IMPLANTS 2016 CONFERENCEPARIS I FRANCETuesday, June 7th 2016 Étoile Saint-Honoré Conference Center

Two tutorials on the orthopaedic market and contract manufacturing

Keynote speakers from major companies

www.implants-event.com

12TH EDITION

2 0 16International conference on innovation

for orthopaedic implants and orthobiologics

mplants is a high-level conference for contract manufacturers and orthopaedic companies that will focus on changes in manufacturing techniques and purchasing strategies. The focal point will be on how

orthopaedic contract manufacturers can position themselves in the face of a rapidly changing marketplace due to new technologies, materials, regulations and the emergence of BRIC countries.

More than 200 top level decision makers attended the June 2015 conference in Paris for a full day of learning and business networking.

The 2016 conference will be held in Paris on June 7th and will feature the following topics:

How OEM and CM collaborations can drive innovation

Additive Manufacturing: From highly complex and customized manufacturing today to the mass market tomorrow?

Implants of the Future: Smart Implants, Robotic and assisted surgery, Biologics, bioresorbable raw materials, Anti-infection

Join us at Implants 2016 in Paris!

Ali MADANI, CEO of Avicenne consulting and Founder of the IMPLANTS event

I

LOCATION:

ÉTOILE SAINT-HONORÉ CONFERENCE CENTER

21/25, rue Balzac - 75008 Paris (France)Subway: Charles-de-Gaulle-Etoile, George V, Ternes (lines 1, 2 & 6)

MPLANTSConférence internationale pour l’innovationdes implants orthopédiques et des biomatériaux

MPLANTSInternational conference on innovations & solutionsfor orthopaedic implants and orthobiologics

MEET THE MAIN PLAYERS IN THE ORTHOPAEDIC MARKETPURCHASING MANAGERS FROM ORTHOPAEDIC COMPANIES AND CONTRACT MANUFACTURERS WILL ANSWER THE FOLLOWING QUESTIONS:

What are the general trends and changes in orthopaedics contract manufacturing? Are the major OEMs relying more on contract manufacturing?

What are the key growth factors and barriers to development for orthopaedics contract manufacturing?

What roles will BRIC (especially China, India and Brazil) and Central European countries play in the future of contract manufacturing?

Which products are the priorities? What are the risks for contract manufacturers in developed countries?

What is the impact of regulations and certifi cations? Will this mean more inspections and audits, and stricter controls for contract manufacturers?

What are the needs of orthopaedic OEMs? One-stop shopping, shared responsibilities, co-invention and co-development agreements, etc.

What is the signifi cance of provision of raw materials and associated services?

What are the long-term trends affecting casting, forging, machining, coating and fi nishing processes?

How will the availability of generic instrumentation affect spine and trauma surgery in low-cost countries?

How has contract manufacturing of the coating process changed?

How do the major OEMs work with product markings, packaging and sterilization?

SPECIAL FOCUS ON ADDITIVE MANUFACTURING: STRATEGIES USED BY ORTHOPAEDIC COMPANIES

Will additive manufacturing be a key technology for the orthopaedics industry in the years to come?

What strategies are the major orthopaedic companies adopting relative to additive manufacturing?

Buy or Build? Will the OEMs develop the capabilities internally to maintain a strategic advantage or do they prefer buying or subcontracting this technology?

Technologies: Electron Beam Melting, Selective Laser Melting, Trabecular Titanium, Trabecular Tantalum, Trabecular Metal, Powder Technology, 3D printing.

Applications: acetabular cups, knee replacement components, intervertebral cages, disc replacement, shoulder glenoid component, CMF implants, dental implants.

More than 200 top level decision makers attended the 2015 conference

In 2015, the IMPLANTS conference celebrated its 11th anniversary. The 2015 conference attendees were from the following locations:

France 40%

Switzerland 13%

Germany 12%

USA 12%

UK 9%

Europe and ROW 14%

They represented these types of companies and institutions:

Contract manufacturer 62%

Orthopaedic OEM 28%

Private Equity 6%

Consulting 2%

Media 2%

40%

62%

28%

6%2%

2%

14%

13%

12%

12%

9%

UK

Germany

Contract manufacturer

USA

Europe and Row France

Orthopaedic OEM

Privateequity

Switzerland

Media

Consulting

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TUTORIALS

TUTORIAL DEVOTED TO ORTHOPAEDIC MARKET PERSPECTIVES AND MAIN ISSUESAli Madani, CEO, Avicenne consulting

