Proced. 1994;12:120.

18. Janssen PML, Honda H, Koiwa Y. The effect of diastolic sinusoidal length perturbation on the relaxation of rat papillary muscle. J Mus Res Cell Motil. 1995;16:342.

19. Wannenburg T, Heijne G, Geerdink JH, Janssen PML, de Tombe PP. Sarcomere length does not affect cross-bridge kinetics in rat myocardium. Circulation 1995;92:I65.

20. Wannenburg T, Janssen PML, de Tombe PP. Force, not sarcomere length determines cardiac myofibrillar ATP consumption. Circulation 1995;92:I590.

21. Janssen PML, Honda H, Koiwa Y. The effect of diastolic sinusoidal length perturbation on the relaxation of rat papillary muscle. J Mus Res Cell Motil. 1995;16:342.

22. Janssen PML, de Tombe PP. Fura-2 intracellular calcium transients in sarcomere isometric twitches of rat trabeculae. Biophys J. 1996;70:A271.

23. Naya T, Honda H, Janssen PML, Koiwa Y. Applied velocity of sinusoidal perturbation determines tension depressive magnitude in rat papillary muscle. J Cardiovascular Diag & Proced. 1996;13:286.

24. Janssen PML, de Tombe PP. Lack of effect of PKA on sarcomere shortening velocity in rat cardiac trabeculae. Biophys. J., 1997.

25. Janssen PML, Lehnart SE, Prestle J, Lynker JC, Hasenfuss G. Die ex-vivo Herzmuskelcultur: Eine neue Methode zur Messung kontraktiler Parameter über mehrere Tage unter physiologischen Bedingungen. Z Kardiol. 1998.

26. Janssen PML, Prestle J, Lehnart SE, Lynker JC, Hasenfuss G. Contractile parameters of twitching cardiac muscle preparations in a muscle culture system. Biophys. J. 1998;74:A351.

27. Lehnart SE, Janssen PML, Prestle J, Hasenfuss G. The impact of adenovirus-mediated gene transfer on the long-term contractility of myocardial trabecula preparations. Eur Heart J. 1998;19(suppl.):178.

28. Lehnart SE, Prestle J, Janssen PML, Hasenfuss G.. Efficient adenovirus-mediated gene transfer into isolated myocardium. J Mol Cell Cardiol. 1998;30:A48.

29. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Multi-day measurement of contractile function in twitching cardiac muscle preparations. Cardiovascular Diag & Proced. 1998;15:136.

30. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Contractile function and signaling pathways in intact multi-day cultured multicellular preparations. Circulation 1998;98:I-259.

31. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Human multicellular contracting cardiac muscle preparations in multi-day. Biophys J. 1999;76:A309.

32. Lehnart SE, Janssen PML, Prestle J, Hasenfuss G. Preservation of signal transduction pathways in multi-day cultured cardiac muscle preparations. Biophys. J. 1999;76:A313.

33. Lehnart SE, Janssen PML, Prestle J, Hasenfuss G. Adenoviraler Gentransfer in funktionell intaktes Myokard. Z Kardiol. 1999;88(Suppl. I):119.

34. Prestle J, Baudet S, Weisser J, Beulich K, Janssen PML, Janssen AP, Pieske B, Hasenfuss G. Steigerung der Kontraktilität durch Überexpression der Protein-kinase C epsilon in adulten ventrikulären Kaninchen-Myozyten. Z Kardiol. 1999;88(Suppl. I):128.

35. Weisser J, von Lewinsky D, Bisping E, Maier LS, Janssen PML, Pieske B. Unterscheiden sich isolierte menschliche Herzmuskelzellen und Muskelstreifenpräparate in ihrem kontraktielen Verhalten? – Isometrische Kraft vs. isotonische Verkürzung. Z Kardiol. 1999;88(Suppl. I):166.

36. Prestle J, Lehnart SE, Janssen PML, Janssen AP, Zeitz O, Hasenfuss G. Adenoviraler Gentransfer von FKBP12.6 steigert die Kontraktilität von Ventrikulären Kaninchen-Myozyten. Z Kardiol. 1999;88 (Suppl. I):181.

37. Janssen PML, Zeitz O, Hasenfuss G. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effect of nebivolol. Cardiovasc Drugs Ther. 1999;13:7.

38. Weisser J, von Lewinsky D, Bisping E, Maier LS, Janssen PML, Pieske B. Contractile behavior of isolated ventricular myocytes and muscle strip preparations from human hearts- isometric force versus isotonic shortening. Eur J Heart Failure 1999;1(Suppl.):26.

39. Prestle J, Janssen AP, Lehnart SE, Zeitz O, Janssen PML, Hasenfuss G. Role of FKBP12.6 in excitation-contraction coupling in rabbit ventricular myocytes. Eur Heart J. 1999;20:44.

40. Prestle J, Baudet S, Janssen PML, Weisser J, Janssen AP, Pieske B, Hasenfuss G. Blunted positive inotropic response to endothelin-1 in rabbit ventricular myocytes overexpressing protein kinase C. Eur Heart J. 20:46, 1999.

41. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Contracting human myocardium in multi-day cell culture. Eur Heart J. 1999;20:46.

42. Keweloh B, Hünlich M, Siegel U, Zeitz O, Janssen PML, Hasenfuss G. Pyruvate acts positive inotropic and does not change economy of myocardial contraction in rabbit and human myocardium. Eur Heart J. 1999;20:140.

43. Janssen PML, Zeitz O, Keweloh B, Siegel U, Maier LS, Pieske B, Prestle J, Lehnart SE, Hasenfuss G. Direct cardio-depressive effect of Cyclosporin A in human and rabbit myocardium: measurements of contractile parameters, SR calcium-content, and myofilament responsiveness. Eur Heart J. 1999;20:542.

44. Zeitz O, Rahman A, Hasenfuss G, Janssen PML. Hydroxyl radicals increase calcium sensitivity of cardiac muscle. Eur Heart J. 1999;20:612.

45. Janssen PML, Hasenfuss G. Nebivolol: protective effect on oxidative stress. Milano, 1999. 46. Lehnart SE, Janssen PML, Donahue JK, Franz WM, Prestle J, Hasenfuss G. Adenovirus

mediated gene transfer in isometrically contracting myocardial preparations. Circulation. 1999;100:I-123.

47. Prestle J, Baudet S, Janssen AP, Weisser J, Pieske B, Janssen PML, Hasenfuss G. Blunted positive inotropic response to endothelin-1 in rabbit ventricular myocytes upon adenovirus-mediated overexpression of protein kinase C. Circulation. 1999;100:I-191.

