pathology Lap
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Transcript of pathology Lap
Cysts
Pathology Lab
Amin Abusallamh
Dentigerous cyst
1. Stratified squamous epithelium with goblet & mucous cells .2. C.T. conatining numerous fibroblasts & collagen fibers
stratified squamous epithelium
Cystic cavity
B M
C T
goblet
Keratocyst:
- stratified squamous epithelium .- corregated epithelial lining .- polarized basal cell with tomb stone pattern .
stratified squamous epithelium
Cystic cavity fill with keratin
Junction between epith. And CT is flat
Calcifying Epithelial Odontogenic Cyst
- tall columnar epithelium .- hyperchromatic nucleous away from the basal cells .- stellate reticulum containig ameloblastic-like cells between the inner and outer enamel epithelium ,
Cyst cavity
tall columnar epithelium
CT
B M
keratinized epithelium (ghost cell)
stratified squamous epithelium
Radicular cyst:
- thick stratified squamous epithelium because of chronic inflammation .- C.T containing lymphocytes + inflammatory cells .- characteristis feature is >>> eosinophilic bodies ( rashtom's )
Cyst cavity
stratified squamous epithelium
Basement membrane C.T containing lymphocytes + inflammatory cells
eosinophilic bodies
Aneurysmal bone cyst
- pseudocyst .- neumerous blood sinusoids with RBCs .- multinucleated giant cells in C.T. stroma .- reactive osteoid tissue .
Cyst cavity
reactive osteoid tissue
giant cells
RBC
Mucocele (Mucous extravasation Phenomenon
- mucous secretion located in the center .- it has a granulation tissue .- numerous minro salivary glands .
mucous secretion
granulation tissue
minro salivary glands
Odontogenic tumors
Ameloblastoma
Picture 1 : Follicular ameloblastoma .- epithelial follicles in C.T stroma .
- in the follicle : * pripheral columnar cells ( ameloblast like cells ) .* central cells ( stellate reticulum like cells ) .
Picture 2 : Plyxiform ameloblastoma .- pripheral tall columnar cells ( ameloblast like cells ) .- central cells ( stellate reticulum like cells ) .- C.T. stroma in between .
C.T
central cells
pripheral columnar
follicle epithelium
Adenomatoid Odontogenic Tumors (AOT)
-sheets of polyhidral odontogenic epithelium .
-- duct like structures lined by one or two layers of columnar cells ( ameloblast like cells ) with band of eosinophilic material in between .
Cannulated tubule Tall columnar
Basal cell
Cementoifying fibroma
-mesenchymal odontogenic tumor ,
-fibrous proliferating delicate C.T. ( fibers + fibroblasts ) scattered with numerous calcification which either cementum or bone trabeculae .
cementum or bone trabeculae
Cementoblastoma
-proliferating cementume-like structures .
--masses of cementum formed by cementoblasts in priphery with fibroblast in the center .
cementume
Fibrous stroma
Ameloblastic Fibroma
rosets/islands of epithelial tissue in proliferating neoplastic delicated fibrous C.T .- in the priphery : columnar cells ( ameloblast-like cells ) .- in the center : stellate reticulum-like cells .
islands of epithelial
C.T
columnar cells
stellate reticulum-like cells
Bone Diseases
Osteogenesis Imperfecta (OI)
1. Replacing of bone with irregular ammature woven bone 2. Incearse number of oteocyte and osteoblast3. Osteoid non mineralization
Osteoid non mineralization
woven bone
Incearse number of oteocyte and osteoblast
Osteopetrosis
1. dense thick bone trabeculae with numerous inactive multinucleated osteoclast
2. Decease the bone marrow and its fiber
multinucleated osteoclast
Cherubism
1. Replacing of bone by fibrous tissue2. (Highly fibroblast + blood vessels + collagen fiber + multinucleated giant
cells + ossteoed tissue)
multinucleated giant ossteoed tissue)blood vessels
fibrous tissue
Fibrous dysplasia of bone (FD
1. Thin slender irregular bone trabeculae in fibrous tissue stroma take the shape of Chinese letter.
2. Replacing of bone with fibrous tissue.
Thin slender irregular bone trabeculae
fibrous tissue
Brown node of hyperparathyroidism
Replacing of bone with highly cellular connective tissue with numerous multinucleated giant cell + BV + pigment hemosiderin
hemosiderin
BV
giant cell
connective tissue
Paget’s disease of bone
1. High dense thick irregular bone trabeculae with numerous multinucleated giant cell + BV + prominent reversal line + prominent osteoblast and osteoclast
2. The marrow has been replaced by fibrous tissue
reversal line
prominent osteoblast and osteoclast
giant cell
Chronic focal sclerosing osteomyelitis
1. thick irregular bone trabeculae with multinucleated giant cell + BV + reversal line + empty lacuna of death osteocyte
2. Fibrotic Bone marrow with chronic inflammatory cells
chronic inflammatory cells
giant cell
BV
empty lacuna of death osteocyte
reversal line