Orthopaedic Worldwide market historical revenues: Hip, Knee, Shoulder, Trauma, Spine, Biologics, The Worldwide orthopaedic market, historical growth: 2000 - 2010 CAGR, 2010-2014 CAGR, 2014-2020 CAGR

Worldwide implants market by area: USA, Europe, Japan, Australia, South Korea, China, Brazil, Row ASP & Procedures by area Major Worldwide players: Position, market shares, Strength, Weakness : Depuy- Synthes, Medtronic Zimmer- Biomet,, Stryker, Smith&Nephew. The Challengers

European players (> 100 ) , market shares for each country, position, Strength & Weakness Challengers are gaining market shares Vs Majors: trends Drivers & limiters for orthopaedic products Hip growth product trends, market, dynamics, market shares: Hip dual mobility, Mini hip & Shorter stem, Anterior surgical approach , Trabecular Metal, Blockbuster products (Corail, Exeter, Mueller,..)

Knee growth product trends Shoulder growth product trends Spine growth product trends Focus in Europe: Germany, UK, Fr, Spain, Italy Vs Belgium, Denmark, Finland, Sweden, Main segments and bearings detailed : cemented, cementless, hybrid, M/Pe, Cer/Pe, Ce/Ce,.. Reimbursement and regulatory trends Market forecasts by 2020: data, heavy trends. Perspectives, main issues, trends.

TUTORIAL DEVOTED TO CONTRACT MANUFACTURING Ali Madani, CEO, Avicenne consulting

Orthopaedic market value chain in 2015: Implants, instruments, cases & trays, coating, ceramics, packaging, sterilization, others

Outsourcing rates by capability for Majors and for Challengers in 2015: Forging, casting, machining, coating, packaging, and by products-> Hip, Knee, Shoulder, Trauma, Spine, instruments for each products, cases & trays

Orthopaedic contract manufacturing Vs home-made costs: Depuy- Synthes, Medtronic Zimmer, Stryker, Biomet, Smith& Nephew & the Challengers: Aesculap, Lima, Tornier, Exactech, Link, Amplitude, .. and other mid-size companies

Challengers impacting the contract manufacturing market, due to their high outsourcing rate Contract manufacturing market by segment: Instruments, spine & trauma machining, casting, hip & knee machining & Forging contract manufacturing.

Orthopaedic contract manufacturing by customer for 2015: Depuy- Synthes, Medtronic, Zimmer, Biomet, Stryker, Smith& Nephew, Challengers

OEM needs : data center of all Contract Manufacturing needs by OEM, volume, value Orthopaedic top 20 Contract Manufacturers positions, revenues, SWOT analysis, Contract manufacturing in Low Labor Cost Countries impact: movements for implants & instruments

Contract manufacturing in Low Labor Cost Countries impact: cases of complex instruments Vs Generic instruments

Contract manufacturing in Low Labor Cost: Trend by 2020 Raw material sourcing: Titanium, CoCr, Stainless Steel, Peek, Plastics, Powders,.. OEM facility disinvestments trends Additive Manufacturing for orthopaedics past, present, futur Orthopaedic Contract manufacturing market Forecasts Perspectives, main issues, trends

2016 CONFERENCE PROGRAM

CONTRACT MANUFACTURINGHOW OEM AND CM COLLABORATIONS CAN DRIVE INNOVATION

Simon Adam, Senior Director, Supplier Quality - DePuy SynthesMedAccred - Industry led oversight of Medical Device Critical processes

Overview of program and value proposition Accomplishments to date Future plans

Mark Kemp, President & COO, Tecomet Symmetry Strategic Partnering and Long-term Collaboration in Orthopedics Outsourcing

Global Supply Chain Solutions Risk Sharing Long Term Collaboration/Planning

Bryan McMillan, CEO, CoorsTek Medical Orthopaedic Contract Manufacturing: Mapping out the way forward for the next decade?

What are the needs of orthopaedic OEMs? (One-stop shopping / Shared responsibilities / Co-innovation and co-development agreements) Outsourcing more capabilities: Reducing risk, cost and time to market How to meet the major OEM’s needs today and tomorrow? Global manufacturing, how CoorsTek Medical supports customers in Europe, Asia and the Americas

Tobias W. Buck, CEO, President & Chairman of the Board, Paragon Medical Inc. Contract Manufacturers competing in a Global margin compression context

Where we were as Strategic CMO’s Where we are as Strategic CMO’s Where we are headed as Global Strategic CMO’s Ideology vs reality in today’s OEM/CMO relational sourcing dynamic: what does strategic syupplier really mean ? Emerging markets - perspective of a Global Player

Mario Powierski, Supplier Quality Specialist, ZimmerBiomet Supplier Performance Measurement

Initial Supplier Assessment & Approval Continuous Supplier Performance Measurement Communication with Suppliers

ADDITIVE MANUFACTURINGFROM HIGHLY COMPLEX AND CUSTOMIZED MANUFACTURING TODAY TO THE MASS MARKET TOMORROW?

