Pathogenic Micro-Organisms in Gastrointestinal Tract
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Transcript of Pathogenic Micro-Organisms in Gastrointestinal Tract
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Pathogenic Micro-organisms in
Gastrointestinal Tract
Dr. A.Aziz DjamalMSc.DTM&H.SpMK(K)
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Gastro-intestinal tract )
Respiratory tract ) All withcomplex
Genitourinary tract ) mucosal
defence mechanism
It is necessary as an interfacebetween non-sterile
part of body and the sterile
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Mouth / Oral :
ormall!
The most n"mero"s n"m#er o$ #acterialspecies
The most a#"n%ant #acterial content.
Pathogens
Streptococcus pyogenes
Staphylococcus aureus
Streptococcus mutans
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'esophag"s The less prone to get in$ection %"e to
micro#e.
'esophagitis is commonl! ca"se% #!irritation an%
errosie inamation %"e to gastric aci%
re"*.
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Gaster
The onl! reporte% pathogenic #acteriaHelicobacter pylory :
Spiral shape
+-, micron in length . / 0. micron in 1i%th
Gram negatie
2rease pro%"cing
+-3 "nipolar agel
Microaerophilic
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Other haracteristic :
4an not a5or% to the high
'*!gen Press"re ( nee% onl! +- 6 o$ '+ )
4omple* "trient nee%
arro1 temp range 7, / , 8 4
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!rimary "ost :
H"man'ther primates
Animal Model
Mo"se
Mongolian Ger#il
G"inea Pig
Gnoto#iotic Piglet
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#ransmission :
Mostly human to humantransmission
'ral to oral
9ecal to oral
Deeloping co"ntries
:arl! chil%hoo%
; 6 o$ pop"lation are in$ecte%.
Deelope% co"ntries
Mostl! a%olescent an% a%"lt
, 6 o$ pop"lation are in$ecte%
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H. pylory could be detected from $
%ali&a
'omitus
Gastric re(ux eces
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Other %pecies :
H. $elis Host 4at Dog
Mice
H. mestelae Host 9erret
H. acinon!chis Host 4heetah<Tiger<
'ther#ig cats
H. Heelmannii Host H"man<
Dog< 4at<
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!atholo*y
Gastritis
!eptic ulcerdisease
Gastric adenoma
MA+# +ymphoma
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#ype of Gastritis
0. !an-*astritis 4hronic inammation Atroph!
>ntestinal metaplasia
Aci% secretion ?e%"ce%
D"o%enal M"co"s ormal
4linical 4on%ition Gastric "lcer
Gastric cancer
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+, Antral Gastritis
4hronic inammation Pol!morph actiit!
Aci% secretion >ncrease
D"o%enal Gastricmetaplasia
Actie chronic
inammation 4linical 4on%ition D"o%enal 2lcer
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", pylory has been associated
with : 4oronar! heart %isease Dermatological %isor%er i%iopathic"rticaria
A"toimm"ne th!roi% %isease
Throm#oc!topathic p"rp"ra
>ron De@cienc! anemia
?a!na"% s %isease
Sclero%erma
Migrain
G"llain Barre S n%rome
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ia*nosis :
>nasie :n%oscop! Gastric m"co"s #iops! 4"lt"re
Histolog!
on-inasie
Bloo% Salia
2rine
$eces
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I.#%#I.A+
D"o%en"m Cej"n"m
>le"m
?e%"ce% o$ '*!gen content
Al=aline
Bile secretions
ormall! Anaero#ic #acteria is the
pre%ominant Bacteroi%es sp
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!atho*enic micro-or*anisms inintestinal : Some Species o$ :ntero#acteriaceae
Some species o$ i#rionaceae
Some iral species
amily nterobacteriaceae :
Genus : :scherichia
Salmonella
Shigella Kle#siella
:ntero#acter
Eersinia
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sherichia coli :
:nteroto*igenic :. coli -- St an% Ft:nteroto*in
:nteroinasie :. coli / Shiga li=e to*in :nteropathogenic :. coli /inammator!
:nterohaemorrhagic :. coli / to*in an%hemol!sin
:nteroa%herent :. coli -- M"ltila!er
colon!
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%almonella :
Salmonella t!phi
Salmonella parat!phi A < B< 4
T!phoi% 9eer an% Salmonellosis Mostl! 9oo% #orne %isease
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%hi*ella :
Shigella %!senteriae Shigella sonnei
Shigella shigae
ot in >ntestine #"t in 4olon
ecrotizing to*in
Focal inammation 1ith
pse"%omem#rane
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'ibrionaceae :
i#rio cholerae 4lassic an%
:l Tor
Strong:nteroto*in
ater
#orne %isease i#rio parahaemol!tic"s
9oo%
poisoning
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!atho*enic 'irus :
?ota ir"s
Mostl! chil%ren "n%er !ears
>nammator! on intestinal
m"co"s :pithelial change in intestinalm"co"s
Damage on M"cosal cilia "tritional an% 1atera#sorption
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!atho*enesis :
0.A%here con%"cte% #! a gro"p o$ $actorsadhesins
+. >nasion #! seeral s"#stances
in&asins7. 'ercome the host %e$ence s!stem #!man!
$actors calle% efensins,. Damage o$ the host tiss"e or cells #! agro"p o$
s"#stances calle% a**ressins,
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ia*nosis
Mostl! #! %etection o$ the #acteria Iantigen $rom
gastrointestinal secretion I content.
Serolog! Molec"lar