PARAS GUPTAPermanent Add: A-377 Anand Nagar, Bahodapur, Gwalior, Madhya Pradesh, India.Mob no: 07566656222Home: 07512497634E-Mail: paras.guptarx@gmail.com

CAREER OBJECTIVE:

To add innovative ideas to the work, I do for achieving the organizational goal and to have a continuous self-development by way of learning and exposure to new assignments.

AREA OF SPECIALIZATION:

M. PHARMACY (Pharmacology)

CAREER INTEREST:

1) Toxicology.

SUMMARY OF SKILLS:

M. Pharma (Pharmacology) has acquired extensive conceptual knowledge and experience in Research and development, Project Handling & laboratory operations.

Experience of more than 25 months in Toxicology/Preclinical and also having 5 months experience in Quality Control (Projects Handling & Laboratory operations).

A flexible & detail oriented attitude with an ability to work independently as well as part of a multidisciplinary team.

An out of the box thinker having problem solving & organizational abilities.

ACADEMIC / TECHNICAL CREDENTIALS:

M. PHARMACY (Pharmacology) 66% - 2011I.S.F. College of Pharmacy, Moga, Under- Punjab Technical University, Jalandhar (Punjab)

B.PHARMACY 67% - 2009Shree Ram College of Pharmacy, Banmore, Under- Rajiv Gandhi Technical University, Bhopal

INTERMEDIATE 66% M.P Board - 2005

EXPERENCE:

Dabur Research Foundation, Ghaziabad (Uttar Pradesh): March 2015 - At PresentDesignation: Research scientistJob Responsibilities: Performing Sub Chronic & Chronic Toxicological studies as per Principles of OECD and

Schedule Y-India. Repeated 180 days Dermal Toxicity Study in Rat. Repeated Dose 28 days Oral Toxicity studies in Rats. Repeated Dose 14 days Sub-cutaneous Toxicity studies in Rats.

Performing day to day activity related to Toxicological Studies. Preparation of Standard Operating Procedure, Study Reports, Study Plans,

Archiving, etc. Various Routes of Dosing in Rats. Euthanasia, Blood collection and Necropsy of Rats. Performing exercises for Dose Formulation, Body Weight, Feed intake, Organ

Weight, Test Item/Chemical Weighing, etc. Performing other activities related to study and other laboratory operations.

Involved in validation of Acute, Sub-Chronic and Chronic Toxicity Studies for GLP Submission.

Jai Research Foundation, Vapi (Gujarat): Feb 2014 - March 2015Designation: Jr. Research Officer (Study Personal).Job Responsibilities: Performed Acute Toxicological studies mentioned below, as per Principles of OECD-

Good Laboratory Practice. Acute Oral Toxicity Studies in Laboratory Rats and Mice. Acute Dermal Toxicity Studies in Laboratory Rats. Guinea pig skin sensitization study by Guinea Pig Maximization Test and Buehler

Test method. Acute Eye and Dermal Irritation/Corrosion in Rabbits. Inhalation Toxicity Study in Laboratory Rats.

Performed day to day activity related to toxicological studies. Involved in Preparation of Study Reports, Study Plans, Archive, etc. Various Routes of Dosing in Rat, Mice and Guinea pig. Recorded of Body Weight, Temperature, Humidity, etc. Performed other activities related to study and laboratory operations.

Also completed the GLP validation of Bovine Corneal Opacity and Permeability Test.

Amol Pharmaceuticals, Jaipur (RJ): Aug 2012 - Jan 2013Designation: Jr. Chemist in Department of Quality control.Job responsibilities: Analyze sample for its quality and stability. Performed analysis on analytical instruments like (UV, ICP, AAS, Dissolution test

apparatus, HPLC). Performed qualitative analysis, preparation & reviewing documents for the same

sample.

OTHER RESEARCH SKILLS:

Brief detail of Methods and Techniques used: Experienced in Animal Handling and Dosing (by Various Route of Drug

Administration). Performed Blood Collection Techniques in Rodents and Non-Rodents by (Retro Orbital

Sinus, Heart Puncture, Tail Vein and Sublingual Vein and by Marginal Ear Vein). Extracted of Plant Extract. Recorded Blood Pressure in Anaesthetized Dog. Recorded Blood Pressure, Heart Rate and Coronary Effluent in Rats using Langendorff

Apparatus. Intra cerebro ventricular (ICV) Cannulation and Dosing in Rats using Stereotaxic

Apparatus.

