PARKINSON’S| a biweekly report

a report

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Links to Related Articles

■ The Therapeutic Potential of Cannabinoids for Movement Disorders

■ Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson disease ■ The Endocannabinoid System as an Emerging Target of Pharmacotherapy

■ Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis

Definition of ConditionParkinson’s disease is a slow, progressive disorder of the nervous system. Symptoms develop over time, often with a barely noticeable tremor. Aside from tremors, stiffness or slowing of movement

are also common symptoms of the disease. While no cure exists for Parkinson’s disease, medications have been shown to help many significantly improve

their symptoms.

The use of medicinal cannabis shows promise in the treatment of some symptoms of Parkinson’s Disease such as cognitive symptoms, sleep issues and tremors. Currently there are a small number of clinical trials specific to the treatment of Parkinson’s Disease symptoms, especially due to the conditions small sample size as a whole. However, Parkinson’s

shares symptoms with many other conditions showing great promise in cannabis treatments. The lack of studies currently available is mainly due

to issues surrounding the current federal classification of cannabis, as well as issues with standardizing dosing and understanding of cannabinoid effects. As the

medicinal use of cannabis is becoming accepted by many countries around the world, more research is finally being conducted in order to better understand the full effects of cannabis.

Learn more about Parkinson’s disease.

Population Statistics

The population

of Potbot users who identify as

treating Parkinson’s make up 0.02% of the

entire Potbot population.

0.03% of the male user population

identifies as treating Parkinson’s.

0.01% of the female user population

identifies as treating Parkinson’s.

Cannabis Experience

64,000 PotBot users answered questions about their cannabis usage. Here is a key regarding their answers:

NEVER

“I have never medicated with cannabis”

RARELY

“I have medicated with cannabis a handful

of times”

modERAtE

“I medicate with cannabis once to twice a month”

oFtEN

“I medicate with cannabis once to twice a week”

dAILY

“I medicate with cannabis on a daily basis”

THCOH

OH

H

0–16.1%

redu

ces

stre

ss •

stim

ulat

es appetite • dulls pain • minim

izes inf amm

ation

CBNOH

O0–0.79%

aids s

leep

• re

lieve

s pain

• stimulates appetite • reduces ocular pressure

0–0.11%

THCVOH

OH

H

energetic eff

ects

• a

nti-

conv

ulsi

ve •

hastens THC’s effect • blocks sensations to eat unhealthy foods

CBD

HO

OHH

H

prev

ents

par

anoi

a •

redu

ces stress • relieves pain • suppresses appetite1.8%–12.6%

CBG

HO

OH

an

ti-in

f am

mat

ory

• re

duce

s ocular pressure • relieves stress • neuroprotectant

0.04%–0.81%

OH

O CH3CH3

CH3

CH3 CBC

anti-

inf a

mm

ator

y •

pain

relie

ver • anti-depressant • stimulates bone growth

0.09%–0.87%

Optimal Cannabinoid Ratios

for Treating Parkinson’s

NoN-PSYCHoACt

IVE

PSYCHoACtIVE

18–25 26–33 34–40 41–48

49–56 57–64 65–72 73–80

51%

of men responding are 18–25

of women responding are 18–25

of these men report

having Parkinson’s

3%1%

of these women report having

Parkinson’s

of men responding are 26–33

of men responding are 34–40

of men responding are 41–48

of women responding are 26–33

of women responding are 34–40

of women responding are 41–48

21%19%

12%11%

7%9%

of these men report

having Parkinson’s

3%1%

of these women report having

Parkinson’s

of these men report

having Parkinson’s

2%1%

of these women report having

Parkinson’s

of these men report

having Parkinson’s

2%1%

of these women report having

Parkinson’s

of men responding are 49–56

of women responding are 49–56

4%6%

of men responding are 49–56

of women responding are 49–56

3%4%

of these men report

having Parkinson’s

2%2%

of these women report having

Parkinson’s

of these men report

having Parkinson’s

2%2%

of these women report having

Parkinson’s

50%

of men responding are 49–56

of women responding are 49–56

2%1%

of men responding are 49–56

of women responding are 49–56

0.002%0.003%

of these men report

having Parkinson’s

5%6%

of these women report having

Parkinson’s

of these men report

having Parkinson’s

11%5%

of these women report having

Parkinson’s

Of those surveyed:

oF tHoSE REPoRtING

NEVER:

oF tHoSE REPoRtING

RARELY:

oF tHoSE REPoRtING modERAtE:

oF tHoSE REPoRtING

oFtEN:

oF tHoSE REPoRtING

dAILY:

Breaking it down by gender:

1.3% are males with Parkinson’s.

1.2% are females with Parkinson’s.

1.3% are males with Parkinson’s.

0.8% are females with Parkinson’s.

1.3% are males with Parkinson’s.

1.2% are females with Parkinson’s.

1.4% are males with Parkinson’s.

0.8% are females with Parkinson’s.

1.2% are males with Parkinson’s.

0.8% are females with Parkinson’s.

2.5% report having Parkinson’s.

2.0% report having Parkinson’s.

2.0% report having Parkinson’s.

2.2% report having Parkinson’s.

2.0% report having Parkinson’s.

modERAtE: 52.7%

RARELY: 13.6%

NEVER: 15.6% dAILY: 9.2%

oFtEN: 8.9%