48. Prestle J, Janssen PML, Janssen AP, Lehnart SE, Zeitz O, Hasenfuss G. Adenovirus mediated gene transfer of FKBP12.6 increases contractility in isolated rabbit ventricular myocytes. Circulation. 1999;100:I-629.

49. Janssen PML, Hasenfuss G, Zeitz O, Lehnart SE, Darmer D, Holtz J, Schumann H. Load dependent induction of apoptosis in multicellular myocardial preparations. Circulation. 1999;100:I-758.

50. Janssen PML, Lehnart SE, Prestle J, Hasenfuss G. Preservation of contractile characteristics of human myocardium in multi-day cell culture. Circulation. 1999;100:I-760.

51. Janssen PML, Lehnart SE, Zeitz O, Hasenfuss G, Darmer D, Holtz J, Schumann H. Is apoptosis in contracting myocardial preparations preload- or afterload dependent? Biophys J. 2000;78:108A.

52. Zeitz O, Rahman A, Hasenfuss G, Janssen PML. Impact of -adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium. Biophys J. 2000;78:225A.

53. Keweloh B, Zeitz O, Siegel U, Wehling M, Datz N, Hermann HP, Hasenfuss G, Janssen PML. Pyruvat wirkt positiv inotrop, erhöht den SR-Ca2+-Gehalt und hat keinen Einfluss auf die Ökonomie der myokardialen Kontraktion. Z Kardiol. 2000;

54. Janssen PML, Schillinger W, Zeitz O, Donahue JK, Hasenfuss G, Eschenhagen T, Prestle J. Verminderte -adrenerge Antwort nach Überexpression von Gi-2 in multizellulären Muskelpräparaten und Kardiomyozyten. Z Kardiol. 2000

55. Janssen PML, Zeitz O, Lehnart SE, Hasenfuss G, Darmer D, Holtz J, Schumann H. Vorlast- und Nachlast-induzierte Apoptose in multizellulären Herzmuskelpräparaten. Z Kardiol. 2000;

56. Janssen PML, Zeitz O, Keweloh B, Siegel U, Barckhausen P, Maier LS, Prestle J, Lehnart SE, Hasenfuss G. Einfluß von Cyclosporin A auf Kontraktilität, Calcium-Stoffwechsel und Kontraktionsökonomie in isoliertem Human- und Kaninchenmyokard. Z Kardiol. 2000;

57. Zeitz O, Maass AE, van Nguyen P, Hasenfuss G, Janssen PML. EInfluss von Hydroxylradikalen auf die Myokardfunktion - Bedeutung der Calcium-Sensitivierung durch TnT-Degradation. Z Kardiol. 2000;

58. Hermann HP, Zeitz O, Hasenfuss G, Janssen PML. Pyruvat potenziert die inotropen Effekte von Isoproterenol und Calcium am isolierten Kaninchen- und Humanmyokard. Z Kardiol. 2000;

59. Weisser J, Dieterich E, Schmidt-Schweda S, Janssen PML, Alecsic I, Baryalei M, Dembowsky K, Pieske B. Funktionelle Effekte von Adrenomedullin, Endothelin und Bradykinin an isolierten humanen Kardiomyozyten. Z Kardiol. 2000;

60. Zeitz O, AE Maass, van Nguyen P, Hasenfuss G, Janssen PML. Hydroxyl-radical induced contractile dysfunction is independent of SR function. Eur Heart J. 2000;21(Suppl):44.

61. Most P, Zeitz O, Janssen PML, Ehlermann P, Reppel M, G. Hasenfuss, H.A. Katus, and A. Remppis. S100A1 modulates Ca2+ sensitivity of cardiac myofilaments. Eur. Heart J. 2000;21(Suppl):60.

62. Prestle J, Janssen PML, Hasenfuss G, Smith GL. Reduced ryanodine receptor-mediated SR Ca2+-leak in isolated adult cardiomyocytes upon adenovirus-mediated overexpression of FKBP12.6. Eur Heart J. 2000;21(Suppl):61.

63. Zeitz O, Rahman A, Hasenfuss G, Janssen PML Impact of -adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium. Eur Heart J. 2000;21(Suppl):439.

64. Zeitz O, AE Maass, van Nguyen P, Hasenfuss G, Janssen PML. Hydroxyl radical exposure induces degradation of cardiac troponin T and calcium sensitization of cardiac muscle from the rabbit. Eur. Heart. J. 2000;21(Suppl):475.

65. Schillinger W, Janssen PML, Emami S, Henderson S, Ross R, Philipson KD, Hasenfuss G, PrestleJ. Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral transfer of Na+-Ca2+ exchanger cDNA. Eur Heart J. 2000;21(Suppl):505.

66. Janssen PML, Schillinger W, Donahue JK, Zeitz O, S. Emami, Hasenfuss G, Eschenhagen T, Prestle J. Gi-2 overexpression depresses the -adrenergic response in multicellular preparations and single myocytes. Eur Heart J. 2000;21(Suppl):530.

67. Janssen PML, Datz N, Zeitz O, Hasenfuss G. Levosimendan improves diastolic and systolic function in failing human myocardium. Eur. Heart. J. 2000;21(Suppl.):540.

68. Hermann HP, Zeitz O, Lehnart SE, Keweloh B, Datz N, Hasenfuss G, Janssen PML. Potentiation of -adrenergic inotropic response with pyruvate in failing human heart. Eur Heart J. 2000;21(Suppl.):666.

69. Janssen PML, Hermann HP, Zeitz O, Keweloh B, Hasenfuss G. Effect of pyruvate on calcium handling and cross-bridge kinetics in human myocardium. Heart and Vessels. 2000.

70. Zeitz O, Maass AE, van Nguyen P, Hasenfuss G, Janssen PML. Hydroxyl radical induced injury: relevance of sarcoplasmic reticulum function and sensitization by degradation of troponin T. Circulation. 2000;102:II-124.

71. Schillinger W, Janssen PML, Emami S, Henderson SA, Ross RS, Philipson KD, Prestle J, Hasenfuss G. Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na+-Ca2+ Exchanger. Circulation. 2000;102:II-140.

72. Prestle J, Janssen PML, Bruce L, Hasenfuss G, Smith GL. Overexpression of FK506-binding protein FKBP12.6 in cardiac myocytes reduces ryanodine receptor-mediated Ca2+-leak from the sarcoplasmic reticulum. Circulation. 2000;102-II-202.

