Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math...
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Transcript of Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math...
Patterns of Inheritance
Gregor Mendel“Father” of geneticsMid 1800sAustrian monkStudied math and science in
ViennaTaught high schoolTended to the monastery gardenConducted his genetic studies in
pea plants
Anatomy of a Flower
True-breeding StrainsMendel used “self-pollination” to
obtain true breeders
Cross-Pollination
Characteristics vs. Traits
CharacteristicPlant height
Pea color
Flower color
Pea shape
Flower position
TraitTall, short
Yellow, green
Purple, white
Wrinkled, smooth
Axial, terminal
Mendel’s 4 Hypotheses1. There are alternative versions
of genes that account for variations in characteristics.
Mendel’s 4 Hypotheses2. For each characteristic, an
organism inherits 2 alleles—one from each parent.
Mendel’s 4 Hypotheses3. If the 2 alleles of an inherited
pair differ, then one determines the organism’s appearance.
Mendel’s 4 Hypotheses4. A sperm or egg carries only 1
allele for each characteristic because the 2 alleles segregate (separate) during meiosis.
Law of
Segregatio
n
Dihybrid Crosses: Mendel’s Law of Independent Assortment
Dihybrid Crosses: Mendel’s Law of Independent Assortment
X
In Dihybrid Crosses, Why Don’t We See This….?
The Rules of Probability
Traits Thought to be Controlled by a Single Gene
Family Pedigrees
Autosomal Recessive Pedigree
Why We Have Laws Against Marrying Your First Cousin!
Single-Gene Autosomal Disorders
WELCOME TO NON-MENDELIAN GENETICS
(WHICH IS MOST OF HUMAN GENETICS!)
Incomplete Dominance
Incomplete Dominance
Incomplete Dominance
Codominance: ABO Blood Groups
Codominance: ABO Blood Groups
Codominance: ABO Blood Groups
Why is it so important to give a patient the correct blood type?
PleiotropyOne gene has the ability to
influence several characteristics
Polygenic InheritanceThe additive effects of 2 or more
genes on a single phenotypic characteristic.
Polygenic Inheritance
Polygenic Inheritance
Don’t Forget About the Influence of the Environment!
SEX CHROMOSOMES AND SEX-LINKED GENES
Sex Determination in Humans
Sex Determination in Humans
Red-Green Colorblindness: A Sex-Linked Recessive Trait
Red-Green Colorblindness: A Sex-Linked Recessive Trait
Red-Green Colorblindness: A Sex-Linked Recessive Trait
Hemophilia in the Russian Royal Family
The Genetics of Calico Cats: Why they are always female!
Barr Body Formation
The Genetics of Calico Cats: Why they are always female!