Pathophysiology of DM (Type 2)
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PATHOPHYSIOLOGY PREDISPOSING FACTORS Age Hereditary PRECIPITATING FACTORS Obesity Dietary intake Stress Lifestyle INSULIN RESISTANCE DERANGED INSULIN RELEASE ↑ed hepatic glucose uptake ↓ed glucose uptake Hyperglycemia DM (TYPE II) S/S: Glycosu ria Polyuri a Nocturi a Polydip sia Diabetic ketoacidosis S/S: Polyuria Polydipsia N and V Hypotension Tachycardia Fruity smell Kussmaul breathing Nephropathy Retinopathy Blindness Atherosclerosis Sugar deposits like fat in the wall of the blood vessel Myocardial infarction Neuropathy Skin break Impaired pain sensation Impaired host defenses Infection ↑ed serum glucose level Prone to injury Blockage of tiny blood vessels ↓ed blood supply in the eye Blurry vision Destruction of retinal blood vessels Death Severe infection ↓ed size of the lumen ↓ed renal perfusion Impaired renal function Renal failure Coma
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DM (Type 2) pathophysiology and complications.
Transcript of Pathophysiology of DM (Type 2)
PATHOPHYSIOLOGY
PREDISPOSING FACTORS Age Hereditary
PRECIPITATING FACTORS Obesity Dietary intake Stress Lifestyle
INSULIN RESISTANCE
DERANGED INSULIN RELEASE
↑ed hepatic glucose uptake
↓ed glucose uptake
Hyperglycemia
DM (TYPE II)
S/S: Glycosuria Polyuria Nocturia Polydipsia
Diabetic ketoacidosisS/S: Polyuria Polydipsia N and V Hypotension Tachycardia Fruity smell Kussmaul breathing
NephropathyRetinopathy
Blindness
Atherosclerosis
Sugar deposits like fat in the wall of the blood vessel
Myocardial infarction
Neuropathy
Skin break
Impaired pain sensation
Impaired host defenses
Infection
↑ed serum glucose level
Prone to injuryBlockage of tiny blood
vessels
↓ed blood supply in the eye
Blurry vision
Destruction of retinal blood vessels
Death
Severe infection
↓ed size of the lumen
↓ed renal perfusion
Impaired renal function
Renal failure
Coma