73. Janssen PML, Schillinger W, Donahue JK, Zeitz O, Emami S, Lehnart SE, Weil J, Eschenhagen T, Hasenfuss G, Prestle J. Gi-2 overexpression depresses the -adrenergic response in multicellular preparations and single myocytes. Circulation. 2000;102-II269.

74. Hermann HP, Zeitz O, Lehnart SE, Keweloh B, Datz N, Hasenfuss G, Janssen PML. Potentiation of -adrenergic inotropic response by pyruvate in failing human myocardium. Circulation. 2000;102:II-720.

75. Zeitz O, Maass AE, van Nguyen P, Hasenfuss G, Janssen PML. Hydroxyl radical induced injury: relevance of sarcoplasmic reticulum function and sensitization by degradation of troponin T. Biophys J. 2001;80:2633.

76. Janssen PML, Hermann HP, Zeitz O, Keweloh B, Hasenfuss G. Effect of pyruvate on calcium handling and cross-bridge kinetics in human myocardium. Biophys J. 2001;80:2713.

77. Keweloh B, Lehnart SE, Wehling M, Domeier E, Janssen PML, Hasenfuss G. Influence of amino-pyruvate on contractility and cardiac energy metabolism in isolated myocardial trabeculae. Biophys J. 2001;80:2635.

78. Janssen PML, Prestle J, Zeitz O, Blanz J, von Figura K, Saftig P. Depressed cardiac contractile function in LAMP-2 deficient mice. Z. Kardiol 2001.

79. Janssen PML, Datz N, Hermann HP. Levosimendan improves diastolic and systolic function in failing human myocardium and healthy rabbit myocardium. Z. Kardiol 2001.

80. Schillinger W, Janssen PML, Emami S, Henderson S, Ross RS, Teucher N, Zeitz O, Philipson KD, Prestle J, Hasenfuss G. Kontraktile Dysfunktion kultivierter Kaninchenmyozyten nach adenoviralem Gentransfer des Na+-Ca2+-Austauschers. Z. Kardiol 2001.

81. Janssen PML, Hermann HP, Zeitz O, Keweloh B, Hasenfuss G. Der Effekt von Pyruvat auf die Calcium-Homöostase und die Querbrückenkinetik im humanen Herzen. Z. Kardiol 2001.

82. Zeitz O, Janssen PML, Maass AE, Van Nguyen P, Hensmann G, Moller K, Hasenfuss G, Kogler H. Hydroxyl radical-induced acute diastolic dysfunction: relevance of intracellular calcium overload and myofilament responsiveness. Eur Heart J. 2001;22:302.

83. Hermann HP, Arp J, Pieske B, Kögler H, Baron S, Janssen PML, Hasenfuss G. Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure. Eur Heart J. 2001;22:498.

84. Zeitz O, Maas AHEM, Van Nguyen P, Hensmann G, Kögler H, Möller K, Hasenfuss G, Janssen PML. Degradation of troponin I in rat myocardium is inducible by hydroxyl radicals. Eur Heart J. 2001;22:690.

85. Most P, Janssen PML, Smith GL, Eschenhagen T, Koch WJ, Katus HA, and Remppis A. S100A1: a novel regulator of myocardial contractility. Circulation 2001;104:246.

86. Soergel D, Stull LB, Janssen PML, and Murphy A. Transgenic mice with “constitutive” phosphorylation of PKA sites of cardiac troponin I. Pediatric Research 2002;51:186.

87. Janssen PML, Stull LB, and Marban E. Effects of temperature and stimulation frequency on calcium handling, contractile activation and relaxation in rat ventricular muscle. J Mus Res Cell Motil. 2001;22:615-616.

88. Stull LB, Janssen PML, Gao WD, and Marban E. Mechanism of enhancment of cardiac-calcium activated force by allopurinol. Biophys J. 2002;82:71a.

89. Soergel D, Stull LB, Janssen PML, and Murphy A. Transgenic mice with “constitutive” phosphorylation of PKA sites of cardiac troponin I. Biophys J. 2002;82:396a.

90. Janssen PML. Multi-day in vitro cardiac muscle culture, linking protein expression to physiological contractile function. Pharma transfer (e-publication).

91. Rau T, Janssen PML, Peppel K, Hasenfuss G, Koch W, and Eschenhagen T. Adenoviral GI-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae. J Mol Cell Cardiol. 2002, 34:A53

92. Janssen PML, Stull LB, and Marban E. Physiological determinants of contractile force generation and calcium handling in mouse myocardium. Heart and vessels (in press).

93. Georgakopoulos D, Janssen PML, Seidman CE, Seidman JG, and Kass DA. Novel role for cardiac myosin binding protein C (MYBP-C) in maintaining ventricular systolic elastance. Heart and Vessels, 2002.

94. Georgakopoulos D, Janssen PML, Seidman CE, Seidman JG, and Kass DA. Novel role for cardiac myosin binding protein C (MYBP-C) in maintaining ventricular systolic elastance. Circulation. 106:1173, Suppl. S, 2002.

95. Janssen PML, Stull LB, Leppo MK, and Marban E. Comparison of contractile function of isolated myocardium from FVB/N, C57BL/6, and SV129 mice under physiological conditions. Biophys. J. 43, 2003.

96. Babu GJ, Zheng ZL, Wheeler D, Janssen PML, Periasamy M. Sarcolipin, a low molecular weight SR protein plays an important role in Ca2+ Homeostasis. Circulation 108:382 Suppl. S, 2003.

97. Hiranandani N, Janssen PML. Effect of Hydroxyl Radicals Injury on Contractile Parameters of Mouse Papillary Muscle. Biophysical Journal, 88:481A, 2005.

98. Raman S, Kelley MA, Janssen PML. Effect of Muscle Dimensions on Trabecular Contractile Performance under Physiological Conditions. Biophysical Journal, 88:539A, 2005.

99. Torres CAA, Kelley MA, Janssen PML. Assessment of the contractile response of myocardium to heart rate variability independent of cardiac loading conditions. Biophysical Journal, 2005.

100. Hiranandani N, Janssen PML. Serca 1a over expression rescues the murine myocardium from hydroxyl radical injury. Circulation 112:suppl. II-1106, 2005.

101. Torres CAA, Varian KD, Janssen PML. Heart Rate Variability Influences Myocardial Contractility. Annual Meeting of the Society for Academic Emergency Medicine.

102. Bupha-Intr T, Janssen PML. Rapid dowregulation of Connexin 43 in isolated cultured myocardium. Circulation :suppl. II-, 2006.

103. Varian K, Janssen PML. Frequency dependent acceleration of relaxation involves decreased myofilament calcium sensitivity. Biophys J. 2007.

