PATIENT-CENTERED RESEARCH INTO OUTCOMES STROKE PATIENTS PREFER

AND EFFECTIVENESS RESEARCH

What is PCORI?

PROSPER is funded by PCORI PCORI =Patient Centered

Outcomes Research InstituteNonprofit organization established by the Affordable Care Act in 2010

PCORI’s MissionTo fund research that offers patients and caregivers the information they need to make important healthcare

decisions

What is PROSPER?

Patient-centered Research into Outcomes Stroke Patients prefer and Effectiveness Research

Above all, PROSPER is a research collaboration Patients Doctors Caregivers Researchers

Multiple perspectives and experiences = better understanding!

Why are we doing PROSPER?

Stroke is a major public health problem 800,000 each year in the US: that’s 1 every 40

seconds! 4th leading cause of death Leading cause of disability

What we don’t know: Common therapies like statins and blood thinners help

avoid another stroke, but how do they affect functional status, time at home, quality of life?

Certain therapies may be effective for certain patients, but what about for less well-studied patient groups like women, minorities, and the elderly?

A Few Questions…

Are statins as beneficial for older adults as for

younger adults?

What are the tradeoffs between long-term health and potential

negative effects of my medications?

How well do these therapies work over

the long-term?

How do the new anticoagulants affect

my likelihood of having another

stroke?

Can antidepressants improve my quality of

life after stroke?

How do we plan to answer these questions?

Clinical data sources Get With the Guidelines (GWTG) – Stroke

National registry of over 2 million acute stroke patients Measures the medical treatment received during

hospitalization Can use this data to see where doctors and hospitals can

improve their stroke care Medicare-CMS

Use of healthcare services by people enrolled in Medicare

Information about rehospitalizations after the initial stroke and how much time is spent at home during the year after discharge

Patient questionnaire

Days alive and at home (“home-time”)

Any fatigue or depression experienced as a result of the stroke

Quality of life Mobility Whether patient can complete

normal activities like dressing, eating, shopping

How well patients are tolerating their medications/any side effects they are experiencing

Patient data source: phone interviews at 3 and 6 months after discharge to assess:

How do we think this will help patients?

Use results to develop patient tools available on an interactive online portal Stroke warning signs/symptoms How to reduce risk of having another stroke What therapies are associated with more time at home and better quality of

life

Provide results back to providers Unique data on treatments that are preferred by patients Promote shared decision-making

Generate scientific knowledge Build a research platform so that

additional questions prioritized by stroke survivors can be answered in the future

How can patients help?

Ideas Volunteer with AHA/ASA Join local stroke support group Send us your feedback

Investigative Team

DCRIAdrian Hernandez, Ying Xian, Emily O’Brien, Melissa Greiner, Jingjing Wu, Tina Harding, Laura Drew, Eric

Peterson, Michael Pencina

Patient Co-InvestigatorsLesley Maisch, Deidre Hanna, Brianna Lindholm

Steering CommitteeGregg Fonarow (UCLA), Lee Schwamm (MGH), Daiwai

Olson (UTSW)

GWTG Stroke Science Liaisons Eric Smith (Alberta), Deepak Bhatt (BWH)