Assessed Infract Size and Ulcer Index. Induced Neuropathic Pain by Sciatic Nerve Ligation method. Recorded Non-Invasive Blood Pressure by Tail-Cuff method. Cotton-Pellet Induced Granuloma for Chronic Inflammation. Pylorus ligation for Assessment of Ulcer. Hepatic Artery Ligation for Assessment of Hepatic Ischemia. Bile Duct Ligation and Cannulation for Assessment of Hepatic Damage. Both Right and Left Carotid Artery Ligation for Global CNS Ischemia. Jugular Vein and Femoral Vein Cannulation for Blood Sampling & Drug Administration. Disease models: Conceptual and practical knowledge of In-Vivo Pharmacological

Animal Models and Techniques in CNS, CVS, GIT, Oncology, Respiratory, Inflammation/Pain and Metabolic disorders.

Instruments handled: NIBP- Biopac MP 100 [USA]. UV-Visible Spectrophotometer (Perkin Elmer). Gas Chromatograph. Inductive Coupled Plasma Spectrophotometer (ICP). Atomic Adsorption Spectroscopy. Bio-Pac system for ECG, Pressure & Force measurement of heart. Rotaroad Apparatus. Actophotometer for measurement of CNS activity. Plethysmograph for measurement of paw oedema. Planter test Apparatus. (UGO – Basile). REMI-CPR30 Cooling Centrifuge.

Computer proficiency: Proficient in use of Computer Systems Particularly Microsoft Office Tools (Word, Excel,

PowerPoint, publisher, etc.), Adobe Acrobat, Corel Draw, Graph Pad Prism Capable of retrieving information from Internet and Various research related Database.

PUBLICATIONS:

1) Paras Gupta1, Rohit Goyal2*, Yamini Chauhan2 and Pyare Lal sharma1. Possible Modulation of FAS and PTP-1B Signaling in Ameliorative Potential of Bombax ceiba against High Fat Diet Induced Obesity. BMC Complementary and Alternative Medicine 2013, 13:281, doi: 10. 1186/1472-6882-13-281.

2) Paras Gupta*, Sandeep Tyagi, Minky Mukhija, Arminder Singh Saini, Rohit Goyal, Pyare Lal Sharma. Obesity: An Introduction and Evaluation. Journal of Advanced Pharmacy Education & Research. 2011, 2, 125-137, ISSN 2249-3379.

3) Sandeep Tyagi, Paras Gupta, Arminder Singh Saini, Chaitnya Kaushal, Saurabh Sharma. The peroxisome proliferators-activated receptor: A family of nuclear receptors role in various diseases. Journal of Advanced Pharmaceutical Technology & Research. 2011, 2, 4, 236-240.

RESEARCH PROJECTS:

1) Title: The Effect of Bombax Ceiba Linn. against Experimental Obesity in wistar rats under kind supervision of Prof. P. L. Sharma and co-supervision of Dr. Rohit Goyal.Role: Project Associate.Description: The study was carried out in High fat diet treated rats at 3 different doses regimen. In this study Parameters was evaluated; Anthropometric parameters, Free fatty acid level (FFA), Serum lipid & hepatic markers, Tissue biochemical

markers and Histological study was done to check the efficacy of the drug. On the basis of the results obtained in present study, it may be concluded that the methanolic extract of Bombax ceiba Linn. has significant anti-obesity potential against HFD induced experimental obesity, possibly due to modulation of FAS and PTP-1B signaling in rat.

2) Title: The Ameliorative Potential of Bombax Ceiba Linn. against Experimental Hypertension in wistar rats under Kind supervision of Prof. P.L. Sharma and co-supervision of Dr. Rohit Goyal.Role: Project Associate.Description: This study was carried out in two different models; HFD induced Hypertension and DOCA salt induced Hypertension. In these study parameters was evaluated; Systolic-Diastolic blood pressure, Anthropometric parameters and Serum Biochemical markers was done to check the effectiveness of drug. After the completion of study all results showing that the extract of Bombay CIBA Linn. having Anti-Hypertensive Potential on two different doses.

PERSONAL DOSSIER:

Name : Paras Gupta Marital Status : SingleFather’s Name : Mr. J. P. Gupta Sex : MaleMother’s Name : Mrs. Manju Lata Gupta Nationality : IndianDate of Birth : 16th June. 1987 Languages Known : English & Hindi

Declaration: I hereby declare that all the above information given by me is true to my consent.

Signature:(PARAS GUPTA)