104. Bupha-Intr T, Janssen PML. Early endothelin induced myocardial hypertrophy through calcium-dependent protein phosphorylation. Biophys J. 2007.

105. Hiranandani N, Kohr M, Wang H, Varian KD, Ziolo MT, Janssen PML. Transient and sustained impact of hydroxyl radicals on calcium handling and contractile function in isolated myocardium. Biophys J. 2007.

106. Rodino-Klapac LR, Janssen PML, Montgomery CL, Jensen R, Chicoine LG, Clark KR, Mendell JR. A Clinically Relevant Gene Therapy Approach for Duchenne Muscular Dystrophy by Vascular Delivery of Micro-dystrophin. Gene Therapy Meeting, 2007.

107. Varian KD, Janssen PML. Staurosporine inhibits Frequency Dependent Myofilament Desensitization in Intact Rabbit Trabeculae. Circulation, 2007.

108. Monasky MM, Varian KD, Davis JP, Janssen PML. Dissociation of calcium decline from force decline by preload in isolated rabbit myocardium. Biophys. J. 2008;1479.

109. Varian KD, Janssen PML. Staurosporine inhibits Frequency Dependent Myofilament Desensitization in Intact Rabbit Trabeculae. Biophys. J. 2008;1447.

110. Torres CAA, Varian KD, Janssen PML. Determining the Inotropic Mechanism of Pyruvate. Biophys. J. 2008;1471.

111. Hiranandani N, Janssen PML. Impact of Hydroxyl Radicals on Calcium Handling and Myofilament Sensitivity in Isolated Myocardium. Biophys. J. 2008;1544.

112. Torres CA, Varian KD, Janssen PM. Myofilament Calcium Sensitivity: The Heart of Pyruvate’s Inotropic Mechanism. Circulation, 2008.

113. Chandrasekharan K, Yoon JH, Camboni M, Mendell JR, Sahenk Z, Janssen PML, Varki A, Martin PT. Humanizing mouse glycosylation to build a better mdx model for DMD. Neuromuscular Disorders 2008:18:782.

114. Varian KD, Xu Y, Torres CAA, Janssen PML. Contribution of Cycle Length History to Myocardial Contractility in Isolated Rabbit Myocardium under Physiological Conditions. Biophys. J. 2009;96:515a

115. Monasky MM, Janssen PML. The Positive Force-Frequency Relationship Is Maintained In Absence of Sarcoplasmic Reticulum Function In Rabbit, But Not In Rat Myocardium. Biophys. J. 2009:96;620a

116. Hiranandani N, Janssen PML. Impact of Hydroxyl Radicals on Calcium Handling and Myofilament sensitivity in Isolated Myocardium. FASEB J. 2009 23:988.3

117. Varian KD, Kijtawornrat A, Gupta SC, Torres CAA, Monasky MM, Hiranandani N, Periasamy M, Hamlin RL, Janssen PML. Frequency dependent myofilament desensitization is impaired in rabbit right ventricular hypertrophy. FASEB J. 2009 23:953.1

118. Monasky MM, Janssen PML. The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium. FASEB J. 2009 23:953.2

119. Kota J, Montgomery CL, Eagle A, Tucker D, Handy C, Haidet AM, Rodino-Klapac LR, Shontz KM, Davis Y, Van Wagoner ZD, Shilling CJ, Therlfall WR, Weisbrode SE, Janssen PML , Clark KR, Sahenk Z, Mendell JR, Kaspar BK. AAV-Follistatin Gene Therapy Targeting Neuromuscular Diseases with Weakness and Atrophy of the Quadriceps Muscle. Neurology 2009;72:A393.

120. Rodino-Klapac LR, Janssen PML, Shontz KM, Eagle A, Montgom-Ery CL, Clark KR, Mendell J, Kaspar B.Restoration of Normal Function by Combinational Gene Replacement Using Follistatin and MicroDystrophin in Mdx Mice. Neurology 2009;72:A394.

121. Chandrasekharan K, Yoon JH, Xu Y, Devries S, Camboni M, Janssen PML, Varki A, Martin PT. Humanizing Mouse Sialylation Humanizes Disease Progression in the Mdx Mouse Model for Duchenne Muscular Dystrophy. Glycobiology, 2009:19:1289.

122. Xu R, DeVries S, Camboni M, Janssen PML, Martin PT. Overexpression of Galgt2 in Skeletal Muscles Via AAV Prevents Muscle Damage and Inhibits Muscle Pathology in Mouse Models of Muscular Dystrophy. Mol. They. 2009:17:S201.

123. Monasky MM, Janssen PML. Increased Phosphorylation of Myofilament Proteins after Stretch in Rabbit Ventricular Myocardium. Biophysical Journal, 2010:98;717a.

124. Xu Y, Rafael-Fortney JA, Janssen PML. Contraction-Mediated Damage in mdx Mice Trabeculae: A Model for Cardiomyopathy in Duchene Muscular Dystrophy. Biophysical Journal 2010:98;715a.

125. Haizlip KM, Janssen PML. Effects of Development of Compensatory Hypertrophy on Force Frequency Response. 2010. National Graduate Research Festival, National Institutes of Health. Biophysical Journal 98;720a-721a.

126. Haizlip KM, Janssen PML. Effects of Development of Compensatory Hypertrophy on Force Frequency Response. 2010. Cardiovascular Systems Dynamic Society Fukuoka, Japan

127. Haizlip KM, Janssen PML. Frequency Induced Alterations in Calcium Signaling. 2010. Ohio Physiological Society. Cleveland, Ohio.

128. Haizlip KM, Janssen PML. Frequency Induced Alterations in Calcium Signaling. Biophysical Journal 2011:100;298a.

129. Stevens SCW, Abraham JL, Janssen PML, Gyorke S. Synchronization of Spontaneous Calcium Waves in Cardiac Muscle. Biophysical Journal 2011:100;291a.

130. Xu Y, Janssen PML. Dynamic Regulation of Myocardium Contractility in Positive Force-Frequency Relationship. Biophysical Journal 2011:100;298a.

131. Abraham JL, Stevens SCW, Janssen PML. Ventricular Mechanics in Intact Rat Trabeculae Under High Frequency ConditionsBiophysical Journal 2011:100; 298a.

132. Schill KE, Zang KE, Barnum JA, Delfín DA, Bogan D, Kornegay J, Janssen PML, Rafael-Fortney JA. Claudin-5 reductions are an early step in heart failure pathogenesis. Keystone Symposia: Molecular Cardiology: Disease Mechanisms and Ex-perimental Therapeutics, Keystone, Colorado, February 2011.