Mark Morrison, Principal Research Scientist, Smith & NephewThe Advancement and Realities of Additive Manufacturing in Orthopaedics

Virtually all major orthopaedic companies are either investigating or have already launched additive-manufactured devices Initial applications involve patient-specifi c instruments/implants or porous structures for bone ingrowth Expansion to additional applications in orthopaedics will require improvements in properties and cost

Frank Herzog, President & CEO, Concept Laser GmbHMetal Additive Manufacturing for Medical and Orthopaedic Industry

Introduction of the LaserCUSING® technology and background / company information Fields of application in medecine : the particular case of Orthopaedics , Dental and other application Quality management / Introduction of QM meltpool Forecast of productivity improvements in the next years

Nelso Antolotti, CEO, EurocoatingAdditive Manufacturing Vs coating for the next decade

Coating : Heavy trend for the Majors, Strategy of supplying Powder, Innovations Additive Manufacturing: Opponent technology or Complementary service, Integrated solutions, the next future of Additive Manufacturing Take home messages

CONTRACT MANUFACTURINGSESSION 1

ADDITIVE MANUFACTURINGSESSION 2

“ I appreciated the meeting and fruitful discussions with you and colleagues from other companies as well as the very impressive presentations! I can say I learned a lot and would be glad to attend IMPLANTS again. Very good organization and high level conference. Congratulations! ”

PD Dr. med. Ulrich MaternManager Clinical & Medical SciencesSTRYKER Germany

“ I enjoyed the conference and hope to work with you again in the future ”

Gordon Hunter, PhDGroup Manager, Materials Quality & Strategic Manufacturing Advanced Surgical DevicesSmith & Nephew

“ I certainly would be willing to attend another Implants conference, whether as speaker or attendee ”

Mario PowierskiQuality ManagementBiomet Deutschland

“ Congratulation for your excellent organization and the quality of the presentations ”

Hervé ReignacPresidentExactech France

2015 TESTIMONIALS

SESSION 3 IMPLANTS OF THE FUTURESMART IMPLANTS, ROBOTIC AND ASSISTED SURGERY, BIOLOGICS, BIORESORBABLE RAW MATERIALS, ANTI-INFECTIONRobin Stamp, Associate Manager - Advanced Technology, Stryker OrthopaedicsTechnologies transforming the design of Orthopedic implants

The impact of additive manufacturing, robotics and medical imaging on Orthopaedics Future directions in implant design and surgical procedures The regulatory strategy for new technologies

Claude Rieker, Director European Scientifi c Affairs, ZimmerBiometThe Prosthetic Joint Infections (PJI), one of the last challenge for the orthopaedic community

The Prosthetic Joint Infections (PJI) are a major issue and can be defi ned as one of the most challenging complications of total joint arthroplasties and their incidence are steadily increasing.

PJI is the cause of about 15% of THA revisions and the most common cause of TKA revisions (about 25%).

The estimated costs of PJI is a large burden for all health care systems. Currently, the orthopaedic industry is working on different approaches (surface modifi cations, coatings, …) to potentially lower the risks of PJI.

The early detection of PJI is also quite important to optimize the possible treatments. Different new detection methods are currently under evaluation.

YOU MISSED THE 2015 EVENT? WATCH THE VIDEOS!

The videos and proceedings of IMPLANTS 2015 are available in HD format (more than 300 minutes). The package includes:

