Paraxial and Intermediate Mesoderm
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Transcript of Paraxial and Intermediate Mesoderm
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Paraxial and Intermediate Mesoderm• Formation of Somites• Muscle and bone formation• Intermediate mesoderm: Kidney formation
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Trunk Mesoderm
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Mesoderm fate during Gastrulation/Neurulation
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Somite Formation• Periodicity• Fissure formation• Epithelialization• specification
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Somite Formation: Periodicity• Notch and Wnt Signaling pathways• In chick embryos, new somite every 90 min.
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Somite Formation: Periodicity
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Somite Formation: Notch Signaling
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Somite Formation: Notch Signaling
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Somite Formation: Separation
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Epithelialization of Somites• Ectodermal Signal: MET• Cdc42 downregulated; N-cadherin upregulated
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Somite specification
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Somite Differentiation
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Somite Differentiation
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Specification Patterning of Somites
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Building muscle
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Building Bone• Neural Crest Cells- Intramembranous ossification• Endochondrial ossification
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Vertebrae Formation
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Dorsal Aorta Formation
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The Syndetome: Tendon Formation
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Intermediate Mesoderm: Kidney Formation
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Kidney Formation• Induction between Paraxial and Intermediate Mesoderm.
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Kidney Formation: Reciprocal Induction
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GDNF and Kidney formation
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Who else? Wnt!
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Development of Bladder and ducts