133. Delfín DA, Xu Y, Peterson JM, Guttridge DC, Rafael-Fortney JA, Janssen PML. Improvement of cardiac contractile func-tion by peptide-based inhibition of NF-kB in the utrophin-dystrophin double knockout murine model of muscular dystro-phy. Keystone Symposia: Molecular

Cardiology: Disease Mechanisms and Experimental Therapeutics, Keystone, Colorado, February 2011.

134. Chimanji R, Xu Y, Schill KE, Tran T, Canan B, Delfín DA, Mays TA, Janssen PML, Raman SV, Rafael-Fortney JA. A com-binatorial drug treatment improves functional and histological indicators of cardiomyopathy in a dystrophic mouse model. Keystone Symposia: Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics, Keystone, Colorado, February 2011.

135. Delfín DA, Xu Y, Schill KE, Janssen PML, Rafael-Fortney JA. Sustained claudin-5 levels rescue cardiomyopathy and heart failure in a sever muscular dystrophy mouse model. Keystone Symposia: Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics, Keystone, Colorado, February 2011.

136. Delfín DA, Schill KE, Xu Y, Canan B, Chamberlain JS, Janssen PML, Rafael-Fortney JA. A novel treatment strategy for muscular dystrophy-based cardiomyopathy and heart failure: gene therapy using the tight junction protein claudin-5. Muscular Dystrophy Association Conference, Las Vegas, Nevada, March 2011.

137. Delfín DA, Xu Y, Peterson JM, Guttridge DC, Rafael-Fortney JA, Janssen PML. Improvement of cardiac contractile func-tion by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy. Muscular Dystrophy Association Conference, Las Vegas, Nevada, March 2011.

138. Haizlip KM, Janssen PML. Short and long term effects on the force frequency response in health and disease. 2011. International Society for Heart Research.

139. Slabaugh JL, Brunello L, Gyorke S, Janssen PML. Synchronization of Ca2+ Release in Multicellular Cardiac Preparations. Biophysical Journal 2012:102;103a.

140. Haizlip KM, Janssen PML. Dissociation Between Force and Calcium after a Step Change in Frequency. Biophysical Journal 2012:102;350a.

141. Monasky MM, Taglieri DM, Jacobson AK, Haizlip KM, Solaro RJ, Janssen PML. Post-Translational Modifications of Myofilament Proteins Involved in Length-Dependent Prolongation of Relaxation in Rabbit Right Ventricular Myocardium. Biophysical Journal 2012:102;614a.

142. Little SC, Janssen PML, Davis JP. Cross-Talk between Neighboring Troponins in Ventricular Myofibrils. Biophysical Journal, 2012:102;156a.

143. Grose W, Griffin D, Shontz K, Malik V, Montgomery C, Janssen PML, Clark JR, Mendell JR, Rodino-Klapac L. Correction of Membrane Repair Defects in Dysferlin Deficient Muscle Following AAV5 Gene Transfer. Neurology:78;S55.

144. Milani-Nejad N, Xu Y, Davis JP, Janssen PML. Cross-Bridge Cycling Kinetics in Intact Multicellular Cardiac Muscle at Physiological Temperature: Impact of Muscle Length. Biophysical Journal, 2012:102;351a.

145. Heller KN, Montgomery CL, Malik V, Shontz KM, Janssen PML, Clark KR, Rodino-Klapac LR, Mendell JR. Increased Overexpression of Human Alpha7 lntegrin as a Potential Therapy for Duchenne Muscular Dystrophy. Molecular Therapy, 2012:20:S71-S72.

146. Brunello L, Slabaugh JL, Ho HT, Belevych AE, Volpe P, Priori SG, Janssen PML, Györke S. Synchronization of proarrhythmic Ca2+ signaling in cardiac muscle harboring a calsequestrin 2 mutation linked to Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. 2012.

147. Delfín DA, Schill KE, Xu Y, Swager S, Janssen PML, Rafael-Fortney JA. Cardiac Pathology Is Worsened by Loss of the Cell Junction Protein Claudin-5 and Improved by Claudin-5 Gene Therapy. Circulation Research, 2012:111:A85.

148. Torres CAA, Varian KD, Canan CH, Davis JP, Janssen PML. Pyruvate: Inotropic Mechanisms in the Normal and Failing Heart. ACEP meeting. 2012.

149. Milani-Nejad N, Xu Y, Davis JP, Campbell KS, Billman GE, Kilic A, Higgins RSD, Janssen PML. Muscle Length is a Determinant of Cross-Bridge Cycling Rate in Intact Cardiac Trabeculae: Studies from Rodents to Humans. Biophysical Journal 2013:104;315a-316a.

150. Elnakish MT, Hassanain HH, Janssen PML. Role of Rac1 in Thyroxin-Induced Cardiovascular AbnormalitiesBiophysical Journal 2013:104;316a.

151. Slabaugh JL, Brunello L, Gyorke S, Janssen PML. Synchronization of Ca2+ Release in Multicellular Cardiac Preparations. Biophysical Journal 2013:104;439a.

152. Aeffner F, Joseph LM, Gaughan AA, Abdulrahman B, Hickman-Davis JM, Janssen PML, Hayes D, Amer A, Bedwell DM, Sorscher EJ, Davis IC. Mice heterozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel display attenuated cardiopulmonary dysfunction and lung injury after influenza H1N1 infection; 32nd Annual Symposium of the Society of Toxicologic Pathology; Portland OR, USA. (2013)

153. Davis IC, Aeffner F, Abdulrahman B, Hickman-Davis JM, Janssen PML, Hayes D, Amer A, Bedwell DM, Sorscher EJ. Influenza-induced Cardiopulmonary Dysfunction and Lung Injury Are Attenuated In Mice Heterozygous for the F508del Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel; American Thoracic Society International Conference; Philadelphia PA, USA. (2013)

154. Davis IC, Aeffner F, Abdulrahman B, Hickman-Davis JM, Janssen PML, Hayes D, Amer A, Bedwell DM, Sorscher EJ. Influenza-induced cardiopulmonary dysfunction and alveolar fluid clearance inhibition are attenuated in F508del CFTR-heterozygous mice; Experimental Biology 2013; Boston, MA, USA. (2013)

155. Aeffner F, Joseph LM, Gaughan AA, Abdulrahman B, Hickman-Davis JM, Janssen PML, Hayes D, Amer A, Bedwell DM, Sorscher EJ, Davis IC. Mice heterozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel display attenuated cardiopulmonary dysfunction and lung injury after influenza H1N1 infection; 64th Annual meeting of the American College of Veterinary Pathologists; Montreal, Canada. (2013).