Two tutorials from Ali Madani, CEO of Avicenne Consulting

Mike Miller, CEO, Orchid Orthopedic Solutions, LLC

Daniel Delfosse, Innovation & Technology Director, Mathys

Stefano Adami, Regulatory Affairs Senior Specialist, Zimmer

Magnus René, CEO, ARCAM

Peter Mercelis, Director Applied Technologies, Healthcare, 3DSystems

Stephanie Kochbeck, Business Development Manager Medical, EOS GmbH

Mario Powierski, Supplier Quality Specialist, Biomet Deutschland GmbH

Ulrich Matern, Manager Clinical and Medical Sciences, Stryker CMF

Steve Smith, President, Edge International

Monir El Azzouzi, Quality & Regulatory Compliance Manager, Johnson & Johnson

WATCH THE TEASER AT: www.implants-event.com/videos-en/

UNITED KINGDOM & IRELAND:BODYCOTE HEAT TREATMENTS LIMITED - Regional Sales Development Manager (UK)ENSINGER LTD - Technical And Applications Manager (UK)ENSINGER PRECISION ENGINEERING - Head Of Sales (UK)JRI ORTHOPAEDICS LTD - Operations Director (UK)ORCHID ORTHOPEDIC SOLUTIONS - Vp Sales (IRELAND)ORCHID ORTHOPEDIC SOLUTIONS - Sales Engineer (UK)ORTHO CONNECTIONS - Director (UK)ORTHOPLASTICS - Technical Sales Manager (UK)STRYKER - Manager, Business & Process Development (IRELAND)STRYKER IRELAND - Research Engineer (IRELAND)TECOMET LTD - Sales Director (UK) USA & CANADA:4WEB MEDICAL - CEO (USA)AVALIGN TECHNOLOGIES - Vice President, R&D (USA)AVALIGN TECHNOLOGIES - Area Sales Manager (USA)BROWN PRECISION - Medical Device Machine Manufacturer (USA)EDGE INTERNATIONAL - President (USA)MICROPULSE, INC. - President & CEO (USA)MODEL3D - Director of Business Development (CANADA)ORCHID ORTHOPEDIC SOLUTIONS LLC - CEO (USA)ORTHOPEDIC DESIGN & TECHNOLOGY - Editorial Director (USA)SMITH & NEPHEW - Materials Quality & Strategic Manufact. (USA)STRYKER - Supervising Senior Engineer (USA)TECOMET - CEO (USA)TORNIER - Group Manager, R&D (USA)V-CUBE - Operations Manager (USA) SWITZERLAND:CILAG GMBH INTERN. - Quality & Regulatory Compliance ManagerGFMS - Junior Business AnalystINNOTOOL & GREMINGER - General ManagerJOSSI ORTHOPEDICS Ltd - Chief Technical Offi cerLAUENER SA - Marketing and SalesLAUENER SA - R&D And Instrumentation DirectorMATHYS - Innovation & Technology DirectorMEDILIANT - R&D and Industrial DirectorMPS PRECIMED - CEOPARAGON MEDICAL - AMG Program ManagerPARAGON MEDICAL - European Business Develop. ManagerSYNERGY HEALTH DÄNIKEN AG - Sales ManagerSMB MEDICAL SA - CEOTIRUS INTERNATIONAL SA - Head of Business DevelopmentZIMMER - Regulatory Senior SpecialistZIMMER - Director ResearchZIMMER - Director Quality Assurance GERMANY:AESCULAP AG - R & D EngineerBIOMET - Quality ManagementCERAMTEC - Director OperationsEOS - Business Development Manager MedicalERCATA GMBH - CEOJENOPTIK INDUSTRIAL METROLOGY - Sales SupportMEMRY GMBH - General ManagerMERETE MEDICAL - Plant ManagerQUADRANT EPP DEUTSCHLAND GmbH - Sales Engineer MeditechRÖSLER OBERFLÄCHENTECHNIK GmbH - Export Sales ManagerSTRYKER - Clinical ExpertULRICH - Product Manager Implants & InstrumentsVDM METALS GMBH - VP Business DevelopmentWALDEMAR LINK - Head Of Supply Chain & Manufacturing

FRANCE:2WIN’MARKETS - Marketing Industriel3D MEDICAL - CEOAIP - Medical Unit ManagerAVICENNE - CEO

