patogenesis jaringan parut
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Transcript of patogenesis jaringan parut
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Patofsiologi Jaringan Parut
dan Striae
Pembimbing: Dr.dr.Nelva K Jusu,SpKK(K)
Penyai:dr.!"a Sya#rini
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Proses Penyembuhan Luka
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$ase Penyembu#an %u"a
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Patogenesis Proses Penyembu#an %u"a&bnormal
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Jaringan Parut ' Sar
!s#ara (a#asa latin)
*eradi "arena terbentu"nya aringan i"atyang abnormal pada proses penyembu#an
lu"a
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+ %u"a pada "ulit manusia, diper"aya ole# beragamprotein matri e"straseluler, growth factor dansito"in yang seara normal tida" terdapat pada
"ulit yang utu#.
+ Patofsiologi ar. parut abnormal belum di"eta#uisepenu#nya namun diduga adanya
"etida"seimbangan antara deposisi dandegradasi matri e"straseluler
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• *-$β dan *-$β/ $a"tor "uni pada ase prolierasi
0engeluar"an sinyal le1at S0&D dan 2nt s"ar• *-$β3 4eseptor antagonis mengurangi s"ar
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5%6 dan 5%7 die"spresi"an segera setela# teradinya lu"a menga"ti"an sel in8amasi $ase in8amasi yang
ber"epanangan a"tivitas fbroblast 99 deposisi !0;;
s"ar
5%<0eng#ambat infltrasi neutrofl dan ma"roag pada
lu"a dan menurun"an e"presi sito"in proin8amasi menurun"an pembentu"an s"ar
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+ 0empengaru#i degradasi !0 dan remodeling+ 00Ps memediasi pemea#an "olagen tipe 5 dan
555
+ 00P>/ degradasi "olagenmatri remodeling
+ 00P>? perbai"an lu"a a1al degradasi "olagentipe 5@ dan @,elastin dan fbronetin
+ Pada "eloid dan #ipertropi sar 00P>/ tinggi
sedang"an 00P>? renda#.
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+ Normalnya: apoptosis dari miofbroblas teradipada / #ari setela# lu"a.
+ Pada #ipertropi" sar: ma"simal apoptosis
?>3< bulan setela# inuri
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Jenis Jaringan Parut
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Striae
Kondisi "ulit yang ditandai dengan pita#alus yang linear dari "ulit yang
atrof yang teradi "arenadipengaru#i proses peregangan
Stretch marks
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+ !tiologi:
A Ke#amilan
A &drenoortial yang berlebi#an
A Peruba#an pada "ondisi tubu# peruba#aberat badan yang drastis
A -eneti"
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Peruba#an "omponen matri"s e"stra seluler
Fibirilin, elastin dan kolagen
striae
+ Dermal sarring ruptur "olagen dermal
+ Peruba#an pada elastolisis dii"uti dengan
degenerasi sel mast
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geneti" &gen me"ani"
Bormonal dan a"tor bio"imia
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+ &danya "eendrungan amilial
+ $a"tor geneti" sindrom e#ler danlos,0aran, !todermal dysplasia dan
autosomal dominant amilial striaedistensae
+ &danya mutasi pada seumla# gen yangmeng"ode "olagen, elastin dan fbrone"tin
peruba#an metabolisme fbroblast
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+ -angguan pada serat elasti" "arenaadanya stres me"ani".
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+ Penelitian : Pening"atan yang signif"an padae"spresi androgen, glu"o"orti"oid dan reseptorestrogen pada a1al striae.
+ Bormon berperan pada regulasi dan reorganisasi!0.
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