156. Hansen BJ, Csepe TA, Kalyanasundaram A, Kamalov G, Zhao J, Janssen PM, Mohler PJ, Davies EA, Weiss R, Fedorov VV. Leading Reentry Circuit(s) in the Right Atrial Free Wall Underlies Adenosine-Induced Atrial Fibrillation in Coronary Perfused Human Hearts. Heart Rhythym 2013;10:1745.

157. Bonilla IM, Long VP, Wright P, Janssen PML, Binkley PF, Mohler PJ, Carnes CA. Apamin Sensitive Current (IKCa) Modulates Ventricular (but Not Atrial) Repolarization in Human Heart Failure. Circulation. 2013:128;A18389.

158. Radwański PB, Brunello L, Veeraraghavan R, Ho HT, Belevych AE, Priori SG, Volpe P, Janssen PM, Bridge JHB, Poelzing S, Györke S. Neuronal Na+ Channels Contribute to Arrhythmogenic Diastolic Ca2+ Release Through the Microdomain Na+/Ca2+ Signaling.

159. Brunello L, Knollmann BC, Janssen PML, Gyorke S. Relative Contribution of Purkinje Fibers to Ca2+-Dependent Arrhythmias in a Murine Model of CPVT. Biophysical Journal 2014:106;112a.

160. Milani-Nejad N, Davis JP, Fedorov VV, Mohler PJ, Kilic A, Higgins RSD, Janssen PML. Existence of Length-Dependent Modulation of Cross-Bridge Cycling Kinetics in Right Ventricles of Non-Failing and Failing Human Myocardium. Biophysical Journal 2014:106;348a.

161. Hansen BJ, Zhao J, Csepe TA, Jayne LA, Li N, Moore B, Higgins RSD, Kilic A, PJ Mohler, Janssen PML, Weiss R, Hummle JD, Fedorov VV. Human atrial fibrillation terminated by targeted ablation of localized reentrant drivers guided by simultaneous epicardial and endocardial mapping. Heart Rhythm. 2014:11;2129-2130.

162. Csepe TA, Zhao J, Hansen BJ, Li N, Jayne L, Moore B, Lim P, Bratasz A, Powell KA, Simonetti O, Higgins RSD, Kilic A, Mohler PJ, Janssen PML, Weiss R, Hummel JD, Fedorov vv. Integration of gadolinium-enhanced MRI and simultaneous epicardial-endocardial optical mapping reveals microanatomic substrates anchoring reentrant drivers during sustained atrial fibrillation in human heart. Heart Rhythm. 2014:11;2131-2132.

163. Simmons TR, Vulin A, Wein N, Rutherford AM, Janssen PML, Flanigan KM. Intravenous Delivery of a rAAV9 U7snRNA Vector Targeting Exon 2 Results in Widespread Dystrophin Expression in the Dup2 DMD mouse model. Molecular Therapy. 2014:22;S51-S51.

164. Heller K, Montgomery C, Shontz K, Janssen PML, Clark R, Mendell JR, Rodino-Klapac L. Human α7 Integrin Gene (ITGΑ7) Delivered By Adeno-Associated Virus Reverses The Phenotype Of The Double Knock Out (DKO) Mouse Devoid Of Dystrophin And Utrophin. Neurology. 2014:82;P5.099.

165. Flanigan K, Vulin-Chaffiol A, Wein N, Janssen PML. Restoration Of Dystrophin Expression In A Novel Duchenne Mouse Model, The Dup2 Mouse, by IRES-Mediated Translation Of A Highly Functional N-Truncated Dystrophin Protein. Neurology. 2014:82;S61.001.

166. Li N, Hansen BJ, Csepe TA, Jayne L, Zhao J, Moore B, Higgins RS, Weiss R, Kilic A, Rosen MR, Mohler PJ, Biesiadecki BJ, Janssen PML, Fedorov VV. Functional and Molecular Characteristics of the Latent Atrial Pacemaker Clusters in Explanted Human Hearts. Circulation. 2014:130;A18888-A18888.

167. Li N, Hansen BJ, Zhao J, Jayne L, Moore B, Csepe TA, Higgins RS. Kilic A, Weiss R, Mohler PJ, Janssen PML, Biesiadecki BJ, Hummel JD, Fedorov VV. Functional and Molecular Arrhythmogenic Substrates of Atrial Fibrillation Drivers (Reentrant Rotors) in Explanted Human Hearts. Circulation. 2014:130;A19293-A19293.

168. Martin BL, Gallagher TL, Rastogi N, Beattie CE, Amacher SL, Janssen PML. Direct Assessment of Skeletal Muscle Contractile Strength in Live Wildtype and Rbfox Morphant Zebrafish Larvae. Biophysical Journal 2015:108;589a.

169. Shettigar V, Little SC, Zhang B, Zhang J, Roof S, Xu Z, Brundage EA, Biesiadecki BJ, Weisleder N, Janssen PML, Ziolo MT, Davis JP. Engineering Cardiac Troponin C: Potential Therapeutic for Heart Failure. Biophysical Journal 2015:108;596a.

170. Salhi HE, Walton SD, Hassel NC, Brundage EA, de Tombe PP, Janssen PML, Davis JP, Biesiadecki BJ. Cardiac Troponin I Ser-23/24 and Tyr-26 Phosphorylation Crosstalk. Biophysical Journal. 2015:108;597a-598a.

171. Krishnamurthy K, Alloush J, Xu Z, Beck EX, Mohler PJ, Janssen PML, Weisleder N. Tripartite Motif Protein 58 (trim58) is a Novel Regulator of Membrane Repair With Increased Expression in Failing Cardiac Muscle. Circulation Research, 2015:117;A359.

172. Csepe TA, Zhao J, Hansen BJ, Li N, Wang Y, Bratasz A, Powell K, Higgins RD, Simonetti OP, Kilic A, Raman SV, Simonetti OP, Mohler PJ, Janssen PML, Fedorov VV. First Noninvasive Visualization of Sinoatrial Node Fibrosis via High-Resolution 3D Gadolinium Enhanced MRI of Intact Human Hearts. Circulation, 2015:132;A12533.

173. Hansen BJ, Briggs C, Moore BT, Csepe TA, Li N, Zhao J, Garikipati NV, Janssen PML, Mohler PJ, Hummel JD, Fedorov VV. Human Atrial Fibrillation Drivers Seen Simultaneously by Focal Impulse and Rotor Mapping and High-resolution Optical Mapping. Circulation, 2015:132;A18402.

