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Principal Investigator/Program Director (Last, first, middle): Pascual, Jaime

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page ___7___ Continuation Format Page

9. De Pereda, J., Waas, W.F., Jan, Y., Ruoslahti, E., Schimmel, P., Pascual, J. Crystal structure ofa human peptidyl tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activityJ. Biol. Chem. 279:811-15 (2004).

10. Mukasa, T., Santelli, E., Reed, J.C., Pascual, J. Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31 Acta Crystallographica Section F63:297-9(2007).

11. Low, L.Y., Mukasa, T., Reed, J.C., Pascual, J. Characterization of a TIR-like protein fromParacoccus denitrificans Biochem. Biophys. Res. Commun. 356:481-6 (2007).

12. Pimienta, G., Ficarro, S.B., Gutierrez, G.J., Bhoumik, A., Peters, E.C., Ronai, Z., Pascual, JAutophosphorylation properties of inactive and active JNK2 Cell Cycle6:1762-71 (2007).

13. Pimienta, G., Pascual, J. Canonical and alternative MAPK signaling Cell Cycle 6:2628-32(2007).

14. Reixach, N., Foss, TR, Santelli, E., Pascual, J., Kelly, JW., Buxbaum, JN. Human-murinetransthyretin heterotetramers are kinetically stable and non-amyloidogenic J. Biol. Chem283:2098-107 (2008).

15. Kairouz-Wahbe, R., Biliran, H., Luo, X., Khor, I., Wankell, M., Besch-Williford, C., Pascual, JOshima, R., Ruoslahti, E. Anoikis effector Bit1 negatively regulates Erk activity PNAS105:152832 (2008).

16. Chan SL, Low LY, Hsu S, Li S, Liu T, Santelli E, Le Negrate G, Reeed JC, Woods VL, PascualJ. Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. J. Biol.Chem. 284:21386-92 (2009).

17. Chan SL, Mukasa T, Low LY, Santelli E, Pascual J. The crystal structure of a TIR domain fromArabidopsis thaliana. Prot. Science19:155-161 (2010).

C. Research SupportEXPIRED1 P01 AI 55789-01A1 07/01/04-06/30/09Sponsor: NIH/NIAIDTitle: Virulence Factors and Cell DeathSubject: Protein preparation for structural studiesRole: Core Leader1 P01 CA 102583-01A1 09/22/04-08/31/09Sponsor: NIH/NCITitle: Regulation of apoptosis by integrinsSubject: Study of the apoptosis pathway mediated by Bit1Role: co-PI1 R21 AI065602-01 07/01/05-06/30/08Sponsor: NIH/NIAIDTitle: Bacterial infection through TIR-like virulent factorsSubject: Regulation of the innate immune response by bacterial TIR containing proteins.

Role: PI