AVICENNE - ConsultantCADUCEUM - Development ManagerDEVICEMED FRANCE - Editorial directorEPF PARTNERS - AssociateEPF PARTNERS - Account ManagerESI France - ConsultantEXACTECH FRANCE SAS - PresidentFIVE ARROWS MANAGERS - Managing DirectorFIVE ARROWS MANAGERS - AssociateFORECREU - CEOFORECREU - Quality ManagerGREATBATCH MEDICAL - Executive Operations DirectorGREATBATCH MEDICAL - New Projects ManagerIMPLANET - R&D Project ManagerIMPLANET - Director of R&DINTECH MEDICAL - CEOJENOPTIK INDUSTRIAL METROLOGY - MarketingJSM PERRIN - Business DevelopmentKEENSIGHT CAPITAL - Managing PartnerKEENSIGHT CAPITAL - Investment DirectorKISCO INTERNATIONAL - Vice PresidentKISCO INTERNATIONAL - Manufacturing DirectorLDR MEDICAL - International Logistics & Purchasing DirectorLDR MEDICAL - Project ManagerLES ATELIERS MODERNES - Medical Affairs ManagerLISI MEDICAL ORTHOPAEDICS - Sales DirectorMEDICAL DEVICE DAILY - Europe EditorMONTAGU PRIVATE EQUITY - AssociateMULTISTATION - CEONOWAK - Project ManagerNIXEN PARTNERS - Senior PartnerPYXIDIS - Sales ManagerPOLY-SHAPE - Polymer R&D ManagerPOTOMAC CAPITAL CONSEIL - ManagerQUADRANT EPP FRANCE - Regional Sales Manager - ExportRÖSLER FRANCE - Technical Sales AssistantSMITH & NEPHEW - Product ManagerSORIN CRM SAS - Advanced Research Mechanical EngineerSPARTACUS3D - General ManagerSPINEVISION - R&D EngineerSTAINLESS - Technical ManagerTECOMET FRANCE - General ManagerTECOMET FRANCE - Sales ManagerTEKNA - Technical Sales and R&D ManagerTORNIER - Design Group LeaderTORNIER - Design ExpertTORNIER - Product Life Cycle EngineerWICHARD - Assistant General Manager BENELUX:3D-SIDE - CEO (BE)FMI INSTRUMED - Area Sales Manager (NL)FMI INSTRUMED - Managing Director (NL)LAYERWISE - Director Applied Technologies, Healthcare (BE)LAYERWISE - 3D SYSTEMS - Sales Engineer (BE)LEADER BIOMEDICAL GROUP - General Manager (NL)MATERIALISE NV - Business Developer (BE)MATERIALISE NV - Account Manager (BE)NELIPAK HEALTHCARE PACKAGING - Sales Manager (NL) OTHER COUNTRIES:ARCAM AB - CEO (SWEDEN)BALTIC ORTHOSERVICE - Project Manager (LITHUANIA)BALTIC ORTHOSERVICE - Intern (LITHUANIA)BEZNOSKA S.R.O. - Sales Manager (CZECH REPUBLIC)BEZNOSKA S.R.O. - CEO (CZECH REPUBLIC)EUROCOATING - Scientifi c Marketing Manager (ITALY)EUROCOATING - Sales Manager (ITALY)F COLOMBO srl - Managing Director (ITALY)GLOBAL ORTHOPAEDIC TECHNOLOGY - Chief Technology Offi cer (AUSTRALIA)PERMEDICA S.P.A. - Clinical Monitor (ITALY)VSMPO-AVISMA CORPORATION - Senior Sales Manager (RUSSIA)

IMPLANTS 2015 BUSINESS NETWORKING: LIST OF ATTENDEES BY COUNTRY

“ I enjoyed all the presentations ”

Bill DowCEO - TECOMET

“ I enjoyed the opportunity to attend ”

Mike MillerCEO - ORCHID

“ It was impressive to see the type of audience you had drawn. Congratulations on a great event! ”

Magnus RenéPresident & CEOARCAM

“ I appreciated the conference and the detailed information provided ”

Brian G Emerick, CEOMicropulse Incorporated

“ The conference was very interesting for me. I greatly enjoyed the variety and the richness of the presentations ”

Olivier Pernois, Sales DirectorLISI Medical

2015 TESTIMONIALS

PLATINIUM SPONSOR:

GOLD SPONSOR:

MEDIA PARTNERS:

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SPONSORING

MICRO-BOOTH

For any questions related to the organization of the IMPLANTS 2015 conference, you can contact the organizers by email:

CONTACTS

Monica Visinoni, Conference Manager &

Sponsorship: m.visinoni@implants-event.com

Ali Madani, Chairman:

a.madani@implants-event.com Claude Foubert, Event Director:

c.foubert@implants-event.com

IMPLANTS 2016 offers a unique opportunity to position your organization as a leader in the orthopaedic industry. Several levels of sponsorship are available, with customizable possibilities, such as:

Session sponsor recognition / Coffee-break or lunch recognition / Signage recognition

Brochure advertisement (half or quarter page) / Promotional material distribution / Feature article in newsletter

FOR MORE INFORMATION, please contact Monica Visinoni at m.visinoni@implants-event.com

Complete your participation at the IMPLANTS 2016 conference with a micro-booth. This unique space allows you to showcase your products, share documentation and meet your future clients.1 meter square, 1 customized desk, possibility of adding a display case (on request).

FOR MORE INFORMATION, please contact Monica Visinoni at m.visinoni@implants-event.com