174. Li N, Csepe TA, Hansen BJ, Dobrzynski H, Higgins RS, Kilic A, Mohler PJ, Janssen PML, Rosen MR, Biesiadecki BJ, Fedorov VV. HCN Channel Distribution in the Human Sinoatrial Node and Latent Atrial Pacemakers (Best of Basic Science Abstract). Circulation, 2015:132;A18171.

175. Adelman SH, Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PML, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ. Circulation, 2015:132:A19972.

176. Li N, Petkova M, Hansen BJ, Ssekayombya PS, Yanni J, Biesiadecki BJ, Kilic A, Mohler PJ, Janssen PML, Davis JP, Accornero F, Boyett MR, Dobrzynski H, Fedorov VV. Heart Failure Induced Upregulations of MicroRNAs in the Human Sinoatrial Node Associated with Pacemaker Dysfunction. Circulation 2017;136:A24075.

177. Campbell KS, Janssen PML, Campbell SG. Force-Dependent Recruitment of Cross-Bridges from the Myosin Off-State can Contribute to Length-Dependent Activation. Biophysical Journal 2017:112:119a.

178. Tikunova S, Gyorke S, Brozovich F, Biesiadecki BJ, Janssen PML, Ziolo MT, Davis JP. Designing Calcium Binding Proteins as Therapeutics against Muscle Diseases. Biophysical Journal 2017:112:425a.

179. Chen MP, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PML. A Novel Approach to Identify the Role of Single Molecule Titin Mechanics in Human Heart Failure. Biophysical Journal 2017:112:121a.

180. Chung JH, Martin B, Canan BD, Elnakish MT, Saad NS, Kilic A, Chen MP, Milani-Nejad N, Mohler PJ, Fedorov VV, Janssen PML. Contractile Force and Kinetics in Failing versus Non-Failing Human Myocardium. Biophysical Journal 2017:112:482a.

181. Chung JH, Milani-Nejad N, Karaze T, Kilic A, Mohler PJ, Janssen PML. Effect of Stimulation Frequency Modification on Kinetic Parameters of Explanted Human Myocardium. Biophysical Journal 2017:112:423a.

182. Saad NS, Floyd K, Repas S, Janssen PML, Elnakish MT. Assessment of Thyroid Hormone Induced Hemodynamic Alterations and Cardiac Irregularities following Antithyroid Drug Treatment and Thyroxin Usage Recovery. Biophysical Journal 2017:112:121a.

183. Devenport S, Penton CM, Salgado N, Wang H, Flanigan K, Janssen PML, Montanaro F. Reduced Hedgehog signalling in Duchenne muscular dystrophy impairs muscle regeneration and function. Neuromuscular Disorders 2017:27;S13.

184. Manring HR, Ng R, Albertelli T, Bobbili PJ, Carter O, Stevens T, Jacoby J, Janssen PML, Kilic A, Wright N, Campbell S, Ackermann MA. Defining a Unifying Mechanism for Select Cariomyopathy-Linked Variants of Desmoplakin. Biophysical Journal 2018;114:500a.

185. Manring HR, Bobbili PJ, Beer A, Janssen PML, Kilic A, Ackermann MA. Defining a Novel Mechanism Mediating the Rate of Heart Failure Progression. Biophysical Journal 2018;114:500a.

186. Chen M, Kiduko SA, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PML. Stretching Single Titin Molecules from Failing Human Hearts at Cardiac Cycle Reveals Titin’s Role in Cardiac Kinetic Reserve. The FASEB Journal. 2018:32;S1-903.6.

187. Elnakish MT, Repas SJ, Whitson BA, Mohler PJ, Janssen PML. Antiarrhythmic Activity of NMDA Receptor Antagonists in Humans Versus Animal Models. The FASEB Journal. 2018:32;S1.

188. Chung JH, Canan BD, Whitson B, Kilic A, Mohler P, Janssen PML. Force-frequency Relationship and Early Relaxation Kinetics Are Preserved Upon SR Blockade in Human Myocardium. The FASEB Journal. 2018:32;S1.

189. Peczkowski KK, Rastogi N, Schultz EJ, Rafael-Fortney JA, Janssen PML. Submaximal Level Single Twitch Kinetics Dependent on Disease State in Duchenne Muscular Dystrophy Mouse ModelThe FASEB Journal. 2018:32;S1.

190. Santini J, Repas SJ, Canan BD, Billman GE, Kilic A, Whitson B, Janssen PML. Contraction and Relaxation Coupling Unaffected by Disease in Canine and Human Myocardium. FASEB Journal. 2018:32;S1.

Invited lectures (host): 11-1992 University of Washington, Department of Bioengineering (Dr. G.H. Pollack). 10-1993 Wake Forest University, Department of Cardiology (Dr. P.P. de Tombe). 11-1993 Johns Hopkins University, Department of Cardiology (Dr. D.A. Kass). 10-1994 Tohoku University, Department of Internal Medicine I (Dr. K. Shirato). 07-1996 University of Wisconsin, Department of Physiology (Dr. R.L. Moss). 08-1996 University of Freiburg, Div. of Cardiology (Dr. G. Hasenfuss). 09-1998 Maastricht University, Department of Physiology (Dr. R.S. Reneman). 11-1998 Loyola University Chicago, Department of Physiology (Dr. D.M. Bers). 01-1999 Free University of Amsterdam, Department of Physiology (Dr. G. Stienen). 02-1999 Johns Hopkins University, Institute of Molecular Cardiobiology (Dr. E. Marban). 11-1999 Nurenberg, Fall-meeting of the German Cardiac Society (program committee). 08-2000 Temple University, Department of Physiology (Dr. S.R. Houser). 12-2000 Berlin, 4th Symposium Unfallkrankenhaus Berlin (Dr. F.X. Kleber). 06-2001 The Ohio State University, Department of Physiology and Cell Biology (Dr. M.

Periasamy). 01-2003 The Ohio State University, Department of Physiology and Cell Biology (Dr. M.

Periasamy).

05-2004 Department of Physiology and Biophysics, University of Illinois at Chicago (Dr. P. de Tombe)

07-2004 Division of Cardiology, University of Calgary (Dr. J. Tyberg) 03-2005 The Ohio State University, Department of Physiology and Cell Biology (Dr. M.

