Vasculitis a Review of Pathogenesis, Vasculitis a Review of Pathogenesis,
Pathogenesis BIO220 – Introductory Microbiology Copyright 2009, John Ireland.
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Transcript of Pathogenesis BIO220 – Introductory Microbiology Copyright 2009, John Ireland.
Copyright 2009, John Ireland
Pathogenesis
BIO220 – Introductory Microbiology
Copyright 2009, John Ireland
Key Concepts
• Portal of Entry• Attachment• Initial Evasion• Growth and Development• Portal of Exit
Copyright 2009, John Ireland
Disease Progression
Entry into Host
Attachment
Evasion of Immune System
Damage to Host Cells
Exit from Host
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Portals of Entry
Skin
Mucosal Membranes
Parenteral
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Attachment
Some form of attachment is utilized to keep a microbe in a specific location through a type of protein interaction.
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Evasion of the Immune System
Evasion
Cell Wall & Capsule
EnzymesIntracellular Growth
Invasins Antigen Variation
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Damage
Effects
Nutrient Acquisition
ToxinsDirect Damage
Lysogenic Transformation Cytopathic Effects
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Nutrient Acquisition
Human blood has a free concentration for iron of 10-24 mol/L
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Toxins
Exotoxin (G+) Endotoxin (G-)
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Cytopathic Effects
The visible effects of viral infection, varied in severity and form.
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Lysogenic Transformation
Many pathogenic microbes are made pathogenic by a phage infecting them and either activating or carrying pathogenic components
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Direct Damage
Contrast the effects of toxins with those of Direct Damage
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Portals of Exit
Skin
Mucosal Membranes
Parenteral
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Case Study – Cholera
“If everybody contemplates the infinite instead of fixing the drains, many of us will die of cholera.”John Rich (Drexel University)
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Number of People in Refugee Camps
Over 21 million people are classified as refugees by the United Nations High Commissioner for Refugees in 2007
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Clean Water
Only Forty-Six Percent of Africa have access to safe drinking waterWHO, 2006
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Start of Outbreak
The UNHCR has only 6300 employees in over 110 countries
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Pathology and Exit from Host
Three Billion people worldwide do not have access to adequate sanitation facilities.WHO, 2006
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Cholera in Africa