Periasamy). 08-2005 Childrens Research Institute, University of Cincinnati 09-2005 The Ohio State University, Davis Heart Lung Research Institute (Dr. Zweier) 04-2006 The Ohio State University, Davis Heart Lung Research Institute (Dr. Zweier) 10-2006 Mathematical Biology Institute, The Ohio State University (Dr. McGulloch) 01-2007 Department of Physiology and Biophysics, University of Illinois at Chicago (Dr. P. de

Tombe) 05-2007 Division of Pharmacology, College of Pharmacy, OSU (Dr. Hu). 06-2007 Metrohealth Heart and Vascular Res. Center, Case Western Reserve Univ. (Dr.

Donahue). 12-2007 American Heart Association, Columbus (Mr. Duffy). 04-2007 Florida State University, Tallahassee, FL (Dr. Chase). 05-2008 Thin and Thick Myofilament Meeting, Madison, Wisconsin (Drs. Moss and Solaro). 06-2008 The Ohio State University, Davis Heart Lung Research Institute (Dr. Zweier) 09-2008 The Ohio State University, Dept. of Mol. Virology, Immunology, Med. Genetics (Dr.

Huebner) 01-2008 Metrohealth Heart and Vascular Res. Center, Case Western Reserve Univ. (Dr.

Rosenbaum). 07-2009 The Ohio State University, Davis Heart Lung Research Institute (Dr. Yong) 12-2009 BIT Congress on Cardiology, Shanghai, China (committee) 01-2010 University of Missouri, Columbia, MO (Dr. McDonald) 04-2010 Experimental Biology, Bowditch Award Lecture, Anaheim, CA (APS) 09-2010 CSDS Meeting, plenary session speaker, Fukuoka, Japan (Dr. Sunagawa) 11-2010 University of Kentucky, KY (Dr. Campbell) 05-2011 ISHR meeting, Philadelphia, invited plenary session speaker 11-2011 Action Duchenne Conference, London, UK, invited plenary session speaker 01-2012 University of Otago, New Zealand, invited seminar speaker 02-2012 Biophysical Society Meeting, invited speaker and session chair 08-2012 Loyola University, invited speaker, Chicago, IL. 10-2012 DHLRI Research day, speaker. 10-2012 Cardiac Physiome Workshop, invited speaker, San Diego, CA. 01-2013 Columbus Museum of Art, invited speaker, Columbus, OH. 03-2013 Freshman Orientation Day, OSU, invited speaker, Columbus, OH. 10-2014 University of Miami, invited speaker, Miami, FL. 05-2015 The Ohio State University, Davis Heart Lung Research Institute (Dr. Weisleder) 06-2016 Myofilament meeting, Madison, WI (Dr. Solaro). 02-2017 Biophysiocal Society Meeting, invited speaker and session chair, New Orleans, LA. 03-2018 University of Toledo, OH, invited seminar speaker (Dr. Aboualaiwi). 05-2018 Myofilament Meeting, Madison, WI (Dr. Pogessi). 10-2018 Department of Physiology, University of Arizona (Dr. Granzier). 02-2019 Department of Physiology, Wayne State University (Dr. Jin). 04-2019 Department of Pharmacy, British University of Egypt, Cairo, Egypt (Dr. Elamzar). Non-Academic Vitae:

Employment: • Paper Delivery Route, 475 homes, twice weekly, 1982-1985. • Supermarket (Edah) Employee, 25-50 hours/week, 1985-1987, shift manager 1986-1987. • Garbage Collection (back of truck), ~15 weeks full time, 1990-1992. • Software Macro Writer / file conversion specialist, Eli Lilly Company, ~2 weeks, 1991.

• Forklift operator (diesel and electric), multiple companies via temp. agency, 1989-1992. • Land surveyor, Nederlandse Aardunie (Dutch Gas Company), ~4 weeks, via temp agency,

1991.

Youth Camp Participant/Councillor: • Annual cultural exchange of sister cities (Roermond (NL), Moenchengladbach (GER), Bradford

(UK), and Roubaix (FR)) of 10 underpriviledged youth (15-20 years old), to spend a 14 day program together. I was a participant 1985-1987, then joined the organizing foundation as head organizer/councillor (create a 2-week full-time program for 50 participants including lodging, meals, and (inter-)national transportation), 1989-1993.

Athletics/Sports:

• Soccer, club teams R.K.A.V.C. and S.C. Victoria, 1978-1986. • High school soccer team, 1985-1986. • Distance walking, completed Nijmegen Vierdaagse (>50 km/day, 4 days in a row), and

Kennedy Mars Sittard (>80 km in one day), 1987. • Rowing, USR Triton (Utrecht Uiversity), club record holder for most wins over 4 years as a

coxswain (30 wins, 1988-1991), and most wins in a single season (10 wins, 1988). International races with Netherlands National Junior team in Kiev (Ukraine) 1990, Barcelona (Spain), 1991.

• Intramural indoor soccer, Utrecht University, 1989-1992. • Intramural co-ed softbal, Johns Hopkins University, 1993. • Intramural soccer, Utrecht University, 1989-1992. • Distance running, completed 4 half and 2 full marathons, 2015-2017.

Dancing:

• Completed highest level of standard training (Gold) in Ballroom dance (1985-1988) • Completed highest level of standard training (Gold) in Latin American dance (1985-1988) • Completed training level Bronze and Silver in Rock’n’Roll dance (1986-1989) • Several paid performances at various venues (1986-1989).

Lego:

• Co-founder of the Central Ohio Lego Train Club, now OhioLUG. 2004. • President, Central Ohio Lego Train Club, 2004-2014, member 2015-present. • 50+ public showings (several paid) of LEGO Art creations, 2004-present. • Official National LEGO building contest “Build the Trust“, Washington D.C., winner, 2005. • Official National LEGO building contest “Rebuild New Orleans“, Washington D.C., winner,

2006. • Builder of the Ohio Stadium in LEGO bricks, appeared on several TV channels, national radio

interviews (PBS/ESPN/NBC/CBS), 100+ newspaper articles. Used for fundraising, raised >$80.000 for cardiovascular research at OSU, 2011-present.

• 2 solo displays and 5 group displays at the Columbus Museum of Art, 2013-present. Entrepeneurship:

• Owner/Sole Proprietor of “Missing Brick“, an on-line LEGO parts selling store (>30.000 orders), 2001-present.

• Owner/Sole Proprietor of “Ohio Brick Models, LLC“, store on an Amazon.com, 2010-present. • Trade-show artist (3 appearances, Chicago, San Diego, and Seatlle), on-site building of an 8-

foot LEGO model of an antibody for Seattle Genetics, via Navicor advertisement agency (highlighted in a Wall Street Journal article), 2010-2011.